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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 74031532.

Reduced Mrp2 surface availability as PI3Kγ-mediated hepatocytic dysfunction reflecting a hallmark of cholestasis in sepsis

Anne J. Beer, David Hertz, Eric Seemann, Martina Beretta, Martin Westermann, Reinhard Bauer, Michael Bauer, Michael M. Kessels, Britta Qualmann

Sci Rep. 2020; 10: 13110. Published online 2020 Aug 4. doi: 10.1038/s41598-020-69901-3

PMCID:: PMC7403153

Abstract Article PDF–7.0M

Select item 60340763.

Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration during Streptococcus pneumoniae Lung Infection

Andrew Zukauskas, Randall J. Mrsny, Paula Cortés Barrantes, Jerrold R. Turner, John M. Leong, Beth A. McCormick

mSphere. 2018 Jul-Aug; 3(4): e00303-18. Published online 2018 Jul 5. doi: 10.1128/mSphere.00303-18

PMCID:: PMC6034076

Abstract Article PDF–1.0M

Select item 52958214.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 52838985.

CFTR-associated ligand is a negative regulator of Mrp2 expression

Man Li, Carol J. Soroka, Kathy Harry, James L. Boyer

Am J Physiol Cell Physiol. 2017 Jan 1; 312(1): C40–C46. Published online 2016 Nov 9. doi: 10.1152/ajpcell.00100.2016

PMCID:: PMC5283898

Abstract Article

Select item 45983566.

Maternal bile acid transporter deficiency promotes neonatal demise

Yuanyuan Zhang, Fei Li, Yao Wang, Aaron Pitre, Zhong-ze Fang, Matthew W. Frank, Christopher Calabrese, Kristopher W. Krausz, Geoffrey Neale, Sharon Frase, Peter Vogel, Charles O. Rock, Frank J. Gonzalez, John D. Schuetz

Nat Commun. 2015; 6: 8186. Published online 2015 Sep 29. doi: 10.1038/ncomms9186

PMCID:: PMC4598356

Abstract Article PDF–1.5M

Select item 45198237.

Dependence of erythromycin metabolism on ABCC2 (MRP2) transport function

RM Franke, CS Lancaster, CJ Peer, A Gibson, AM Kosloske, SJ Orwick, RH Mathijssen, WD Figg, SD Baker, A Sparreboom

Clin Pharmacol Ther. Author manuscript; available in PMC 2015 Jul 30.

Published in final edited form as: Clin Pharmacol Ther. 2011 May; 89(5): 693–701. Published online 2011 Mar 30. doi: 10.1038/clpt.2011.25

PMCID:: PMC4519823

Abstract Article PDF–1.0M

Select item 44900288.

Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide is Dependent on Abcc2, Abcc3, and Oatp1a/1b

Aksana Vasilyeva, Selvi Durmus, Lie Li, Els Wagenaar, Shuiying Hu, Alice A. Gibson, John C. Panetta, Sridhar Mani, Alex Sparreboom, Sharyn D. Baker, Alfred H. Schinkel

Cancer Res. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: Cancer Res. 2015 Jul 1; 75(13): 2729–2736. Published online 2015 May 7. doi: 10.1158/0008-5472.CAN-15-0280

PMCID:: PMC4490028

Abstract Article PDF–2.2M

Select item 43348139.

Novel Hg²⁺-Induced Nephropathy in Rats and Mice Lacking Mrp2: Evidence of Axial Heterogeneity in the Handling of Hg²⁺ Along the Proximal Tubule

Rudolfs K. Zalups, Lucy Joshee, Christy C. Bridges

Toxicol Sci. 2014 Nov 1; 142(1): 250–260. Published online 2014 Aug 21. doi: 10.1093/toxsci/kfu171

PMCID:: PMC4334813

Abstract Article PDF–10M

Select item 400598910.

Transgenic Expression of the Human MRP2 Transporter Reduces Cisplatin Accumulation and Nephrotoxicity in Mrp2-Null Mice

Xia Wen, Brian Buckley, Elizabeth McCandlish, Michael J. Goedken, Samira Syed, Ryan Pelis, José E. Manautou, Lauren M. Aleksunes

Am J Pathol. 2014 May; 184(5): 1299–1308. doi: 10.1016/j.ajpath.2014.01.025

PMCID:: PMC4005989

Abstract Article PDF–2.1M

Select item 396495511.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977

PMCID:: PMC3964955

Abstract Article PDF–5.7M

Select item 376405712.

Glutathione Status and the Renal Elimination of Inorganic Mercury in the Mrp2^−/− Mouse

Christy C. Bridges, Lucy Joshee, Jeroen J. M. W. van den Heuvel, Frans G. M. Russel, Rudolfs K. Zalups

PLoS One. 2013; 8(9): e73559. Published online 2013 Sep 5. doi: 10.1371/journal.pone.0073559

PMCID:: PMC3764057

Abstract Article PDF–876K

Select item 357241013.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 355484114.

Metallothionein blocks oxidative DNA damage in vitro

Wei Qu, Jingbo Pi, Michael P. Waalkes

Arch Toxicol. Author manuscript; available in PMC 2014 Feb 1.

Published in final edited form as: Arch Toxicol. 2013 Feb; 87(2): 311–321. Published online 2012 Aug 23. doi: 10.1007/s00204-012-0927-y

PMCID:: PMC3554841

Abstract Article PDF–1.9M

Select item 354363215.

The hepatic bile acid transporters Ntcp and Mrp2 are downregulated in experimental necrotizing enterocolitis

Nathan J. Cherrington, Teresa E. Estrada, Harrison A. Frisk, Mark J. Canet, Rhiannon N. Hardwick, Bohuslav Dvorak, Katie Lux, Melissa D. Halpern

Am J Physiol Gastrointest Liver Physiol. 2013 Jan 1; 304(1): G48–G56. Published online 2012 Nov 1. doi: 10.1152/ajpgi.00317.2012

PMCID:: PMC3543632

Abstract Article

Select item 326679016.

Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver

Evita van de Steeg, Viktor Stránecký, Hana Hartmannová, Lenka Nosková, Martin Hřebíček, Els Wagenaar, Anita van Esch, Dirk R. de Waart, Ronald P.J. Oude Elferink, Kathryn E. Kenworthy, Eva Sticová, Mohammad al-Edreesi, A.S. Knisely, Stanislav Kmoch, Milan Jirsa, Alfred H. Schinkel

J Clin Invest. 2012 Feb 1; 122(2): 519–528. Published online 2012 Jan 9. doi: 10.1172/JCI59526

PMCID:: PMC3266790

Abstract Article PDF–1.1M

Select item 324793617.

The Src Family Kinase Fyn Mediates Hyperosmolarity-induced Mrp2 and Bsep Retrieval from Canalicular Membrane

Miriam Cantore, Roland Reinehr, Annika Sommerfeld, Martin Becker, Dieter Häussinger

J Biol Chem. 2011 Dec 30; 286(52): 45014–45029. Published online 2011 Nov 4. doi: 10.1074/jbc.M111.292896

PMCID:: PMC3247936

Abstract Article PDF–5.4M

Select item 319890018.

Dose-Dependent Disposition of Methotrexate in Abcc2 and Abcc3 Gene Knockout Murine Models

Zhan Wang, Qingyu Zhou, Gary D. Kruh, James M. Gallo

Drug Metab Dispos. 2011 Nov; 39(11): 2155–2161. doi: 10.1124/dmd.111.041228

PMCID:: PMC3198900

Abstract Article PDF–789K

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 310858620.

Strain- and Sex-Dependent Circadian Changes in Abcc2 Transporter Expression: Implications for Irinotecan Chronotolerance in Mouse Ileum

Alper Okyar, Enza Piccolo, Constance Ahowesso, Elisabeth Filipski, Virginie Hossard, Catherine Guettier, Rosanna La Sorda, Nicola Tinari, Stefano Iacobelli, Francis Lévi

PLoS One. 2011; 6(6): e20393. Published online 2011 Jun 3. doi: 10.1371/journal.pone.0020393

PMCID:: PMC3108586

Abstract Article PDF–566K

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