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Select item 110720211.

PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As₂O₃ by stabilizing oncoprotein PML-RARα

Xinping Huang, Yongfeng Yang, Dan Zhu, Yan Zhao, Min Wei, Ke Li, Hong-hu Zhu, Xiaofeng Zheng

Cell Mol Life Sci. 2022 Jun; 79(6): 319. Published online 2022 May 27. doi: 10.1007/s00018-022-04358-3

PMCID:: PMC11072021

Abstract Article PDF–9.5M

Select item 110670312.

PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells

Casey D. S. Katerndahl, Olivia R. S. Rogers, Ryan B. Day, Ziheng Xu, Nichole M. Helton, Sai Mukund Ramakrishnan, Christopher A. Miller, Timothy J. Ley

Proc Natl Acad Sci U S A. 2024 Apr 30; 121(18): e2317690121. Published online 2024 Apr 22. doi: 10.1073/pnas.2317690121

PMCID:: PMC11067031

Abstract Article PDF–7.2M

Select item 109054643.

Clinical Relevance of Differential RARα and PPARβ/δ Expression in Myelodysplastic Syndromes

NIKOLAY KALITIN, GALINA DUDINA, NATALIA KOSTRITSA, ANASTASIYA SIVIRINOVA, ANDREY VAIMAN, AIDA KARAMYSHEVA

In Vivo. 2024 Mar-Apr; 38(2): 657–664. Published online 2024 Mar 3. doi: 10.21873/invivo.13486

PMCID:: PMC10905464

Abstract Article PDF–417K

Select item 100428634.

Hyperthermia promotes degradation of the acute promyelocytic leukemia driver oncoprotein ZBTB16/RARα

Qian-qian Wang, Liaqat Hussain, Pei-han Yu, Chang Yang, Chen-ying Zhu, Ya-fang Ma, Si-chun Wang, Tao Yang, Yuan-yuan Kang, Wen-juan Yu, Yasen Maimaitiyiming, Hua Naranmandura

Acta Pharmacol Sin. 2023 Apr; 44(4): 822–831. Published online 2022 Oct 10. doi: 10.1038/s41401-022-01001-6

PMCID:: PMC10042863

Abstract Article PDF–3.7M

Select item 99114105.

Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia

William Villiers, Audrey Kelly, Xiaohan He, James Kaufman-Cook, Abdurrahman Elbasir, Halima Bensmail, Paul Lavender, Richard Dillon, Borbála Mifsud, Cameron S. Osborne

Nat Commun. 2023; 14: 724. Published online 2023 Feb 9. doi: 10.1038/s41467-023-36262-0

PMCID:: PMC9911410

Abstract Article PDF–3.7M

Select item 97080866.

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers

Martina Oravcová, Minghua Nie, Nicola Zilio, Shintaro Maeda, Yasaman Jami-Alahmadi, Eros Lazzerini-Denchi, James A Wohlschlegel, Helle D Ulrich, Takanori Otomo, Michael N Boddy

eLife. 2022; 11: e79676. Published online 2022 Nov 14. doi: 10.7554/eLife.79676

PMCID:: PMC9708086

Abstract Article PDF–8.5M

Select item 92796437.

Blockade of deubiquitinase YOD1 degrades oncogenic PML/RARα and eradicates acute promyelocytic leukemia cells

Xuejing Shao, Yingqian Chen, Wei Wang, Wenxin Du, Xingya Zhang, Minyi Cai, Shaowei Bing, Ji Cao, Xiaojun Xu, Bo Yang, Qiaojun He, Meidan Ying

Acta Pharm Sin B. 2022 Apr; 12(4): 1856–1870. Published online 2021 Oct 23. doi: 10.1016/j.apsb.2021.10.020

PMCID:: PMC9279643

Abstract Article PDF–3.5M

Select item 89643178.

RIP1-dependent Apoptosis and Differentiation Regulated by Skp2 and Akt/GSK3β in Acute Myeloid Leukemia

Wenran Dan, Liang Zhong, Zhonghui Zhang, Peng Wan, Yang Lu, Xiao Wang, Zhenyan Liu, Xuan Chu, Beizhong Liu

Int J Med Sci. 2022; 19(3): 525–536. Published online 2022 Mar 6. doi: 10.7150/ijms.68385

PMCID:: PMC8964317

Abstract Article PDF–1.8M

Select item 84923269.

Signaling through retinoic acid receptors is essential for mammalian uterine receptivity and decidualization

Yan Yin, Meade E. Haller, Sangappa B. Chadchan, Ramakrishna Kommagani, Liang Ma

JCI Insight. 2021 Sep 8; 6(17): e150254. Published online 2021 Sep 8. doi: 10.1172/jci.insight.150254

PMCID:: PMC8492326

Abstract Article PDF–3.4M

Select item 822039110.

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα

Evelyn Ramberger, Valeria Sapozhnikova, Elisabeth Kowenz-Leutz, Karin Zimmermann, Nathalie Nicot, Petr V. Nazarov, Daniel Perez-Hernandez, Ulf Reimer, Philipp Mertins, Gunnar Dittmar, Achim Leutz

iScience. 2021 Jun 25; 24(6): 102686. Published online 2021 Jun 4. doi: 10.1016/j.isci.2021.102686

PMCID:: PMC8220391

Abstract Article PDF–4.4M

Select item 820961811.

Mutational profile of ZBTB16‐RARA‐positive acute myeloid leukemia

Emiliano Fabiani, Laura Cicconi, Anna Maria Nardozza, Antonio Cristiano, Marianna Rossi, Tiziana Ottone, Giulia Falconi, Mariadomenica Divona, Anna Maria Testi, Ombretta Annibali, Roberto Castelli, Vladimir Lazarevic, Eduardo Rego, Pau Montesinos, Jordi Esteve, Adriano Venditti, Matteo Della Porta, William Arcese, Francesco Lo‐Coco, Maria Teresa Voso

Cancer Med. 2021 Jun; 10(12): 3839–3847. Published online 2021 May 27. doi: 10.1002/cam4.3904

PMCID:: PMC8209618

Abstract Article PDF–829K

Select item 819607012.

A novel fusion protein TBLR1-RARα acts as an oncogene to induce murine promyelocytic leukemia: identification and treatment strategies

Shouyun Li, Xue Yang, Shuang Liu, Yirui Chen, Haiyan Xing, Kejing Tang, Zheng Tian, Yingxi Xu, Qing Rao, Min Wang, Jianxiang Wang

Cell Death Dis. 2021 Jun; 12(6): 607. Published online 2021 Jun 11. doi: 10.1038/s41419-021-03889-0

PMCID:: PMC8196070

Abstract Article PDF–4.9M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 811377714.

Epilepsy-Associated UBE3A Deficiency Downregulates Retinoic Acid Signalling Pathway

Meimiao Fang, Yali Li, Jin Ren, Ronggui Hu, Xiaobo Gao, Liang Chen

Front Genet. 2021; 12: 681295. Published online 2021 Apr 28. doi: 10.3389/fgene.2021.681295

PMCID:: PMC8113777

Abstract Article PDF–1.9M

Select item 800904815.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 797651116.

A PML/RARα direct target atlas redefines transcriptional deregulation in acute promyelocytic leukemia

Yun Tan, Xiaoling Wang, Huan Song, Yi Zhang, Rongsheng Zhang, Shufen Li, Wen Jin, Saijuan Chen, Hai Fang, Zhu Chen, Kankan Wang

Blood. 2021 Mar 18; 137(11): 1503–1516. Prepublished online 2020 Aug 27. doi: 10.1182/blood.2020005698

PMCID:: PMC7976511

Abstract Article

Select item 772812917.

Microfluidic-Based Detection of AML-Specific Biomarkers Using the Example of Promyelocyte Leukemia

Benedikt Emde, Heike Kreher, Nicole Bäumer, Sebastian Bäumer, Dominique Bouwes, Lara Tickenbrock

Int J Mol Sci. 2020 Dec; 21(23): 8942. Published online 2020 Nov 25. doi: 10.3390/ijms21238942

PMCID:: PMC7728129

Abstract Article PDF–1.9M

Select item 765186218.

TRIM37 Mediates Chemoresistance and Maintenance of Stemness in Pancreatic Cancer Cells via Ubiquitination of PTEN and Activation of the AKT–GSK-3β–β-Catenin Signaling Pathway

Shiyu Chen, Zhiwei He, Changhao Zhu, Yanqing Liu, Lin Li, Lu Deng, Jun Wang, Chao Yu, Chengyi Sun

Front Oncol. 2020; 10: 554787. Published online 2020 Oct 16. doi: 10.3389/fonc.2020.554787

PMCID:: PMC7651862

Abstract Article PDF–5.4M

Select item 758109219.

Does acute promyelocytic leukemia patient with the STAT5B/RARa fusion gene respond well to decitabine?: A case report and literature review

Lei Wang, Xiaojing Yan, Juan He

Medicine (Baltimore) 2020 Oct 23; 99(43): e22923. Published online 2020 Oct 23. doi: 10.1097/MD.0000000000022923

PMCID:: PMC7581092

Abstract Article PDF–322K

Select item 748141020.

PML-RARα interaction with TRIB3 impedes PPARγ/RXR function and triggers dyslipidemia in acute promyelocytic leukemia

Ke Li, Feng Wang, Zhao-Na Yang, Bing Cui, Ping-Ping Li, Zhen-Yu Li, Zhuo-Wei Hu, Hong-Hu Zhu

Theranostics. 2020; 10(22): 10326–10340. Published online 2020 Aug 15. doi: 10.7150/thno.45924

PMCID:: PMC7481410

Abstract Article PDF–3.3M

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