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Select item 113869121.

UBR1 is a prognostic biomarker and therapeutic target associated with immune cell infiltration in gastric cancer

Weiwei Yuan, Jianye Han, Chen Chen, Yue Qiu, Yuanmin Xu, Yang Huang, Zhangming Chen, Aman Xu, Minzhi Sun

Aging (Albany NY) 2024 Aug 31; 16(16): 12029–12049. Published online 2024 Aug 23. doi: 10.18632/aging.206079

PMCID:: PMC11386912

Abstract Article PDF–3.6M

Select item 112379302.

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein

Xiao Tang, Yang Liu, Jinhui Wang, Teng Long, Bobo Wing Yee Mok, Yan Huang, Ziqing Peng, Qinyu Jia, Chengxi Liu, Pui-Kin So, Sirius Pui-Kam Tse, Cheuk Hei NG, Shiyi Liu, Fei Sun, Shaojun Tang, Zhong-Ping Yao, Honglin Chen, Yusong Guo

J Biol Chem. 2024 Jun; 300(6): 107390. Published online 2024 May 21. doi: 10.1016/j.jbc.2024.107390

PMCID:: PMC11237930

Abstract Article PDF–3.8M

Select item 112099353.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 102374224.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 102358835.

Identification of Ubr1 as an amino acid sensor of steatosis in liver and muscle

Wanni Zhao, Yansong Zhang, Siyuan Lin, Yajuan Li, Alan Jian Zhu, Hanping Shi, Min Liu

J Cachexia Sarcopenia Muscle. 2023 Jun; 14(3): 1454–1467. Published online 2023 Apr 13. doi: 10.1002/jcsm.13233

PMCID:: PMC10235883

Abstract Article PDF–8.9M

Select item 99868176.

METTL3 protects METTL14 from STUB1‐mediated degradation to maintain m⁶A homeostasis

Zhan‐Cheng Zeng, Qi Pan, Yu‐Meng Sun, Heng‐Jing Huang, Xiao‐Tong Chen, Tian‐Qi Chen, Bo He, Hua Ye, Shun‐Xin Zhu, Ke‐Jia Pu, Ke Fang, Wei Huang, Yue‐Qin Chen, Wen‐Tao Wang

EMBO Rep. 2023 Mar; 24(3): e55762. Published online 2023 Jan 4. doi: 10.15252/embr.202255762

PMCID:: PMC9986817

Abstract Article PDF–3.5M

Select item 92792857.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 89583258.

A series of xanthenes inhibiting Rad6 function and Rad6-Rad18 interaction in the PCNA ubiquitination cascade

Gabriel Fenteany, Gaurav Sharma, Paras Gaur, Attila Borics, Edit Wéber, Ernő Kiss, Lajos Haracska

iScience. 2022 Apr 15; 25(4): 104053. Published online 2022 Mar 10. doi: 10.1016/j.isci.2022.104053

PMCID:: PMC8958325

Abstract Article PDF–3.2M

Select item 88884849.

Ubr1-induced selective endophagy/autophagy protects against the endosomal and Ca²⁺-induced proteostasis disease stress

Ben B. Wang, Haijin Xu, Sandra Isenmann, Cheng Huang, Xabier Elorza-Vidal, Grigori Y. Rychkov, Raúl Estévez, Ralf B. Schittenhelm, Gergely L. Lukacs, Pirjo M. Apaja

Cell Mol Life Sci. 2022 Mar; 79(3): 167. Published online 2022 Mar 1. doi: 10.1007/s00018-022-04191-8

PMCID:: PMC8888484

Abstract Article PDF–14M

Select item 868567110.

The N-terminal cysteine is a dual sensor of oxygen and oxidative stress

Ah Jung Heo, Su Bin Kim, Chang Hoon Ji, Dohyun Han, Su Jin Lee, Su Hyun Lee, Min Ju Lee, Ji Su Lee, Aaron Ciechanover, Bo Yeon Kim, Yong Tae Kwon

Proc Natl Acad Sci U S A. 2021 Dec 14; 118(50): e2107993118. Published online 2021 Dec 10. doi: 10.1073/pnas.2107993118

PMCID:: PMC8685671

Abstract Article PDF–3.1M

Select item 816503011.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 794896412.

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1

Lee D. Harris, Janic Le Pen, Nico Scholz, Juliusz Mieszczanek, Natalie Vaughan, Simon Davis, Georgina Berridge, Benedikt M. Kessler, Mariann Bienz, Julien D.F. Licchesi

J Biol Chem. 2021 Jan-Jun; 296: 100246. Published online 2021 Jan 8. doi: 10.1074/jbc.RA120.015162

PMCID:: PMC7948964

Abstract Article PDF–2.7M

Select item 773380713.

The Arg/N-degron pathway targets transcription factors and regulates specific genes

Tri T. M. Vu, Dylan C. Mitchell, Steven P. Gygi, Alexander Varshavsky

Proc Natl Acad Sci U S A. 2020 Dec 8; 117(49): 31094–31104. Published online 2020 Nov 23. doi: 10.1073/pnas.2020124117

PMCID:: PMC7733807

Abstract Article PDF–1.4M

Select item 766982114.

The ATF3 Transcription Factor Is a Short-Lived Substrate of the Arg/N-Degron Pathway

Tri T. M. Vu, Alexander Varshavsky

Biochemistry. Author manuscript; available in PMC 2020 Nov 17.

Published in final edited form as: Biochemistry. 2020 Aug 4; 59(30): 2796–2812. Published online 2020 Jul 21. doi: 10.1021/acs.biochem.0c00514

PMCID:: PMC7669821

Abstract Article PDF–1.9M

Select item 739233415.

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells

Seung W. Ryu, Rose Stewart, D. Chase Pectol, Nicolette A. Ender, Oshadi Wimalarathne, Ji-Hoon Lee, Carlos P. Zanini, Antony Harvey, Jon M. Huibregtse, Peter Mueller, Tanya T. Paull

PLoS Biol. 2020 Jul; 18(7): e3000606. Published online 2020 Jul 20. doi: 10.1371/journal.pbio.3000606

PMCID:: PMC7392334

Abstract Article PDF–2.7M

Select item 724509616.

Five enzymes of the Arg/N-degron pathway form a targeting complex: The concept of superchanneling

Jang-Hyun Oh, Ju-Yeon Hyun, Shun-Jia Chen, Alexander Varshavsky

Proc Natl Acad Sci U S A. 2020 May 19; 117(20): 10778–10788. Published online 2020 May 4. doi: 10.1073/pnas.2003043117

PMCID:: PMC7245096

Abstract Article PDF–1.7M

Select item 676379117.

Systematic Affinity Purification Coupled to Mass Spectrometry Identified p62 as Part of the Cannabinoid Receptor CB2 Interactome

Ahmed Sharaf, Leonore Mensching, Christina Keller, Sebastian Rading, Marina Scheffold, Lysann Palkowitsch, Nevena Djogo, Meriem Rezgaoui, Hans A. Kestler, Barbara Moepps, Antonio Virgilio Failla, Meliha Karsak

Front Mol Neurosci. 2019; 12: 224. Published online 2019 Sep 20. doi: 10.3389/fnmol.2019.00224

PMCID:: PMC6763791

Abstract Article PDF–3.6M

Select item 650097218.

Poly(ADP‐ribosyl)ation of BRD7 by PARP1 confers resistance to DNA‐damaging chemotherapeutic agents

Kaishun Hu, Wenjing Wu, Yu Li, Lehang Lin, Dong Chen, Haiyan Yan, Xing Xiao, Hengxing Chen, Zhen Chen, Yin Zhang, Shuangbing Xu, Yabin Guo, H Phillip Koeffler, Erwei Song, Dong Yin

EMBO Rep. 2019 May; 20(5): e46166. Published online 2019 Apr 2. doi: 10.15252/embr.201846166

PMCID:: PMC6500972

Abstract Article PDF–4.2M

Select item 589141719.

Proteomic profiling of VCP substrates links VCP to K6‐linked ubiquitylation and c‐Myc function

Jan B Heidelberger, Andrea Voigt, Marina E Borisova, Giuseppe Petrosino, Stefanie Ruf, Sebastian A Wagner, Petra Beli

EMBO Rep. 2018 Apr; 19(4): e44754. Published online 2018 Feb 21. doi: 10.15252/embr.201744754

PMCID:: PMC5891417

Abstract Article PDF–1.0M

Select item 582692620.

VIRMA mediates preferential m⁶A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu

Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0

PMCID:: PMC5826926

Abstract Article PDF–2.3M

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