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Select item 110884621.

DLK signaling in axotomized neurons triggers complement activation and loss of upstream synapses

Elham Asghari Adib, Jennifer L. Shadrach, Lauren Reilly-Jankowiak, Manish K. Dwivedi, Abigail E. Rogers, Shameena Shahzad, Ryan Passino, Roman J. Giger, Brian A. Pierchala, Catherine A. Collins

Cell Rep. Author manuscript; available in PMC 2024 May 11.

Published in final edited form as: Cell Rep. 2024 Feb 27; 43(2): 113801. Published online 2024 Feb 14. doi: 10.1016/j.celrep.2024.113801

PMCID:: PMC11088462

Abstract Article PDF–3.9M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 94590953.

Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects

Shaili D. Patel, Deepti Anand, Hozumi Motohashi, Fumiki Katsuoka, Masayuki Yamamoto, Salil A. Lachke

Front Cell Dev Biol. 2022; 10: 981893. Published online 2022 Aug 26. doi: 10.3389/fcell.2022.981893

PMCID:: PMC9459095

Abstract Article PDF–5.1M

Select item 90878164.

A Critical Role for DLK and LZK in Axonal Repair in the Mammalian Spinal Cord

Junmi M. Saikia, Carmine L. Chavez-Martinez, Noah D. Kim, Sahar Allibhoy, Hugo J. Kim, Lidiya Simonyan, Samraa Smadi, Kristen M. Tsai, Daniel Romaus-Sanjurjo, Yishi Jin, Binhai Zheng

J Neurosci. 2022 May 4; 42(18): 3716–3732. doi: 10.1523/JNEUROSCI.2495-21.2022

PMCID:: PMC9087816

Abstract Article PDF–7.8M

Select item 88102005.

MiR-191-5p alleviates microglial cell injury by targeting Map3k12 (mitogen-activated protein kinase kinase kinase 12) to inhibit the MAPK (mitogen-activated protein kinase) signaling pathway in Alzheimer’s disease

Wenjun Wan, Ganzhe Liu, Xia Li, Yu Liu, Ying Wang, Haisong Pan, Jun Hu

Bioengineered. 2021; 12(2): 12678–12690. Published online 2021 Dec 22. doi: 10.1080/21655979.2021.2008638

PMCID:: PMC8810200

Abstract Article PDF–2.1M

Select item 87917986.

A Phase 1 study of GDC‐0134, a dual leucine zipper kinase inhibitor, in ALS

Jonathan S. Katz, Jeffrey D. Rothstein, Merit E. Cudkowicz, Angela Genge, Björn Oskarsson, Avis B. Hains, Chen Chen, Joshua Galanter, Braydon L. Burgess, William Cho, Geoffrey A. Kerchner, Felix L. Yeh, Arundhati Sengupta Ghosh, Sravanthi Cheeti, Logan Brooks, Lee Honigberg, Jessica A. Couch, Michael E. Rothenberg, Flavia Brunstein, Khema R. Sharma, Leonard van den Berg, James D. Berry, Jonathan D. Glass

Ann Clin Transl Neurol. 2022 Jan; 9(1): 50–66. Published online 2022 Jan 10. doi: 10.1002/acn3.51491

PMCID:: PMC8791798

Abstract Article PDF–291K

Select item 78701387.

Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength

Yunbo Li, Erin M Ritchie, Christopher L Steinke, Cai Qi, Lizhen Chen, Binhai Zheng, Yishi Jin

eLife. 2021; 10: e63509. Published online 2021 Jan 21. doi: 10.7554/eLife.63509

Correction in:: eLife. 2023; 12: e86472.

PMCID:: PMC7870138

Abstract Article PDF–8.1M

Select item 74022918.

Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions

Sunil Goodwani, Celia Fernandez, Paul J. Acton, Virginie Buggia-Prevot, Morgan L. McReynolds, Jiacheng Ma, Cheng Hui Hu, Mary E. Hamby, Yongying Jiang, Kang Le, Michael J. Soth, Philip Jones, William J. Ray

Int J Mol Sci. 2020 Jul; 21(14): 4849. Published online 2020 Jul 9. doi: 10.3390/ijms21144849

PMCID:: PMC7402291

Abstract Article PDF–4.2M

Select item 66748599.

The c-Jun N-Terminal Kinase Activator Dual Leucine Zipper Kinase Regulates Axon Growth and Neuronal Migration in the Developing Cerebral Cortex

Syu-ichi Hirai, De Feng Cui, Takaki Miyata, Masaharu Ogawa, Hiroshi Kiyonari, Yoko Suda, Shinichi Aizawa, Yumi Banba, Shigeo Ohno

J Neurosci. 2006 Nov 15; 26(46): 11992–12002. doi: 10.1523/JNEUROSCI.2272-06.2006

PMCID:: PMC6674859

Abstract Article PDF–759K

Select item 662267610.

Axon Formation in Neocortical Neurons Depends on Stage-Specific Regulation of Microtubule Stability by the Dual Leucine Zipper Kinase–c-Jun N-Terminal Kinase Pathway

Syu-ichi Hirai, Yumi Banba, Tomoko Satake, Shigeo Ohno

J Neurosci. 2011 Apr 27; 31(17): 6468–6480. doi: 10.1523/JNEUROSCI.5038-10.2011

PMCID:: PMC6622676

Abstract Article PDF–5.6M

Select item 658844311.

DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury

Jung Eun Shin, Hongseok Ha, Yoon Ki Kim, Yongcheol Cho, Aaron DiAntonio

Neurobiol Dis. Author manuscript; available in PMC 2020 Jul 1.

Published in final edited form as: Neurobiol Dis. 2019 Jul; 127: 178–192. Published online 2019 Feb 5. doi: 10.1016/j.nbd.2019.02.001

PMCID:: PMC6588443

Abstract Article PDF–2.1M

Select item 654929412.

High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity

Marlies Verschuuren, Peter Verstraelen, Gerardo García-Díaz Barriga, Ines Cilissen, Emma Coninx, Mieke Verslegers, Peter H. Larsen, Rony Nuydens, Winnok H. De Vos

Acta Neuropathol Commun. 2019; 7: 6. Published online 2019 Jun 4. doi: 10.1186/s40478-019-0741-3

Correction in:: Acta Neuropathol Commun. 2019; 7: 131.

PMCID:: PMC6549294

Abstract Article PDF–5.6M

Select item 602984613.

Dual leucine zipper kinase is required for mechanical allodynia and microgliosis after nerve injury

Josette J Wlaschin, Jacob M Gluski, Eileen Nguyen, Hanna Silberberg, James H Thompson, Alexander T Chesler, Claire E Le Pichon

eLife. 2018; 7: e33910. Published online 2018 Jul 3. doi: 10.7554/eLife.33910

PMCID:: PMC6029846

Abstract Article PDF–4.7M

Select item 555355514.

Enhanced functional genomic screening identifies novel mediators of dual leucine zipper kinase-dependent injury signaling in neurons

Derek S. Welsbie, Katherine L. Mitchell, Vinod Ranganathan, Valentin M. Sluch, Zhiyong Yang, Jessica Kim, Eugen Buehler, Amit Patel, Scott E. Martin, Ping-Wu Zhang, Yan Ge, Yukan Duan, John Fuller, Byung-Jin Kim, Eman Hamed, Xitiz Chamling, Lei Lei, Iain D.C. Fraser, Ze’ev A. Ronai, Cynthia A. Berlinicke, Donald J. Zack

Neuron. Author manuscript; available in PMC 2018 Jun 21.

Published in final edited form as: Neuron. 2017 Jun 21; 94(6): 1142–1154.e6. doi: 10.1016/j.neuron.2017.06.008

PMCID:: PMC5553555

Abstract Article PDF–959K

Select item 540492415.

Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult

Martin Larhammar, Sarah Huntwork-Rodriguez, Zhiyu Jiang, Hilda Solanoy, Arundhati Sengupta Ghosh, Bei Wang, Joshua S Kaminker, Kevin Huang, Jeffrey Eastham-Anderson, Michael Siu, Zora Modrusan, Madeline M Farley, Marc Tessier-Lavigne, Joseph W Lewcock, Trent A Watkins

eLife. 2017; 6: e20725. Published online 2017 Apr 25. doi: 10.7554/eLife.20725