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Select item 109332671.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 106066012.

Effects of Mithramycin on BCL11A Gene Expression and on the Interaction of the BCL11A Transcriptional Complex to γ-Globin Gene Promoter Sequences

Alessia Finotti, Jessica Gasparello, Cristina Zuccato, Lucia Carmela Cosenza, Enrica Fabbri, Nicoletta Bianchi, Roberto Gambari

Genes (Basel) 2023 Oct; 14(10): 1927. Published online 2023 Oct 11. doi: 10.3390/genes14101927

PMCID:: PMC10606601

Abstract Article PDF–2.7M

Select item 99406343.

HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription

Peng Huang, Scott A. Peslak, Ren Ren, Eugene Khandros, Kunhua Qin, Cheryl A. Keller, Belinda Giardine, Henry W. Bell, Xianjiang Lan, Malini Sharma, John R. Horton, Osheiza Abdulmalik, Stella T. Chou, Junwei Shi, Merlin Crossley, Ross C. Hardison, Xiaodong Cheng, Gerd A. Blobel

Nat Genet. Author manuscript; available in PMC 2023 Feb 20.

Published in final edited form as: Nat Genet. 2022 Sep; 54(9): 1417–1426. Published online 2022 Aug 8. doi: 10.1038/s41588-022-01152-6

Correction in:: Nat Genet. 2023 Jul 31

PMCID:: PMC9940634

Abstract Article PDF–5.3M

Select item 99007004.

BCL11A Facilitates Cell Proliferation and Metastasis in Neuroblastoma via Regulating the PI3K/Akt Signaling Pathway

Qianya Jin, Yanmin Chen, Shibei Du, Dongqing Xu, Juanqing Yue, Lei Cai, Xiaojun Yuan

Curr Cancer Drug Targets. 2022 Oct 14; 22(11): 919–930. Published online 2022 Oct 14. doi: 10.2174/1568009622666220728123748

PMCID:: PMC9900700

Abstract Article PDF–5.7M

Select item 92594965.

Whole-genome sequencing reveals host factors underlying critical COVID-19

Athanasios Kousathanas, Erola Pairo-Castineira, Konrad Rawlik, Alex Stuckey, Christopher A. Odhams, Susan Walker, Clark D. Russell, Tomas Malinauskas, Yang Wu, Jonathan Millar, Xia Shen, Katherine S. Elliott, Fiona Griffiths, Wilna Oosthuyzen, Kirstie Morrice, Sean Keating, Bo Wang, Daniel Rhodes, Lucija Klaric, Marie Zechner, Nick Parkinson, Afshan Siddiq, Peter Goddard, Sally Donovan, David Maslove, Alistair Nichol, Malcolm G. Semple, Tala Zainy, Fiona Maleady-Crowe, Linda Todd, Shahla Salehi, Julian Knight, Greg Elgar, Georgia Chan, Prabhu Arumugam, Christine Patch, Augusto Rendon, David Bentley, Clare Kingsley, Jack A. Kosmicki, Julie E. Horowitz, Aris Baras, Goncalo R. Abecasis, Manuel A. R. Ferreira, Anne Justice, Tooraj Mirshahi, Matthew Oetjens, Daniel J. Rader, Marylyn D. Ritchie, Anurag Verma, Tom A. Fowler, Manu Shankar-Hari, Charlotte Summers, Charles Hinds, Peter Horby, Lowell Ling, Danny McAuley, Hugh Montgomery, Peter J. M. Openshaw, Paul Elliott, Timothy Walsh, Albert Tenesa, GenOMICC investigators, 23andMe investigators, COVID-19 Human Genetics Initiative, Angie Fawkes, Lee Murphy, Kathy Rowan, Chris P. Ponting, Veronique Vitart, James F. Wilson, Jian Yang, Andrew D. Bretherick, Richard H. Scott, Sara Clohisey Hendry, Loukas Moutsianas, Andy Law, Mark J. Caulfield, J. Kenneth Baillie

Nature. 2022; 607(7917): 97–103. Published online 2022 Mar 7. doi: 10.1038/s41586-022-04576-6

PMCID:: PMC9259496

Abstract Article PDF–8.1M

Select item 92448156.

Genetic modifiers of fetal hemoglobin affect the course of sickle cell disease in patients treated with hydroxyurea

Pierre Allard, Nareen Alhaj, Stephan Lobitz, Holger Cario, Andreas Jarisch, Regine Grosse, Lena Oevermann, Dani Hakimeh, Laura Tagliaferri, Elisabeth Kohne, Annette Kopp-Schneider, Andreas E. Kulozik, Joachim B. Kunz

Haematologica. 2022 Jul 1; 107(7): 1577–1588. Published online 2021 Oct 28. doi: 10.3324/haematol.2021.278952

PMCID:: PMC9244815

Abstract Article PDF–1.6M

Select item 92192467.

Metabolic sensor O-GlcNAcylation regulates erythroid differentiation and globin production via BCL11A

Sudjit Luanpitpong, Xing Kang, Montira Janan, Kanjana Thumanu, Jingting Li, Pakpoom Kheolamai, Surapol Issaragrisil

Stem Cell Res Ther. 2022; 13: 274. Published online 2022 Jun 23. doi: 10.1186/s13287-022-02954-5

Correction in:: Stem Cell Res Ther. 2022; 13: 396.

PMCID:: PMC9219246

Abstract Article PDF–4.5M

Select item 91197368.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 91052359.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 894147310.

BCL11A promotes myeloid leukemogenesis by repressing PU.1 target genes

Yoshitaka Sunami, Takashi Yokoyama, Seiko Yoshino, Tomoko Takahara, Yukari Yamazaki, Hironori Harada, Takuro Nakamura

Blood Adv. 2022 Mar 22; 6(6): 1827–1843. Published online 2022 Mar 16. doi: 10.1182/bloodadvances.2021004558

PMCID:: PMC8941473

Abstract Article PDF–3.4M

Select item 882889511.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 853030112.

Pathogenic BCL11A variants provide insights into the mechanisms of human fetal hemoglobin silencing

Yong Shen, Rick Li, Kristian Teichert, Kara E. Montbleau, Jeffrey M. Verboon, Richard A. Voit, Vijay G. Sankaran

PLoS Genet. 2021 Oct; 17(10): e1009835. Published online 2021 Oct 11. doi: 10.1371/journal.pgen.1009835

PMCID:: PMC8530301

Abstract Article PDF–2.7M

Select item 824686313.

Cross‐linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex

Cornelia G. Spruijt, Cathrin Gräwe, Simone C. Kleinendorst, Marijke P. A. Baltissen, Michiel Vermeulen

FEBS J. 2021 May; 288(10): 3231–3245. Published online 2020 Dec 14. doi: 10.1111/febs.15650

PMCID:: PMC8246863

Abstract Article PDF–3.1M

Select item 822039114.

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα

Evelyn Ramberger, Valeria Sapozhnikova, Elisabeth Kowenz-Leutz, Karin Zimmermann, Nathalie Nicot, Petr V. Nazarov, Daniel Perez-Hernandez, Ulf Reimer, Philipp Mertins, Gunnar Dittmar, Achim Leutz

iScience. 2021 Jun 25; 24(6): 102686. Published online 2021 Jun 4. doi: 10.1016/j.isci.2021.102686

PMCID:: PMC8220391

Abstract Article PDF–4.4M

Select item 816503015.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 803897116.

Transcription factor competition at the γ-globin promoters controls hemoglobin switching

Nan Liu, Shuqian Xu, Qiuming Yao, Qian Zhu, Yan Kai, Jonathan Y. Hsu, Phraew Sakon, Luca Pinello, Guo-Cheng Yuan, Daniel E. Bauer, Stuart H. Orkin

Nat Genet. Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: Nat Genet. 2021 Apr; 53(4): 511–520. Published online 2021 Mar 1. doi: 10.1038/s41588-021-00798-y

Correction in:: Nat Genet. 2021 Apr; 53(4): 586.

PMCID:: PMC8038971

Abstract Article PDF–3.9M

Select item 745012517.

The transcriptional repressor BCL11A promotes breast cancer metastasis

Darcie D. Seachrist, Molly M. Hannigan, Natasha N. Ingles, Bryan M. Webb, Kristen L. Weber-Bonk, Peng Yu, Gurkan Bebek, Salendra Singh, Steven T. Sizemore, Vinay Varadan, Donny D. Licatalosi, Ruth A. Keri

J Biol Chem. 2020 Aug 14; 295(33): 11707–11719. Published online 2020 Jun 23. doi: 10.1074/jbc.RA120.014018

PMCID:: PMC7450125

Abstract Article PDF–1.9M

Select item 743811218.

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency

Joana G Marques, Berkley E Gryder, Blaz Pavlovic, Yeonjoo Chung, Quy A Ngo, Fabian Frommelt, Matthias Gstaiger, Young Song, Katharina Benischke, Dominik Laubscher, Marco Wachtel, Javed Khan, Beat W Schäfer

eLife. 2020; 9: e54993. Published online 2020 Aug 3. doi: 10.7554/eLife.54993

PMCID:: PMC7438112

Abstract Article PDF–4.5M

Select item 731145519.

Comparative targeting analysis of KLF1, BCL11A, and HBG1/2 in CD34⁺ HSPCs by CRISPR/Cas9 for the induction of fetal hemoglobin

Andrés Lamsfus-Calle, Alberto Daniel-Moreno, Justin S. Antony, Thomas Epting, Lukas Heumos, Praveen Baskaran, Jakob Admard, Nicolas Casadei, Ngadhnjim Latifi, Darina M. Siegmund, Michael S. D. Kormann, Rupert Handgretinger, Markus Mezger

Sci Rep. 2020; 10: 10133. Published online 2020 Jun 23. doi: 10.1038/s41598-020-66309-x

PMCID:: PMC7311455

Abstract Article PDF–3.4M

Select item 729009720.

The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

Peng Huang, Scott A. Peslak, Xianjiang Lan, Eugene Khandros, Jennifer A. Yano, Malini Sharma, Cheryl A. Keller, Belinda Giardine, Kunhua Qin, Osheiza Abdulmalik, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood. 2020 Jun 11; 135(24): 2121–2132. Prepublished online 2020 Apr 16. doi: 10.1182/blood.2020005301

PMCID:: PMC7290097

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