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Select item 111716421.

Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic Ca²⁺ Influx

Johannes Brockhaus, Iris Kahl, Mohiuddin Ahmad, Daniele Repetto, Carsten Reissner, Markus Missler

Cells. 2024 Jun; 13(11): 981. Published online 2024 Jun 5. doi: 10.3390/cells13110981

PMCID:: PMC11171642

Abstract Article PDF–3.7M

Select item 110770832.

Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development

Eleonora Cesari, Donatella Farini, Vanessa Medici, Ingrid Ehrmann, Marika Guerra, Erika Testa, Chiara Naro, Maria Concetta Geloso, Vittoria Pagliarini, Livia La Barbera, Marcello D’Amelio, Tiziana Orsini, Stefano Farioli Vecchioli, Luca Tamagnone, Philippe Fort, Maria Teresa Viscomi, David J Elliott, Claudio Sette

Nucleic Acids Res. 2024 May 8; 52(8): 4167–4184. Published online 2024 Feb 7. doi: 10.1093/nar/gkae071

PMCID:: PMC11077083

Abstract Article PDF–3.3M

Select item 110688833.

Conditional deletion of neurexin-2 impaired behavioral flexibility to alterations in action–outcome contingency

Sheraz Khoja, Lulu Y. Chen

Sci Rep. 2024; 14: 10187. Published online 2024 May 3. doi: 10.1038/s41598-024-60760-w

PMCID:: PMC11068883

Abstract Article PDF–4.0M

Select item 109896854.

Structural and functional characterization of the IgSF21-neurexin2α complex and its related signaling pathways in the regulation of inhibitory synapse organization

Nicolas Chofflet, Yusuke Naito, Anthony John Pastore, Nirmala Padmanabhan, Phuong Trang Nguyen, Christian Poitras, Benjamin Feller, Nayoung Yi, Jeremie Van Prooijen, Husam Khaled, Benoit Coulombe, Steven J. Clapcote, Steve Bourgault, Tabrez J. Siddiqui, Gabby Rudenko, Hideto Takahashi

Front Mol Neurosci. 2024; 17: 1371145. Published online 2024 Mar 20. doi: 10.3389/fnmol.2024.1371145

PMCID:: PMC10989685

Abstract Article PDF–11M

Select item 109176605.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108170566.

Distinct Alterations in Dendritic Spine Morphology in the Absence of β-Neurexins

Leonie Mohrmann, Jochen Seebach, Markus Missler, Astrid Rohlmann

Int J Mol Sci. 2024 Jan; 25(2): 1285. Published online 2024 Jan 20. doi: 10.3390/ijms25021285

PMCID:: PMC10817056

Abstract Article PDF–6.0M

Select item 104355797.

Combinatorial expression of neurexins and LAR-type phosphotyrosine phosphatase receptors instructs assembly of a cerebellar circuit

Alessandra Sclip, Thomas C. Südhof

Nat Commun. 2023; 14: 4976. Published online 2023 Aug 17. doi: 10.1038/s41467-023-40526-0

PMCID:: PMC10435579

Abstract Article PDF–9.2M

Select item 103078528.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 100278469.

Conditional deletion of Neurexin-2 alters neuronal network activity in hippocampal circuitries and leads to spontaneous seizures

Mulatwa T. Haile, Sheraz Khoja, Gregory de Carvalho, Robert F. Hunt, Lulu Y. Chen

Transl Psychiatry. 2023; 13: 97. Published online 2023 Mar 20. doi: 10.1038/s41398-023-02394-6

PMCID:: PMC10027846

Abstract Article PDF–4.3M

Select item 988427810.

Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions

Karen Perez de Arce, Adema Ribic, Dhrubajyoti Chowdhury, Katherine Watters, Garth J. Thompson, Basavaraju G. Sanganahalli, Elizabeth T. C. Lippard, Astrid Rohlmann, Stephen M. Strittmatter, Markus Missler, Fahmeed Hyder, Thomas Biederer

Nat Commun. 2023; 14: 459. Published online 2023 Jan 28. doi: 10.1038/s41467-023-36042-w

PMCID:: PMC9884278

Abstract Article PDF–4.0M

Select item 982187411.

Neurexin-2: An inhibitory neurexin that restricts excitatory synapse formation in the hippocampus

Pei-Yi Lin, Lulu Y. Chen, Man Jiang, Justin H. Trotter, Erica Seigneur, Thomas C. Südhof

Sci Adv. 2023 Jan; 9(1): eadd8856. Published online 2023 Jan 6. doi: 10.1126/sciadv.add8856

PMCID:: PMC9821874

Abstract Article PDF–1.8M

Select item 967136812.

Cbln1 regulates axon growth and guidance in multiple neural regions

Peng Han, Yuanchu She, Zhuoxuan Yang, Mengru Zhuang, Qingjun Wang, Xiaopeng Luo, Chaoqun Yin, Junda Zhu, Samie R. Jaffrey, Sheng-Jian Ji

PLoS Biol. 2022 Nov; 20(11): e3001853. Published online 2022 Nov 17. doi: 10.1371/journal.pbio.3001853

PMCID:: PMC9671368

Abstract Article PDF–6.3M

Select item 884141513.

Deletion of β-Neurexins in Mice Alters the Distribution of Dense-Core Vesicles in Presynapses of Hippocampal and Cerebellar Neurons

Shima Ferdos, Johannes Brockhaus, Markus Missler, Astrid Rohlmann

Front Neuroanat. 2021; 15: 757017. Published online 2022 Jan 31. doi: 10.3389/fnana.2021.757017

PMCID:: PMC8841415

Abstract Article PDF–5.4M

Select item 868299614.

Molecular self-avoidance in synaptic neurexin complexes

Cosmos Yuqi Wang, Justin H. Trotter, Kif Liakath-Ali, Sung-Jin Lee, Xinran Liu, Thomas C. Südhof

Sci Adv. 2021 Dec; 7(51): eabk1924. Published online 2021 Dec 17. doi: 10.1126/sciadv.abk1924

PMCID:: PMC8682996

Abstract Article PDF–16M

Select item 806252715.

Neurexins regulate presynaptic GABA_B-receptors at central synapses

Fujun Luo, Alessandra Sclip, Sean Merrill, Thomas C. Südhof

Nat Commun. 2021; 12: 2380. Published online 2021 Apr 22. doi: 10.1038/s41467-021-22753-5

PMCID:: PMC8062527

Abstract Article PDF–5.6M

Select item 775806416.

Specific Neuroligin3–αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus

Motokazu Uchigashima, Kohtarou Konno, Emily Demchak, Amy Cheung, Takuya Watanabe, David G Keener, Manabu Abe, Timmy Le, Kenji Sakimura, Toshikuni Sasaoka, Takeshi Uemura, Yuka Imamura Kawasawa, Masahiko Watanabe, Kensuke Futai

eLife. 2020; 9: e59545. Published online 2020 Dec 23. doi: 10.7554/eLife.59545