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Select item 110824511.

Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect

Tamara Kögl, Hsin-Fang Chang, Julian Staniek, Samuel C.C. Chiang, Gudrun Thoulass, Jessica Lao, Kristoffer Weißert, Viviane Dettmer-Monaco, Kerstin Geiger, Paul T. Manna, Vivien Beziat, Mana Momenilandi, Szu-Min Tu, Selina J. Keppler, Varsha Pattu, Philipp Wolf, Laurence Kupferschmid, Stefan Tholen, Laura E. Covill, Karolina Ebert, Tobias Straub, Miriam Groß, Ruth Gather, Helena Engel, Ulrich Salzer, Christoph Schell, Sarah Maier, Kai Lehmberg, Tatjana I. Cornu, Hanspeter Pircher, Mohammad Shahrooei, Nima Parvaneh, Roland Elling, Marta Rizzi, Yenan T. Bryceson, Stephan Ehl, Peter Aichele, Sandra Ammann

J Exp Med. 2024 Jul 1; 221(7): e20221122. Published online 2024 May 9. doi: 10.1084/jem.20221122

Correction in:: J Exp Med. 2024 Jul 1; 221(7): e2022112205142024c.

PMCID:: PMC11082451

Abstract Article PDF–8.0M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 93142593.

TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages

Ev-Marie Schuster, Maximilian W. Epple, Katharina M. Glaser, Michael Mihlan, Kerstin Lucht, Julia A. Zimmermann, Anna Bremser, Aikaterini Polyzou, Nadine Obier, Nina Cabezas-Wallscheid, Eirini Trompouki, Andrea Ballabio, Jörg Vogel, Joerg M. Buescher, Alexander J. Westermann, Angelika S. Rambold

Nat Metab. 2022; 4(7): 856–866. Published online 2022 Jul 21. doi: 10.1038/s42255-022-00605-w

PMCID:: PMC9314259

Abstract Article PDF–11M

Select item 90145594.

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat

Nature. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2

PMCID:: PMC9014559

Abstract Article PDF–6.6M

Select item 89860815.

Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis

Li-Chung Tsao, Erika J. Crosby, Timothy N. Trotter, Junping Wei, Tao Wang, Xiao Yang, Amanda N. Summers, Gangjun Lei, Christopher A. Rabiola, Lewis A. Chodosh, William J. Muller, Herbert Kim Lyerly, Zachary C. Hartman

JCI Insight. 2022 Mar 22; 7(6): e155636. Published online 2022 Mar 22. doi: 10.1172/jci.insight.155636

PMCID:: PMC8986081

Abstract Article PDF–1.3M

Select item 88936056.

Deficiency in Lyst function leads to accumulation of secreted proteases and reduced retinal adhesion

Xiaojie Ji, Lihong Zhao, Ankita Umapathy, Bernard Fitzmaurice, Jieping Wang, David S. Williams, Bo Chang, Jürgen K. Naggert, Patsy M. Nishina

PLoS One. 2022; 17(3): e0254469. Published online 2022 Mar 3. doi: 10.1371/journal.pone.0254469

PMCID:: PMC8893605

Abstract Article PDF–2.5M

Select item 74159917.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 64948098.

Mouse models and strain-dependency of Chédiak-Higashi syndrome-associated neurologic dysfunction

Adam Hedberg-Buenz, Laura M. Dutca, Demelza R. Larson, Kacie J. Meyer, Dana A. Soukup, Carly J. van der Heide, Hannah E. Mercer, Kai Wang, Michael G. Anderson

Sci Rep. 2019; 9: 6752. Published online 2019 May 1. doi: 10.1038/s41598-019-42159-0

PMCID:: PMC6494809

Abstract Article PDF–3.7M

Select item 60283019.

Update on Animal Models of Exfoliation Syndrome

Michael G. Anderson, Kacie J. Meyer, Adam Hedberg-Buenz, John H. Fingert

J Glaucoma. Author manuscript; available in PMC 2019 Jul 1.

Published in final edited form as: J Glaucoma. 2018 Jul; 27(Suppl 1): S78–S82. doi: 10.1097/IJG.0000000000000911

PMCID:: PMC6028301

Abstract Article PDF–578K

Select item 601866810.

Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction

Serena Zacchigna, Valentina Martinelli, Silvia Moimas, Andrea Colliva, Marco Anzini, Andrea Nordio, Alessia Costa, Michael Rehman, Simone Vodret, Cristina Pierro, Giulia Colussi, Lorena Zentilin, Maria Ines Gutierrez, Ellen Dirkx, Carlin Long, Gianfranco Sinagra, David Klatzmann, Mauro Giacca

Nat Commun. 2018; 9: 2432. Published online 2018 Jun 26. doi: 10.1038/s41467-018-04908-z

PMCID:: PMC6018668

Abstract Article PDF–2.9M

Select item 598462211.

Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter

Ruili Yang, Tingting Yu, Xiaoxing Kou, Xiang Gao, Chider Chen, Dawei Liu, Yanheng Zhou, Songtao Shi

Nat Commun. 2018; 9: 2143. Published online 2018 Jun 1. doi: 10.1038/s41467-018-04464-6

PMCID:: PMC5984622

Abstract Article PDF–2.8M

Select item 580150212.

Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next‐generation human artificial chromosomes for Duchenne muscular dystrophy

Sara Benedetti, Narumi Uno, Hidetoshi Hoshiya, Martina Ragazzi, Giulia Ferrari, Yasuhiro Kazuki, Louise Anne Moyle, Rossana Tonlorenzi, Angelo Lombardo, Soraya Chaouch, Vincent Mouly, Marc Moore, Linda Popplewell, Kanako Kazuki, Motonobu Katoh, Luigi Naldini, George Dickson, Graziella Messina, Mitsuo Oshimura, Giulio Cossu, Francesco Saverio Tedesco

EMBO Mol Med. 2018 Feb; 10(2): 254–275. Published online 2017 Dec 14. doi: 10.15252/emmm.201607284

PMCID:: PMC5801502

Abstract Article PDF–4.6M

Select item 529582113.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 522502014.

IL-23 Inhibits Melanoma Development by Augmenting DNA Repair and Modulating T-cell Subpopulations

Tahseen H. Nasti, J. Barry Cochran, Raj V Vachhani, Kristopher McKay, Yuko Tsuruta, Mohammad Athar, Laura Timares, Craig A. Elmets

J Immunol. Author manuscript; available in PMC 2018 Jan 15.

Published in final edited form as: J Immunol. 2017 Jan 15; 198(2): 950–961. Published online 2016 Dec 21. doi: 10.4049/jimmunol.1601455

PMCID:: PMC5225020

Abstract Article PDF–5.6M

Select item 520649015.

Lysosomal trafficking regulator Lyst links membrane trafficking to toll-like receptor–mediated inflammatory responses

Andreas Westphal, Weijia Cheng, Jinbo Yu, Guntram Grassl, Martina Krautkrämer, Otto Holst, Niko Föger, Kyeong-Hee Lee

J Exp Med. 2017 Jan; 214(1): 227–244. doi: 10.1084/jem.20141461

PMCID:: PMC5206490

Abstract Article PDF–3.5M

Select item 505010816.

Stimulation of natural killer cell-mediated tumor immunity by an IL-15/TGF-ß neutralizing fusion protein

Spencer Ng, Jiusheng Deng, Raghavan Chinnadurai, Shala Yuan, Andrea Pennati, Jacques Galipeau

Cancer Res. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Cancer Res. 2016 Oct 1; 76(19): 5683–5695. Published online 2016 Aug 3. doi: 10.1158/0008-5472.CAN-16-0386

PMCID:: PMC5050108

Abstract Article PDF–1.2M

Select item 469781717.

Dual Requirement of Cytokine and Activation Receptor Triggering for Cytotoxic Control of Murine Cytomegalovirus by NK Cells

Bijal A. Parikh, Sytse J. Piersma, Melissa A. Pak-Wittel, Liping Yang, Robert D. Schreiber, Wayne M. Yokoyama

PLoS Pathog. 2015 Dec; 11(12): e1005323. Published online 2015 Dec 31. doi: 10.1371/journal.ppat.1005323

PMCID:: PMC4697817

Abstract Article PDF–2.7M

Select item 448439218.

Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders

Heather Fairfield, Anuj Srivastava, Guruprasad Ananda, Rangjiao Liu, Martin Kircher, Anuradha Lakshminarayana, Belinda S. Harris, Son Yong Karst, Louise A. Dionne, Coleen C. Kane, Michelle Curtain, Melissa L. Berry, Patricia F. Ward-Bailey, Ian Greenstein, Candice Byers, Anne Czechanski, Jocelyn Sharp, Kristina Palmer, Polyxeni Gudis, Whitney Martin, Abby Tadenev, Laurent Bogdanik, C. Herbert Pratt, Bo Chang, David G. Schroeder, Gregory A. Cox, Paul Cliften, Jeffrey Milbrandt, Stephen Murray, Robert Burgess, David E. Bergstrom, Leah Rae Donahue, Hanan Hamamy, Amira Masri, Federico A. Santoni, Periklis Makrythanasis, Stylianos E. Antonarakis, Jay Shendure, Laura G. Reinholdt

Genome Res. 2015 Jul; 25(7): 948–957. doi: 10.1101/gr.186882.114

PMCID:: PMC4484392

Abstract Article PDF–604K

Select item 426266619.

Crisp1 and Alopecia Areata in C3H/HeJ Mice

John P. Sundberg, Alexander Awgulewitsch, Nathan D. Pruett, Christopher S. Potter, Kathleen A. Silva, Timothy M. Stearns, Beth A. Sundberg, Mariana Weigel Muñoz, Patricia S. Cuasnicu, Lloyd E. King, Jr., Robert H. Rice

Exp Mol Pathol. Author manuscript; available in PMC 2015 Dec 1.

Published in final edited form as: Exp Mol Pathol. 2014 Dec; 97(3): 525–528. Published online 2014 Oct 29. doi: 10.1016/j.yexmp.2014.10.010

PMCID:: PMC4262666

Abstract Article PDF–471K

Select item 373076020.

Milky Spots Promote Ovarian Cancer Metastatic Colonization of Peritoneal Adipose in Experimental Models

Robert Clark, Venkatesh Krishnan, Michael Schoof, Irving Rodriguez, Betty Theriault, Marina Chekmareva, Carrie Rinker-Schaeffer

Am J Pathol. 2013 Aug; 183(2): 576–591. doi: 10.1016/j.ajpath.2013.04.023

PMCID:: PMC3730760

Abstract Article PDF–4.1M

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