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Items: 1 to 20 of 99

1.
Hippo–YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass
Sungwoo Choi, Ju-Gyeong Kang, Yen T. H. Tran, Sun-Hye Jeong, Kun-Young Park, Hyemi Shin, Young Hoon Kim, Myungsun Park, Hahn Nahmgoong, Taejun Seol, Haeyon Jeon, Yeongmin Kim, Sanghee Park, Hee-joo Kim, Min-Seob Kim, Xiaoxu Li, Maroun Bou Sleiman, Eries Lee, Jinhyuk Choi, David Eisenbarth, Sang Heon Lee, Suhyeon Cho, David D. Moore, Johan Auwerx, Il-Young Kim, Jae Bum Kim, Jong-Eun Park, Dae-Sik Lim, Jae Myoung Suh
Nat Metab. 2024; 6(5): 847–860. Published online 2024 May 29. doi: 10.1038/s42255-024-01045-4
PMCID:
PMC11136666
AbstractArticlePDF–18M
2.
Proximal Tubular Lats2 Ablation Exacerbates Ischemia/Reperfusion Injury (IRI)-Induced Renal Maladaptive Repair through the Upregulation of P53
Chi Zhang, Zhihuang Zheng, Kexin Xu, Guozhe Cheng, Huijuan Wu, Jun Liu
Int J Mol Sci. 2023 Oct; 24(20): 15258. Published online 2023 Oct 17. doi: 10.3390/ijms242015258
PMCID:
PMC10607662
AbstractArticlePDF–22M
3.
Lats2 deficiency protects the heart against myocardial infarction by reducing inflammation and inhibiting mitochondrial fission and STING/p65 signaling
Libao Liu, Shuai Huang, Yingzhen Du, Hao Zhou, Kai Zhang, Jinyuan He
Int J Biol Sci. 2023; 19(11): 3428–3440. Published online 2023 Jul 3. doi: 10.7150/ijbs.84426
PMCID:
PMC10367568
AbstractArticlePDF–7.2M
4.
Regenerative reprogramming of the intestinal stem cell state via Hippo signaling suppresses metastatic colorectal cancer
Priscilla Cheung, Jordi Xiol, Michael T. Dill, Wei-Chien Yuan, Riccardo Panero, Jatin Roper, Fernando G. Osorio, Dejan Maglic, Qi Li, Basanta Gurung, Raffaele A. Calogero, Ömer H. Yilmaz, Junhao Mao, Fernando D. Camargo
Cell Stem Cell. Author manuscript; available in PMC 2023 Apr 19.
Published in final edited form as: Cell Stem Cell. 2020 Oct 1; 27(4): 590–604.e9. Published online 2020 Jul 29. doi: 10.1016/j.stem.2020.07.003
PMCID:
PMC10114498
AbstractArticlePDF–2.4M
5.
A Stk4 -Foxp3-P65 Transcriptional Complex Promotes Treg Cell Activation and Homeostasis
Ye Cui, Mehdi Benamar, Klaus Schmitz-Abe, Varsha Poondi-Krishnan, Qian Chen, Bat-Erdene Jugder, Benoit Fatou, Jason Fong, Yuelin Zhong, Stuti Mehta, Altantsetseg Buyanbat, Beray Selver Eklioglu, Esra Karabiber, Safa Baris, Ayca Kiykim, Sevgi Keles, Emmanuel Stephen-Victor, Claudia Angelini, Louis-Marie Charbonnier, Talal A. Chatila
Sci Immunol. Author manuscript; available in PMC 2023 Jan 6.
Published in final edited form as: Sci Immunol. 2022 Sep 23; 7(75): eabl8357. Published online 2022 Sep 23. doi: 10.1126/sciimmunol.abl8357
PMCID:
PMC9816918
AbstractArticlePDF–3.0M
6.
Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas
Joseph G. Kern, Andrew M. Tilston-Lunel, Anthony Federico, Boting Ning, Amy Mueller, Grace B. Peppler, Eleni Stampouloglou, Nan Cheng, Randy L. Johnson, Marc E. Lenburg, Jennifer E. Beane, Stefano Monti, Xaralabos Varelas
Nat Commun. 2022; 13: 7198. Published online 2022 Nov 28. doi: 10.1038/s41467-022-34864-8
PMCID:
PMC9705439
AbstractArticlePDF–6.2M
7.
Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate
Nour Abou Nader, Amélie Ménard, Adrien Levasseur, Guillaume St-Jean, Derek Boerboom, Gustavo Zamberlam, Alexandre Boyer
Int J Mol Sci. 2022 Nov; 23(21): 13585. Published online 2022 Nov 5. doi: 10.3390/ijms232113585
PMCID:
PMC9655313
AbstractArticlePDF–4.1M
8.
Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy
Lai Man Natalie Wu, Feng Zhang, Rohit Rao, Mike Adam, Kai Pollard, Sara Szabo, Xuezhao Liu, Katie A. Belcher, Zaili Luo, Sean Ogurek, Colleen Reilly, Xin Zhou, Li Zhang, Joshua Rubin, Long-sheng Chang, Mei Xin, Jiyang Yu, Mario Suva, Christine A. Pratilas, Steven Potter, Q. Richard Lu
Sci Adv. 2022 Nov; 8(44): eabo5442. Published online 2022 Nov 2. doi: 10.1126/sciadv.abo5442
PMCID:
PMC9629745
AbstractArticlePDF–16M
9.
LATS1/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation
Idaliz M. Martínez Traverso, Jeffrey D. Steimle, Xiaolei Zhao, Jun Wang, James F. Martin
Development. 2022 Sep 15; 149(18): dev200860. Published online 2022 Sep 20. doi: 10.1242/dev.200860
PMCID:
PMC9587805
AbstractArticle
10.
The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis
Hongyu Shen, Xun Huang, Yiheng Zhao, Dongmei Wu, Kaili Xue, Jingfei Yao, Yushuang Wang, Nan Tang, Yifu Qiu
Nat Commun. 2022; 13: 6030. Published online 2022 Oct 13. doi: 10.1038/s41467-022-33800-0
PMCID:
PMC9562301
AbstractArticlePDF–6.0M
11.
Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal Myofibroblasts in the Developing Mouse Kidney
Keri A. Drake, Christopher Chaney, Mohita Patel, Amrita Das, Julia Bittencourt, Martin Cohn, Thomas J. Carroll
J Am Soc Nephrol. 2022 Sep; 33(9): 1694–1707. Published online 2022 Sep. doi: 10.1681/ASN.2021121559
Correction in:
J Am Soc Nephrol. 2023 Mar; 34(3): 515–516.
PMCID:
PMC9529188
AbstractArticle
12.
Inactivation of the Hippo tumor suppressor pathway promotes melanoma
Marc A. Vittoria, Nathan Kingston, Kristyna Kotynkova, Eric Xia, Rui Hong, Lee Huang, Shayna McDonald, Andrew Tilston-Lunel, Revati Darp, Joshua D. Campbell, Deborah Lang, Xiaowei Xu, Craig J. Ceol, Xaralabos Varelas, Neil J. Ganem
Nat Commun. 2022; 13: 3732. Published online 2022 Jun 29. doi: 10.1038/s41467-022-31399-w
PMCID:
PMC9243107
AbstractArticlePDF–7.2M
13.
NANOG initiates epiblast fate through the coordination of pluripotency genes expression
Nicolas Allègre, Sabine Chauveau, Cynthia Dennis, Yoan Renaud, Dimitri Meistermann, Lorena Valverde Estrella, Pierre Pouchin, Michel Cohen-Tannoudji, Laurent David, Claire Chazaud
Nat Commun. 2022; 13: 3550. Published online 2022 Jun 21. doi: 10.1038/s41467-022-30858-8
PMCID:
PMC9213552
AbstractArticlePDF–4.4M
14.
Myofibroblast YAP/TAZ activation is a key step in organ fibrogenesis
Xiaolin He, Monica F. Tolosa, Tianzhou Zhang, Santosh Kumar Goru, Luisa Ulloa Severino, Paraish S. Misra, Caitríona M. McEvoy, Lauren Caldwell, Stephen G. Szeto, Feng Gao, Xiaolan Chen, Cassandra Atin, Victoria Ki, Noah Vukosa, Catherine Hu, Johnny Zhang, Christopher Yip, Adriana Krizova, Jeffrey L. Wrana, Darren A. Yuen
JCI Insight. 2022 Feb 22; 7(4): e146243. Published online 2022 Feb 22. doi: 10.1172/jci.insight.146243
PMCID:
PMC8876427
AbstractArticlePDF–28M
15.
Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload
Dan Shao, Peiyong Zhai, Chengchen Hu, Risa Mukai, Sebastiano Sciarretta, Dominic Del Re, Junichi Sadoshima
Sci Rep. 2021; 11: 23469. Published online 2021 Dec 6. doi: 10.1038/s41598-021-02846-3
PMCID:
PMC8648781
AbstractArticlePDF–7.1M
16.
The aryl hydrocarbon receptor promotes differentiation during mouse preimplantational embryo development
Ana Nacarino-Palma, Francisco J. González-Rico, Claudia M. Rejano-Gordillo, Ana Ordiales-Talavero, Jaime M. Merino, Pedro M. Fernández-Salguero
Stem Cell Reports. 2021 Sep 14; 16(9): 2351–2363. Published online 2021 Sep 2. doi: 10.1016/j.stemcr.2021.08.002
PMCID:
PMC8452532
AbstractArticlePDF–3.1M
17.
The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis
Ting Yuan, Karthika Annamalai, Shruti Naik, Blaz Lupse, Shirin Geravandi, Anasua Pal, Aleksandra Dobrowolski, Jaee Ghawali, Marina Ruhlandt, Kanaka Durga Devi Gorrepati, Zahra Azizi, Dae-Sik Lim, Kathrin Maedler, Amin Ardestani
Nat Commun. 2021; 12: 4928. Published online 2021 Aug 13. doi: 10.1038/s41467-021-25145-x
PMCID:
PMC8363615
AbstractArticlePDF–7.0M
18.
Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma
Phoebe Carter, Ulrike Schnell, Christopher Chaney, Betty Tong, Xinchao Pan, Jianhua Ye, Glenda Mernaugh, Jennifer L. Cotton, Vitaly Margulis, Junhao Mao, Roy Zent, Bret M. Evers, Payal Kapur, Thomas J. Carroll
J Clin Invest. 2021 Jun 1; 131(11): e144108. Published online 2021 Jun 1. doi: 10.1172/JCI144108
PMCID:
PMC8159698
AbstractArticlePDF–49M
19.
Inactivation of Lats1 And Lats2 Highlights the Role of Hippo Pathway Effector YAP in Larynx and Vocal Fold Epithelium Morphogenesis
Vidisha Mohad, Vlasta Lungova, Jamie Verherden, Susan L. Thibeault
Dev Biol. Author manuscript; available in PMC 2022 May 1.
Published in final edited form as: Dev Biol. 2021 May; 473: 33–49. Published online 2021 Jan 28. doi: 10.1016/j.ydbio.2021.01.012
PMCID:
PMC7987763
AbstractArticlePDF–4.8M
20.
Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions
Jana L. Raynor, Chaohong Liu, Yogesh Dhungana, Cliff Guy, Nicole M. Chapman, Hao Shi, Geoffrey Neale, Hiromi Sesaki, Hongbo Chi
J Exp Med. 2020 Jun 1; 217(6): e20191157. Published online 2020 Apr 14. doi: 10.1084/jem.20191157
PMCID:
PMC7971129
AbstractArticlePDF–7.3M

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