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Select item 115798741.

Reversal of cognitive deficits in FUS^R521G amyotrophic lateral sclerosis mice by arimoclomol and a class I histone deacetylase inhibitor independent of heat shock protein induction

Mari Carmen Pelaez, Frédéric Fiore, Nancy Larochelle, Afrooz Dabbaghizadeh, Mario Fernández Comaduran, Danielle Arbour, Sandra Minotti, Laetitia Marcadet, Martine Semaan, Richard Robitaille, Josephine N. Nalbantoglu, Chantelle F. Sephton, Heather D. Durham

Neurotherapeutics. 2024 Sep; 21(5): e00388. Published online 2024 Jul 6. doi: 10.1016/j.neurot.2024.e00388

PMCID:: PMC11579874

Abstract Article PDF–4.4M

Select item 113819212.

A genetically small fetus impairs placental adaptations near term

Ionel Sandovici, Olatejumoye Knee, Jorge Lopez-Tello, Norman Shreeve, Abigail L. Fowden, Amanda N. Sferruzzi-Perri, Miguel Constância

Dis Model Mech. 2024 Aug 1; 17(8): dmm050719. Published online 2024 Aug 29. doi: 10.1242/dmm.050719

PMCID:: PMC11381921

Abstract Article

Select item 112476763.

In vivo validation of late‐onset Alzheimer's disease genetic risk factors

Michael Sasner, Christoph Preuss, Ravi S. Pandey, Asli Uyar, Dylan Garceau, Kevin P. Kotredes, Harriet Williams, Adrian L. Oblak, Peter Bor‐Chian Lin, Bridget Perkins, Disha Soni, Cindy Ingraham, Audrey Lee‐Gosselin, Bruce T. Lamb, Gareth R. Howell, Gregory W. Carter

Alzheimers Dement. 2024 Jul; 20(7): 4970–4984. Published online 2024 Apr 30. doi: 10.1002/alz.13840

PMCID:: PMC11247676

Abstract Article PDF–3.3M

Select item 112161734.

Diverse Fgfr1 signaling pathways and endocytic trafficking regulate mesoderm development

James F. Clark, Philippe Soriano

Genes Dev. 2024 May 1; 38(9-10): 393–414. doi: 10.1101/gad.351593.124

PMCID:: PMC11216173

Abstract Article PDF–17M

Select item 110651755.

A germline point mutation in the MYC-FBW7 phosphodegron initiates hematopoietic malignancies

Brian Freie, Patrick A. Carroll, Barbara J. Varnum-Finney, Erin L. Ramsey, Vijay Ramani, Irwin Bernstein, Robert N. Eisenman

Genes Dev. 2024 Mar 1; 38(5-6): 253–272. doi: 10.1101/gad.351292.123

PMCID:: PMC11065175

Abstract Article PDF–14M

Select item 109297486.

Cystin is required for maintaining fibrocystin (FPC) levels and safeguarding proteome integrity in mouse renal epithelial cells: A mechanistic connection between the kidney defects in cpk mice and human ARPKD

Yiming J. Zhang, Chaozhe Yang, Wei Wang, Naoe Harafuji, Piotr Stasiak, P. Darwin Bell, Ljubica Caldovic, Elizabeth Sztul, Lisa M. Guay‐Woodford, Zsuzsanna Bebok

FASEB J. 2023 Jul; 37(7): e23008. Published online 2023 Jun 15. doi: 10.1096/fj.202300100R

PMCID:: PMC10929748

Abstract Article PDF–5.9M

Select item 108218747.

Single-cell multiomics decodes regulatory programs for mouse secondary palate development

Fangfang Yan, Akiko Suzuki, Chihiro Iwaya, Guangsheng Pei, Xian Chen, Hiroki Yoshioka, Meifang Yu, Lukas M. Simon, Junichi Iwata, Zhongming Zhao

Nat Commun. 2024; 15: 821. Published online 2024 Jan 27. doi: 10.1038/s41467-024-45199-x

PMCID:: PMC10821874

Abstract Article PDF–6.4M

Select item 107626508.

Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer

Pamoda Galhenage, Yunlan Zhou, Erica Perry, Brenda Loc, Kelly Fietz, Sonia Iyer, Ferenc Reinhardt, Tiego Da Silva, Vladimir Botchkarev, Jie Chen, Christopher P. Crum, Robert A. Weinberg, Shailja Pathania

Cell Rep. Author manuscript; available in PMC 2024 Jan 3.

Published in final edited form as: Cell Rep. 2023 Oct 31; 42(10): 113144. Published online 2023 Sep 19. doi: 10.1016/j.celrep.2023.113144

PMCID:: PMC10762650

Abstract Article PDF–2.5M

Select item 105793739.

Fibrocystin/Polyductin releases a C-terminal fragment that translocates into mitochondria and suppresses cystogenesis

Rebecca V Walker, Qin Yao, Hangxue Xu, Anthony Maranto, Kristen F Swaney, Sreekumar Ramachandran, Rong Li, Laura Cassina, Brian M Polster, Patricia Outeda, Alessandra Boletta, Terry Watnick, Feng Qian

Nat Commun. 2023; 14: 6513. Published online 2023 Oct 16. doi: 10.1038/s41467-023-42196-4

PMCID:: PMC10579373

Abstract Article PDF–12M

Select item 1039087710.

Enhancers of the PAIR4 regulatory module promote distal V_H gene recombination at the Igh locus

Louisa Hill, Markus Jaritz, Hiromi Tagoh, Karina Schindler, Daniela Kostanova‐Poliakova, Qiong Sun, Tanja A Schwickert, Martin Leeb, Meinrad Busslinger

EMBO J. 2023 Aug; 42(15): e112741. Published online 2023 Jun 20. doi: 10.15252/embj.2022112741

PMCID:: PMC10390877

Abstract Article PDF–1.5M

Select item 971882311.

DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal

Paola Cattaneo, Michael G. B. Hayes, Nina Baumgarten, Dennis Hecker, Sofia Peruzzo, Galip S. Aslan, Paolo Kunderfranco, Veronica Larcher, Lunfeng Zhang, Riccardo Contu, Gregory Fonseca, Simone Spinozzi, Ju Chen, Gianluigi Condorelli, Stefanie Dimmeler, Marcel H. Schulz, Sven Heinz, Nuno Guimarães-Camboa, Sylvia M. Evans

Nat Commun. 2022; 13: 7444. Published online 2022 Dec 2. doi: 10.1038/s41467-022-35070-2

PMCID:: PMC9718823

Abstract Article PDF–9.4M

Select item 967485312.

Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration

Viviane Tran, Sarah Nahlé, Amélie Robert, Inès Desanlis, Ryan Killoran, Sophie Ehresmann, Marie-Pier Thibault, David Barford, Kodi S. Ravichandran, Martin Sauvageau, Matthew J. Smith, Marie Kmita, Jean-François Côté

Nat Commun. 2022; 13: 7077. Published online 2022 Nov 18. doi: 10.1038/s41467-022-34806-4

PMCID:: PMC9674853

Abstract Article PDF–3.6M

Select item 930678013.

Transcription factor mesenchyme homeobox protein 2 (MEOX2) modulates nociceptor function

Tomislav Kokotović, Ewelina M. Lenartowicz, Michiel Langeslag, Cosmin I. Ciotu, Christopher W. Fell, Angelica Scaramuzza, Michael J. M. Fischer, Michaela Kress, Josef M. Penninger, Vanja Nagy

FEBS J. 2022 Jun; 289(12): 3457–3476. Published online 2022 Feb 16. doi: 10.1111/febs.16347

PMCID:: PMC9306780

Abstract Article PDF–1.8M

Select item 880618314.

Differential regulation of cranial and cardiac neural crest by serum response factor and its cofactors

Colin J Dinsmore, Philippe Soriano

eLife. 2022; 11: e75106. Published online 2022 Jan 19. doi: 10.7554/eLife.75106

PMCID:: PMC8806183

Abstract Article PDF–9.5M

Select item 875164015.

The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth

Ionel Sandovici, Aikaterini Georgopoulou, Vicente Pérez-García, Antonia Hufnagel, Jorge López-Tello, Brian Y.H. Lam, Samira N. Schiefer, Chelsea Gaudreau, Fátima Santos, Katharina Hoelle, Giles S.H. Yeo, Keith Burling, Moritz Reiterer, Abigail L. Fowden, Graham J. Burton, Cristina M. Branco, Amanda N. Sferruzzi-Perri, Miguel Constância

Dev Cell. 2022 Jan 10; 57(1): 63–79.e8. doi: 10.1016/j.devcel.2021.12.005

PMCID:: PMC8751640

Abstract Article

Select item 854796316.

NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load

Theresa Pohlkamp, Xunde Xian, Connie H Wong, Murat S Durakoglugil, Gordon Chandler Werthmann, Takaomi C Saido, Bret M Evers, Charles L White, III, Jade Connor, Robert E Hammer, Joachim Herz

eLife. 2021; 10: e72034. Published online 2021 Oct 7. doi: 10.7554/eLife.72034

PMCID:: PMC8547963

Abstract Article PDF–12M

Select item 852828517.

The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis

Patrick A. Carroll, Brian W. Freie, Pei Feng Cheng, Sivakanthan Kasinathan, Haiwei Gu, Theresa Hedrich, James A. Dowdle, Vivek Venkataramani, Vijay Ramani, Xiaoying Wu, Daniel Raftery, Jay Shendure, Donald E. Ayer, Charles H. Muller, Robert N. Eisenman

PLoS Biol. 2021 Oct; 19(10): e3001085. Published online 2021 Oct 20. doi: 10.1371/journal.pbio.3001085

PMCID:: PMC8528285

Abstract Article PDF–7.1M

Select item 846386318.

Ablation of liver Fxr results in an increased colonic mucus barrier in mice

Noortje Ijssennagger, Kristel S. van Rooijen, Stefanía Magnúsdóttir, José M. Ramos Pittol, Ellen C.L. Willemsen, Marcel R. de Zoete, Matthijs J.D. Baars, Paul B. Stege, Carolina Colliva, Roberto Pellicciari, Sameh A. Youssef, Alain de Bruin, Yvonne Vercoulen, Folkert Kuipers, Saskia W.C. van Mil

JHEP Rep. 2021 Oct; 3(5): 100344. Published online 2021 Aug 4. doi: 10.1016/j.jhepr.2021.100344