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Items: 1 to 20 of 61

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
The Anaphase-Promoting Complex controls a ubiquitination-phosphoprotein axis in chromatin during neurodevelopment
Leya Ledvin, Brandon M. Gassaway, Jonathan Tawil, Olivia Urso, Donald Pizzo, Kaeli A. Welsh, Derek L. Bolhuis, Daniel Fisher, Azad Bonni, Steven P. Gygi, Nicholas G. Brown, Cole J. Ferguson
Dev Cell. Author manuscript; available in PMC 2024 Dec 4.
Published in final edited form as: Dev Cell. 2023 Dec 4; 58(23): 2666–2683.e9. Published online 2023 Oct 23. doi: 10.1016/j.devcel.2023.10.002
PMCID:
PMC10872926
AbstractArticlePDF–2.5M
3.
The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells
Shizhen Zhang, Xiahong You, Yawen Zheng, Yanwen Shen, Xiufang Xiong, Yi Sun
J Clin Invest. 2023 Feb 15; 133(4): e162434. Published online 2023 Feb 15. doi: 10.1172/JCI162434
PMCID:
PMC9927933
AbstractArticlePDF–11M
4.
Efficient terminal erythroid differentiation requires the APC/C cofactor Cdh1 to limit replicative stress in erythroblasts
Myriam Cuadrado, Javier Garzón, Sergio Moreno, Irene García-Higuera
Sci Rep. 2022; 12: 10489. Published online 2022 Jun 21. doi: 10.1038/s41598-022-14331-6
PMCID:
PMC9213546
AbstractArticlePDF–5.3M
5.
APC7 Mediates Ubiquitin Signaling in Constitutive Heterochromatin in the Developing Mammalian Brain
Cole J. Ferguson, Olivia Urso, Tatyana Bodrug, Brandon M. Gassaway, Edmond R. Watson, Jesuraj R. Prabu, Pablo Lara-Gonzalez, Raquel C. Martinez-Chacin, Dennis Y. Wu, Karlla W. Brigatti, Erik G. Puffenberger, Cora M. Taylor, Barbara Haas-Givler, Robert N. Jinks, Kevin A. Strauss, Arshad Desai, Harrison W. Gabel, Steven P. Gygi, Brenda A. Schulman, Nicholas G. Brown, Azad Bonni
Mol Cell. Author manuscript; available in PMC 2023 Jan 6.
Published in final edited form as: Mol Cell. 2022 Jan 6; 82(1): 90–105.e13. Published online 2021 Dec 22. doi: 10.1016/j.molcel.2021.11.031
PMCID:
PMC8741739
AbstractArticlePDF–4.4M
6.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
7.
FZR1 as a novel biomarker for breast cancer neoadjuvant chemotherapy prediction
Shuo Liu, Haobin Wang, Jun Li, Jianhui Zhang, Jian Wu, Yi Li, Yongjun Piao, Leiting Pan, Rong Xiang, Shijing Yue
Cell Death Dis. 2020 Sep; 11(9): 804. Published online 2020 Sep 25. doi: 10.1038/s41419-020-03004-9
PMCID:
PMC7519164
AbstractArticlePDF–3.7M
8.
Phosphorylation of the Anaphase Promoting Complex activator FZR1/CDH1 is required for Meiosis II entry in mouse male germ cell
Nobuhiro Tanno, Shinji Kuninaka, Sayoko Fujimura, Kazumasa Takemoto, Kaho Okamura, Naoki Takeda, Kimi Araki, Masatake Araki, Hideyuki Saya, Kei-ichiro Ishiguro
Sci Rep. 2020; 10: 10094. Published online 2020 Jun 22. doi: 10.1038/s41598-020-67116-0
PMCID:
PMC7308413
AbstractArticlePDF–3.8M
9.
Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism
Arielle N. Valdez-Sinon, Austin Lai, Liang Shi, Carly L. Lancaster, Avanti Gokhale, Victor Faundez, Gary J. Bassell
iScience. 2020 May 22; 23(5): 101132. Published online 2020 May 1. doi: 10.1016/j.isci.2020.101132
PMCID:
PMC7236060
AbstractArticlePDF–6.1M
10.
Oocytes mount a noncanonical DNA damage response involving APC-Cdh1–mediated proteolysis
Goutham Narayanan Subramanian, Jessica Greaney, Zhe Wei, Olivier Becherel, Martin Lavin, Hayden Anthony Homer
J Cell Biol. 2020 Apr 6; 219(4): e201907213. Published online 2020 Mar 30. doi: 10.1083/jcb.201907213
PMCID:
PMC7147104
AbstractArticlePDF–4.2M
11.
A Cdh1–FoxM1–Apc axis controls muscle development and regeneration
Zhe Chen, Lei Li, Shuangnian Xu, Zhilong Liu, Chengfang Zhou, Zhigang Li, Yuanyuan Liu, Weiru Wu, Yongxiu Huang, Mei Kuang, Shijun Fan, Hui Li, Xi Li, Guanbin Song, Wen-Shu Wu, Jieping Chen, Yu Hou
Cell Death Dis. 2020 Mar; 11(3): 180. Published online 2020 Mar 9. doi: 10.1038/s41419-020-2375-6
PMCID:
PMC7062904
AbstractArticlePDF–5.8M
12.
Cdh1/Hct1-APC Is Essential for the Survival of Postmitotic Neurons
Angeles Almeida, Juan P. Bolaños, Sergio Moreno
J Neurosci. 2005 Sep 7; 25(36): 8115–8121. doi: 10.1523/JNEUROSCI.1143-05.2005
PMCID:
PMC6725543
AbstractArticlePDF–466K
13.
Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis
Tao Han, Shulong Jiang, Hong Zheng, Qing Yin, Mengyu Xie, Margaret R Little, Xiu Yin, Ming Chen, Su Jung Song, Amer A. Beg, Pier Paolo Pandolfi, Lixin Wan
Nat Commun. 2019; 10: 3716. Published online 2019 Aug 16. doi: 10.1038/s41467-019-11618-7
PMCID:
PMC6697746
AbstractArticlePDF–2.6M
14.
The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites
Kyungsoo Ha, Chengxian Ma, Han Lin, Lichun Tang, Zhusheng Lian, Fang Zhao, Ju-Mei Li, Bei Zhen, Huadong Pei, Suxia Han, Marcos Malumbres, Jianping Jin, Huan Chen, Yongxiang Zhao, Qing Zhu, Pumin Zhang
Nat Commun. 2017; 8: 15751. Published online 2017 Jun 12. doi: 10.1038/ncomms15751
Correction in:
Nat Commun. 2017; 8: 16156.
PMCID:
PMC5472795
AbstractArticlePDF–5.0M
15.
APC/CCdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity
Ahmed Rattani, Randy Ballesteros Mejia, Katherine Roberts, Maurici B. Roig, Jonathan Godwin, Michael Hopkins, Manuel Eguren, Luis Sanchez-Pulido, Elwy Okaz, Sugako Ogushi, Magda Wolna, Jean Metson, Alberto M. Pendás, Marcos Malumbres, Béla Novák, Mary Herbert, Kim Nasmyth
Curr Biol. 2017 May 22; 27(10): 1462–1476.e5. doi: 10.1016/j.cub.2017.04.023
PMCID:
PMC5457479
AbstractArticlePDF–6.2M
16.
New Functions of APC/C Ubiquitin Ligase in the Nervous System and Its Role in Alzheimer’s Disease
Tanja Fuchsberger, Ana Lloret, Jose Viña
Int J Mol Sci. 2017 May; 18(5): 1057. Published online 2017 May 14. doi: 10.3390/ijms18051057
PMCID:
PMC5454969
AbstractArticlePDF–1.6M
17.
PTEN mediates Notch-dependent stalk cell arrest in angiogenesis
Helena Serra, Iñigo Chivite, Ana Angulo-Urarte, Adriana Soler, James D. Sutherland, Amaia Arruabarrena-Aristorena, Anan Ragab, Radiance Lim, Marcos Malumbres, Marcus Fruttiger, Michael Potente, Manuel Serrano, Àngels Fabra, Francesc Viñals, Oriol Casanovas, Pier Paolo Pandolfi, Anna Bigas, Arkaitz Carracedo, Holger Gerhardt, Mariona Graupera
Nat Commun. 2015; 6: 7935. Published online 2015 Jul 31. doi: 10.1038/ncomms8935
PMCID:
PMC5426521
AbstractArticlePDF–5.9M
18.
APC/CCdh1-Rock2 pathway controls dendritic integrity and memory
Verónica Bobo-Jiménez, María Delgado-Esteban, Julie Angibaud, Irene Sánchez-Morán, Antonio de la Fuente, Javier Yajeya, U. Valentin Nägerl, José Castillo, Juan P. Bolaños, Angeles Almeida
Proc Natl Acad Sci U S A. 2017 Apr 25; 114(17): 4513–4518. Published online 2017 Apr 10. doi: 10.1073/pnas.1616024114
PMCID:
PMC5410848
AbstractArticlePDF–1.4M
19.
FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia
Jo Ishizawa, Eiji Sugihara, Shinji Kuninaka, Kaoru Mogushi, Kensuke Kojima, Christopher B. Benton, Ran Zhao, Dhruv Chachad, Norisato Hashimoto, Rodrigo O. Jacamo, Yihua Qiu, Suk Young Yoo, Shinichiro Okamoto, Michael Andreeff, Steven M. Kornblau, Hideyuki Saya
Blood. 2017 Apr 6; 129(14): 1958–1968. Prepublished online 2017 Jan 31. doi: 10.1182/blood-2016-07-726216
PMCID:
PMC5383867
AbstractArticle
20.
The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function
Lixin Wan, Ming Chen, Juxiang Cao, Xiangpeng Dai, Qing Yin, Jinfang Zhang, Su-Jung Song, Ying Lu, Jing Liu, Hiroyuki Inuzuka, Jesse M. Katon, Kelsey Berry, Jacqueline Fung, Christopher Ng, Pengda Liu, Min Sup Song, Lian Xue, Roderick T. Bronson, Marc W. Kirschner, Rutao Cui, Pier Paolo Pandolfi, Wenyi Wei
Cancer Discov. Author manuscript; available in PMC 2018 Apr 1.
Published in final edited form as: Cancer Discov. 2017 Apr; 7(4): 424–441. Published online 2017 Feb 7. doi: 10.1158/2159-8290.CD-16-0647
PMCID:
PMC5380472
AbstractArticlePDF–2.7M

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