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Select item 107497101.

Dynamic regulation of EXO1 promotes the progression from liver fibrosis to HCC through TGF-β1/Smad signaling feedback loop

Mengting Li, Fengxing Huang, Weining Zhu, Yanan Peng, Fei Xu, Wenjie Li, Qiu Zhao, Lan Liu

Hepatol Commun. 2024 Jan; 8(1): e0342. Published online 2023 Dec 22. doi: 10.1097/HC9.0000000000000342

PMCID:: PMC10749710

Abstract Article PDF–2.7M

Select item 93718902.

Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1^D173A mice

Shanzhi Wang, Kyeryoung Lee, Stephen Gray, Yongwei Zhang, Catherine Tang, Rikke B Morrish, Elena Tosti, Johanna van Oers, Mohammad Ruhul Amin, Paula E Cohen, Thomas MacCarthy, Sergio Roa, Matthew D Scharff, Winfried Edelmann, Richard Chahwan

Nucleic Acids Res. 2022 Aug 12; 50(14): 8093–8106. Published online 2022 Jul 18. doi: 10.1093/nar/gkac616

PMCID:: PMC9371890

Abstract Article PDF–5.1M

Select item 83132393.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 70160974.

ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis

Jacob Paiano, Wei Wu, Shintaro Yamada, Nicholas Sciascia, Elsa Callen, Ana Paola Cotrim, Rajashree A. Deshpande, Yaakov Maman, Amanda Day, Tanya T. Paull, André Nussenzweig

Nat Commun. 2020; 11: 857. Published online 2020 Feb 12. doi: 10.1038/s41467-020-14654-w

PMCID:: PMC7016097

Abstract Article PDF–2.5M

Select item 65884845.

Ca²⁺-stimulated AMPK-dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection

Shan Li, Zeno Lavagnino, Delphine Lemacon, Lingzhen Kong, Alessandro Ustione, Xuewen Ng, Yuanya Zhang, Yingchun Wang, Bin Zheng, Helen Piwnica-Worms, Alessandro Vindigni, David W. Piston, Zhongsheng You

Mol Cell. Author manuscript; available in PMC 2020 Jun 20.

Published in final edited form as: Mol Cell. 2019 Jun 20; 74(6): 1123–1137.e6. Published online 2019 Apr 30. doi: 10.1016/j.molcel.2019.04.003

PMCID:: PMC6588484

Abstract Article PDF–2.7M

Select item 62002706.

MutLγ promotes repeat expansion in a Fragile X mouse model while EXO1 is protective

Xiaonan Zhao, Yongwei Zhang, Kenneth Wilkins, Winfried Edelmann, Karen Usdin

PLoS Genet. 2018 Oct; 14(10): e1007719. Published online 2018 Oct 12. doi: 10.1371/journal.pgen.1007719

PMCID:: PMC6200270

Abstract Article PDF–1.3M

Select item 60562287.

DNA repair and cell cycle checkpoint defects in a mouse model of ‘BRCAness’ are partially rescued by 53BP1 deletion

Sarah M. Misenko, Dharm S. Patel, Joonyoung Her, Samuel F. Bunting

Cell Cycle. 2018; 17(7): 881–891. Published online 2018 May 15. doi: 10.1080/15384101.2018.1456295

PMCID:: PMC6056228

Abstract Article PDF–1.7M

Select item 55840598.

EXO1 suppresses double-strand break induced homologous recombination between diverged sequences in mammalian cells

Chun-Chin Chen, Elena Avdievich, Yongwei Zhang, Yu Zhang, Kaichun Wei, Kyeryoung Lee, Winfried Edelmann, Maria Jasin, Jeannine R. LaRocque

DNA Repair (Amst) Author manuscript; available in PMC 2018 Sep 1.

Published in final edited form as: DNA Repair (Amst). 2017 Sep; 57: 98–106. Published online 2017 Jul 10. doi: 10.1016/j.dnarep.2017.07.003

PMCID:: PMC5584059

Abstract Article PDF–654K

Select item 52871129.

PHF11 promotes DSB resection, ATR signaling, and HR

Yi Gong, Naofumi Handa, Stephen C. Kowalczykowski, Titia de Lange

Genes Dev. 2017 Jan 1; 31(1): 46–58. doi: 10.1101/gad.291807.116

PMCID:: PMC5287112

Abstract Article PDF–664K

Select item 516151910.

Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development

Lina Zhou, Huifang Dai, Jian Wu, Mian Zhou, Hua Yuan, Juan Du, Lu Yang, Xiwei Wu, Hong Xu, Yuejin Hua, Jian Xu, Li Zheng, Binghui Shen

FASEB J. 2017 Jan; 31(1): 132–147. Published online 2016 Sep 30. doi: 10.1096/fj.201600631R

PMCID:: PMC5161519

Abstract Article

Select item 455192911.

EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele

Katrin Rein, Diana A. Yanez, Berta Terré, Lluís Palenzuela, Suvi Aivio, Kaichun Wei, Winfried Edelmann, Jeremy M. Stark, Travis H. Stracker

Nucleic Acids Res. 2015 Sep 3; 43(15): 7371–7387. Published online 2015 Jul 8. doi: 10.1093/nar/gkv691

PMCID:: PMC4551929

Abstract Article PDF–7.1M

Select item 404265012.

CtIP-mediated resection is essential for viability and can operate independently of BRCA1

Federica Polato, Elsa Callen, Nancy Wong, Robert Faryabi, Samuel Bunting, Hua-Tang Chen, Marina Kozak, Michael J. Kruhlak, Colleen R. Reczek, Wen-Hwa Lee, Thomas Ludwig, Richard Baer, Lionel Feigenbaum, Stephen Jackson, André Nussenzweig

J Exp Med. 2014 Jun 2; 211(6): 1027–1036. doi: 10.1084/jem.20131939

PMCID:: PMC4042650

Abstract Article PDF–1.6M

Select item 401192813.

Exonuclease 1 is a critical mediator of survival during DNA double strand break repair in non-quiescent hematopoietic stem and progenitor cells

Amar Desai, Yulan Qing, Stanton L. Gerson

Stem Cells. Author manuscript; available in PMC 2015 Feb 1.

Published in final edited form as: Stem Cells. 2014 Feb; 32(2): 582–593. doi: 10.1002/stem.1596

PMCID:: PMC4011928

Abstract Article PDF–1.8M

Select item 389849614.

siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/− with susceptibility versus C57BL/6-Trp53+/− mice with resistance to mammary tumors

M Böhringer, K Obermeier, N Griner, D Waldraff, E Dickinson, K Eirich, D Schindler, M Hagen, D J Jerry, L Wiesmüller

Oncogene. 2013 Nov 28; 32(48): 5458–5470. Published online 2013 Feb 25. doi: 10.1038/onc.2013.38

PMCID:: PMC3898496

Abstract Article PDF–1.6M

Select item 370403415.

Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes

Sonja Schaetzlein, Richard Chahwan, Elena Avdievich, Sergio Roa, Kaichun Wei, Robert L. Eoff, Rani S. Sellers, Alan B. Clark, Thomas A. Kunkel, Matthew D. Scharff, Winfried Edelmann

Proc Natl Acad Sci U S A. 2013 Jul 2; 110(27): E2470–E2479. Published online 2013 Jun 10. doi: 10.1073/pnas.1308512110

PMCID:: PMC3704034

Abstract Article PDF–1.4M

Select item 367720516.

Class Switch Recombination Efficiency and Junction Microhomology Patterns in Msh2-, Mlh1-, and Exo1-Deficient Mice Depend on the Presence of μ Switch Region Tandem Repeats

Jennifer Eccleston, Carol E. Schrader, Karen Yuan, Janet Stavnezer, Erik Selsing

J Immunol. Author manuscript; available in PMC 2013 Jun 10.

Published in final edited form as: J Immunol. 2009 Jul 15; 183(2): 1222–1228. Published online 2009 Jun 24. doi: 10.4049/jimmunol.0900135

PMCID:: PMC3677205

Abstract Article PDF–1.1M

Select item 365150317.

Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells

Lan N. Truong, Yongjiang Li, Linda Z. Shi, Patty Yi-Hwa Hwang, Jing He, Hailong Wang, Niema Razavian, Michael W. Berns, Xiaohua Wu

Proc Natl Acad Sci U S A. 2013 May 7; 110(19): 7720–7725. Published online 2013 Apr 22. doi: 10.1073/pnas.1213431110

PMCID:: PMC3651503

Abstract Article PDF–849K

Select item 354970918.

Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching

Anne Bothmer, Philipp C. Rommel, Anna Gazumyan, Federica Polato, Colleen R. Reczek, Matthias F. Muellenbeck, Sonja Schaetzlein, Winfried Edelmann, Phang-Lang Chen, Robert M. Brosh, Jr., Rafael Casellas, Thomas Ludwig, Richard Baer, André Nussenzweig, Michel C. Nussenzweig, Davide F. Robbiani

J Exp Med. 2013 Jan 14; 210(1): 115–123. doi: 10.1084/jem.20121975