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Items: 1 to 20 of 196

1.
Loss of SREBP-1c ameliorates iron-induced liver fibrosis by decreasing lipocalin-2
Eun-Ho Lee, Jae-Ho Lee, Do-Young Kim, Young-Seung Lee, Yunju Jo, Tam Dao, Kyung Eun Kim, Dae-Kyu Song, Ji Hae Seo, Young-Kyo Seo, Je Kyung Seong, Changjong Moon, Eugene Han, Mi Kyung Kim, Seungwan Ryu, Minsang Shin, Gu Seob Roh, Hye Ra Jung, Timothy F. Osborne, Dongryeol Ryu, Tae-Il Jeon, Seung-Soon Im
Exp Mol Med. 2024 Apr; 56(4): 1001–1012. Published online 2024 Apr 16. doi: 10.1038/s12276-024-01213-2
PMCID:
PMC11058876
AbstractArticlePDF–6.2M
2.
DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER
Shunxing Rong, Mingfeng Xia, Goncalo Vale, Simeng Wang, Chai-Wan Kim, Shili Li, Jeffrey G. McDonald, Arun Radhakrishnan, Jay D. Horton
Cell Metab. Author manuscript; available in PMC 2024 Mar 14.
Published in final edited form as: Cell Metab. 2024 Mar 5; 36(3): 617–629.e7. Published online 2024 Feb 9. doi: 10.1016/j.cmet.2024.01.011
PMCID:
PMC10939742
AbstractArticlePDF–1.7M
3.
The role of KLF2 in regulating hepatic lipogenesis and blood cholesterol homeostasis via the SCAP/SREBP pathway
Yuhong Huang, Yi Fan Wang, Xiong Zhong Ruan, Chi Wai Lau, Li Wang, Yu Huang
J Lipid Res. 2024 Jan; 65(1): 100472. Published online 2023 Nov 9. doi: 10.1016/j.jlr.2023.100472
PMCID:
PMC10805670
AbstractArticlePDF–3.4M
4.
Macrophage SREBP1 regulates skeletal muscle regeneration
Yumiko Oishi, Hiroyuki Koike, Naoki Kumagami, Yoshimi Nakagawa, Masaya Araki, Yoshitaka Taketomi, Yoshimi Miki, Shigeru Matsuda, Hyeree Kim, Takashi Matsuzaka, Hitoshi Ozawa, Hitoshi Shimano, Makoto Murakami, Ichiro Manabe
Front Immunol. 2023; 14: 1251784. Published online 2024 Jan 8. doi: 10.3389/fimmu.2023.1251784
Correction in:
Front Immunol. 2024; 15: 1382077.
PMCID:
PMC10800357
AbstractArticlePDF–7.7M
5.
miR-195b is required for proper cellular homeostasis in the elderly
Maria del Mar Muñoz-Gallardo, Carlos Garcia-Padilla, Cristina Vicente-Garcia, Jaime Carvajal, Amelia Arenega, Diego Franco
Sci Rep. 2024; 14: 810. Published online 2024 Jan 8. doi: 10.1038/s41598-024-51256-8
PMCID:
PMC10774362
AbstractArticlePDF–3.7M
6.
Exogenous H2S promotes ubiquitin‐mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S‐sulfhydration
Shiwu Zhang, Mengyi Wang, Hongxia Li, Qianzhu Li, Ning Liu, Shiyun Dong, Yajun Zhao, Kemiao Pang, Jiayi Huang, Cheng Ren, Yan Wang, Zhen Tian, Fanghao Lu, Weihua Zhang
J Cachexia Sarcopenia Muscle. 2023 Dec; 14(6): 2719–2732. Published online 2023 Oct 30. doi: 10.1002/jcsm.13347
PMCID:
PMC10751422
AbstractArticlePDF–3.4M
7.
Upregulation of WDR6 drives hepatic de novo lipogenesis in insulin resistance in mice
Zhenyu Yao, Ying Gong, Wenbin Chen, Shanshan Shao, Yongfeng Song, Honglin Guo, Qihang Li, Sijin Liu, Ximing Wang, Zhenhai Zhang, Qian Wang, Yunyun Xu, Yingjie Wu, Qiang Wan, Xinya Zhao, Qiuhui Xuan, Dawei Wang, Xiaoyan Lin, Jiawen Xu, Jun Liu, Christopher G. Proud, Xuemin Wang, Rui Yang, Lili Fu, Shaona Niu, Junjie Kong, Ling Gao, Tao Bo, Jiajun Zhao
Nat Metab. 2023; 5(10): 1706–1725. Published online 2023 Sep 21. doi: 10.1038/s42255-023-00896-7
PMCID:
PMC10590755
AbstractArticlePDF–24M
8.
Caspase-11 contributes to site-1 protease cleavage and SREBP1 activation in the inflammatory response of macrophages
Yinglan Cheng, Ichiro Manabe, Sumio Hayakawa, Yusuke Endo, Yumiko Oishi
Front Immunol. 2023; 14: 1009973. Published online 2023 Jan 27. doi: 10.3389/fimmu.2023.1009973
PMCID:
PMC9912839
AbstractArticlePDF–8.2M
9.
Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice
Batuhan Yenilmez, Mark Kelly, Guo-Fang Zhang, Nicole Wetoska, Olga R. Ilkayeva, Kyounghee Min, Leslie Rowland, Chloe DiMarzio, Wentao He, Naideline Raymond, Lawrence Lifshitz, Meixia Pan, Xianlin Han, Jun Xie, Randall H. Friedline, Jason K. Kim, Guangping Gao, Mark A. Herman, Christopher B. Newgard, Michael P. Czech
J Biol Chem. 2022 Oct; 298(10): 102401. Published online 2022 Aug 18. doi: 10.1016/j.jbc.2022.102401
PMCID:
PMC9490592
AbstractArticlePDF–1.6M
10.
The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation
Ziyi Song, Alus M. Xiaoli, Youlei Li, Gerile Siqin, Tian Wu, Randy Strich, Jeffrey E. Pessin, Fajun Yang
Mol Metab. 2022 Oct; 64: 101548. Published online 2022 Jul 19. doi: 10.1016/j.molmet.2022.101548
PMCID:
PMC9386464
AbstractArticlePDF–6.6M
11.
The Effects of Maternal Intake of EPA and DHA Enriched Diet During Pregnancy and Lactation on Offspring’s Muscle Development and Energy Homeostasis
Saeed Ghnaimawi, Shilei Zhang, Jamie I. Baum, Yan Huang
Front Physiol. 2022; 13: 881624. Published online 2022 Jun 6. doi: 10.3389/fphys.2022.881624
PMCID:
PMC9207413
AbstractArticlePDF–6.0M
12.
Srebf1c preserves hematopoietic stem cell function and survival as a switch of mitochondrial metabolism
Yukai Lu, Zihao Zhang, Song Wang, Yan Qi, Fang Chen, Yang Xu, Mingqiang Shen, Mo Chen, Naicheng Chen, Lijing Yang, Shilei Chen, Fengchao Wang, Yongping Su, Mengjia Hu, Junping Wang
Stem Cell Reports. 2022 Mar 8; 17(3): 599–615. Published online 2022 Feb 10. doi: 10.1016/j.stemcr.2022.01.011
PMCID:
PMC9039836
AbstractArticlePDF–6.1M
13.
CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing
Han Zeng, Hong Qin, Meng Liao, Enze Zheng, Xiaoqing Luo, Anhua Xiao, Yiyu Li, Lin Chen, Li Wei, Lei Zhao, Xiong Z. Ruan, Ping Yang, Yaxi Chen
Mol Metab. 2022 Mar; 57: 101428. Published online 2021 Dec 30. doi: 10.1016/j.molmet.2021.101428
PMCID:
PMC8810570
AbstractArticlePDF–4.7M
14.
Adipose-Specific PPARα Knockout Mice Have Increased Lipogenesis by PASK–SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue
Terry D. Hinds, Jr., Zachary A. Kipp, Mei Xu, Frederique B. Yiannikouris, Andrew J. Morris, Donald F. Stec, Walter Wahli, David E. Stec
Cells. 2022 Jan; 11(1): 4. Published online 2021 Dec 21. doi: 10.3390/cells11010004
PMCID:
PMC8750478
AbstractArticlePDF–4.4M
15.
Impairment of ULK1 sulfhydration-mediated lipophagy by SREBF1/SREBP-1c in hepatic steatosis
Thuy T.P. Nguyen, Do-Young Kim, Seung-Soon Im, Tae-Il Jeon
Autophagy. 2021; 17(12): 4489–4490. Published online 2021 Aug 30. doi: 10.1080/15548627.2021.1968608
PMCID:
PMC8726704
AbstractArticlePDF–428K
16.
SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1
Chaoyu Zhu, Menghao Huang, Hyeong-Geug Kim, Kushan Chowdhury, Jing Gao, Sheng Liu, Jun Wan, Li Wei, X. Charlie Dong
Biochim Biophys Acta Mol Basis Dis. Author manuscript; available in PMC 2022 Dec 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2021 Dec 1; 1867(12): 166249. Published online 2021 Aug 21. doi: 10.1016/j.bbadis.2021.166249
PMCID:
PMC8488016
AbstractArticlePDF–1.4M
17.
FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue
Yingyi Zhang, Jielu Hao, Mariana G. Tarrago, Gina M. Warner, Nino Giorgadze, Qing Wei, Yan Huang, Kai He, Chuan Chen, Thais R. Peclat, Thomas A. White, Kun Ling, Tamar Tchkonia, James L. Kirkland, Eduardo N. Chini, Jinghua Hu
Cell Rep. Author manuscript; available in PMC 2021 Sep 9.
Published in final edited form as: Cell Rep. 2021 Aug 3; 36(5): 109481. doi: 10.1016/j.celrep.2021.109481
PMCID:
PMC8428195
AbstractArticlePDF–3.5M
18.
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption
Bethan L. Clifford, Leslie R. Sedgeman, Kevin J. Williams, Pauline Morand, Angela Cheng, Kelsey E. Jarrett, Alvin P. Chan, Madelaine C. Brearley-Sholto, Annika Wahlström, Julianne W. Ashby, William Barshop, James Wohlschlegel, Anna C. Calkin, Yingying Liu, Anders Thorell, Peter J. Meikle, Brian G. Drew, Julia J. Mack, Hanns-Ulrich Marschall, Elizabeth J. Tarling, Peter A. Edwards, Thomas Q. de Aguiar Vallim
Cell Metab. Author manuscript; available in PMC 2022 Aug 3.
Published in final edited form as: Cell Metab. 2021 Aug 3; 33(8): 1671–1684.e4. Published online 2021 Jul 15. doi: 10.1016/j.cmet.2021.06.012
PMCID:
PMC8353952
AbstractArticlePDF–3.1M
19.
Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildup
Francesc X Guix, Ana Marrero Capitán, Álvaro Casadomé-Perales, Irene Palomares-Pérez, Inés López del Castillo, Verónica Miguel, Leigh Goedeke, Mauricio G Martín, Santiago Lamas, Héctor Peinado, Carlos Fernández-Hernando, Carlos G Dotti
Life Sci Alliance. 2021 Aug; 4(8): e202101055. Published online 2021 Jun 28. doi: 10.26508/lsa.202101055
PMCID:
PMC8321659
AbstractArticlePDF–2.9M
20.
SREBP-1c Deficiency Affects Hippocampal Micromorphometry and Hippocampus-Dependent Memory Ability in Mice
Mary Jasmin Ang, Sueun Lee, Mai Wada, Poornima D. E. Weerasinghe-Mudiyanselage, Sung-Ho Kim, Taekyun Shin, Tae-Il Jeon, Seung-Soon Im, Changjong Moon
Int J Mol Sci. 2021 Jun; 22(11): 6103. Published online 2021 Jun 5. doi: 10.3390/ijms22116103
PMCID:
PMC8201143
AbstractArticlePDF–2.0M

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