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Items: 1 to 20 of 416

1.
Telomeric DNA breaks in human induced pluripotent stem cells trigger ATR-mediated arrest and telomerase-independent telomere damage repair
Katrina N Estep, John W Tobias, Rafael J Fernandez, Brinley M Beveridge, F Brad Johnson
J Mol Cell Biol. 2024 Mar; 16(3): mjad058. Published online 2023 Sep 28. doi: 10.1093/jmcb/mjad058
PMCID:
PMC11429528
AbstractArticlePDF–2.6M
2.
DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples
Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang
J Proteome Res. Author manuscript; available in PMC 2024 Aug 3.
Published in final edited form as: J Proteome Res. 2024 Aug 2; 23(8): 3269–3279. Published online 2024 Feb 9. doi: 10.1021/acs.jproteome.3c00832
PMCID:
PMC11296914
AbstractArticlePDF–1.7M
3.
Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein
Xiao Tang, Yang Liu, Jinhui Wang, Teng Long, Bobo Wing Yee Mok, Yan Huang, Ziqing Peng, Qinyu Jia, Chengxi Liu, Pui-Kin So, Sirius Pui-Kam Tse, Cheuk Hei NG, Shiyi Liu, Fei Sun, Shaojun Tang, Zhong-Ping Yao, Honglin Chen, Yusong Guo
J Biol Chem. 2024 Jun; 300(6): 107390. Published online 2024 May 21. doi: 10.1016/j.jbc.2024.107390
PMCID:
PMC11237930
AbstractArticlePDF–3.8M
4.
EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells
Néstor García-Rodríguez, Iria Domínguez-García, María del Carmen Domínguez-Pérez, Pablo Huertas
Nucleic Acids Res. 2024 Jun 24; 52(11): 6376–6391. Published online 2024 May 9. doi: 10.1093/nar/gkae317
PMCID:
PMC11194085
AbstractArticlePDF–2.4M
5.
Alterations in ATR in nasal NK/T‐cell lymphoma and chronic active Epstein–Barr virus infection
Angen Liu, Tetsuya Takakuwa, Wen‐Juan Luo, Shigeki Fujita, Katsuyuki Aozasa
Cancer Sci. 2006 Jul; 97(7): 605–610. Published online 2006 May 15. doi: 10.1111/j.1349-7006.2006.00226.x
PMCID:
PMC11159954
AbstractArticlePDF–165K
6.
Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non‐small‐cell lung cancer
Min Kim, Hyo‐Gyoung Kang, Shin Yup Lee, Hyung Cheol Lee, Eung Bae Lee, Yi Young Choi, Won Kee Lee, Sukki Cho, Guang Jin, Hyo‐Sung Jheon, Ji Woong Son, Myung‐Hoon Lee, Deuk Kju Jung, Seung Ick Cha, Chang Ho Kim, Young Mo Kang, Sin Kam, Tae Hoon Jung, Sanghoon Jheon, Jae Yong Park
Cancer Sci. 2010 Nov; 101(11): 2436–2442. Published online 2010 Jul 31. doi: 10.1111/j.1349-7006.2010.01699.x
PMCID:
PMC11159840
AbstractArticlePDF–209K
7.
New insights into ATR inhibition in muscle invasive bladder cancer: The role of apolipoprotein B mRNA editing catalytic subunit 3B
HYUNHO KIM, UIJU CHO, SOOK HEE HONG, HYUNG SOON PARK, IN-HO KIM, HO JUNG AN, BYOUNG YONG SHIM, JIN HYOUNG KANG
Oncol Res. 2024; 32(6): 1021–1030. Published online 2024 May 23. doi: 10.32604/or.2024.048919
PMCID:
PMC11136685
AbstractArticlePDF–38M
8.
SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner
Anke Geng, Jiahui Sun, Huanyin Tang, Yang Yu, Xiyue Wang, Jingyuan Zhang, Xiaona Wang, Xiaoxiang Sun, Xiaofang Zhou, Neng Gao, Rong Tan, Zhu Xu, Ying Jiang, Zhiyong Mao
Nucleic Acids Res. 2024 May 22; 52(9): 5107–5120. Published online 2024 Mar 30. doi: 10.1093/nar/gkae190
PMCID:
PMC11109957
AbstractArticlePDF–2.3M
9.
The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation
Christopher B. Nelson, Samuel Rogers, Kaushik Roychoudhury, Yaw Sing Tan, Caroline J. Atkinson, Alexander P. Sobinoff, Christopher G. Tomlinson, Anton Hsu, Robert Lu, Eloise Dray, Michelle Haber, Jamie I. Fletcher, Anthony J. Cesare, Rashmi S. Hegde, Hilda A. Pickett
Nat Commun. 2024; 15: 1385. Published online 2024 Feb 15. doi: 10.1038/s41467-024-45683-4
PMCID:
PMC10869800
AbstractArticlePDF–9.3M
10.
ATR phosphorylates DHX9 at serine 321 to suppress R-loop accumulation upon genotoxic stress
Mei-Yin Liu, Keng-Ru Lin, Yuh-Ling Chien, Bing-Ze Yang, Li-Yu Tsui, Hsueh-Ping Catherine Chu, Ching-Shyi Peter Wu
Nucleic Acids Res. 2024 Jan 11; 52(1): 204–222. Published online 2023 Nov 1. doi: 10.1093/nar/gkad973
PMCID:
PMC10783509
AbstractArticlePDF–2.3M
11.
ADAR1 links R-loop homeostasis to ATR activation in replication stress response
Biao Zhang, Yi Li, Jieyou Zhang, Yuejiao Wang, Can Liang, Ting Lu, Chunyong Zhang, Ling Liu, Yan Qin, Jiahuan He, Xiangnan Zhao, Jia Yu, Jihui Hao, Jie Yang, Mulin Jun Li, Zhi Yao, Shuai Ma, Hui Cheng, Tao Cheng, Lei Shi
Nucleic Acids Res. 2023 Nov 27; 51(21): 11668–11687. Published online 2023 Oct 13. doi: 10.1093/nar/gkad839
PMCID:
PMC10681745
AbstractArticlePDF–3.8M
12.
ATR Promotes Clearance of Damaged DNA and Damaged Cells by Rupturing Micronuclei
Yoon Ki Joo, Elizabeth M. Black, Isabelle Trier, Wisse Haakma, Lee Zou, Lilian Kabeche
Mol Cell. Author manuscript; available in PMC 2024 Oct 19.
Published in final edited form as: Mol Cell. 2023 Oct 19; 83(20): 3642–3658.e4. Published online 2023 Oct 2. doi: 10.1016/j.molcel.2023.09.003
PMCID:
PMC10599252
AbstractArticlePDF–2.9M
13.
DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C
Marton Tibor Kovacs, Marie Vallette, Pauline Wiertsema, Florent Dingli, Damarys Loew, Guilherme Pedreira de Freitas Nader, Matthieu Piel, Raphael Ceccaldi
Mol Cell. 2023 Oct 19; 83(20): 3659–3668.e10. doi: 10.1016/j.molcel.2023.09.023
PMCID:
PMC10597398
AbstractArticle
14.
Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1
Devashish Dwivedi, Daniela Harry, Patrick Meraldi
Nat Commun. 2023; 14: 6088. Published online 2023 Sep 29. doi: 10.1038/s41467-023-41753-1
PMCID:
PMC10541884
AbstractArticlePDF–9.6M
15.
Long Noncoding RNA ZBED5-AS1 Facilitates Tumor Progression and Metastasis in Lung Adenocarcinoma via ZNF146/ATR/Chk1 Axis
Feng Jiang, Xiaolu Huang, Liqun Ling, Shiyi Tang, Huixin Zhou, Xueding Cai, Yumin Wang
Int J Mol Sci. 2023 Sep; 24(18): 13925. Published online 2023 Sep 10. doi: 10.3390/ijms241813925
PMCID:
PMC10530271
AbstractArticlePDF–7.0M
16.
ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms
Wendy Leung, Antoine Simoneau, Sneha Saxena, Jessica Jackson, Parasvi S. Patel, Mangsi Limbu, Alessandro Vindigni, Lee Zou
Cell Rep. Author manuscript; available in PMC 2023 Sep 27.
Published in final edited form as: Cell Rep. 2023 Jul 25; 42(7): 112792. Published online 2023 Jul 16. doi: 10.1016/j.celrep.2023.112792
PMCID:
PMC10529362
AbstractArticlePDF–2.8M
17.
Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk
Naomi Wilcox, Martine Dumont, Anna González-Neira, Sara Carvalho, Charles Joly Beauparlant, Marco Crotti, Craig Luccarini, Penny Soucy, Stéphane Dubois, Rocio Nuñez-Torres, Guillermo Pita, Eugene J. Gardner, Joe Dennis, M. Rosario Alonso, Nuria Álvarez, Caroline Baynes, Annie Claude Collin-Deschesnes, Sylvie Desjardins, Heiko Becher, Sabine Behrens, Manjeet K. Bolla, Jose E. Castelao, Jenny Chang-Claude, Sten Cornelissen, Thilo Dörk, Christoph Engel, Manuela Gago-Dominguez, Pascal Guénel, Andreas Hadjisavvas, Eric Hahnen, Mikael Hartman, Belén Herráez, SGBCC Investigators, Audrey Jung, Renske Keeman, Marion Kiechle, Jingmei Li, Maria A. Loizidou, Michael Lush, Kyriaki Michailidou, Mihalis I. Panayiotidis, Xueling Sim, Soo Hwang Teo, Jonathan P. Tyrer, Lizet E. van der Kolk, Cecilia Wahlström, Qin Wang, John R. B. Perry, Javier Benitez, Marjanka K. Schmidt, Rita K. Schmutzler, Paul D. P. Pharoah, Arnaud Droit, Alison M. Dunning, Anders Kvist, Peter Devilee, Douglas F. Easton, Jacques Simard
Nat Genet. 2023; 55(9): 1435–1439. Published online 2023 Aug 17. doi: 10.1038/s41588-023-01466-z
Correction in:
Nat Genet. 2023; 55(11): 2009.
PMCID:
PMC10484782
AbstractArticlePDF–3.5M
18.
A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells
Sana Ahmed-Seghir, Manisha Jalan, Helen E Grimsley, Aman Sharma, Shyam Twayana, Settapong T Kosiyatrakul, Christopher Thompson, Carl L Schildkraut, Simon N Powell
eLife. 2023; 12: RP87357. Published online 2023 Aug 30. doi: 10.7554/eLife.87357
PMCID:
PMC10468204
AbstractArticlePDF–5.3M
19.
Alteration of replication protein A binding mode on single-stranded DNA by NSMF potentiates RPA phosphorylation by ATR kinase
Yujin Kang, Ye Gi Han, Keon Woo Khim, Woo Gyun Choi, Min Kyung Ju, Kibeom Park, Kyeong Jin Shin, Young Chan Chae, Jang Hyun Choi, Hongtae Kim, Ja Yil Lee
Nucleic Acids Res. 2023 Aug 25; 51(15): 7936–7950. Published online 2023 Jun 28. doi: 10.1093/nar/gkad543
PMCID:
PMC10450186
AbstractArticlePDF–1.6M
20.
Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe
Jinal A Patel, Camryn Zezelic, Julie Rageul, Joanne Saldanha, Arafat Khan, Hyungjin Kim
Nucleic Acids Res. 2023 Jul 7; 51(12): 6246–6263. Published online 2023 May 5. doi: 10.1093/nar/gkad363
PMCID:
PMC10325925
AbstractArticlePDF–1.9M

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