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Items: 1 to 20 of 40

1.
Activation and substrate specificity of the human P4-ATPase ATP8B1
Thibaud Dieudonné, Felix Kümmerer, Michelle Juknaviciute Laursen, Charlott Stock, Rasmus Kock Flygaard, Syma Khalid, Guillaume Lenoir, Joseph A. Lyons, Kresten Lindorff-Larsen, Poul Nissen
Nat Commun. 2023; 14: 7492. Published online 2023 Nov 18. doi: 10.1038/s41467-023-42828-9
PMCID:
PMC10657443
AbstractArticlePDF–10M
2.
Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell
Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low
Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120
PMCID:
PMC10151615
AbstractArticlePDF–2.9M
3.
ATP8B1 Deficiency Results in Elevated Mitochondrial Phosphatidylethanolamine Levels and Increased Mitochondrial Oxidative Phosphorylation in Human Hepatoma Cells
Valentina E. Gómez-Mellado, Jung-Chin Chang, Kam S. Ho-Mok, Carmen Bernardino Morcillo, Remco H. J. Kersten, Ronald P. J. Oude Elferink, Arthur J. Verhoeven, Coen C. Paulusma
Int J Mol Sci. 2022 Oct; 23(20): 12344. Published online 2022 Oct 15. doi: 10.3390/ijms232012344
PMCID:
PMC9604224
AbstractArticlePDF–2.3M
4.
Clinical phenotype of adult‐onset liver disease in patients with variants in ABCB4, ABCB11, and ATP8B1
Jeremy S. Nayagam, Pierre Foskett, Sandra Strautnieks, Kosh Agarwal, Rosa Miquel, Deepak Joshi, Richard J. Thompson
Hepatol Commun. 2022 Oct; 6(10): 2654–2664. Published online 2022 Jul 27. doi: 10.1002/hep4.2051
PMCID:
PMC9512461
AbstractArticlePDF–814K
5.
Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding
Meng-Ting Cheng, Yu Chen, Zhi-Peng Chen, Xin Liu, Zhiyong Zhang, Yuxing Chen, Wen-Tao Hou (侯文韬), Cong-Zhao Zhou
Proc Natl Acad Sci U S A. 2022 Apr 5; 119(14): e2118656119. Published online 2022 Mar 29. doi: 10.1073/pnas.2118656119
PMCID:
PMC9168909
AbstractArticlePDF–1.8M
6.
Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders
Thibaud Dieudonné, Sara Abad Herrera, Michelle Juknaviciute Laursen, Maylis Lejeune, Charlott Stock, Kahina Slimani, Christine Jaxel, Joseph A Lyons, Cédric Montigny, Thomas Günther Pomorski, Poul Nissen, Guillaume Lenoir
eLife. 2022; 11: e75272. Published online 2022 Apr 13. doi: 10.7554/eLife.75272
PMCID:
PMC9045818
AbstractArticlePDF–5.8M
7.
Impact of Genotype, Serum Bile Acids, and Surgical Biliary Diversion on Native Liver Survival in FIC1 Deficiency
Daan B.E. van Wessel, Richard J. Thompson, Emmanuel Gonzales, Irena Jankowska, Benjamin L. Shneider, Etienne Sokal, Tassos Grammatikopoulos, Agustina Kadaristiana, Emmanuel Jacquemin, Anne Spraul, Patryk Lipiński, Piotr Czubkowski, Nathalie Rock, Mohammad Shagrani, Dieter Broering, Talal Algoufi, Nejat Mazhar, Emanuele Nicastro, Deirdre Kelly, Gabriella Nebbia, Henrik Arnell, Björn Fischler, Jan B.F. Hulscher, Daniele Serranti, Cigdem Arikan, Dominique Debray, Florence Lacaille, Cristina Goncalves, Loreto Hierro, Gema Muñoz Bartolo, Yael Mozer‐Glassberg, Amer Azaz, Jernej Brecelj, Antal Dezsőfi, Pier Luigi Calvo, Dorothee Krebs‐Schmitt, Steffen Hartleif, Wendy L. van der Woerd, Jian‐She Wang, Li‐ting Li, Özlem Durmaz, Nanda Kerkar, Marianne Hørby Jørgensen, Ryan Fischer, Carolina Jimenez‐Rivera, Seema Alam, Mara Cananzi, Noémie Laverdure, Cristina Targa Ferreira, Felipe Ordonez, Heng Wang, Valerie Sency, Kyung Mo Kim, Huey‐Ling Chen, Elisa Carvalho, Alexandre Fabre, Jesus Quintero Bernabeu, Estella M. Alonso, Ronald J. Sokol, Frederick J. Suchy, Kathleen M. Loomes, Patrick J. McKiernan, Philip Rosenthal, Yumirle Turmelle, Girish S. Rao, Simon Horslen, Binita M. Kamath, Maria Rogalidou, Wikrom W. Karnsakul, Bettina Hansen, Henkjan J. Verkade, Natural Course and Prognosis of PFIC and Effect of Biliary Diversion Consortium
Hepatology. 2021 Aug; 74(2): 892–906. Published online 2021 Jul 13. doi: 10.1002/hep.31787
PMCID:
PMC8456904
AbstractArticlePDF–464K
8.
Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy
Tengfei Xiao, Wei Li, Xiaoqing Wang, Han Xu, Jixin Yang, Qiu Wu, Ying Huang, Joseph Geradts, Peng Jiang, Teng Fei, David Chi, Chongzhi Zang, Qi Liao, Jonathan Rennhack, Eran Andrechek, Nanlin Li, Simone Detre, Mitchell Dowsett, Rinath M. Jeselsohn, X. Shirley Liu, Myles Brown
Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): 7869–7878. Published online 2018 Jul 9. doi: 10.1073/pnas.1722617115
PMCID:
PMC6077722
AbstractArticlePDF–2.4M
9.
Assessment of ATP8B1 Deficiency in Pediatric Patients With Cholestasis Using Peripheral Blood Monocyte-Derived Macrophages
Hisamitsu Hayashi, Sotaro Naoi, Takao Togawa, Yu Hirose, Hiroki Kondou, Yasuhiro Hasegawa, Daiki Abukawa, Mika Sasaki, Koji Muroya, Satoshi Watanabe, Satoshi Nakano, Kei Minowa, Ayano Inui, Akinari Fukuda, Mureo Kasahara, Hironori Nagasaka, Kazuhiko Bessho, Mitsuyoshi Suzuki, Hiroyuki Kusuhara
EBioMedicine. 2018 Jan; 27: 187–199. Published online 2017 Oct 7. doi: 10.1016/j.ebiom.2017.10.007
PMCID:
PMC5828058
AbstractArticlePDF–2.0M
10.
VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation
Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu
Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0
PMCID:
PMC5826926
AbstractArticlePDF–2.3M
11.
Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing
Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown
Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114
PMCID:
PMC5495225
AbstractArticlePDF–1.3M
12.
ABCB4 missense mutations D243A, K435T, G535D, I490T, R545C, and S978P significantly impair the lipid floppase and likely predispose to secondary pathologies in the human population
Edward J. Andress, Michael Nicolaou, Farrell McGeoghan, Kenneth J. Linton
Cell Mol Life Sci. 2017 Jul; 74(13): 2513–2524. Published online 2017 Feb 20. doi: 10.1007/s00018-017-2472-6
PMCID:
PMC5487885
AbstractArticlePDF–2.6M
13.
Prognostic roles of tetrahydroxy bile acids in infantile intrahepatic cholestasis
Chee-Seng Lee, Akihiko Kimura, Jia-Feng Wu, Yen-Hsuan Ni, Hong-Yuan Hsu, Mei-Hwei Chang, Hiroshi Nittono, Huey-Ling Chen
J Lipid Res. 2017 Mar; 58(3): 607–614. Published online 2017 Feb 27. doi: 10.1194/jlr.P070425
PMCID:
PMC5335591
AbstractArticlePDF–686K
14.
Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4
Vincent A. van der Mark, Mohammed Ghiboub, Casper Marsman, Jing Zhao, Remco van Dijk, Johan K. Hiralall, Kam S. Ho-Mok, Zoë Castricum, Wouter J. de Jonge, Ronald P. J. Oude Elferink, Coen C. Paulusma
Cell Mol Life Sci. 2017 Feb; 74(4): 715–730. Published online 2016 Sep 14. doi: 10.1007/s00018-016-2360-5
Correction in:
Cell Mol Life Sci. 2017 Apr; 74(7): 1365.
PMCID:
PMC5272906
AbstractArticlePDF–4.2M
15.
The Features of GGT in Patients with ATP8B1 or ABCB11 Deficiency Improve the Diagnostic Efficiency
Neng-Li Wang, Li-Ting Li, Bing-Bing Wu, Jing-Yu Gong, Kuerbanjiang Abuduxikuer, Gang Li, Jian-She Wang
PLoS One. 2016; 11(4): e0153114. Published online 2016 Apr 6. doi: 10.1371/journal.pone.0153114
PMCID:
PMC4822785
AbstractArticlePDF–355K
16.
Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION
Israr-ul H. Ansari, Melissa J. Longacre, Coen C. Paulusma, Scott W. Stoker, Mindy A. Kendrick, Michael J. MacDonald
J Biol Chem. 2015 Sep 18; 290(38): 23110–23123. Published online 2015 Aug 3. doi: 10.1074/jbc.M115.655027
PMCID:
PMC4645617
AbstractArticlePDF–1.5M
17.
Dynamic regulation of cardiolipin by the lipid pump, ATP8b1, determines the severity of lung injury in experimental bacterial pneumonia
Nancy B. Ray, Lakshmi Durairaj, Bill B. Chen, Bryan J. McVerry, Alan J. Ryan, Michael Donahoe, Alisa K. Waltenbaugh, Christopher P. O’Donnell, Florita C. Henderson, Christopher A. Etscheidt, Diann M. McCoy, Marianna Agassandian, Emily C. Hayes-Rowan, Tiffany A. Coon, Phillip L. Butler, Lokesh Gakhar, Satya N. Mathur, Jessica C. Sieren, Yulia Y. Tyurina, Valerian E. Kagan, Geoffrey McLennan, Rama K. Mallampalli
Nat Med. Author manuscript; available in PMC 2015 Jul 13.
Published in final edited form as: Nat Med. 2010 Oct; 16(10): 1120–1127. Published online 2010 Sep 19. doi: 10.1038/nm.2213
PMCID:
PMC4500192
AbstractArticlePDF–1.0M
18.
Phospholipid Flippase ATP10A Translocates Phosphatidylcholine and Is Involved in Plasma Membrane Dynamics
Tomoki Naito, Hiroyuki Takatsu, Rie Miyano, Naoto Takada, Kazuhisa Nakayama, Hye-Won Shin
J Biol Chem. 2015 Jun 12; 290(24): 15004–15017. Published online 2015 May 6. doi: 10.1074/jbc.M115.655191
PMCID:
PMC4463445
AbstractArticlePDF–4.2M
19.
Genetic loci associated with circulating levels of very long-chain saturated fatty acids
Rozenn N. Lemaitre, Irena B. King, Edmond K. Kabagambe, Jason H. Y. Wu, Barbara McKnight, Ani Manichaikul, Weihua Guan, Qi Sun, Daniel I. Chasman, Millennia Foy, Lu Wang, Jingwen Zhu, David S. Siscovick, Michael Y. Tsai, Donna K. Arnett, Bruce M. Psaty, Luc Djousse, Yii-Der I. Chen, Weihong Tang, Lu-Chen Weng, Hongyu Wu, Majken K. Jensen, Audrey Y. Chu, David R. Jacobs, Jr., Stephen S. Rich, Dariush Mozaffarian, Lyn Steffen, Eric B. Rimm, Frank B. Hu, Paul M. Ridker, Myriam Fornage, Yechiel Friedlander
J Lipid Res. 2015 Jan; 56(1): 176–184. doi: 10.1194/jlr.M052456
PMCID:
PMC4274065
AbstractArticlePDF–1.1M
20.
Phospholipid Flippase Activities and Substrate Specificities of Human Type IV P-type ATPases Localized to the Plasma Membrane
Hiroyuki Takatsu, Gaku Tanaka, Katsumori Segawa, Jun Suzuki, Shigekazu Nagata, Kazuhisa Nakayama, Hye-Won Shin
J Biol Chem. 2014 Nov 28; 289(48): 33543–33556. Published online 2013 Oct 14. doi: 10.1074/jbc.M114.593012
Correction in:
J Biol Chem. 2016 Oct 7; 291(41): 21421.
PMCID:
PMC4246107
AbstractArticlePDF–3.8M

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