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Select item 90375511.

Silencing PEX26 as an unconventional mode to kill drug-resistant cancer cells and forestall drug resistance

Michael S. Dahabieh, Fan Huang, Christophe Goncalves, Raúl Ernesto Flores González, Sathyen Prabhu, Alicia Bolt, Erminia Di Pietro, Elie Khoury, John Heath, Zi Yi Xu, Joelle Rémy-Sarrazin, Koren K. Mann, Alexandre Orthwein, François-Michel Boisvert, Nancy Braverman, Wilson H. Miller, Sonia V. del Rincón

Autophagy. 2022; 18(3): 540–558. Published online 2021 Jun 21. doi: 10.1080/15548627.2021.1936932

PMCID:: PMC9037551

Abstract Article PDF–4.7M

Select item 82827642.

N6-methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation

Yuanming Cheng, Wei Xie, Brian F Pickering, Karen L Chu, Angela M Savino, Xuejing Yang, Hanzhi Luo, Diu TT Nguyen, Shanlan Mo, Ersilia Barin, Anthony Velleca, Thomas Rohwetter, Dinshaw J Patel, Samie R Jaffrey, Michael G Kharas

Cancer Cell. Author manuscript; available in PMC 2022 Jul 12.

Published in final edited form as: Cancer Cell. 2021 Jul 12; 39(7): 958–972.e8. Published online 2021 May 27. doi: 10.1016/j.ccell.2021.04.017

PMCID:: PMC8282764

Abstract Article PDF–3.4M

Select item 71699833.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 69095784.

Expanding the clinical and genetic spectrum of Heimler syndrome

Feng-Juan Gao, Fang-Yuan Hu, Ping Xu, Yu-He Qi, Jian-Kang Li, Yong-Jin Zhang, Fang Chen, Qing Chang, Fang Song, Si-Mai Shen, Ge-Zhi Xu, Ji-Hong Wu

Orphanet J Rare Dis. 2019; 14: 290. Published online 2019 Dec 12. doi: 10.1186/s13023-019-1243-x

PMCID:: PMC6909578

Abstract Article PDF–2.1M

Select item 68910975.

Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability

Divya Achuthankutty, Roshan Singh Thakur, Peter Haahr, Saskia Hoffmann, Alexandros P. Drainas, Anna H. Bizard, Joachim Weischenfeldt, Ian D. Hickson, Niels Mailand

J Cell Biol. 2019 Dec 2; 218(12): 3943–3953. Published online 2019 Oct 15. doi: 10.1083/jcb.201905064

PMCID:: PMC6891097

Abstract Article PDF–2.7M

Select item 63717446.

A newly identified mutation in the PEX26 gene is associated with a milder form of Zellweger spectrum disorder

Akemi J. Tanaka, Kanji Okumoto, Shigehiko Tamura, Yuichi Abe, Yoel Hirsch, Liyong Deng, Joseph Ekstein, Wendy K. Chung, Yukio Fujiki

Cold Spring Harb Mol Case Stud. 2019 Feb; 5(1): a003483. doi: 10.1101/mcs.a003483

PMCID:: PMC6371744

Abstract Article PDF–12M

Select item 62077567.

Chemically monoubiquitinated PEX5 binds to the components of the peroxisomal docking and export machinery

Vera Hagmann, Stefanie Sommer, Patrick Fabian, Jan Bierlmeier, Nadine van Treel, Henning D. Mootz, Dirk Schwarzer, Jorge E. Azevedo, Gabriele Dodt

Sci Rep. 2018; 8: 16014. Published online 2018 Oct 30. doi: 10.1038/s41598-018-34200-5

PMCID:: PMC6207756

Abstract Article PDF–1.7M

Select item 57038788.

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery

Ramesh Kumar, Román González-Prieto, Zhenyu Xiao, Matty Verlaan-de Vries, Alfred C. O. Vertegaal

Nat Commun. 2017; 8: 1809. Published online 2017 Nov 27. doi: 10.1038/s41467-017-01900-x

PMCID:: PMC5703878

Abstract Article PDF–3.7M

Select item 48821909.

Widespread expansion of protein interaction capabilities by alternative splicing

Xinping Yang, Jasmin Coulombe-Huntington, Shuli Kang, Gloria M. Sheynkman, Tong Hao, Aaron Richardson, Song Sun, Fan Yang, Yun A. Shen, Ryan R. Murray, Kerstin Spirohn, Bridget E. Begg, Miquel Duran-Frigola, Andrew MacWilliams, Samuel J. Pevzner, Quan Zhong, Shelly A. Wanamaker, Stanley Tam, Lila Ghamsari, Nidhi Sahni, Song Yi, Maria D. Rodriguez, Dawit Balcha, Guihong Tan, Michael Costanzo, Brenda Andrews, Charles Boone, Xianghong J. Zhou, Kourosh Salehi-Ashtiani, Benoit Charloteaux, Alyce A. Chen, Michael A. Calderwood, Patrick Aloy, Frederick P. Roth, David E. Hill, Lilia M. Iakoucheva, Yu Xia, Marc Vidal

Cell. Author manuscript; available in PMC 2017 Feb 11.

Published in final edited form as: Cell. 2016 Feb 11; 164(4): 805–817. doi: 10.1016/j.cell.2016.01.029

PMCID:: PMC4882190

Abstract Article PDF–1.9M

Select item 466718710.

Conserved targeting information in mammalian and fungal peroxisomal tail-anchored proteins

Judith Buentzel, Fabio Vilardi, Amelie Lotz-Havla, Jutta Gärtner, Sven Thoms

Sci Rep. 2015; 5: 17420. Published online 2015 Dec 2. doi: 10.1038/srep17420

PMCID:: PMC4667187

Abstract Article PDF–1.0M

Select item 414886211.

AAA Peroxins and Their Recruiter Pex26p Modulate the Interactions of Peroxins Involved in Peroxisomal Protein Import

Shigehiko Tamura, Naomi Matsumoto, Ryota Takeba, Yukio Fujiki

J Biol Chem. 2014 Aug 29; 289(35): 24336–24346. Published online 2014 Jul 11. doi: 10.1074/jbc.M114.588038

PMCID:: PMC4148862

Abstract Article PDF–959K

Select item 358783712.

Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway

Yuichi Yagita, Takahide Hiromasa, Yukio Fujiki

J Cell Biol. 2013 Mar 4; 200(5): 651–666. doi: 10.1083/jcb.201211077

PMCID:: PMC3587837

Abstract Article PDF–3.4M

Select item 317805913.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 292868714.

The peroxisomal receptor Pex19p forms a helical mPTS recognition domain

Nicole Schueller, Simon J Holton, Krisztian Fodor, Morlin Milewski, Petr Konarev, Will A Stanley, Janina Wolf, Ralf Erdmann, Wolfgang Schliebs, Young-Hwa Song, Matthias Wilmanns

EMBO J. 2010 Aug 4; 29(15): 2491–2500. Published online 2010 Jun 8. doi: 10.1038/emboj.2010.115

PMCID:: PMC2928687

Abstract Article PDF–1.3M

Select item 268304715.

Ubiquitin-mediated proteolysis of HuR by heat shock

Kotb Abdelmohsen, Subramanya Srikantan, Xiaoling Yang, Ashish Lal, Hyeon Ho Kim, Yuki Kuwano, Stefanie Galban, Kevin G Becker, Davida Kamara, Rafael de Cabo, Myriam Gorospe

EMBO J. 2009 May 6; 28(9): 1271–1282. Published online 2009 Mar 26. doi: 10.1038/emboj.2009.67

PMCID:: PMC2683047

Abstract Article PDF–1.4M

Select item 264996716.

Identification of Novel Mutations and Sequence Variation in the Zellweger Syndrome Spectrum of Peroxisome Biogenesis Disorders

Wing Yan Yik, Steven J. Steinberg, Ann B. Moser, Hugo W. Moser, Joseph G. Hacia

Hum Mutat. Author manuscript; available in PMC 2009 Mar 2.

Published in final edited form as: Hum Mutat. 2009 Mar; 30(3): E467–E480. doi: 10.1002/humu.20932

PMCID:: PMC2649967

Abstract Article PDF–853K

Select item 135612917.

Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes

Kouichi Kimura, Ai Wakamatsu, Yutaka Suzuki, Toshio Ota, Tetsuo Nishikawa, Riu Yamashita, Jun-ichi Yamamoto, Mitsuo Sekine, Katsuki Tsuritani, Hiroyuki Wakaguri, Shizuko Ishii, Tomoyasu Sugiyama, Kaoru Saito, Yuko Isono, Ryotaro Irie, Norihiro Kushida, Takahiro Yoneyama, Rie Otsuka, Katsuhiro Kanda, Takahide Yokoi, Hiroshi Kondo, Masako Wagatsuma, Katsuji Murakawa, Shinichi Ishida, Tadashi Ishibashi, Asako Takahashi-Fujii, Tomoo Tanase, Keiichi Nagai, Hisashi Kikuchi, Kenta Nakai, Takao Isogai, Sumio Sugano

Genome Res. 2006 Jan; 16(1): 55–65. doi: 10.1101/gr.4039406

PMCID:: PMC1356129

Abstract Article PDF–438K

Select item 119645618.

Alternative Splicing Suggests Extended Function of PEX26 in Peroxisome Biogenesis

Sabine Weller, Ivelisse Cajigas, James Morrell, Cassandra Obie, Gary Steel, Stephen J. Gould, David Valle

Am J Hum Genet. 2005 Jun; 76(6): 987–1007. Published online 2005 Apr 27. doi: 10.1086/430637

PMCID:: PMC1196456

Abstract Article PDF–7.9M

Select item 118036419.

Mutations in Novel Peroxin Gene PEX26 That Cause Peroxisome-Biogenesis Disorders of Complementation Group 8 Provide a Genotype-Phenotype Correlation

Naomi Matsumoto, Shigehiko Tamura, Satomi Furuki, Non Miyata, Ann Moser, Nobuyuki Shimozawa, Hugo W. Moser, Yasuyuki Suzuki, Naomi Kondo, Yukio Fujiki

Am J Hum Genet. 2003 Aug; 73(2): 233–246. Published online 2003 Jul 8. doi: 10.1086/377004

PMCID:: PMC1180364

Abstract Article PDF–691K

Select item 54560420.

A genome annotation-driven approach to cloning the human ORFeome

John E Collins, Charmain L Wright, Carol A Edwards, Matthew P Davis, James A Grinham, Charlotte G Cole, Melanie E Goward, Begoña Aguado, Meera Mallya, Younes Mokrab, Elizabeth J Huckle, David M Beare, Ian Dunham

Genome Biol. 2004; 5(10): R84. Published online 2004 Sep 30. doi: 10.1186/gb-2004-5-10-r84

PMCID:: PMC545604

Abstract Article PDF–762K

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