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Select item 112869651.

Deficiency of SIAH1 promotes the formation of filopodia by increasing the accumulation of FASN in liver cancer

Zhiyi Liu, Qinghe Hu, Kuan Cao, Jun Sun, Licheng Cui, Mengxuan Ji, Wengang Shan, Weichao Yang, Guowei Zhang, Zilu Tian, Hengliang Shi, Bin Zhang, Renhao Wang

Cell Death Dis. 2024 Jul; 15(7): 537. Published online 2024 Jul 29. doi: 10.1038/s41419-024-06929-7

PMCID:: PMC11286965

Abstract Article PDF–9.0M

Select item 111589742.

SIAH1 induced apoptosis by activation of the JNK pathway and inhibited invasion by inactivation of the ERK pathway in breast cancer cells

Yuan‐Yuan Wen, Zhi‐Qiang Yang, Min Song, Bai‐Lin Li, Ji‐Jiang Zhu, En‐Hua Wang

Cancer Sci. 2010 Jan; 101(1): 73–79. Published online 2009 Sep 2. doi: 10.1111/j.1349-7006.2009.01339.x

PMCID:: PMC11158974

Abstract Article PDF–1.3M

Select item 111583593.

Hypoxia‐induced β‐catenin downregulation involves p53‐dependent activation of Siah‐1

Dapeng Wang, Yongxing Wang, Tao Kong, Feiyue Fan, Yongguang Jiang

Cancer Sci. 2011 Jul; 102(7): 1322–1328. Published online 2011 May 12. doi: 10.1111/j.1349-7006.2011.01950.x

PMCID:: PMC11158359

Abstract Article PDF–765K

Select item 111054654.

PUM1 and PUM2 exhibit different modes of regulation for SIAH1 that involve cooperativity with NANOS paralogues

Marcin Sajek, Damian Mikolaj Janecki, Maciej Jerzy Smialek, Barbara Ginter-Matuszewska, Anna Spik, Slawomir Oczkowski, Erkut Ilaslan, Kamila Kusz-Zamelczyk, Maciej Kotecki, Jacek Blazewicz, Jadwiga Jaruzelska

Cell Mol Life Sci. 2019 Jan; 76(1): 147–161. Published online 2018 Sep 29. doi: 10.1007/s00018-018-2926-5

PMCID:: PMC11105465

Abstract Article PDF–1.6M

Select item 108974895.

The NSP3 protein of SARS-CoV-2 binds fragile X mental retardation proteins to disrupt UBAP2L interactions

Dimitriya H Garvanska, R Elias Alvarado, Filip Oskar Mundt, Richard Lindqvist, Josephine Kerzel Duel, Fabian Coscia, Emma Nilsson, Kumari Lokugamage, Bryan A Johnson, Jessica A Plante, Dorothea R Morris, Michelle N Vu, Leah K Estes, Alyssa M McLeland, Jordyn Walker, Patricia A Crocquet-Valdes, Blanca Lopez Mendez, Kenneth S Plante, David H Walker, Melanie Bianca Weisser, Anna K Överby, Matthias Mann, Vineet D Menachery, Jakob Nilsson

EMBO Rep. 2024 Feb; 25(2): 902–926. Published online 2024 Jan 2. doi: 10.1038/s44319-023-00043-z

PMCID:: PMC10897489

Abstract Article PDF–8.2M

Select item 103302996.

Ubiquitin ligases Siah1a/2 control alveolar macrophage functions to limit carcinogen-induced lung adenocarcinoma

Marzia Scortegagna, Yuanning Du, Linda M. Bradley, Kun Wang, Alfredo Molinolo, Eytan Ruppin, Rabi Murad, Ze’ev A. Ronai

Cancer Res. Author manuscript; available in PMC 2023 Dec 15.

Published in final edited form as: Cancer Res. 2023 Jun 15; 83(12): 2016–2033. doi: 10.1158/0008-5472.CAN-23-0258

PMCID:: PMC10330299

Abstract Article PDF–2.6M

Select item 102095407.

Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation

Chengming Zhang, Zhiyi Liu, Xiaotian Wang, Bin Zhang, Licheng Cui, Qinghe Hu, Bin Hu, Kuan Cao, Wengang Shan, Hengliang Shi, Renhao Wang

iScience. 2023 Jun 16; 26(6): 106852. Published online 2023 May 9. doi: 10.1016/j.isci.2023.106852

PMCID:: PMC10209540

Abstract Article PDF–5.8M

Select item 101358838.

Structural Basis of the Interaction between Human Axin2 and SIAH1 in the Wnt/β-Catenin Signaling Pathway

Lianqi Chen, Yan-Ping Liu, Li-Fei Tian, Mingzhou Li, Shuyu Yang, Song Wang, Wenqing Xu, Xiao-Xue Yan

Biomolecules. 2023 Apr; 13(4): 647. Published online 2023 Apr 4. doi: 10.3390/biom13040647

PMCID:: PMC10135883

Abstract Article PDF–3.5M

Select item 101059499.

SIAH1 ubiquitination-modified HMGCR inhibits lung cancer progression and promotes drug sensitivity through cholesterol synthesis

Hongmei Yuan, Hongge Wu, Jing Cheng, Jie Xiong

Cancer Cell Int. 2023; 23: 71. Published online 2023 Apr 16. doi: 10.1186/s12935-023-02914-w

PMCID:: PMC10105949

Abstract Article PDF–12M

Select item 981728010.

LINC00963 promotes the malignancy and metastasis of lung adenocarcinoma by stabilizing Zeb1 and exosomes-induced M2 macrophage polarization

Ronghang Hu, Baobin Xu, Jiajun Ma, Linfeng Li, Liming Zhang, Li Wang, Jiebo Zhu, Tao Guo, Heng Zhang, Shaoqiang Wang

Mol Med. 2023; 29: 1. Published online 2023 Jan 5. doi: 10.1186/s10020-022-00598-y

PMCID:: PMC9817280

Abstract Article PDF–14M

Select item 974150511.

SIAH proteins regulate the degradation and intra‐mitochondrial aggregation of PINK1: Implications for mitochondrial pathology in Parkinson's disease

Fatimah Abd Elghani, Hazem Safory, Haya Hamza, Mor Savyon, Malik Farhoud, Michal Toren‐Hershoviz, Zagorka Vitic, Kirsten Ebanks, Vered Shani, Sleman Bisharat, Lihi Shaulov, Claude Brodski, Zhiyin Song, Rina Bandopadhyay, Simone Engelender

Aging Cell. 2022 Dec; 21(12): e13731. Published online 2022 Oct 28. doi: 10.1111/acel.13731

PMCID:: PMC9741505

Abstract Article PDF–5.1M

Select item 971352112.

FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1

Yan Wang, Kai Wang, Jiale Fu, Yu Zhang, Yufei Mao, Xu Wang, Xiang Wang, Rutong Yu, Xiuping Zhou

Neuro Oncol. 2022 Dec; 24(12): 2107–2120. Published online 2022 Jun 20. doi: 10.1093/neuonc/noac156

PMCID:: PMC9713521

Abstract Article PDF–51M

Select item 944497713.

MAB21L4 deficiency drives squamous cell carcinoma via activation of RET

Ankit Srivastava, Cristina Tommasi, Dane Sessions, Angela Mah, Tomas Bencomo, Jasmine M. Garcia, Tiffany Jiang, Michael Lee, Joseph Y. Shen, Lek Wei Seow, Audrey Nguyen, Kimal Rajapakshe, Cristian Coarfa, Kenneth Y. Tsai, Vanessa Lopez-Pajares, Carolyn S. Lee

Cancer Res. Author manuscript; available in PMC 2023 Mar 2.

Published in final edited form as: Cancer Res. 2022 Sep 2; 82(17): 3143–3157. doi: 10.1158/0008-5472.CAN-22-0047

PMCID:: PMC9444977

Abstract Article PDF–3.8M

Select item 934857614.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 934345515.

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis

Natalie Vaughan, Nico Scholz, Catherine Lindon, Julien D. F. Licchesi

Sci Rep. 2022; 12: 13160. Published online 2022 Aug 1. doi: 10.1038/s41598-022-16965-y

PMCID:: PMC9343455

Abstract Article PDF–3.7M

Select item 912252916.

P-TEFb is degraded by Siah1/2 in quiescent cells

Fang Huang, Yongmei Feng, B Matija Peterlin, Koh Fujinaga

Nucleic Acids Res. 2022 May 20; 50(9): 5000–5013. Published online 2022 May 7. doi: 10.1093/nar/gkac291

PMCID:: PMC9122529

Abstract Article PDF–6.1M

Select item 910523517.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 899544318.

Reactive oxygen species‐induced SIAH1 promotes granulosa cells' senescence in premature ovarian failure

Li Lin, Wujiang Gao, Yumei Chen, Taoqiong Li, Chunli Sha, Lu Chen, Meiling Yang, Hong Wei, Yunpeng Chen, Xiaolan Zhu

J Cell Mol Med. 2022 Apr; 26(8): 2417–2427. Published online 2022 Mar 9. doi: 10.1111/jcmm.17264

PMCID:: PMC8995443

Abstract Article PDF–1.6M

Select item 896577019.

m⁶A-induced repression of SIAH1 facilitates alternative splicing of androgen receptor variant 7 by regulating CPSF1

Lei Xia, Qing Han, Xuehui Duan, Yinjie Zhu, Jiahua Pan, Baijun Dong, Weiliang Xia, Wei Xue, Jianjun Sha

Mol Ther Nucleic Acids. 2022 Jun 14; 28: 219–230. Published online 2022 Mar 15. doi: 10.1016/j.omtn.2022.03.008

PMCID:: PMC8965770

Abstract Article PDF–2.7M

Select item 891366320.

SIAH1 reverses chemoresistance in epithelial ovarian cancer via ubiquitination of YBX-1

Wujiang Gao, Lu Chen, Li Lin, Meiling Yang, Taoqiong Li, Hong Wei, Chunli Sha, Jie Xing, Mengxue Zhang, Shijie Zhao, Qi Chen, Wenlin Xu, Yuefeng Li, Xiaolan Zhu

Oncogenesis. 2022 Dec; 11(1): 13. Published online 2022 Mar 10. doi: 10.1038/s41389-022-00387-6

PMCID:: PMC8913663

Abstract Article PDF–6.0M

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