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Select item 104052021.

Cytokine receptor IL27RA is an NF-κB–responsive gene involved in CD38 upregulation in multiple myeloma

Rebecca J. Brownlie, Ruth Kennedy, Erica B. Wilson, Maja Milanovic, Claire F. Taylor, Dapeng Wang, John R. Davies, Heather Owston, Emma J. Adams, Sophie Stephenson, Rebecca Caeser, Benjamin E. Gewurz, Peter V. Giannoudis, Claudio Scuoppo, Dennis McGonagle, Daniel J. Hodson, Reuben M. Tooze, Gina M. Doody, Gordon Cook, David R. Westhead, Ulf Klein

Blood Adv. 2023 Aug 8; 7(15): 3874–3890. Published online 2023 Mar 8. doi: 10.1182/bloodadvances.2022009044

PMCID:: PMC10405202

Abstract Article PDF–1.8M

Select item 98491412.

A proteome-scale map of the SARS-CoV-2–human contactome

Dae-Kyum Kim, Benjamin Weller, Chung-Wen Lin, Dayag Sheykhkarimli, Jennifer J. Knapp, Guillaume Dugied, Andreas Zanzoni, Carles Pons, Marie J. Tofaute, Sibusiso B. Maseko, Kerstin Spirohn, Florent Laval, Luke Lambourne, Nishka Kishore, Ashyad Rayhan, Mayra Sauer, Veronika Young, Hridi Halder, Nora Marín-de la Rosa, Oxana Pogoutse, Alexandra Strobel, Patrick Schwehn, Roujia Li, Simin T. Rothballer, Melina Altmann, Patricia Cassonnet, Atina G. Coté, Lena Elorduy Vergara, Isaiah Hazelwood, Betty B. Liu, Maria Nguyen, Ramakrishnan Pandiarajan, Bushra Dohai, Patricia A. Rodriguez Coloma, Juline Poirson, Paolo Giuliana, Luc Willems, Mikko Taipale, Yves Jacob, Tong Hao, David E. Hill, Christine Brun, Jean-Claude Twizere, Daniel Krappmann, Matthias Heinig, Claudia Falter, Patrick Aloy, Caroline Demeret, Marc Vidal, Michael A. Calderwood, Frederick P. Roth, Pascal Falter-Braun

Nat Biotechnol. 2023; 41(1): 140–149. Published online 2022 Oct 10. doi: 10.1038/s41587-022-01475-z

PMCID:: PMC9849141

Abstract Article PDF–7.1M

Select item 95357663.

Structural insights into the assembly and activation of the IL‐27 signaling complex

Yibo Jin, Paul K Fyfe, Scott Gardner, Stephan Wilmes, Doryen Bubeck, Ignacio Moraga

EMBO Rep. 2022 Oct; 23(10): e55450. Published online 2022 Aug 3. doi: 10.15252/embr.202255450

PMCID:: PMC9535766

Abstract Article PDF–5.6M

Select item 93570734.

Interleukin-27 signaling serves as an immunological checkpoint for innate cytotoxic cells to promote hepatocellular carcinoma

Turan Aghayev, Aleksandra M. Mazitova, Jennifer R. Fang, Iuliia O. Peshkova, Matthew Rausch, Manhsin Hung, Kerry F. White, Ricard Masia, Elizaveta K. Titerina, Aliia R. Fatkhullina, Isabelle Cousineau, Simon Turcotte, Dmitry Zhigarev, Anastasiia Marchenko, Svetlana Khoziainova, Petr Makhov, Yin Fei Tan, Andrew V. Kossenkov, David L. Wiest, John Stagg, Xin Wei Wang, Kerry S. Campbell, Amiran K. Dzutsev, Giorgio Trinchieri, Jonathan A. Hill, Sergei I. Grivennikov, Ekaterina K. Koltsova

Cancer Discov. Author manuscript; available in PMC 2023 Feb 5.

Published in final edited form as: Cancer Discov. 2022 Aug 5; 12(8): 1960–1983. doi: 10.1158/2159-8290.CD-20-1628

PMCID:: PMC9357073

Abstract Article PDF–4.0M

Select item 87487895.

Systematic identification of NF90 target RNAs by iCLIP analysis

Valeria Lodde, Matteo Floris, Rachel Munk, Jennifer L. Martindale, Davide Piredda, Catello Mario Panu Napodano, Francesco Cucca, Sergio Uzzau, Kotb Abdelmohsen, Myriam Gorospe, Ji Heon Noh, M. Laura Idda

Sci Rep. 2022; 12: 364. Published online 2022 Jan 10. doi: 10.1038/s41598-021-04101-1

PMCID:: PMC8748789

Abstract Article PDF–4.2M

Select item 83529646.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 81902707.

WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression

Man Wu, Xueqing Xia, Jiemiao Hu, Natalie Wall Fowlkes, Shulin Li

Nat Commun. 2021; 12: 3500. Published online 2021 Jun 9. doi: 10.1038/s41467-021-23864-9

PMCID:: PMC8190270

Abstract Article PDF–5.2M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 73684619.

Loss of the IL-27R Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses

Gaia M Coppock, Lillian R Aronson, Jihwan Park, Chengxiang Qiu, Jeongho Park, Jonathan H. DeLong, Enrico Radaelli, Katalin Suszták, Christopher A Hunter

J Immunol. Author manuscript; available in PMC 2021 Jul 15.

Published in final edited form as: J Immunol. 2020 Jul 15; 205(2): 377–386. Published online 2020 Jun 10. doi: 10.4049/jimmunol.1901463

PMCID:: PMC7368461

Abstract Article PDF–1.8M

Select item 716998310.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 553392011.

Identification of Interleukin-27 (IL-27)/IL-27 Receptor Subunit Alpha as a Critical Immune Axis for In Vivo HIV Control

M. Ruiz-Riol, D. Berdnik, A. Llano, B. Mothe, C. Gálvez, S. Pérez-Álvarez, B. Oriol-Tordera, A. Olvera, S. Silva-Arrieta, M. Meulbroek, F. Pujol, J. Coll, J. Martinez-Picado, C. Ganoza, J. Sanchez, G. Gómez, T. Wyss-Coray, C. Brander

J Virol. 2017 Aug 15; 91(16): e00441-17. Prepublished online 2017 Jun 7. Published online 2017 Jul 27. doi: 10.1128/JVI.00441-17

PMCID:: PMC5533920

Abstract Article PDF–2.5M

Select item 553161112.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 460899713.

Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef

Nicholas J. Matheson, Jonathan Sumner, Kim Wals, Radu Rapiteanu, Michael P. Weekes, Raphael Vigan, Julia Weinelt, Michael Schindler, Robin Antrobus, Ana S.H. Costa, Christian Frezza, Clary B. Clish, Stuart J.D. Neil, Paul J. Lehner

Cell Host Microbe. 2015 Oct 14; 18(4): 409–423. doi: 10.1016/j.chom.2015.09.003

PMCID:: PMC4608997

Abstract Article PDF–3.8M

Select item 454805414.

Interleukin 27R regulates CD4⁺ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection

Egidio Torrado, Jeffrey J. Fountain, Mingfeng Liao, Michael Tighe, William W. Reiley, Rachel P. Lai, Graeme Meintjes, John E. Pearl, Xinchun Chen, Daniel E. Zak, Ethan G. Thompson, Alan Aderem, Nico Ghilardi, Alejandra Solache, K. Kai McKinstry, Tara M. Strutt, Robert J. Wilkinson, Susan L. Swain, Andrea M. Cooper

J Exp Med. 2015 Aug 24; 212(9): 1449–1463. doi: 10.1084/jem.20141520