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Select item 104523551.

Phosphoserine Aminotransferase Pathogenetic Variants in Serine Deficiency Disorders: A Functional Characterization

Francesco Marchesani, Annalisa Michielon, Elisabetta Viale, Annalisa Bianchera, Davide Cavazzini, Loredano Pollegioni, Giulia Murtas, Andrea Mozzarelli, Stefano Bettati, Alessio Peracchi, Barbara Campanini, Stefano Bruno

Biomolecules. 2023 Aug; 13(8): 1219. Published online 2023 Aug 4. doi: 10.3390/biom13081219

PMCID:: PMC10452355

Abstract Article PDF–2.0M

Select item 103176012.

Exosomal ERBB2IP contributes to tumor growth via elevating PSAT1 expression in non‐small cell lung carcinoma

Xijuan Peng, Lanfu Zhao, Linong Yao, Jingzhi Dong, Wei Wu, Tao Luo

Thorac Cancer. 2023 Jul; 14(19): 1812–1823. Published online 2023 May 16. doi: 10.1111/1759-7714.14926

PMCID:: PMC10317601

Abstract Article PDF–5.8M

Select item 102374223.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101516154.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 100312355.

L‐serine biosynthesis in the human central nervous system: Structure and function of phosphoserine aminotransferase

Francesco Marchesani, Erika Zangelmi, Giulia Murtas, Elisa Costanzi, Raheem Ullah, Alessio Peracchi, Stefano Bruno, Loredano Pollegioni, Andrea Mozzarelli, Paola Storici, Barbara Campanini

Protein Sci. 2023 Apr; 32(4): e4609. Published online 2023 Apr 1. doi: 10.1002/pro.4609

PMCID:: PMC10031235

Abstract Article PDF–7.6M

Select item 100085656.

Downregulation of PSAT1 inhibits cell proliferation and migration in uterine corpus endometrial carcinoma

Min Wang, Song Yue, Zhu Yang

Sci Rep. 2023; 13: 4081. Published online 2023 Mar 11. doi: 10.1038/s41598-023-31325-0

PMCID:: PMC10008565

Abstract Article PDF–7.0M

Select item 99290717.

Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant

Jingwen Jiang, Hai-Ning Chen, Ping Jin, Li Zhou, Liyuan Peng, Zhao Huang, Siyuan Qin, Bowen Li, Hui Ming, Maochao Luo, Na Xie, Wei Gao, Edouard C. Nice, Qiang Yu, Canhua Huang

Signal Transduct Target Ther. 2023; 8: 65. Published online 2023 Feb 15. doi: 10.1038/s41392-022-01266-7

PMCID:: PMC9929071

Abstract Article PDF–7.3M

Select item 98519738.

A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets

Yadi Zhou, Yuan Liu, Shagun Gupta, Mauricio I. Paramo, Yuan Hou, Chengsheng Mao, Yuan Luo, Julius Judd, Shayne Wierbowski, Marta Bertolotti, Mriganka Nerkar, Lara Jehi, Nir Drayman, Vlad Nicolaescu, Haley Gula, Savaş Tay, Glenn Randall, Peihui Wang, John T. Lis, Cédric Feschotte, Serpil C. Erzurum, Feixiong Cheng, Haiyuan Yu

Nat Biotechnol. Author manuscript; available in PMC 2023 Jan 20.

Published in final edited form as: Nat Biotechnol. 2023 Jan; 41(1): 128–139. Published online 2022 Oct 10. doi: 10.1038/s41587-022-01474-0

PMCID:: PMC9851973

Abstract Article PDF–4.0M

Select item 94819339.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 927928510.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 927594711.

Examination of the effects of microRNA-145-5p and phosphoserine aminotransferase 1 in colon cancer

Ruliang Ding, Weiwen Hong, Liang Huang, Jinfan Shao, Wenfeng Yu, Xijuan Xu

Bioengineered. 2022; 13(5): 12794–12806. Published online 2022 May 26. doi: 10.1080/21655979.2022.2071010

PMCID:: PMC9275947

Abstract Article PDF–2.6M

Select item 921632612.

Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression

Georgina D. Barnabas, Joo Sang Lee, Tamar Shami, Michal Harel, Lir Beck, Michael Selitrennik, Livnat Jerby-Arnon, Neta Erez, Eytan Ruppin, Tamar Geiger

Cancer Res. Author manuscript; available in PMC 2022 Jun 22.

Published in final edited form as: Cancer Res. 2021 Mar 15; 81(6): 1443–1456. Published online 2021 Jan 26. doi: 10.1158/0008-5472.CAN-19-3020

PMCID:: PMC9216326

Abstract Article PDF–2.6M

Select item 917141113.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 911973614.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 910272615.

VCP interaction with HMGB1 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway

Zhangya Pu, Dan G. Duda, Yuanyuan Zhu, Siya Pei, Xiaofang Wang, Yan Huang, Panpan Yi, Zebing Huang, Fang Peng, Xingwang Hu, Xuegong Fan

J Transl Med. 2022; 20: 212. Published online 2022 May 13. doi: 10.1186/s12967-022-03416-5

PMCID:: PMC9102726

Abstract Article PDF–15M

Select item 905883616.

The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang

J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009

PMCID:: PMC9058836

Abstract Article PDF–2.9M

Select item 903609217.

Tumor suppressor BAP1 nuclear import is governed by transportin-1

Tzu-Jing Yang, Tian-Neng Li, Rih-Sheng Huang, Max Yu-Chen Pan, Shu-Yu Lin, Steven Lin, Kuen-Phon Wu, Lily Hui-Ching Wang, Shang-Te Danny Hsu

J Cell Biol. 2022 Jun 6; 221(6): e202201094. Published online 2022 Apr 21. doi: 10.1083/jcb.202201094

PMCID:: PMC9036092

Abstract Article PDF–4.0M

Select item 889702218.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 885704919.

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

Tara E. Tracy, Jesus Madero-Pérez, Danielle L. Swaney, Timothy S. Chang, Michelle Moritz, Csaba Konrad, Michael E. Ward, Erica Stevenson, Ruth Hüttenhain, Grant Kauwe, Maria Mercedes, Lauren Sweetland-Martin, Xu Chen, Sue-Ann Mok, Man Ying Wong, Maria Telpoukhovskaia, Sang-Won Min, Chao Wang, Peter Dongmin Sohn, Jordie Martin, Yungui Zhou, Wenjie Luo, John Q. Trojanowski, Virginia M.Y. Lee, Shiaoching Gong, Giovanni Manfredi, Giovanni Coppola, Nevan J. Krogan, Daniel H. Geschwind, Li Gan

Cell. Author manuscript; available in PMC 2022 Feb 19.

Published in final edited form as: Cell. 2022 Feb 17; 185(4): 712–728.e14. Published online 2022 Jan 20. doi: 10.1016/j.cell.2021.12.041

PMCID:: PMC8857049

Abstract Article PDF–3.6M

Select item 884530220.

Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors

Bo-Hyun Choi, Vipin Rawat, Jenny Högström, Philippa A. Burns, Kelly O. Conger, Mete Emir Ozgurses, Jaymin M. Patel, Tejas S. Mehta, Angelica Warren, Laura M. Selfors, Taru Muranen, Jonathan L. Coloff

Cell Rep. Author manuscript; available in PMC 2022 Feb 15.

Published in final edited form as: Cell Rep. 2022 Jan 18; 38(3): 110278. doi: 10.1016/j.celrep.2021.110278

PMCID:: PMC8845302

Abstract Article PDF–2.9M

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