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Select item 110708791.

Impaired dNKAP function drives genome instability and tumorigenic growth in Drosophila epithelia

Ting Guo, Chen Miao, Zhonghua Liu, Jingwei Duan, Yanbin Ma, Xiao Zhang, Weiwei Yang, Maoguang Xue, Qiannan Deng, Pengfei Guo, Yongmei Xi, Xiaohang Yang, Xun Huang, Wanzhong Ge

J Mol Cell Biol. 2023 Dec; 15(12): mjad078. Published online 2023 Dec 6. doi: 10.1093/jmcb/mjad078

PMCID:: PMC11070879

Abstract Article PDF–2.9M

Select item 103542832.

Ataxia-associated DNA repair genes protect the Drosophila mushroom body and locomotor function against glutamate signaling-associated damage

Ilse Eidhof, Alina Krebbers, Bart van de Warrenburg, Annette Schenck

Front Neural Circuits. 2023; 17: 1148947. Published online 2023 Jul 5. doi: 10.3389/fncir.2023.1148947

PMCID:: PMC10354283

Abstract Article PDF–3.5M

Select item 101927203.

HR repair pathway plays a crucial role in maintaining neural stem cell fate under irradiation stress

Xiao Xu, Huanping An, Cheng Wu, Rong Sang, Litao Wu, Yuhan Lou, Xiaohang Yang, Yongmei Xi

Life Sci Alliance. 2023 Aug; 6(8): e202201802. Published online 2023 May 17. doi: 10.26508/lsa.202201802

PMCID:: PMC10192720

Abstract Article PDF–2.9M

Select item 99815354.

A large-scale RNAi screen reveals that mitochondrial function is important for meiotic chromosome organization in oocytes

Karen Jule Nieken, Kathryn O’Brien, Alexander McDonnell, Liudmila Zhaunova, Hiroyuki Ohkura

Chromosoma. 2023; 132(1): 1–18. Published online 2023 Jan 17. doi: 10.1007/s00412-023-00784-9

PMCID:: PMC9981535

Abstract Article PDF–3.4M

Select item 96527055.

REC drives recombination to repair double-strand breaks in animal mtDNA

Anna Klucnika, Peiqiang Mu, Jan Jezek, Matthew McCormack, Ying Di, Charles R. Bradshaw, Hansong Ma

J Cell Biol. 2023 Jan 2; 222(1): e202201137. Published online 2022 Nov 10. doi: 10.1083/jcb.202201137

PMCID:: PMC9652705

Abstract Article PDF–5.4M

Select item 94408936.

Low dose rate γ-irradiation protects fruit fly chromosomes from double strand breaks and telomere fusions by reducing the esi-RNA biogenesis factor Loquacious

A. Porrazzo, F. Cipressa, A. De Gregorio, C. De Pittà, G. Sales, L. Ciapponi, P. Morciano, G. Esposito, M. A. Tabocchini, G. Cenci

Commun Biol. 2022; 5: 905. Published online 2022 Sep 3. doi: 10.1038/s42003-022-03885-w

Correction in:: Commun Biol. 2022; 5: 1033.

PMCID:: PMC9440893

Abstract Article PDF–2.8M

Select item 93393277.

Conserved function of Drosophila Fancd2 monoubiquitination in response to double-strand DNA breaks

Delisa E Clay, Erin A Jezuit, Ruth A Montague, Donald T Fox

G3 (Bethesda) 2022 Aug; 12(8): jkac129. Published online 2022 May 20. doi: 10.1093/g3journal/jkac129

PMCID:: PMC9339327

Abstract Article PDF–851K

Select item 91447388.

Somatic Mobilization: High Somatic Insertion Rate of mariner Transposable Element in Drosophila simulans

Mariana Cancian, Tiago Minuzzi Freire da Fontoura Gomes, Elgion Lucio Silva Loreto

Insects. 2022 May; 13(5): 454. Published online 2022 May 12. doi: 10.3390/insects13050454

PMCID:: PMC9144738

Abstract Article PDF–2.5M

Select item 91434939.

Reduced Environmental Dose Rates Are Responsible for the Increased Susceptibility to Radiation-Induced DNA Damage in Larval Neuroblasts of Drosophila Grown inside the LNGS Underground Laboratory

Antonella Porrazzo, Giuseppe Esposito, Daniela Grifoni, Giovanni Cenci, Patrizia Morciano, Maria Antonella Tabocchini

Int J Mol Sci. 2022 May; 23(10): 5472. Published online 2022 May 13. doi: 10.3390/ijms23105472

PMCID:: PMC9143493

Abstract Article PDF–1.1M

Select item 865111110.

Taming active transposons at Drosophila telomeres: The interconnection between HipHop’s roles in capping and transcriptional silencing

Min Cui, Yaofu Bai, Kaili Li, Yikang S. Rong

PLoS Genet. 2021 Nov; 17(11): e1009925. Published online 2021 Nov 23. doi: 10.1371/journal.pgen.1009925

PMCID:: PMC8651111

Abstract Article PDF–4.4M

Select item 850022511.

Persistent DNA damage signaling and DNA polymerase theta promote broken chromosome segregation

Delisa E. Clay, Heidi S. Bretscher, Erin A. Jezuit, Korie B. Bush, Donald T. Fox

J Cell Biol. 2021 Dec 6; 220(12): e202106116. Published online 2021 Oct 6. doi: 10.1083/jcb.202106116

PMCID:: PMC8500225

Abstract Article PDF–7.2M

Select item 828274912.

Polyploid mitosis and depolyploidization promote chromosomal instability and tumor progression in a Notch-induced tumor model

Xian-Feng Wang, Sheng-An Yang, Shangyu Gong, Chih-Hsuan Chang, Juan Martin Portilla, Deeptiman Chatterjee, Jerome Irianto, Hongcun Bao, Yi-Chun Huang, Wu-Min Deng

Dev Cell. Author manuscript; available in PMC 2022 Jul 12.

Published in final edited form as: Dev Cell. 2021 Jul 12; 56(13): 1976–1988.e4. Published online 2021 Jun 18. doi: 10.1016/j.devcel.2021.05.017

PMCID:: PMC8282749

Abstract Article PDF–3.2M

Select item 696157813.

CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans

Ping Wei, Wen Xue, Yun Zhao, Guang Ning, Jiwu Wang

Genome Res. 2020 Jan; 30(1): 95–106. doi: 10.1101/gr.250811.119

PMCID:: PMC6961578

Abstract Article PDF–3.6M

Select item 691110414.

NBS1 interacts with HP1 to ensure genome integrity

Giuseppe Bosso, Francesca Cipressa, Maria Lina Moroni, Rosa Pennisi, Jacopo Albanesi, Valentina Brandi, Simona Cugusi, Fioranna Renda, Laura Ciapponi, Fabio Polticelli, Antonio Antoccia, Alessandra di Masi, Giovanni Cenci

Cell Death Dis. 2019 Dec; 10(12): 951. Published online 2019 Dec 13. doi: 10.1038/s41419-019-2185-x

PMCID:: PMC6911104

Abstract Article PDF–2.4M

Select item 650653915.

Tissue-specific (ts)CRISPR as an efficient strategy for in vivo screening in Drosophila

Hagar Meltzer, Efrat Marom, Idan Alyagor, Oded Mayseless, Victoria Berkun, Netta Segal-Gilboa, Tamar Unger, David Luginbuhl, Oren Schuldiner

Nat Commun. 2019; 10: 2113. Published online 2019 May 8. doi: 10.1038/s41467-019-10140-0

PMCID:: PMC6506539

Abstract Article PDF–6.5M

Select item 605173016.

Nuclear F-actin and myosins drive relocalization of heterochromatic breaks

Christopher P. Caridi, Carla D’Agostino, Taehyun Ryu, Grzegorz Zapotoczny, Laetitia Delabaere, Xiao Li, Varandt Y. Khodaverdian, Nuno Amaral, Emily Lin, Alesandra Rau, Irene Chiolo

Nature. Author manuscript; available in PMC 2018 Dec 20.

Published in final edited form as: Nature. 2018 Jul; 559(7712): 54–60. Published online 2018 Jun 20. doi: 10.1038/s41586-018-0242-8