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Select item 106763641.

ACO2 deficiency increases vulnerability to Parkinson’s disease via dysregulating mitochondrial function and histone acetylation-mediated transcription of autophagy genes

Junge Zhu, Fanxi Xu, Hong Lai, Huiyao Yuan, Xu-Ying Li, Junya Hu, Wei Li, Lei Liu, Chaodong Wang

Commun Biol. 2023; 6: 1201. Published online 2023 Nov 25. doi: 10.1038/s42003-023-05570-y

PMCID:: PMC10676364

Abstract Article PDF–4.0M

Select item 106655742.

Protein modification regulated autophagy in Bombyx mori and Drosophila melanogaster

Wenmei Wu, Luobin Lin, Yuntao Zhao, Huaqin Li, Rongxin Zhang

Front Physiol. 2023; 14: 1281555. Published online 2023 Nov 9. doi: 10.3389/fphys.2023.1281555

PMCID:: PMC10665574

Abstract Article PDF–1.1M

Select item 105938303.

Metabolic regulation of proteome stability via N-terminal acetylation controls male germline stem cell differentiation and reproduction

Charlotte M. François, Thomas Pihl, Marion Dunoyer de Segonzac, Chloé Hérault, Bruno Hudry

Nat Commun. 2023; 14: 6737. Published online 2023 Oct 23. doi: 10.1038/s41467-023-42496-9

PMCID:: PMC10593830

Abstract Article PDF–3.0M

Select item 103232374.

The oxoglutarate dehydrogenase complex is involved in myofibril growth and Z-disc assembly in Drosophila

Nicanor González Morales, Océane Marescal, Szilárd Szikora, Anja Katzemich, Tuana Correia-Mesquita, Péter Bíró, Miklos Erdelyi, József Mihály, Frieder Schöck

J Cell Sci. 2023 Jul 1; 136(13): jcs260717. Published online 2023 Jun 30. doi: 10.1242/jcs.260717

PMCID:: PMC10323237

Abstract Article

Select item 99442495.

Time-restricted feeding promotes muscle function through purine cycle and AMPK signaling in Drosophila obesity models

Christopher Livelo, Yiming Guo, Farah Abou Daya, Vasanthi Rajasekaran, Shweta Varshney, Hiep D. Le, Stephen Barnes, Satchidananda Panda, Girish C. Melkani

Nat Commun. 2023; 14: 949. Published online 2023 Feb 21. doi: 10.1038/s41467-023-36474-4

PMCID:: PMC9944249

Abstract Article PDF–3.8M

Select item 92957346.

Identification of PSMB5 as a genetic modifier of fragile X–associated tremor/ataxia syndrome

Ha Eun Kong, Junghwa Lim, Alexander Linsalata, Yunhee Kang, Indranil Malik, Emily G. Allen, Yiqu Cao, Lisa Shubeck, Rich Johnston, Yanting Huang, Yanghong Gu, Xiangxue Guo, Michael E. Zwick, Zhaohui Qin, Thomas S. Wingo, Jorge Juncos, David L. Nelson, Michael P. Epstein, David J. Cutler, Peter K. Todd, Stephanie L. Sherman, Stephen T. Warren, Peng Jin

Proc Natl Acad Sci U S A. 2022 May 31; 119(22): e2118124119. Published online 2022 May 26. doi: 10.1073/pnas.2118124119

PMCID:: PMC9295734

Abstract Article PDF–2.3M

Select item 86727897.

Mitochondrial aconitase 1 regulates age‐related memory impairment via autophagy/mitophagy‐mediated neural plasticity in middle‐aged flies

Yun‐Ho Cho, Gye‐Hyeong Kim, Joong‐Jean Park

Aging Cell. 2021 Dec; 20(12): e13520. Published online 2021 Nov 19. doi: 10.1111/acel.13520

PMCID:: PMC8672789

Abstract Article PDF–2.1M

Select item 86644868.

Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes

Ana López-Varea, Patricia Vega-Cuesta, Ana Ruiz-Gómez, Cristina M Ostalé, Cristina Molnar, Covadonga F Hevia, Mercedes Martín, Maria F Organista, Jesus de Celis, Joaquín Culí, Nuria Esteban, Jose F de Celis

G3 (Bethesda) 2021 Dec; 11(12): jkab349. Published online 2021 Oct 2. doi: 10.1093/g3journal/jkab349

PMCID:: PMC8664486

Abstract Article PDF–3.1M

Select item 85753139.

Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila

Neha Agrawal, Katherine Lawler, Catherine M. Davidson, Julia M. Keogh, Robert Legg, INTERVAL, Inês Barroso, I. Sadaf Farooqi, Andrea H. Brand

PLoS Biol. 2021 Nov; 19(11): e3001255. Published online 2021 Nov 8. doi: 10.1371/journal.pbio.3001255

PMCID:: PMC8575313

Abstract Article PDF–2.3M

Select item 836357010.

Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex

Bat-Erdene Jugder, Layla Kamareddine, Paula I Watnick

Immunity. Author manuscript; available in PMC 2022 Aug 10.

Published in final edited form as: Immunity. 2021 Aug 10; 54(8): 1683–1697.e3. Published online 2021 Jun 8. doi: 10.1016/j.immuni.2021.05.017

PMCID:: PMC8363570

Abstract Article PDF–3.4M

Select item 696157811.

CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans

Ping Wei, Wen Xue, Yun Zhao, Guang Ning, Jiwu Wang

Genome Res. 2020 Jan; 30(1): 95–106. doi: 10.1101/gr.250811.119

PMCID:: PMC6961578

Abstract Article PDF–3.6M

Select item 670028212.

Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation

Bruno Hudry, Eva de Goeij, Alessandro Mineo, Pedro Gaspar, Dafni Hadjieconomou, Chris Studd, Joao B. Mokochinski, Holger B. Kramer, Pierre-Yves Plaçais, Thomas Preat, Irene Miguel-Aliaga

Cell. 2019 Aug 8; 178(4): 901–918.e16. doi: 10.1016/j.cell.2019.07.029

PMCID:: PMC6700282

Abstract Article

Select item 639850113.

SOD1 activity threshold and TOR signalling modulate VAP(P58S) aggregation via reactive oxygen species-induced proteasomal degradation in a Drosophila model of amyotrophic lateral sclerosis

Kriti Chaplot, Lokesh Pimpale, Balaji Ramalingam, Senthilkumar Deivasigamani, Siddhesh S. Kamat, Girish S. Ratnaparkhi

Dis Model Mech. 2019 Feb 1; 12(2): dmm033803. Published online 2019 Feb 7. doi: 10.1242/dmm.033803

PMCID:: PMC6398501

Abstract Article

Select item 619724914.

Lon protease inactivation in Drosophila causes unfolded protein stress and inhibition of mitochondrial translation

Gautam Pareek, Ruth E. Thomas, Evelyn S. Vincow, David R. Morris, Leo J. Pallanck

Cell Death Discov. 2018; 4: 51. Published online 2018 Oct 22. doi: 10.1038/s41420-018-0110-1

Correction in:: Cell Death Discov. 2019; 5: 116.

PMCID:: PMC6197249

Abstract Article PDF–1.6M

Select item 617750315.

Potential involvement of Drosophila flightless-1 in carbohydrate metabolism

Jung-Eun Park, Jinho Jang, Eun Ji Lee, Su Jung Kim, Hyun Ju Yoo, Semin Lee, Min-Ji Kang

BMB Rep. 2018 Sep; 51(9): 462–467. Published online 2018 Sep 30. doi: 10.5483/BMBRep.2018.51.9.153

PMCID:: PMC6177503

Abstract Article PDF–5.9M

Select item 607860416.

Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson’s disease

Md Shariful Islam, Hendrik Nolte, Wright Jacob, Anna B. Ziegler, Stefanie Pütz, Yael Grosjean, Karolina Szczepanowska, Aleksandra Trifunovic, Thomas Braun, Hermann Heumann, Rolf Heumann, Bernhard Hovemann, Darren J. Moore, Marcus Krüger

Hum Mol Genet. 2016 Dec 15; 25(24): 5365–5382. Published online 2016 Oct 29. doi: 10.1093/hmg/ddw352