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Items: 1 to 20 of 49

1.
Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels
Heng Liu, Maya M. Polovitskaya, Linlin Yang, Meiling Li, Hongyue Li, Zhen Han, Jianguo Wu, Qiansen Zhang, Thomas J. Jentsch, Jun Liao
Cell Rep. 2023 Aug 29; 42(8): 112926. Published online 2023 Aug 6. doi: 10.1016/j.celrep.2023.112926
PMCID:
PMC10480491
AbstractArticle
2.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
3.
Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell
Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low
Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120
PMCID:
PMC10151615
AbstractArticlePDF–2.9M
4.
Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma
Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li
Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x
PMCID:
PMC9950447
AbstractArticlePDF–8.4M
5.
HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation
Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang
Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005
PMCID:
PMC9772558
AbstractArticlePDF–8.2M
6.
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1
Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen
Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119
PMCID:
PMC9231623
AbstractArticlePDF–6.0M
7.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
8.
Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes
Susheel K. Gunasekar, Litao Xie, Ashutosh Kumar, Juan Hong, Pratik R. Chheda, Chen Kang, David M. Kern, Chau My-Ta, Joshua Maurer, John Heebink, Eva E. Gerber, Wojciech J. Grzesik, Macaulay Elliot-Hudson, Yanhui Zhang, Phillip Key, Chaitanya A. Kulkarni, Joseph W. Beals, Gordon I. Smith, Isaac Samuel, Jessica K. Smith, Peter Nau, Yumi Imai, Ryan D. Sheldon, Eric B. Taylor, Daniel J. Lerner, Andrew W. Norris, Samuel Klein, Stephen G. Brohawn, Robert Kerns, Rajan Sah
Nat Commun. 2022; 13: 784. Published online 2022 Feb 10. doi: 10.1038/s41467-022-28435-0
PMCID:
PMC8831520
AbstractArticlePDF–7.0M
9.
Oxidant-Resistant LRRC8A/C Anion Channels Support Superoxide Production by Nox1
Hyehun Choi, Jeffrey Rohrbough, Hong N. Nguyen, Anna Dikalova, Fred S. Lamb
J Physiol. Author manuscript; available in PMC 2021 Nov 18.
Published in final edited form as: J Physiol. 2021 Jun; 599(12): 3013–3036. Published online 2021 May 26. doi: 10.1113/JP281577
PMCID:
PMC8600960
AbstractArticlePDF–4.0M
10.
SARS‐CoV‐2–host proteome interactions for antiviral drug discovery
Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo
Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396
PMCID:
PMC8552907
AbstractArticlePDF–3.9M
11.
Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry
Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang
Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118
PMCID:
PMC8364181
AbstractArticlePDF–3.0M
12.
LRRC8A homohexameric channels poorly recapitulate VRAC regulation and pharmacology
Toshiki Yamada, Eric E. Figueroa, Jerod S. Denton, Kevin Strange
Am J Physiol Cell Physiol. 2021 Mar 1; 320(3): C293–C303. Published online 2020 Dec 23. doi: 10.1152/ajpcell.00454.2020
PMCID:
PMC8294627
AbstractArticle
13.
LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions
Selma A. Serra, Predrag Stojakovic, Ramon Amat, Fanny Rubio-Moscardo, Pablo Latorre, Gerhard Seisenbacher, David Canadell, René Böttcher, Michael Aregger, Jason Moffat, Eulàlia de Nadal, Miguel A. Valverde, Francesc Posas
Proc Natl Acad Sci U S A. 2021 Jun 8; 118(23): e2025013118. Published online 2021 Jun 3. doi: 10.1073/pnas.2025013118
PMCID:
PMC8201826
AbstractArticlePDF–1.4M
14.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
15.
AMPK, a key regulator of metabolism and autophagy, is activated by lysosomal damage via a novel galectin-directed ubiquitin signal transduction system
Jingyue Jia, Bhawana Bissa, Lukas Brecht, Lee Allers, Seong Won Choi, Yuexi Gu, Mark Zbinden, Mark R. Burge, Graham Timmins, Kenneth Hallows, Christian Behrends, Vojo Deretic
Mol Cell. Author manuscript; available in PMC 2021 Mar 5.
Published in final edited form as: Mol Cell. 2020 Mar 5; 77(5): 951–969.e9. Published online 2020 Jan 28. doi: 10.1016/j.molcel.2019.12.028
PMCID:
PMC7785494
AbstractArticlePDF–2.9M
16.
LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses
Ping Li, Meiqin Hu, Ce Wang, Xinghua Feng, ZhuangZhuang Zhao, Ying Yang, Nirakar Sahoo, Mingxue Gu, Yexin Yang, Shiyu Xiao, Rajan Sah, Timothy L. Cover, Janet Chou, Raif Geha, Fernando Benavides, Richard I. Hume, Haoxing Xu
Proc Natl Acad Sci U S A. 2020 Nov 17; 117(46): 29155–29165. Published online 2020 Nov 2. doi: 10.1073/pnas.2016539117
PMCID:
PMC7682592
AbstractArticlePDF–3.3M
17.
LRRC8/VRAC channels exhibit a noncanonical permeability to glutathione, which modulates epithelial-to-mesenchymal transition (EMT)
Jonas Friard, Alain Corinus, Marc Cougnon, Michel Tauc, Didier F. Pisani, Christophe Duranton, Isabelle Rubera
Cell Death Dis. 2019 Dec; 10(12): 925. Published online 2019 Dec 5. doi: 10.1038/s41419-019-2167-z
PMCID:
PMC6895240
AbstractArticlePDF–4.5M
18.
Glutamate-Releasing SWELL1 Channel in Astrocytes Modulates Synaptic Transmission and Promotes Brain Damage in Stroke
Junhua Yang, Maria del Carmen Vitery, Jianan Chen, James Osei-Owusu, Jiachen Chu, Zhaozhu Qiu
Neuron. Author manuscript; available in PMC 2020 May 22.
Published in final edited form as: Neuron. 2019 May 22; 102(4): 813–827.e6. Published online 2019 Apr 11. doi: 10.1016/j.neuron.2019.03.029
PMCID:
PMC6685291
AbstractArticlePDF–2.5M
19.
FAM105A/OTULINL is a pseudodebuiquitinase of the OTU-class that localizes to the ER membrane
Derek F. Ceccarelli, Sofiia Ivantsiv, Amber Anne Mullin, Etienne Coyaud, Noah Manczyk, Pierre Maisonneuve, Igor Kurinov, Liang Zhao, Chris Go, Anne-Claude Gingras, Brian Raught, Sabine Cordes, Frank Sicheri
Structure. Author manuscript; available in PMC 2020 Jun 4.
Published in final edited form as: Structure. 2019 Jun 4; 27(6): 1000–1012.e6. Published online 2019 May 2. doi: 10.1016/j.str.2019.03.022
PMCID:
PMC6551266
AbstractArticlePDF–3.4M
20.
The LRRC8-mediated volume-regulated anion channel is altered in glaucoma
Xavier Gasull, Marta Castany, Aida Castellanos, Mikel Rezola, Alba Andrés-Bilbé, Maria Isabel Canut, Raúl Estévez, Teresa Borrás, Núria Comes
Sci Rep. 2019; 9: 5392. Published online 2019 Apr 1. doi: 10.1038/s41598-019-41524-3
Correction in:
Sci Rep. 2020; 10: 11443.
PMCID:
PMC6443673
AbstractArticlePDF–2.0M

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