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Items: 17

Select item 61027471.

Quercetin-3-O-β-D-glucoside decreases the bioavailability of cyclosporin A through regulation of drug metabolizing enzymes, transporters and nuclear receptors in rats

Tingyu Yang, Yani Liu, Xixi Huang, Rui Zhang, Chunxiao Yang, Jiali Zhou, Yu Zhang, Jing Wan, Shaojun Shi

Mol Med Rep. 2018 Sep; 18(3): 2599–2612. Published online 2018 Jul 3. doi: 10.3892/mmr.2018.9249

PMCID:: PMC6102747

Abstract Article PDF–1.1M

Select item 56982452.

Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis

Daniela Gabbia, Arianna Dalla Pozza, Laura Albertoni, Roberta Lazzari, Giorgia Zigiotto, Maria Carrara, Vincenzo Baldo, Tatjana Baldovin, Annarosa Floreani, Sara De Martin

World J Gastroenterol. 2017 Nov 14; 23(42): 7519–7530. Published online 2017 Nov 14. doi: 10.3748/wjg.v23.i42.7519

PMCID:: PMC5698245

Abstract Article PDF–1.7M

Select item 55464853.

Impact of chronic unpredicted mild stress-induced depression on repaglinide fate via glucocorticoid signaling pathway

Hongyan Wei, Ting Zhou, Boyu Tan, Lei Zhang, Mingming Li, Zhijun Xiao, Feng Xu

Oncotarget. 2017 Jul 4; 8(27): 44351–44365. Published online 2017 May 15. doi: 10.18632/oncotarget.17874

PMCID:: PMC5546485

Abstract Article PDF–8.2M

Select item 45477324.

Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation

Aimen O. Amer, Philip M. Probert, Michael Dunn, Margaret Knight, Abigail E. Vallance, Paul A. Flecknell, Fiona Oakley, Iain Cameron, Steven A. White, Peter G. Blain, Matthew C. Wright

PLoS One. 2015; 10(8): e0136173. Published online 2015 Aug 24. doi: 10.1371/journal.pone.0136173

PMCID:: PMC4547732

Abstract Article PDF–20M

Select item 44027455.

Oral administration of oleanolic acid, isolated from Swertia mussotii Franch, attenuates liver injury, inflammation, and cholestasis in bile duct-ligated rats

Jin Chai, Xiaohuang Du, Sheng Chen, XinChan Feng, Ying Cheng, Liangjun Zhang, Yu Gao, Shaoxue Li, Xiaochong He, Rongquan Wang, Xiangdong Zhou, Yong Yang, Weizao Luo, Wensheng Chen

Int J Clin Exp Med. 2015; 8(2): 1691–1702. Published online 2015 Feb 15.

PMCID:: PMC4402745

Abstract Article PDF–2.0M

Select item 43488966.

Swertianlarin, isolated from Swertia mussotii Franch, increases detoxification enzymes and efflux transporters expression in rats

Xin-Chan Feng, Xiaohuang Du, Sheng Chen, Dongmei Yue, Ying Cheng, Liangjun Zhang, Yu Gao, Shaoxue Li, Lei Chen, Zhihong Peng, Yong Yang, Weizao Luo, Rongquan Wang, Wensheng Chen, Jin Chai

Int J Clin Exp Pathol. 2015; 8(1): 184–195. Published online 2015 Jan 1.

PMCID:: PMC4348896

Abstract Article PDF–1.7M

Select item 37370687.

Developmental changes in the transcriptome of the rat choroid plexus in relation to neuroprotection

Ingrid Kratzer, Shane A Liddelow, Norman R Saunders, Kate M Dziegielewska, Nathalie Strazielle, Jean-Francois Ghersi-Egea

Fluids Barriers CNS. 2013; 10: 25. Published online 2013 Aug 1. doi: 10.1186/2045-8118-10-25

PMCID:: PMC3737068

Abstract Article PDF–1.6M

Select item 35251248.

Functional constraints on the constitutive androstane receptor inferred from human sequence variation and cross-species comparisons

Emma E Thompson, Hala Kuttab-Boulos, Matthew D Krasowski, Anna Di Rienzo

Hum Genomics. 2005; 2(3): 168–178. Published online 2005 Sep 1. doi: 10.1186/1479-7364-2-3-168

PMCID:: PMC3525124

Abstract Article PDF–257K

Select item 33842399.

Effects of dietary inulin, statin, and their co-treatment on hyperlipidemia, hepatic steatosis and changes in drug-metabolizing enzymes in rats fed a high-fat and high-sucrose diet

Junko Sugatani, Satoshi Sadamitsu, Tadashi Wada, Yasuhiro Yamazaki, Akira Ikari, Masao Miwa

Nutr Metab (Lond) 2012; 9: 23. Published online 2012 Mar 27. doi: 10.1186/1743-7075-9-23

PMCID:: PMC3384239

Abstract Article PDF–927K

Select item 235888610.

Evolution of pharmacologic specificity in the pregnane X receptor

Sean Ekins, Erica J Reschly, Lee R Hagey, Matthew D Krasowski

BMC Evol Biol. 2008; 8: 103. Published online 2008 Apr 2. doi: 10.1186/1471-2148-8-103

PMCID:: PMC2358886

Abstract Article PDF–1.5M

Select item 223181011.

Evolution and Function of the NR1I Nuclear Hormone Receptor Subfamily (VDR, PXR, and CAR) with Respect to Metabolism of Xenobiotics and Endogenous Compounds

E.J. Reschly, M.D. Krasowski

Curr Drug Metab. Author manuscript; available in PMC 2008 Feb 6.

Published in final edited form as: Curr Drug Metab. 2006 May; 7(4): 349–365. doi: 10.2174/138920006776873526

PMCID:: PMC2231810

Abstract Article PDF–1.3M

Select item 188594212.

Keratinocyte serum-free medium maintains long-term liver gene expression and function in cultured rat hepatocytes by preventing the loss of liver-enriched transcription factors

Wan-Chun Li, Kate L. Ralphs, Jonathan M.W. Slack, David Tosh

Int J Biochem Cell Biol. 2007; 39(3): 541–554. doi: 10.1016/j.biocel.2006.10.017

PMCID:: PMC1885942

Abstract Article

Select item 185269513.

Identification of Genes Implicated in Methapyrilene-Induced Hepatotoxicity by Comparing Differential Gene Expression in Target and Nontarget Tissue

J. Todd Auman, Jeff Chou, Kevin Gerrish, Qihong Huang, Supriya Jayadev, Kerry Blanchard, Richard S. Paules

Environ Health Perspect. 2007 Apr; 115(4): 572–578. Published online 2007 Jan 17. doi: 10.1289/ehp.9396

PMCID:: PMC1852695

Abstract Article PDF–788K

Select item 54027714.

Gene and alternative splicing annotation with AIR

Liliana Florea, Valentina Di Francesco, Jason Miller, Russell Turner, Alison Yao, Michael Harris, Brian Walenz, Clark Mobarry, Gennady V. Merkulov, Rosane Charlab, Ian Dew, Zuoming Deng, Sorin Istrail, Peter Li, Granger Sutton

Genome Res. 2005 Jan; 15(1): 54–66. doi: 10.1101/gr.2889405