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Items: 11

Select item 68536381.

TMC1 is an essential component of a leak channel that modulates tonotopy and excitability of auditory hair cells in mice

Shuang Liu, Shufeng Wang, Linzhi Zou, Jie Li, Chenmeng Song, Jiaofeng Chen, Qun Hu, Lian Liu, Pingbo Huang, Wei Xiong

eLife. 2019; 8: e47441. Published online 2019 Oct 29. doi: 10.7554/eLife.47441

PMCID:: PMC6853638

Abstract Article PDF–2.8M

Select item 67899672.

A Tmc1 mutation reduces calcium permeability and expression of mechanoelectrical transduction channels in cochlear hair cells

Maryline Beurg, Amanda Barlow, David N. Furness, Robert Fettiplace

Proc Natl Acad Sci U S A. 2019 Oct 8; 116(41): 20743–20749. Published online 2019 Sep 23. doi: 10.1073/pnas.1908058116

PMCID:: PMC6789967

Abstract Article PDF–1.6M

Select item 64084503.

LMO7 deficiency reveals the significance of the cuticular plate for hearing function

Ting-Ting Du, James B. Dewey, Elizabeth L. Wagner, Runjia Cui, Jinho Heo, Jeong-Jin Park, Shimon P. Francis, Edward Perez-Reyes, Stacey J. Guillot, Nicholas E. Sherman, Wenhao Xu, John S Oghalai, Bechara Kachar, Jung-Bum Shin

Nat Commun. 2019; 10: 1117. Published online 2019 Mar 8. doi: 10.1038/s41467-019-09074-4

PMCID:: PMC6408450

Abstract Article PDF–8.4M

Select item 63605334.

TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells

Bifeng Pan, Nurunisa Akyuz, Xiao-Ping Liu, Yukako Asai, Carl Nist-Lund, Kiyoto Kurima, Bruce H. Derfler, Bence György, Walrati Limapichat, Sanket Walujkar, Lahiru N. Wimalasena, Marcos Sotomayor, David P. Corey, Jeffrey R. Holt

Neuron. Author manuscript; available in PMC 2019 Aug 22.

Published in final edited form as: Neuron. 2018 Aug 22; 99(4): 736–753.e6. doi: 10.1016/j.neuron.2018.07.033

PMCID:: PMC6360533

Abstract Article PDF–3.5M

Select item 60924345.

Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1

Yukako Asai, Bifeng Pan, Carl Nist-Lund, Alice Galvin, Andrei N. Lukashkin, Victoria A. Lukashkina, Tianwen Chen, Wu Zhou, Hong Zhu, Ian J. Russell, Jeffrey R. Holt, Gwenaelle S. G. Géléoc

Sci Rep. 2018; 8: 12124. Published online 2018 Aug 14. doi: 10.1038/s41598-018-28958-x

PMCID:: PMC6092434

Abstract Article PDF–7.3M

Select item 60923396.

Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function

Hiroshi Nakanishi, Kiyoto Kurima, Bifeng Pan, Philine Wangemann, Tracy S. Fitzgerald, Gwenaëlle S. Géléoc, Jeffrey R. Holt, Andrew J. Griffith

Sci Rep. 2018; 8: 12125. Published online 2018 Aug 14. doi: 10.1038/s41598-018-29709-8

PMCID:: PMC6092339

Abstract Article PDF–3.3M

Select item 40765207.

Conductance and block of hair-cell mechanotransducer channels in transmembrane channel–like protein mutants

Maryline Beurg, Kyunghee X. Kim, Robert Fettiplace

J Gen Physiol. 2014 Jul; 144(1): 55–69. doi: 10.1085/jgp.201411173

PMCID:: PMC4076520

Abstract Article PDF–2.3M

Select item 33399728.

Peroxisome Proliferator-activated Receptor β/δ Induces Myogenesis by Modulating Myostatin Activity

Sabeera Bonala, Sudarsanareddy Lokireddy, Harikumar Arigela, Serena Teng, Walter Wahli, Mridula Sharma, Craig McFarlane, Ravi Kambadur

J Biol Chem. 2012 Apr 13; 287(16): 12935–12951. Published online 2012 Feb 23. doi: 10.1074/jbc.M111.319145

Retraction in:: J Biol Chem. 2016 Jul 1; 291(27): 14391.

PMCID:: PMC3339972

Abstract Article

Select item 32230729.

Mechanotransduction in mouse inner ear hair cells requires transmembrane channel–like genes

Yoshiyuki Kawashima, Gwenaëlle S.G. Géléoc, Kiyoto Kurima, Valentina Labay, Andrea Lelli, Yukako Asai, Tomoko Makishima, Doris K. Wu, Charles C. Della Santina, Jeffrey R. Holt, Andrew J. Griffith

J Clin Invest. 2011 Dec 1; 121(12): 4796–4809. Published online 2011 Nov 21. doi: 10.1172/JCI60405