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Select item 105244871.

Altered fibrinogen γ-chain cross-linking in Fibγ^Δ5 mice drives acute liver injury

Lauren G. Poole, Lauren R. Schmitt, Anthony Schulte, Dafna J. Groeneveld, Holly M. Cline, Yaqiu Sang, Woosuk S. Hur, Alisa S. Wolberg, Matthew J. Flick, Kirk C. Hansen, James P. Luyendyk

J Thromb Haemost. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: J Thromb Haemost. 2023 Aug; 21(8): 2175–2188. Published online 2023 Apr 14. doi: 10.1016/j.jtha.2023.04.003

PMCID:: PMC10524487

Abstract Article PDF–2.3M

Select item 42888422.

Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin α_Mβ₂ engagement of fibrinogen

KA Steinbrecher, N Horowitz, EA Blevins, KA Barney, MA Shaw, E Harmel-Laws, FD Finkelman, MJ Flick, MD Pinkerton, KE Talmage, KW Kombrinck, DP Witte, JS Palumbo

Cancer Res. Author manuscript; available in PMC 2015 Jan 9.

Published in final edited form as: Cancer Res. 2010 Apr 1; 70(7): 2634–2643. Published online 2010 Mar 16. doi: 10.1158/0008-5472.CAN-09-3465

PMCID:: PMC4288842

Abstract Article PDF–2.6M

Select item 26763473.

Fibrinogen facilitates the anti-tumor effect of nonnative endostatin

Huadong Tang, Yan Fu, Qingxin Lei, Qing Han, Victoria A. Ploplis, Francis J. Castellino, Ling Li, Yongzhang Luo

Biochem Biophys Res Commun. Author manuscript; available in PMC 2010 Mar 6.

Published in final edited form as: Biochem Biophys Res Commun. 2009 Mar 6; 380(2): 249–253. Published online 2009 Jan 22. doi: 10.1016/j.bbrc.2009.01.045

PMCID:: PMC2676347

Abstract Article PDF–1.0M

Select item 21379084.

The fibrin-derived γ^377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease

Ryan A. Adams, Jan Bauer, Matthew J. Flick, Shoana L. Sikorski, Tal Nuriel, Hans Lassmann, Jay L. Degen, Katerina Akassoglou

J Exp Med. 2007 Mar 19; 204(3): 571–582. doi: 10.1084/jem.20061931

PMCID:: PMC2137908

Abstract Article PDF–3.8M

Select item 18857105.

A Total Fibrinogen Deficiency Is Compatible with the Development of Pulmonary Fibrosis in Mice

Victoria A. Ploplis, Julie Wilberding, Laura McLennan, Zhong Liang, Ivo Cornelissen, Melanie E. DeFord, Elliot D. Rosen, Francis J. Castellino

Am J Pathol. 2000 Sep; 157(3): 703–708. doi: 10.1016/S0002-9440(10)64582-8

PMCID:: PMC1885710

Abstract Article PDF–981K

Select item 4194876.

Leukocyte engagement of fibrin(ogen) via the integrin receptor α_Mβ₂/Mac-1 is critical for host inflammatory response in vivo

Matthew J. Flick, XinLi Du, David P. Witte, Markéta Jiroušková, Dmitry A. Soloviev, Steven J. Busuttil, Edward F. Plow, Jay L. Degen

J Clin Invest. 2004 Jun 1; 113(11): 1596–1606. doi: 10.1172/JCI20741

PMCID:: PMC419487

Abstract Article PDF–661K

Select item 82715797.

Elimination of fibrin γ-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi

Cédric Duval, Adomas Baranauskas, Tímea Feller, Majid Ali, Lih T. Cheah, Nadira Y. Yuldasheva, Stephen R. Baker, Helen R. McPherson, Zaher Raslan, Marc A. Bailey, Richard M. Cubbon, Simon D. Connell, Ramzi A. Ajjan, Helen Philippou, Khalid M. Naseem, Victoria C. Ridger, Robert A. S. Ariëns

Proc Natl Acad Sci U S A. 2021 Jul 6; 118(27): e2103226118. Published online 2021 Jun 28. doi: 10.1073/pnas.2103226118

PMCID:: PMC8271579

Abstract Article PDF–2.1M

Select item 59652818.

The Plasminogen Receptor, Plg-R_KT, is Essential for Mammary Lobuloalveolar Development and Lactation

Lindsey A. Miles, Nagyung Baik, Hongdong Bai, Helen P. Makarenkova, William B. Kiosses, Stan Krajewski, Francis J. Castellino, Alex Valenzuela, Nissi M. Varki, Barbara M. Mueller, Robert J. Parmer

J Thromb Haemost. Author manuscript; available in PMC 2019 May 1.

Published in final edited form as: J Thromb Haemost. 2018 May; 16(5): 919–932. Published online 2018 Apr 1. doi: 10.1111/jth.13988

PMCID:: PMC5965281

Abstract Article PDF–2.7M

Select item 44877959.

Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice

N. Joshi, A. K. Kopec, K. M. O’Brien, K. L. Towery, H. Cline-Fedewa, K.J. Williams, B. L. Copple, M. J. Flick, J. P. Luyendyk

J Thromb Haemost. Author manuscript; available in PMC 2016 Jan 1.

Published in final edited form as: J Thromb Haemost. 2015 Jan; 13(1): 57–71. Published online 2014 Dec 11. doi: 10.1111/jth.12770

PMCID:: PMC4487795

Abstract Article PDF–2.8M

Select item 434441710.

Fibrin, γ’-fibrinogen, and trans-clot pressure gradient control hemostatic clot growth during human blood flow over a collagen/tissue factor wound

Ryan W. Muthard, John D. Welsh, Lawrence F. Brass, Scott L. Diamond

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2016 Mar 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2015 Mar; 35(3): 645–654. Published online 2015 Jan 22. doi: 10.1161/ATVBAHA.114.305054

PMCID:: PMC4344417

Abstract Article PDF–2.7M

Select item 409875911.

The fibrinogen γA/γ’ isoform does not promote acute arterial thrombosis in mice

Bethany L Walton, Todd M Getz, Wolfgang Bergmeier, Feng-Chang Lin, Shirley Uitte de Willige, Alisa S Wolberg

J Thromb Haemost. Author manuscript; available in PMC 2015 May 1.

Published in final edited form as: J Thromb Haemost. 2014 May; 12(5): 680–689. doi: 10.1111/jth.12534

PMCID:: PMC4098759

Abstract Article PDF–2.6M

Select item 359179812.

Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia

Matthew J. Flick, XinLi Du, Joni M. Prasad, Harini Raghu, Joseph S. Palumbo, Emanuel Smeds, Magnus Höök, Jay L. Degen

Blood. 2013 Mar 7; 121(10): 1783–1794. Prepublished online 2013 Jan 8. doi: 10.1182/blood-2012-09-453894

PMCID:: PMC3591798

Abstract Article

Select item 773349013.

The plasminogen receptor, Plg-R_KT, plays a role in inflammation and fibrinolysis during cutaneous wound healing in mice

Lina Ny, Robert J. Parmer, Yue Shen, Sandra Holmberg, Nagyung Baik, Assar Bäckman, Jessica Broden, Malgorzata Wilczynska, Tor Ny, Lindsey A. Miles

Cell Death Dis. 2020 Dec; 11(12): 1054. Published online 2020 Dec 12. doi: 10.1038/s41419-020-03230-1

PMCID:: PMC7733490

Abstract Article PDF–3.0M

Select item 655242314.

Selective cleavage of fibrinogen by diverse proteinases initiates innate allergic and antifungal immunity through CD11b

Cameron T. Landers, Hui-Ying Tung, J. Morgan Knight, Matthew C. Madison, Yifan Wu, Zhimin Zeng, Paul C. Porter, Antony Rodriguez, Matthew J. Flick, Farrah Kheradmand, David B. Corry

J Biol Chem. 2019 May 31; 294(22): 8834–8847. Published online 2019 Apr 16. doi: 10.1074/jbc.RA118.006724

PMCID:: PMC6552423

Abstract Article PDF–2.7M

Select item 447437615.

Fibrin Accumulation Secondary to Loss of Plasmin-Mediated Fibrinolysis Drives Inflammatory Osteoporosis in Mice

Heather A. Cole, Tetsuro Ohba, Jeffry S. Nyman, Haro Hirotaka, Justin M. M. Cates, Matthew J. Flick, Jay L. Degen, Jonathan G. Schoenecker

Arthritis Rheumatol. Author manuscript; available in PMC 2015 Aug 1.

Published in final edited form as: Arthritis Rheumatol. 2014 Aug; 66(8): 2222–2233. doi: 10.1002/art.38639

PMCID:: PMC4474376

Abstract Article PDF–1.0M

Select item 351449816.

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

Dimitrios Davalos, Jae Kyu Ryu, Mario Merlini, Kim M. Baeten, Natacha Le Moan, Mark A. Petersen, Thomas J. Deerinck, Dimitri S. Smirnoff, Catherine Bedard, Hiroyuki Hakozaki, Sara Gonias Murray, Jennie B. Ling, Hans Lassmann, Jay L. Degen, Mark H. Ellisman, Katerina Akassoglou

Nat Commun. 2012 Nov 27; 3: 1227. Published online 2012 Nov 27. doi: 10.1038/ncomms2230

PMCID:: PMC3514498

Abstract Article PDF–6.1M

Select item 349401417.

Loss of Maternal Annexin A5 Increases the Likelihood of Placental Platelet Thrombosis and Foetal Loss

Hiroshi Ueki, Tomona Mizushina, Titaree Laoharatchatathanin, Ryota Terashima, Yasuhiro Nishimura, Duangjai Rieanrakwong, Tomohiro Yonezawa, Shiro Kurusu, Yoshihisa Hasegawa, Bent Brachvogel, Ernst Pöschl, Mitsumori Kawaminami

Sci Rep. 2012; 2: 827. Published online 2012 Nov 9. doi: 10.1038/srep00827

PMCID:: PMC3494014

Abstract Article PDF–4.2M

Select item 266302618.

Fibrinogen has chaperone-like activity

Huadong Tang, Yan Fu, Yujie Cui, Yingbo He, Xing Zeng, Victoria A. Ploplis, Francis J. Castellino, Yongzhang Luo

Biochem Biophys Res Commun. Author manuscript; available in PMC 2010 Jan 16.

Published in final edited form as: Biochem Biophys Res Commun. 2009 Jan 16; 378(3): 662–667. Published online 2008 Dec 4. doi: 10.1016/j.bbrc.2008.11.112

PMCID:: PMC2663026

Abstract Article PDF–1.0M

Select item 263719819.

Reduced thrombin generation increases host susceptibility to group A streptococcal infection

Hongmin Sun, Xixi Wang, Jay L. Degen, David Ginsburg

Blood. 2009 Feb 5; 113(6): 1358–1364. Prepublished online 2008 Dec 3. doi: 10.1182/blood-2008-07-170506

PMCID:: PMC2637198

Abstract Article

Select item 1030762420.

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling

Andrew S. Mendiola, Zhaoqi Yan, Karuna Dixit, Jeffrey R. Johnson, Mehdi Bouhaddou, Anke Meyer-Franke, Min-Gyoung Shin, Yu Yong, Ayushi Agrawal, Eilidh MacDonald, Gayathri Muthukumar, Clairice Pearce, Nikhita Arun, Belinda Cabriga, Rosa Meza-Acevedo, Maria del Pilar S. Alzamora, Scott S. Zamvil, Alexander R. Pico, Jae Kyu Ryu, Nevan J. Krogan, Katerina Akassoglou

Nat Immunol. 2023; 24(7): 1173–1187. Published online 2023 Jun 8. doi: 10.1038/s41590-023-01522-0