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Select item 90907241.

Biallelic PAN2 variants in individuals with a syndromic neurodevelopmental disorder and multiple congenital anomalies

Miriam S. Reuter, Michael Zech, Maja Hempel, Janine Altmüller, Tracy Heung, Laura Pölsler, René Santer, Holger Thiele, Brett Trost, Christian Kubisch, Stephen W. Scherer, Sabine Rudnik-Schöneborn, Anne S. Bassett, Davor Lessel

Eur J Hum Genet. 2022 May; 30(5): 611–618. Published online 2022 Mar 18. doi: 10.1038/s41431-022-01077-y

PMCID:: PMC9090724

Abstract Article PDF–1.2M

Select item 58763482.

USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization

Shangda Yang, Ling Liu, Cheng Cao, Nan Song, Yuejiao Wang, Shuai Ma, Qi Zhang, Na Yu, Xiang Ding, Fuquan Yang, Shanshan Tian, Kai Zhang, Tao Sun, Jie Yang, Zhi Yao, Shaoyuan Wu, Lei Shi

Nat Commun. 2018; 9: 1285. Published online 2018 Mar 29. doi: 10.1038/s41467-018-03588-z

PMCID:: PMC5876348

Abstract Article PDF–4.5M

Select item 84908623.

USP52 inhibits cell proliferation by stabilizing PTEN protein in non-small cell lung cancer

Maoshu Zhu, Hui Zhang, Fuhua Lu, Zhaowei Wang, Yulong Wu, Huoshu Chen, Xin Fan, Zhijiang Yin, Fulong Liang

Biosci Rep. 2021 Oct 29; 41(10): BSR20210486. Published online 2021 Oct 4. doi: 10.1042/BSR20210486

PMCID:: PMC8490862

Abstract Article PDF–1.2M

Select item 75846434.

USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP

Ming Gao, Guijie Guo, Jinzhou Huang, Jake A. Kloeber, Fei Zhao, Min Deng, Xinyi Tu, Wootae Kim, Qin Zhou, Chao Zhang, Ping Yin, Kuntian Luo, Zhenkun Lou

Nat Commun. 2020; 11: 5362. Published online 2020 Oct 23. doi: 10.1038/s41467-020-19202-0

PMCID:: PMC7584643

Abstract Article PDF–2.1M

Select item 65478845.

Molecular Basis for poly(A) RNP Architecture and Recognition by the Pan2-Pan3 Deadenylase

Ingmar B. Schäfer, Masami Yamashita, Jan Michael Schuller, Steffen Schüssler, Peter Reichelt, Mike Strauss, Elena Conti

Cell. 2019 May 30; 177(6): 1619–1631.e21. doi: 10.1016/j.cell.2019.04.013

PMCID:: PMC6547884

Abstract Article

Select item 30199846.

Phosphorylation of Tristetraprolin by MK2 Impairs AU-Rich Element mRNA Decay by Preventing Deadenylase Recruitment

Sandra L. Clement, Claudia Scheckel, Georg Stoecklin, Jens Lykke-Andersen

Mol Cell Biol. 2011 Jan; 31(2): 256–266. Published online 2010 Nov 15. doi: 10.1128/MCB.00717-10

PMCID:: PMC3019984

Abstract Article PDF–1.2M

Select item 21691457.

Human TOB, an Antiproliferative Transcription Factor, Is a Poly(A)-Binding Protein-Dependent Positive Regulator of Cytoplasmic mRNA Deadenylation

Nader Ezzeddine, Tsung-Cheng Chang, Wenmiao Zhu, Akio Yamashita, Chyi-Ying A. Chen, Zhenping Zhong, Yukiko Yamashita, Dinghai Zheng, Ann-Bin Shyu

Mol Cell Biol. 2007 Nov; 27(22): 7791–7801. Published online 2007 Sep 4. doi: 10.1128/MCB.01254-07

PMCID:: PMC2169145

Abstract Article PDF–771K

Select item 20819798.

Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases

Yuji Funakoshi, Yusuke Doi, Nao Hosoda, Naoyuki Uchida, Masanori Osawa, Ichio Shimada, Masafumi Tsujimoto, Tsutomu Suzuki, Toshiaki Katada, Shin-ichi Hoshino

Genes Dev. 2007 Dec 1; 21(23): 3135–3148. doi: 10.1101/gad.1597707

PMCID:: PMC2081979

Abstract Article PDF–1.1M

Select item 56658499.

USP51 promotes deubiquitination and stabilization of ZEB1

Zhicheng Zhou, Peijing Zhang, Xiaoyu Hu, Jongchan Kim, Fan Yao, Zhenna Xiao, Liyong Zeng, Liang Chang, Yutong Sun, Li Ma

Am J Cancer Res. 2017; 7(10): 2020–2031. Published online 2017 Oct 1.

PMCID:: PMC5665849

Abstract Article PDF–1.3M

Select item 514341410.

USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA

Man Zhang, Meng-Xin Zhang, Qiang Zhang, Gao-Feng Zhu, Lei Yuan, Dong-Er Zhang, Qiyun Zhu, Jing Yao, Hong-Bing Shu, Bo Zhong

Cell Res. 2016 Dec; 26(12): 1302–1319. Published online 2016 Nov 1. doi: 10.1038/cr.2016.125

PMCID:: PMC5143414

Abstract Article PDF–5.5M

Select item 388528311.

miRNA repression involves GW182-mediated recruitment of CCR4–NOT through conserved W-containing motifs

Marina Chekulaeva, Hansruedi Mathys, Jakob T Zipprich, Jan Attig, Marija Colic, Roy Parker, Witold Filipowicz

Nat Struct Mol Biol. Author manuscript; available in PMC 2014 Jan 8.

Published in final edited form as: Nat Struct Mol Biol. 2011 Oct 7; 18(11): 10.1038/nsmb.2166. Published online 2011 Oct 7. doi: 10.1038/nsmb.2166

PMCID:: PMC3885283

Abstract Article PDF–2.3M

Select item 694334612.

USP37 is a SNAI1 deubiquitinase

Zhenna Xiao, Liang Chang, Jongchan Kim, Peijing Zhang, Qinglei Hang, Shannon Yap, Youming Guo, Zhicheng Zhou, Liyong Zeng, Xiaoyu Hu, Ashley Siverly, Yutong Sun, Li Ma

Am J Cancer Res. 2019; 9(12): 2749–2759. Published online 2019 Dec 1.

PMCID:: PMC6943346

Abstract Article PDF–1.2M

Select item 617618313.

Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin

Jongchan Kim, Fatemeh Alavi Naini, Yutong Sun, Li Ma

Am J Cancer Res. 2018; 8(9): 1823–1836. Published online 2018 Sep 1.

PMCID:: PMC6176183

Abstract Article PDF–3.1M

Select item 461760614.

A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C

Florencia Cano, Radu Rapiteanu, G. Sebastiaan Winkler, Paul J. Lehner

Nat Commun. 2015; 6: 8670. Published online 2015 Oct 16. doi: 10.1038/ncomms9670

PMCID:: PMC4617606

Abstract Article PDF–1.6M

Select item 377274715.

Nine Loci for Ocular Axial Length Identified through Genome-wide Association Studies, Including Shared Loci with Refractive Error

Ching-Yu Cheng, Maria Schache, M. Kamran Ikram, Terri L. Young, Jeremy A. Guggenheim, Veronique Vitart, Stuart MacGregor, Virginie J.M. Verhoeven, Veluchamy A. Barathi, Jiemin Liao, Pirro G. Hysi, Joan E. Bailey-Wilson, Beate St. Pourcain, John P. Kemp, George McMahon, Nicholas J. Timpson, David M. Evans, Grant W. Montgomery, Aniket Mishra, Ya Xing Wang, Jie Jin Wang, Elena Rochtchina, Ozren Polasek, Alan F. Wright, Najaf Amin, Elisabeth M. van Leeuwen, James F. Wilson, Craig E. Pennell, Cornelia M. van Duijn, Paulus T.V.M. de Jong, Johannes R. Vingerling, Xin Zhou, Peng Chen, Ruoying Li, Wan-Ting Tay, Yingfeng Zheng, Merwyn Chew, Consortium for Refractive Error and Myopia, Kathryn P. Burdon, Jamie E. Craig, Sudha K. Iyengar, Robert P. Igo, Jr., Jonathan H. Lass, Jr., The Fuchs’ Genetics Multi-Center Study Group, Emily Y. Chew, Toomas Haller, Evelin Mihailov, Andres Metspalu, Juho Wedenoja, Claire L. Simpson, Robert Wojciechowski, René Höhn, Alireza Mirshahi, Tanja Zeller, Norbert Pfeiffer, Karl J. Lackner, Wellcome Trust Case Control Consortium 2, Thomas Bettecken, Thomas Meitinger, Konrad Oexle, Mario Pirastu, Laura Portas, Abhishek Nag, Katie M. Williams, Ekaterina Yonova-Doing, Ronald Klein, Barbara E. Klein, S. Mohsen Hosseini, Andrew D. Paterson, The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions, and Complications Research Group, Kari-Matti Makela, Terho Lehtimaki, Mika Kahonen, Olli Raitakari, Nagahisa Yoshimura, Fumihiko Matsuda, Li Jia Chen, Chi Pui Pang, Shea Ping Yip, Maurice K.H. Yap, Akira Meguro, Nobuhisa Mizuki, Hidetoshi Inoko, Paul J. Foster, Jing Hua Zhao, Eranga Vithana, E-Shyong Tai, Qiao Fan, Liang Xu, Harry Campbell, Brian Fleck, Igor Rudan, Tin Aung, Albert Hofman, André G. Uitterlinden, Goran Bencic, Chiea-Chuen Khor, Hannah Forward, Olavi Pärssinen, Paul Mitchell, Fernando Rivadeneira, Alex W. Hewitt, Cathy Williams, Ben A. Oostra, Yik-Ying Teo, Christopher J. Hammond, Dwight Stambolian, David A. Mackey, Caroline C.W. Klaver, Tien-Yin Wong, Seang-Mei Saw, Paul N. Baird

Am J Hum Genet. 2013 Aug 8; 93(2): 264–277. doi: 10.1016/j.ajhg.2013.06.016

PMCID:: PMC3772747

Abstract Article PDF–959K

Select item 352229516.

Direct and Indirect Control of Mitogen-activated Protein Kinase Pathway-associated Components, BRAP/IMP E3 Ubiquitin Ligase and CRAF/RAF1 Kinase, by the Deubiquitylating Enzyme USP15

Sebastian D. Hayes, Han Liu, Ewan MacDonald, Christopher M. Sanderson, Judy M. Coulson, Michael J. Clague, Sylvie Urbé

J Biol Chem. 2012 Dec 14; 287(51): 43007–43018. Published online 2012 Oct 26. doi: 10.1074/jbc.M112.386938

PMCID:: PMC3522295

Abstract Article PDF–2.6M

Select item 435137917.

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci

Meian He, Min Xu, Ben Zhang, Jun Liang, Peng Chen, Jong-Young Lee, Todd A. Johnson, Huaixing Li, Xiaobo Yang, Juncheng Dai, Liming Liang, Lixuan Gui, Qibin Qi, Jinyan Huang, Yanping Li, Linda S. Adair, Tin Aung, Qiuyin Cai, Ching-Yu Cheng, Myeong-Chan Cho, Yoon Shin Cho, Minjie Chu, Bin Cui, Yu-Tang Gao, Min Jin Go, Dongfeng Gu, Weiqiong Gu, Huan Guo, Yongchen Hao, Jie Hong, Zhibin Hu, Yanling Hu, Jianfeng Huang, Joo-Yeon Hwang, Mohammad Kamran Ikram, Guangfu Jin, Dae-Hee Kang, Chiea Chuen Khor, Bong-Jo Kim, Hung Tae Kim, Michiaki Kubo, Jeannette Lee, Juyoung Lee, Nanette R. Lee, Ruoying Li, Jun Li, JianJun Liu, Jirong Longe, Wei Lu, Xiangfeng Lu, Xiaoping Miao, Yukinori Okada, Rick Twee-Hee Ong, Gaokun Qiu, Mark Seielstad, Xueling Sim, Huaidong Song, Fumihiko Takeuchi, Toshihiro Tanaka, Phil R. Taylor, Laiyuan Wang, Weiqing Wang, Yiqin Wang, Chen Wu, Ying Wu, Yong-Bing Xiang, Ken Yamamoto, Handong Yang, Ming Liao, Mitsuhiro Yokota, Terri Young, Xiaomin Zhang, Norihiro Kato, Qing K. Wang, Wei Zheng, Frank B. Hu, Dongxin Lin, Hongbing Shen, Yik Ying Teo, Zengnan Mo, Tien Yin Wong, Xu Lin, Karen L. Mohlke, Guang Ning, Tatsuhiko Tsunoda, Bok-Ghee Han, Xiao-Ou Shu, E. Shyong Tai, Tangchun Wu, Lu Qi

Hum Mol Genet. 2015 Mar 15; 24(6): 1791–1800. Published online 2014 Nov 26. doi: 10.1093/hmg/ddu583

PMCID:: PMC4351379

Abstract Article PDF–436K

Select item 794896418.

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1

Lee D. Harris, Janic Le Pen, Nico Scholz, Juliusz Mieszczanek, Natalie Vaughan, Simon Davis, Georgina Berridge, Benedikt M. Kessler, Mariann Bienz, Julien D.F. Licchesi

J Biol Chem. 2021 Jan-Jun; 296: 100246. Published online 2021 Jan 8. doi: 10.1074/jbc.RA120.015162

PMCID:: PMC7948964

Abstract Article PDF–2.7M

Select item 363208619.

The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability

John S. Bett, Adel F. M. Ibrahim, Amit K. Garg, Van Kelly, Patrick Pedrioli, Sonia Rocha, Ronald T. Hay

Biochem J. 2013 Apr 15; 451(Pt 2): 185–194. Prepublished online 2013 Feb 11. Published online 2013 Mar 28. doi: 10.1042/BJ20130026

PMCID:: PMC3632086

Abstract Article PDF–1.8M

Select item 804593220.

A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition

Yahya Benslimane, María Sánchez‐Osuna, Jasmin Coulombe‐Huntington, Thierry Bertomeu, Danielle Henry, Caroline Huard, Éric Bonneil, Pierre Thibault, Mike Tyers, Lea Harrington

Aging Cell. 2021 Apr; 20(4): e13331. Published online 2021 Mar 4. doi: 10.1111/acel.13331

PMCID:: PMC8045932

Abstract Article PDF–1.9M

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