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Select item 101951491.

RNF8 depletion attenuates hepatocellular carcinoma progression by inhibiting epithelial-mesenchymal transition and enhancing drug sensitivity: The role of RNF8 in EMT and drug sensitivity in HCC

Jingyu Kuang, Ting Duan, Changsong Gao, Chuanyang Liu, Si Chen, Lv-yun Zhu, Lu Min, Chenyu Lu, Wenlun Wang, Lingyun Zhu

Acta Biochim Biophys Sin (Shanghai) 2023 Apr; 55(4): 661–671. Published online 2023 May 6. doi: 10.3724/abbs.2023076

PMCID:: PMC10195149

Abstract Article PDF–2.7M

Select item 72744702.

RNF8 Dysregulation and Down-regulation During HTLV-1 Infection Promote Genomic Instability in Adult T-Cell Leukemia

Huijun Zhi, Xin Guo, Yik-Khuan Ho, Nagesh Pasupala, Hampus Alexander Anders Engstrom, Oliver John Semmes, Chou-Zen Giam

PLoS Pathog. 2020 May; 16(5): e1008618. Published online 2020 May 26. doi: 10.1371/journal.ppat.1008618

PMCID:: PMC7274470

Abstract Article PDF–2.2M

Select item 48932633.

RNF8 promotes epithelial-mesenchymal transition of breast cancer cells

Jingyu Kuang, Li Li, Limei Guo, Yanrong Su, Yuxuan Wang, Yongjie Xu, Xiaozhen Wang, Shucong Meng, Liandi Lei, Luzheng Xu, Genze Shao

J Exp Clin Cancer Res. 2016; 35: 88. Published online 2016 Jun 4. doi: 10.1186/s13046-016-0363-6

PMCID:: PMC4893263

Abstract Article PDF–4.2M

Select item 48910174.

Adenovirus-mediated downregulation of the ubiquitin ligase RNF8 sensitizes bladder cancer to radiotherapy

Mei-Jun Zhao, Yan-Feng Song, Hai-Tao Niu, Ying-Xia Tian, Xu-Guang Yang, Kun Xie, Yu-Hong Jing, De-Gui Wang

Oncotarget. 2016 Feb 23; 7(8): 8956–8967. Published online 2016 Jan 13. doi: 10.18632/oncotarget.6909

PMCID:: PMC4891017

Abstract Article PDF–3.6M

Select item 31213835.

Critical Roles of Ring Finger Protein RNF8 in Replication Stress Responses

Shirley M.-H. Sy, Jun Jiang, Sui-sui Dong, Gabriel Tsz Mei Lok, Jun Wu, Hua Cai, Enoch S. L. Yeung, Jun Huang, Junjie Chen, Yiqun Deng, Michael S. Y. Huen

J Biol Chem. 2011 Jun 24; 286(25): 22355–22361. Published online 2011 May 10. doi: 10.1074/jbc.M111.232041

PMCID:: PMC3121383

Abstract Article PDF–1.8M

Select item 75980696.

Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors

Lulu Wang, Lin Yang, Chen Wang, Wei Zhao, Zhenlin Ju, Wei Zhang, Jianfeng Shen, Yang Peng, Clemens An, Yen T. Luu, Shumei Song, Timothy A. Yap, Jaffer A. Ajani, Gordon B. Mills, Xuetong Shen, Guang Peng

J Clin Invest. 2020 Nov 2; 130(11): 5951–5966. Published online 2020 Oct 5. doi: 10.1172/JCI130445

PMCID:: PMC7598069

Abstract Article PDF–8.7M

Select item 72930227.

RNF8 has both KU-dependent and independent roles in chromosomal break repair

Linda Jillianne Tsai, Felicia Wednesday Lopezcolorado, Ragini Bhargava, Carlos Mendez-Dorantes, Eva Jahanshir, Jeremy M Stark

Nucleic Acids Res. 2020 Jun 19; 48(11): 6032–6052. Published online 2020 May 19. doi: 10.1093/nar/gkaa380

PMCID:: PMC7293022

Abstract Article PDF–4.3M

Select item 54610088.

RNF8 mediates histone H3 ubiquitylation and promotes glycolysis and tumorigenesis

Yan Xia, Weiwei Yang, Ming Fa, Xinjian Li, Yugang Wang, Yuhui Jiang, Yanhua Zheng, Jong-Ho Lee, Jing Li, Zhimin Lu

J Exp Med. 2017 Jun 5; 214(6): 1843–1855. doi: 10.1084/jem.20170015

PMCID:: PMC5461008

Abstract Article PDF–1.6M

Select item 51433989.

Overexpression of the scaffold WD40 protein WRAP53β enhances the repair of and cell survival from DNA double-strand breaks

H Rassoolzadeh, S Böhm, E Hedström, H Gad, T Helleday, S Henriksson, M Farnebo

Cell Death Dis. 2016 Jun; 7(6): e2267. Published online 2016 Jun 16. doi: 10.1038/cddis.2016.172

PMCID:: PMC5143398

Abstract Article PDF–2.2M

Select item 506577910.

INT6/EIF3E controls the RNF8-dependent ubiquitylation pathway and facilitates DNA double-strand break repair in human cells

Christelle Morris, Nozomi Tomimatsu, Sandeep Burma, Pierre Jalinot

Cancer Res. Author manuscript; available in PMC 2017 Oct 15.

Published in final edited form as: Cancer Res. 2016 Oct 15; 76(20): 6054–6065. Published online 2016 Aug 22. doi: 10.1158/0008-5472.CAN-16-0723

PMCID:: PMC5065779

Abstract Article PDF–3.6M

Select item 461504011.

miR-214-mediated downregulation of RNF8 induces chromosomal instability in ovarian cancer cells

Zheng Wang, Hao Yin, Yuanwei Zhang, Yukun Feng, Zhaofeng Yan, Xiaohua Jiang, Ihtisham Bukhari, Furhan Iqbal, Howard J Cooke, Qinghua Shi

Cell Cycle. 2014 Nov 15; 13(22): 3519–3528. Published online 2014 Oct 29. doi: 10.4161/15384101.2014.958413

PMCID:: PMC4615040

Abstract Article PDF–1.1M

Select item 275316112.

Nucleotide excision repair–induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

Jurgen A. Marteijn, Simon Bekker-Jensen, Niels Mailand, Hannes Lans, Petra Schwertman, Audrey M. Gourdin, Nico P. Dantuma, Jiri Lukas, Wim Vermeulen

J Cell Biol. 2009 Sep 21; 186(6): 835–847. doi: 10.1083/jcb.200902150

PMCID:: PMC2753161

Abstract Article PDF–6.6M

Select item 274967813.

RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites

Jun Yan, Anton M. Jetten

Cancer Lett. Author manuscript; available in PMC 2009 Nov 28.

Published in final edited form as: Cancer Lett. 2008 Nov 28; 271(2): 179–190. Published online 2008 Jun 11. doi: 10.1016/j.canlet.2008.04.046

PMCID:: PMC2749678

Abstract Article PDF–679K

Select item 1040683614.

CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma

You Heng Chuah, Emmy Xue Yun Tay, Oleg V. Grinchuk, Jeehyun Yoon, Jia Feng, Srinivasaraghavan Kannan, Matius Robert, Rekha Jakhar, Yajing Liang, Bernice Woon Li Lee, Loo Chien Wang, Yan Ting Lim, Tianyun Zhao, Radoslaw M. Sobota, Guang Lu, Boon Chuan Low, Karen Carmelina Crasta, Chandra Shekhar Verma, Zhewang Lin, Derrick Sek Tong Ong

Cell Death Differ. 2023 Aug; 30(8): 1973–1987. Published online 2023 Jul 19. doi: 10.1038/s41418-023-01192-3

PMCID:: PMC10406836

Abstract Article PDF–5.9M

Select item 901288415.

RNF8 up-regulates AR/ARV7 action to contribute to advanced prostate cancer progression

Tingting Zhou, Shengli Wang, Xiaoyu Song, Wensu Liu, Fang Dong, Yunlong Huo, Renlong Zou, Chunyu Wang, Siyi Zhang, Wei Liu, Ge Sun, Lin Lin, Kai Zeng, Xiang Dong, Qiqiang Guo, Fei Yi, Zhuo Wang, Xiaoman Li, Bo Jiang, Liu Cao, Yue Zhao

Cell Death Dis. 2022 Apr; 13(4): 352. Published online 2022 Apr 15. doi: 10.1038/s41419-022-04787-9

PMCID:: PMC9012884

Abstract Article PDF–5.8M

Select item 793596516.

RNF8 ubiquitinates RecQL4 and promotes its dissociation from DNA double strand breaks

Qunsong Tan, Kaifeng Niu, Yuqi Zhu, Zixiang Chen, Yueyang Li, Mengge Li, Di Wei, Adayabalam S. Balajee, Hongbo Fang, Yongliang Zhao

Oncogenesis. 2021 Mar; 10(3): 24. Published online 2021 Mar 5. doi: 10.1038/s41389-021-00315-0

PMCID:: PMC7935965

Abstract Article PDF–1.8M

Select item 789840917.

The ubiquitin ligase RNF8 regulates Rho GTPases and promotes cytoskeletal changes and motility in triple‐negative breast cancer cells

Bruno Pereira De Carvalho, Yi‐Jye Chern, Jiabei He, Chia‐Hsin Chan

FEBS Lett. 2021 Jan; 595(2): 241–252. Published online 2020 Dec 5. doi: 10.1002/1873-3468.13999

PMCID:: PMC7898409

Abstract Article PDF–2.2M

Select item 729495218.

RNF8 induces β-catenin-mediated c-Myc expression and promotes colon cancer proliferation

Ling Ren, Tingting Zhou, Yang Wang, Yanmei Wu, Hongde Xu, Jingwei Liu, Xiang Dong, Fei Yi, Qiqiang Guo, Zhuo Wang, Xiaoman Li, Ning Bai, Wendong Guo, Min Guo, Bo Jiang, Xuan Wu, Yanling Feng, Xiaoyu Song, Siyi Zhang, Yue Zhao, Liu Cao, Shuai Han, Chengzhong Xing

Int J Biol Sci. 2020; 16(12): 2051–2062. Published online 2020 May 1. doi: 10.7150/ijbs.44119