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Select item 104119511.

LIGHT (TNFSF14) promotes the differentiation of human bone marrow-derived mesenchymal stem cells into functional hepatocyte-like cells

Sook-Kyoung Heo, Ho-Min Yu, Do Kyoung Kim, Hye Jin Seo, Yerang Shin, Sung Ah Kim, Minhui Kim, Youjin Kim, Yoo Jin Lee, Eui-Kyu Noh, Jae-Cheol Jo

PLoS One. 2023; 18(8): e0289798. Published online 2023 Aug 8. doi: 10.1371/journal.pone.0289798

PMCID:: PMC10411951

Abstract Article PDF–2.9M

Select item 103718992.

High levels of LIGHT/TNFSF14 in patients with Prader–Willi syndrome

M. F. Faienza, G. Brunetti, D. Fintini, G. Grugni, M. G. Wasniewska, A. Crinò, G. D’Amato, L. Piacente, A. Oranger, M. Dicarlo, S. Colucci, M. Grano

J Endocrinol Invest. 2023; 46(9): 1901–1909. Published online 2023 Mar 14. doi: 10.1007/s40618-023-02050-2

PMCID:: PMC10371899

Abstract Article PDF–640K

Select item 88661133.

LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms

Mario C. Manresa, Amanda Wu, Quan M. Nhu, Austin W. T. Chiang, Kevin Okamoto, Haruka Miki, Richard Kurten, Elaine Pham, Loan D. Duong, Nathan E. Lewis, Praveen Akuthota, Michael Croft, Seema S. Aceves

Mucosal Immunol. 2022; 15(2): 327–337. Published online 2021 Dec 13. doi: 10.1038/s41385-021-00472-w

PMCID:: PMC8866113

Abstract Article PDF–13M

Select item 78034994.

Tumor necrosis factor superfamily 14 is critical for the development of renal fibrosis

You Li, Ming Tang, Bo Han, Shun Wu, Shu-jing Li, Qian-hui He, Feng Xu, Gui-qing Li, Kun Zhang, Xu Cao, Quan-you Zheng, Jian Chen, Di Yang, Gui-lian Xu, Ke-qin Zhang

Aging (Albany NY) 2020 Dec 31; 12(24): 25469–25486. Published online 2020 Nov 24. doi: 10.18632/aging.104151

PMCID:: PMC7803499

Abstract Article PDF–2.4M

Select item 77267045.

Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype

Mario C. Manresa, Austin W. T. Chiang, Richard C. Kurten, Ranjan Dohil, Howard Brickner, Lucas Dohil, Rana Herro, Praveen Akuthota, Nathan E. Lewis, Michael Croft, Seema S. Aceves

Gastroenterology. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Gastroenterology. 2020 Nov; 159(5): 1778–1792.e13. Published online 2020 Jul 23. doi: 10.1053/j.gastro.2020.07.035

PMCID:: PMC7726704

Abstract Article PDF–2.1M

Select item 74261766.

Levels of the TNF-Related Cytokine LIGHT Increase in Hospitalized COVID-19 Patients with Cytokine Release Syndrome and ARDS

David S. Perlin, Inbal Zafir-Lavie, Lori Roadcap, Shane Raines, Carl F. Ware, Garry A. Neil

mSphere. 2020 Jul-Aug; 5(4): e00699-20. Published online 2020 Aug 12. doi: 10.1128/mSphere.00699-20

PMCID:: PMC7426176

Abstract Article PDF–270K

Select item 73701297.

Shedding “LIGHT” on the Link between Bone and Fat in Obese Children and Adolescents

Giacomina Brunetti, Maria Felicia Faienza, Laura Piacente, Giuseppina Storlino, Angela Oranger, Gabriele D’Amato, Gianpaolo De Filippo, Silvia Colucci, Maria Grano

Int J Mol Sci. 2020 Jul; 21(13): 4739. Published online 2020 Jul 3. doi: 10.3390/ijms21134739

PMCID:: PMC7370129

Abstract Article PDF–1.3M

Select item 62060788.

LIGHT/TNFSF14 as a New Biomarker of Bone Disease in Multiple Myeloma Patients Experiencing Therapeutic Regimens

Giacomina Brunetti, Rita Rizzi, Giuseppina Storlino, Sara Bortolotti, Graziana Colaianni, Lorenzo Sanesi, Luciana Lippo, Maria Felicia Faienza, Anna Mestice, Paola Curci, Giorgina Specchia, Maria Grano, Silvia Colucci

Front Immunol. 2018; 9: 2459. Published online 2018 Oct 23. doi: 10.3389/fimmu.2018.02459

PMCID:: PMC6206078

Abstract Article PDF–1.9M

Select item 45981179.

Increased Serum LIGHT Levels Correlate with Disease Progression and Severity of Interstitial Pneumonia in Patients with Dermatomyositis: A Case Control Study

Takuya Kotani, Tohru Takeuchi, Takaaki Ishida, Ryota Masutani, Kentaro Isoda, Kenichiro Hata, Shuzo Yoshida, Shigeki Makino, Toshiaki Hanafusa

PLoS One. 2015; 10(10): e0140117. Published online 2015 Oct 8. doi: 10.1371/journal.pone.0140117

PMCID:: PMC4598117

Abstract Article PDF–603K

Select item 435034110.

LIGHT/TNFSF14 increases osteoclastogenesis and decreases osteoblastogenesis in multiple myeloma-bone disease

Giacomina Brunetti, Rita Rizzi, Angela Oranger, Isabella Gigante, Giorgio Mori, Grazia Taurino, Teresa Mongelli, Graziana Colaianni, Adriana Di Benedetto, Roberto Tamma, Giuseppe Ingravallo, Anna Napoli, Maria Felicia Faienza, Anna Mestice, Paola Curci, Giorgina Specchia, Silvia Colucci, Maria Grano

Oncotarget. 2014 Dec; 5(24): 12950–12967. Published online 2014 Dec 19. doi: 10.18632/oncotarget.2633

PMCID:: PMC4350341

Abstract Article PDF–7.2M

Select item 428455411.

Licensed human natural killer cells aid dendritic cell maturation via TNFSF14/LIGHT

Tim D. Holmes, Erica B. Wilson, Emma V. I. Black, Andrew V. Benest, Candida Vaz, Betty Tan, Vivek M. Tanavde, Graham P. Cook

Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52): E5688–E5696. Published online 2014 Dec 15. doi: 10.1073/pnas.1411072112

PMCID:: PMC4284554

Abstract Article PDF–1.5M

Select item 398246812.

Effect of Tumor Necrosis Factor Family Member LIGHT (TNFSF14) on the Activation of Basophils and Eosinophils Interacting with Bronchial Epithelial Cells

Huai Na Qiu, Chun Kwok Wong, Jie Dong, Christopher Wai-Kei Lam, Zhe Cai

Mediators Inflamm. 2014; 2014: 136463. Published online 2014 Mar 25. doi: 10.1155/2014/136463

PMCID:: PMC3982468

Abstract Article PDF–2.4M

Select item 362386013.

Shedding LIGHT (TNFSF14) on the tumor microenvironment of colorectal cancer liver metastases

Jian Zhong Qin, Vivek Upadhyay, Bellur Prabhakar, Ajay V Maker

J Transl Med. 2013; 11: 70. Published online 2013 Mar 20. doi: 10.1186/1479-5876-11-70

PMCID:: PMC3623860

Abstract Article PDF–733K

Select item 347418314.

Proinflammatory and prothrombotic effects on human vascular endothelial cells of Immune-cell-derived LIGHT

S Celik, V Shankar, A Richter, H-J Hippe, M Akhavanpoor, F Bea, C Erbel, S Urban, N Blank, N Wambsganss, HA Katus, TJ Dengler

Eur J Med Res. 2009; 14(4): 147–156. Published online 2009 Apr 16. doi: 10.1186/2047-783X-14-4-147

PMCID:: PMC3474183

Abstract Article PDF–2.2M

Select item 339048415.

Increased plasma LIGHT levels in patients with atopic dermatitis

H Kotani, K Masuda, R Tamagawa-Mineoka, T Nomiyama, F Soga, M Nin, J Asai, S Kishimoto, N Katoh

Clin Exp Immunol. 2012 Jun; 168(3): 318–324. doi: 10.1111/j.1365-2249.2012.04576.x

PMCID:: PMC3390484

Abstract Article PDF–260K

Select item 275392216.

The interaction of monocytes with rheumatoid synovial cells is a key step in LIGHT-mediated inflammatory bone destruction

Satoru Ishida, Shoji Yamane, Saori Nakano, Toru Yanagimoto, Yukie Hanamoto, Miki Maeda-Tanimura, Tomoko Toyosaki-Maeda, Jun Ishizaki, Yoshiyuki Matsuo, Naoshi Fukui, Tsunetoshi Itoh, Takahiro Ochi, Ryuji Suzuki

Immunology. 2009 Sep; 128(1 Pt 2): e315–e324. doi: 10.1111/j.1365-2567.2008.02965.x

PMCID:: PMC2753922

Abstract Article PDF–513K

Select item 193756017.

Attenuated Salmonella engineered to produce human cytokine LIGHT inhibit tumor growth

Markus Loeffler, Gaelle Le'Negrate, Maryla Krajewska, John C. Reed

Proc Natl Acad Sci U S A. 2007 Jul 31; 104(31): 12879–12883. Published online 2007 Jul 24. doi: 10.1073/pnas.0701959104

PMCID:: PMC1937560

Abstract Article PDF–350K

Select item 50909718.

LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer.

Y Zhai, R Guo, T L Hsu, G L Yu, J Ni, B S Kwon, G W Jiang, J Lu, J Tan, M Ugustus, K Carter, L Rojas, F Zhu, C Lincoln, G Endress, L Xing, S Wang, K O Oh, R Gentz, S Ruben, M E Lippman, S L Hsieh, D Yang

J Clin Invest. 1998 Sep 15; 102(6): 1142–1151. doi: 10.1172/JCI3492

PMCID:: PMC509097

Summary PDF–412K

Select item 789539519.

LIGHT (TNFSF14) enhances osteogenesis of human bone marrow-derived mesenchymal stem cells

Sook-Kyoung Heo, Yunsuk Choi, Yoo Kyung Jeong, Lan Jeong Ju, Ho-Min Yu, Do Kyoung Kim, Hye Jin Seo, Yoo Jin Lee, Jaekyung Cheon, SuJin Koh, Young Joo Min, Eui-Kyu Noh, Jae-Cheol Jo

PLoS One. 2021; 16(2): e0247368. Published online 2021 Feb 19. doi: 10.1371/journal.pone.0247368