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Select item 85993761.

The recurrent missense mutation p.(Arg367Trp) in YARS1 causes a distinct neurodevelopmental phenotype

Luisa Averdunk, Heinrich Sticht, Harald Surowy, Hermann-Josef Lüdecke, Margarete Koch-Hogrebe, Hessa S. Alsaif, Kimia Kahrizi, Hamad Alzaidan, Bashayer S. Alawam, Mohamed Tohary, Cornelia Kraus, Sabine Endele, Erin Wadman, Julie D. Kaplan, Stephanie Efthymiou, Hossein Najmabadi, André Reis, Fowzan S. Alkuraya, Dagmar Wieczorek

J Mol Med (Berl) 2021; 99(12): 1755–1768. Published online 2021 Sep 18. doi: 10.1007/s00109-021-02124-9

Correction in:: J Mol Med (Berl). 2021; 99(12): 1769–1770.

PMCID:: PMC8599376

Abstract Article PDF–1.6M

Select item 69850852.

YARS as an oncogenic protein that promotes gastric cancer progression through activating PI3K-Akt signaling

Cheng Zhang, Xiaoting Lin, Qian Zhao, Yakun Wang, Fangli Jiang, Congcong Ji, Yanyan Li, Jing Gao, Jian Li, Lin Shen

J Cancer Res Clin Oncol. 2020; 146(2): 329–342. Published online 2020 Jan 8. doi: 10.1007/s00432-019-03115-7

PMCID:: PMC6985085

Abstract Article PDF–9.9M

Select item 63602773.

Homozygosity for a mutation affecting the catalytic domain of tyrosyl-tRNA synthetase (YARS) causes multisystem disease

Katie B Williams, Karlla W Brigatti, Erik G Puffenberger, Claudia Gonzaga-Jauregui, Laurie B Griffin, Erick D Martinez, Olivia K Wenger, Mark A Yoder, Vinay V R Kandula, Michael D Fox, Matthew M Demczko, Laura Poskitt, Katryn N Furuya, Jeffrey G Reid, John D Overton, Aris Baras, Lili Miles, Kadakkal Radhakrishnan, Vincent J Carson, Anthony Antonellis, Robert N Jinks, Kevin A Strauss

Hum Mol Genet. 2019 Feb 15; 28(4): 525–538. Published online 2018 Oct 9. doi: 10.1093/hmg/ddy344

PMCID:: PMC6360277

Abstract Article PDF–48M

Select item 57378014.

Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy

David Blocquel, Sheng Li, Na Wei, Herwin Daub, Mathew Sajish, Maria-Luise Erfurth, Grace Kooi, Jiadong Zhou, Ge Bai, Paul Schimmel, Albena Jordanova, Xiang-Lei Yang

Nucleic Acids Res. 2017 Jul 27; 45(13): 8091–8104. Published online 2017 May 22. doi: 10.1093/nar/gkx455

PMCID:: PMC5737801

Abstract Article PDF–3.9M

Select item 47568565.

Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase

Zhiyi Wei, Zhiwen Xu, Xiaotian Liu, Wing-Sze Lo, Fei Ye, Ching-Fun Lau, Feng Wang, Jie J. Zhou, Leslie A. Nangle, Xiang-Lei Yang, Mingjie Zhang, Paul Schimmel

Nucleic Acids Res. 2016 Feb 18; 44(3): 1247–1255. Published online 2016 Jan 14. doi: 10.1093/nar/gkw002

PMCID:: PMC4756856

Abstract Article PDF–2.3M

Select item 39854596.

Structural Basis of Improved Second-Generation 3-Nitro-tyrosine tRNA Synthetases

Richard B. Cooley, Jessica L. Feldman, Camden M. Driggers, Taylor A. Bundy, Audrey L. Stokes, P. Andrew Karplus, Ryan A. Mehl

Biochemistry. 2014 Apr 1; 53(12): 1916–1924. Published online 2014 Mar 10. doi: 10.1021/bi5001239

PMCID:: PMC3985459

Abstract Article PDF–4.2M

Select item 33087767.

tRNA-controlled Nuclear Import of a Human tRNA Synthetase

Guangsen Fu, Tao Xu, Yi Shi, Na Wei, Xiang-Lei Yang

J Biol Chem. 2012 Mar 16; 287(12): 9330–9334. Published online 2012 Jan 30. doi: 10.1074/jbc.C111.325902

PMCID:: PMC3308776

Abstract Article PDF–1016K

Select item 27060868.

Mutational Separation of Aminoacylation and Cytokine Activities of Human Tyrosyl-tRNA Synthetase

Mili Kapoor, Francella J. Otero, Bonnie M. Slike, Karla L. Ewalt, Xiang-Lei Yang

Chem Biol. Author manuscript; available in PMC 2010 May 29.

Published in final edited form as: Chem Biol. 2009 May 29; 16(5): 531–539. doi: 10.1016/j.chembiol.2009.03.006

PMCID:: PMC2706086

Abstract Article PDF–1.0M

Select item 26934049.

Gain-of-Function Mutational Activation of Human tRNA Synthetase Procytokine

Xiang-Lei Yang, Mili Kapoor, Francella J. Otero, Bonnie M. Slike, Hiro Tsuruta, Ricardo Frausto, Alison Bates, Karla L. Ewalt, David A. Cheresh, Paul Schimmel

Chem Biol. Author manuscript; available in PMC 2009 Jun 9.

Published in final edited form as: Chem Biol. 2007 Dec; 14(12): 1323–1333. doi: 10.1016/j.chembiol.2007.10.016

PMCID:: PMC2693404

Abstract Article PDF–2.1M

Select item 118040410.

Dominant Intermediate Charcot-Marie-Tooth Type C Maps to Chromosome 1p34-p35

Albena Jordanova, Florian P. Thomas, Velina Guergueltcheva, Ivailo Tournev, Francisco A. A. Gondim, Borjana Ishpekova, Els De Vriendt, An Jacobs, Ivan Litvinenko, Neviana Ivanova, Borjan Buzhov, Peter De Jonghe, Ivo Kremensky, Vincent Timmerman

Am J Hum Genet. 2003 Dec; 73(6): 1423–1430. Published online 2003 Nov 6. doi: 10.1086/379792

PMCID:: PMC1180404

Abstract Article PDF–171K

Select item 13772311.

Crystal structure of a human aminoacyl-tRNA synthetase cytokine

Xiang-Lei Yang, Robert J. Skene, Duncan E. McRee, Paul Schimmel

Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24): 15369–15374. Published online 2002 Nov 11. doi: 10.1073/pnas.242611799

PMCID:: PMC137723

Abstract Article PDF–660K

Select item 4019912.

Evidence that two present-day components needed for the genetic code appeared after nucleated cells separated from eubacteria.

L Ribas de Pouplana, M Frugier, C L Quinn, P Schimmel

Proc Natl Acad Sci U S A. 1996 Jan 9; 93(1): 166–170. doi: 10.1073/pnas.93.1.166

PMCID:: PMC40199

Summary Page Browse PDF–1.6M

Select item 436848213.

Human Tyr-tRNA synthetase is a potent PARP-1 activating effector target for resveratrol

Mathew Sajish, Paul Schimmel

Nature. Author manuscript; available in PMC 2015 Sep 19.

Published in final edited form as: Nature. 2015 Mar 19; 519(7543): 370–373. Published online 2014 Dec 22. doi: 10.1038/nature14028

PMCID:: PMC4368482

Abstract Article PDF–3.6M

Select item 117038014.

Genetic code in evolution: switching species-specific aminoacylation with a peptide transplant.

K Wakasugi, C L Quinn, N Tao, P Schimmel

EMBO J. 1998 Jan 2; 17(1): 297–305. doi: 10.1093/emboj/17.1.297

PMCID:: PMC1170380

Summary PDF–480K

Select item 30757515.

Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains

Xiang-Lei Yang, Francella J. Otero, Robert J. Skene, Duncan E. McRee, Paul Schimmel, Lluís Ribas de Pouplana

Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26): 15376–15380. Published online 2003 Dec 11. doi: 10.1073/pnas.2136794100

PMCID:: PMC307575

Abstract Article PDF–571K

Select item 703956716.

Moonlighting matrix metalloproteinase substrates: Enhancement of proinflammatory functions of extracellular tyrosyl-tRNA synthetase upon cleavage

Parker G. Jobin, Nestor Solis, Yoan Machado, Peter A. Bell, Simran K. Rai, Nam Hoon Kwon, Sunghoon Kim, Christopher M. Overall, Georgina S. Butler

J Biol Chem. 2020 Feb 21; 295(8): 2186–2202. Published online 2019 Nov 26. doi: 10.1074/jbc.RA119.010486

PMCID:: PMC7039567

Abstract Article PDF–6.2M

Select item 270225717.

Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot–Marie–Tooth neuropathy

Erik Storkebaum, Ricardo Leitão-Gonçalves, Tanja Godenschwege, Leslie Nangle, Monica Mejia, Inge Bosmans, Tinne Ooms, An Jacobs, Patrick Van Dijck, Xiang-Lei Yang, Paul Schimmel, Koen Norga, Vincent Timmerman, Patrick Callaerts, Albena Jordanova

Proc Natl Acad Sci U S A. 2009 Jul 14; 106(28): 11782–11787. Published online 2009 Jun 26. doi: 10.1073/pnas.0905339106

PMCID:: PMC2702257

Abstract Article PDF–1.8M

Select item 137074318.

Human mitochondrial TyrRS disobeys the tyrosine identity rules

LUC BONNEFOND, MAGALI FRUGIER, RICHARD GIEGÉ, JOËLLE RUDINGER-THIRION

RNA. 2005 May; 11(5): 558–562. doi: 10.1261/rna.7246805

PMCID:: PMC1370743

Abstract Article PDF–291K

Select item 612672019.

Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia

Taisuke Kanaji, My-Nuong Vo, Sachiko Kanaji, Alessandro Zarpellon, Ryan Shapiro, Yosuke Morodomi, Akinori Yuzuriha, Koji Eto, Rajesh Belani, Minh-Ha Do, Xiang-Lei Yang, Zaverio M. Ruggeri, Paul Schimmel

Proc Natl Acad Sci U S A. 2018 Aug 28; 115(35): E8228–E8235. Published online 2018 Aug 13. doi: 10.1073/pnas.1807000115

PMCID:: PMC6126720

Abstract Article PDF–1.6M

Select item 422467020.

Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage

Na Wei, Yi Shi, Lan N. Truong, Kathleen M. Fisch, Tao Xu, Elisabeth Gardiner, Guangsen Fu, Yun-Shiuan Olivia Hsu, Shuji Kishi, Andrew I. Su, Xiaohua Wu, Xiang-Lei Yang

Mol Cell. Author manuscript; available in PMC 2015 Oct 23.

Published in final edited form as: Mol Cell. 2014 Oct 23; 56(2): 323–332. Published online 2014 Oct 2. doi: 10.1016/j.molcel.2014.09.006

PMCID:: PMC4224670

Abstract Article PDF–953K

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