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Items: 1 to 20 of 130

1.
eIF2α interactions with mRNA control accurate start codon selection by the translation preinitiation complex
Anil Thakur, Swati Gaikwad, Anil K Vijjamarri, Alan G Hinnebusch
Nucleic Acids Res. 2020 Oct 9; 48(18): 10280–10296. Published online 2020 Sep 21. doi: 10.1093/nar/gkaa761
PMCID:
PMC7544238
ArticlePDF–4.3M
2.
Yeast translation initiation suppressor sui2 encodes the alpha subunit of eukaryotic initiation factor 2 and shares sequence identity with the human alpha subunit.
A M Cigan, E K Pabich, L Feng, T F Donahue
Proc Natl Acad Sci U S A. 1989 Apr; 86(8): 2784–2788. doi: 10.1073/pnas.86.8.2784
PMCID:
PMC287003
ArticlePDF–1.2M
3.
Enhanced Interaction between Pseudokinase and Kinase Domains in Gcn2 stimulates eIF2α Phosphorylation in Starved Cells
Sebastien Lageix, Stefan Rothenburg, Thomas E. Dever, Alan G. Hinnebusch
PLoS Genet. 2014 May; 10(5): e1004326. Published online 2014 May 8. doi: 10.1371/journal.pgen.1004326
PMCID:
PMC4014428
ArticlePDF–16M
4.
Genome-wide Analysis of tRNA Charging and Activation of the eIF2 Kinase Gcn2p
John M. Zaborske, Jana Narasimhan, Li Jiang, Sheree A. Wek, Kimberly A. Dittmar, Florien Freimoser, Tao Pan, Ronald C. Wek
J Biol Chem. 2009 Sep 11; 284(37): 25254–25267. Published online 2009 Jun 22. doi: 10.1074/jbc.M109.000877
PMCID:
PMC2757228
ArticlePDF–4.0M
5.
A Network of Hydrophobic Residues Impeding Helix αC Rotation Maintains Latency of Kinase Gcn2, Which Phosphorylates the α Subunit of Translation Initiation Factor 2
Andrés Gárriz, Hongfang Qiu, Madhusudan Dey, Eun-Joo Seo, Thomas E. Dever, Alan G. Hinnebusch
Mol Cell Biol. 2009 Mar; 29(6): 1592–1607. Published online 2008 Dec 29. doi: 10.1128/MCB.01446-08
PMCID:
PMC2648240
ArticlePDF–3.8M
6.
Minimum requirements for the function of eukaryotic translation initiation factor 2.
F L Erickson, J Nika, S Rippel, E M Hannig
Genetics. 2001 May; 158(1): 123–132. doi: 10.1093/genetics/158.1.123
PMCID:
PMC1461651
SummaryPDF–408K
7.
Ligand interactions with eukaryotic translation initiation factor 2: role of the gamma-subunit.
F L Erickson, E M Hannig
EMBO J. 1996 Nov 15; 15(22): 6311–6320.
PMCID:
PMC452454
ArticlePDF–2.2M
8.
Multicopy tRNA genes functionally suppress mutations in yeast eIF-2 alpha kinase GCN2: evidence for separate pathways coupling GCN4 expression to unchanged tRNA.
C R Vazquez de Aldana, R C Wek, P S Segundo, A G Truesdell, A G Hinnebusch
Mol Cell Biol. 1994 Dec; 14(12): 7920–7932. doi: 10.1128/mcb.14.12.7920
PMCID:
PMC359331
ArticlePDF–3.3M
9.
The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids.
S A Wek, S Zhu, R C Wek
Mol Cell Biol. 1995 Aug; 15(8): 4497–4506. doi: 10.1128/mcb.15.8.4497
PMCID:
PMC230689
SummaryPDF–458K
10.
Large-scale movement of eIF3 domains during translation initiation modulate start codon selection
Jose L Llácer, Tanweer Hussain, Jinsheng Dong, Laura Villamayor, Yuliya Gordiyenko, Alan G Hinnebusch
Nucleic Acids Res. 2021 Nov 18; 49(20): 11491–11511. Published online 2021 Oct 14. doi: 10.1093/nar/gkab908
PMCID:
PMC8599844
ArticlePDF–6.6M
11.
The structural basis of translational control by eIF2 phosphorylation
Tomas Adomavicius, Margherita Guaita, Yu Zhou, Martin D. Jennings, Zakia Latif, Alan M. Roseman, Graham D. Pavitt
Nat Commun. 2019; 10: 2136. Published online 2019 May 13. doi: 10.1038/s41467-019-10167-3
PMCID:
PMC6513899
ArticlePDF–2.0M
12.
Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes
Martin D Jennings, Christopher J Kershaw, Tomas Adomavicius, Graham D Pavitt
eLife. 2017; 6: e24542. Published online 2017 Mar 18. doi: 10.7554/eLife.24542
PMCID:
PMC5404910
ArticlePDF–1.4M
13.
Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma
Paola Falletta, Luis Sanchez-del-Campo, Jagat Chauhan, Maike Effern, Amy Kenyon, Christopher J. Kershaw, Robert Siddaway, Richard Lisle, Rasmus Freter, Matthew J. Daniels, Xin Lu, Thomas Tüting, Mark Middleton, Francesca M. Buffa, Anne E. Willis, Graham Pavitt, Ze'ev A. Ronai, Tatjana Sauka-Spengler, Michael Hölzel, Colin R. Goding
Genes Dev. 2017 Jan 1; 31(1): 18–33. doi: 10.1101/gad.290940.116
PMCID:
PMC5287109
ArticlePDF–705K
14.
Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2 alpha kinase GCN2.
R C Wek, J F Cannon, T E Dever, A G Hinnebusch
Mol Cell Biol. 1992 Dec; 12(12): 5700–5710. doi: 10.1128/mcb.12.12.5700
PMCID:
PMC360510
ArticlePDF–2.6M
15.
Requirements for intercistronic distance and level of eukaryotic initiation factor 2 activity in reinitiation on GCN4 mRNA vary with the downstream cistron.
C M Grant, P F Miller, A G Hinnebusch
Mol Cell Biol. 1994 Apr; 14(4): 2616–2628. doi: 10.1128/mcb.14.4.2616
PMCID:
PMC358629
ArticlePDF–2.7M
16.
Mutations in the structural genes for eukaryotic initiation factors 2 alpha and 2 beta of Saccharomyces cerevisiae disrupt translational control of GCN4 mRNA.
N P Williams, A G Hinnebusch, T F Donahue
Proc Natl Acad Sci U S A. 1989 Oct; 86(19): 7515–7519. doi: 10.1073/pnas.86.19.7515
PMCID:
PMC298095
ArticlePDF–1.1M
17.
Tight Binding of the Phosphorylated α Subunit of Initiation Factor 2 (eIF2α) to the Regulatory Subunits of Guanine Nucleotide Exchange Factor eIF2B Is Required for Inhibition of Translation Initiation
Thanuja Krishnamoorthy, Graham D. Pavitt, Fan Zhang, Thomas E. Dever, Alan G. Hinnebusch
Mol Cell Biol. 2001 Aug; 21(15): 5018–5030. doi: 10.1128/MCB.21.15.5018-5030.2001
PMCID:
PMC87228
ArticlePDF–587K
18.
The β Subunit of Eukaryotic Translation Initiation Factor 2 Binds mRNA through the Lysine Repeats and a Region Comprising the C2-C2 Motif
Jomar P. Laurino, Glória M. Thompson, Eliza Pacheco, Beatriz A. Castilho
Mol Cell Biol. 1999 Jan; 19(1): 173–181. doi: 10.1128/mcb.19.1.173
Correction in:
Mol Cell Biol. 1999 Apr; 19(4): 3224.
PMCID:
PMC83876
ArticlePDF–1021K
19.
eIF2β zinc-binding domain interacts with the eIF2γ subunit through the guanine nucleotide binding interface to promote Met-tRNAiMet binding
Aranyadip Gayen, Pankaj V. Alone
Biosci Rep. 2024 Jul 31; 44(7): BSR20240438. Published online 2024 Jul 5. doi: 10.1042/BSR20240438
PMCID:
PMC11230868
ArticlePDF–8.7M
20.
Mutational analysis of the alpha subunit of eIF2B provides insights into the role of eIF2B bodies in translational control and VWM disease
Karl Norris, Rachel E. Hodgson, Tawni Dornelles, K. Elizabeth Allen, Ben M. Abell, Mark P. Ashe, Susan G. Campbell
J Biol Chem. 2021 Jan-Jun; 296: 100207. Published online 2021 Jan 30. doi: 10.1074/jbc.RA120.014956
PMCID:
PMC7948505
ArticlePDF–3.9M

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