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Items: 1 to 20 of 78

1.
Tumor suppressive role of the epigenetic master regulator BRD3 in colorectal cancer
Masahiro Hashimoto, Takaaki Masuda, Yusuke Nakano, Taro Tobo, Hideyuki Saito, Kensuke Koike, Junichi Takahashi, Tadashi Abe, Yuki Ando, Yuki Ozato, Kiyotaka Hosoda, Satoshi Higuchi, Yuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, Tsuyoshi Hata, Mamoru Uemura, Hidetoshi Eguchi, Yuichiro Doki, Masaki Mori, Koshi Mimori
Cancer Sci. 2024 Jun; 115(6): 1866–1880. Published online 2024 Mar 17. doi: 10.1111/cas.16129
PMCID:
PMC11145117
AbstractArticlePDF–20M
2.
Kinome-wide screening uncovers a role for Bromodomain Protein 3 in DNA double-stranded break repair
Chen Wang, Doug W. Chan, Eric A. Hendrickson
DNA Repair (Amst) Author manuscript; available in PMC 2023 Jul 18.
Published in final edited form as: DNA Repair (Amst). 2023 Feb; 122: 103445. Published online 2022 Dec 24. doi: 10.1016/j.dnarep.2022.103445
PMCID:
PMC10353298
AbstractArticlePDF–2.5M
3.
Epigenetic readers and lung cancer: the rs2427964C>T variant of the bromodomain and extraterminal domain gene BRD3 is associated with poorer survival outcome in NSCLC
Jang Hyuck Lee, Seung Soo Yoo, Mi Jeong Hong, Jin Eun Choi, Hyo‐Gyoung Kang, Sook Kyung Do, Won Kee Lee, Sun Ha Choi, Yong Hoon Lee, Hyewon Seo, Jaehee Lee, Shin Yup Lee, Seung Ick Cha, Chang Ho Kim, Eung Bae Lee, Sukki Cho, Sanghoon Jheon, Jae Yong Park
Mol Oncol. 2022 Feb; 16(3): 750–763. Published online 2021 Oct 15. doi: 10.1002/1878-0261.13109
PMCID:
PMC8807359
AbstractArticlePDF–5.3M
4.
The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators
Dorothy C. C. Wai, Taylor N. Szyszka, Amy E. Campbell, Cherry Kwong, Lorna E. Wilkinson-White, Ana P. G. Silva, Jason K. K. Low, Ann H. Kwan, Roland Gamsjaeger, James D. Chalmers, Wayne M. Patrick, Bin Lu, Christopher R. Vakoc, Gerd A. Blobel, Joel P. Mackay
J Biol Chem. 2018 May 11; 293(19): 7160–7175. Published online 2018 Mar 22. doi: 10.1074/jbc.RA117.000678
PMCID:
PMC5949996
AbstractArticlePDF–3.9M
5.
The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis
Zhicheng Shao, Ruowen Zhang, Alireza Khodadadi-Jamayran, Bo Chen, Michael R. Crowley, Muhamad A. Festok, David K. Crossman, Tim M. Townes, Kejin Hu
Nat Commun. 2016; 7: 10869. Published online 2016 Mar 7. doi: 10.1038/ncomms10869
PMCID:
PMC4786677
AbstractArticlePDF–3.8M
6.
Identification of a BET family Bromodomain / Casein Kinase II / TAF-containing complex as a regulator of mitotic condensin function
Hyun-Soo Kim, Rituparna Mukhopadhyay, Scott B. Rothbart, Andrea C. Silva, Vincent Vanoosthuyse, Ernest Radovani, Thomas Kislinger, Assen Roguev, Colm J. Ryan, Jiewei Xu, Harlizawati Jahari, Kevin G. Hardwick, Jack F. Greenblatt, Nevan J. Krogan, Jeffrey S. Fillingham, Brian D. Strahl, Eric E. Bouhassira, Winfried Edelmann, Michael-Christopher Keogh
Cell Rep. Author manuscript; available in PMC 2014 Mar 28.
Published in final edited form as: Cell Rep. 2014 Mar 13; 6(5): 892–905. Published online 2014 Feb 22. doi: 10.1016/j.celrep.2014.01.029
PMCID:
PMC3969266
AbstractArticlePDF–4.6M
7.
Distinct Roles for BET Family Members in Estrogen Receptor α Enhancer Function and Gene Regulation in Breast Cancer Cells
Shino Murakami, Rui Li, Anusha Nagari, Minho Chae, Cristel V. Camacho, W. Lee Kraus
Mol Cancer Res. Author manuscript; available in PMC 2020 Jun 1.
Published in final edited form as: Mol Cancer Res. 2019 Dec; 17(12): 2356–2368. Published online 2019 Sep 24. doi: 10.1158/1541-7786.MCR-19-0393
PMCID:
PMC6891197
AbstractArticlePDF–2.8M
8.
Recruitment of Brd3 and Brd4 to acetylated chromatin is essential for proinflammatory cytokine-induced matrix-degrading enzyme expression
Jin Dai, Sheng Zhou, Qiting Ge, Jinzhong Qin, Jianxin Li, Huangxian Ju, Yi Cao, Minghao Zheng, Chaojun Li, Xiang Gao, Huajian Teng, Qing Jiang
J Orthop Surg Res. 2019; 14: 59. Published online 2019 Feb 20. doi: 10.1186/s13018-019-1091-3
PMCID:
PMC6381721
AbstractArticlePDF–2.7M
9.
BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells
Marco Carretta, Annet Z. Brouwers-Vos, Matthieu Bosman, Sarah J. Horton, Joost H. A. Martens, Edo Vellenga, Jan Jacob Schuringa
PLoS One. 2017; 12(12): e0189102. Published online 2017 Dec 14. doi: 10.1371/journal.pone.0189102
PMCID:
PMC5730124
AbstractArticlePDF–3.0M
10.
Opposing effects of cancer type-specific SPOP mutations on BET protein degradation and sensitivity to BET inhibitors
Hana Janouskova, Geniver El Tekle, Elisa Bellini, Namrata D. Udeshi, Anna Rinaldi, Anna Ulbricht, Tiziano Bernasocchi, Gianluca Civenni, Marco Losa, Tanya Svinkina, Craig M. Bielski, Gregory V. Kryukov, Luciano Cascione, Sara Napoli, Radoslav I. Enchev, David G. Mutch, Michael E. Carney, Andrew Berchuck, Boris J.N. Winterhoff, Russell R. Broaddus, Peter Schraml, Holger Moch, Francesco Bertoni, Carlo V. Catapano, Matthias Peter, Steven A. Carr, Levi A. Garraway, Peter J. Wild, Jean-Philippe P. Theurillat
Nat Med. Author manuscript; available in PMC 2018 Feb 14.
Published in final edited form as: Nat Med. 2017 Sep; 23(9): 1046–1054. Published online 2017 Aug 14. doi: 10.1038/nm.4372
PMCID:
PMC5592092
AbstractArticlePDF–2.4M
11.
Structural Basis and Specificity of Acetylated Transcription Factor GATA1 Recognition by BET Family Bromodomain Protein Brd3
Roland Gamsjaeger, Sarah R. Webb, Janine M. Lamonica, Andrew Billin, Gerd A. Blobel, Joel P. Mackay
Mol Cell Biol. 2011 Jul; 31(13): 2632–2640. doi: 10.1128/MCB.05413-11
PMCID:
PMC3133386
AbstractArticlePDF–1.6M
12.
Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis
Pei-Ling Hsu, Chun-Wei Chien, Yen-An Tang, Bo-Wen Lin, Shih-Chieh Lin, Yi-Syuan Lin, Sih-Yu Chen, H. Sunny Sun, Shaw-Jenq Tsai
Sci Adv. 2023 Apr; 9(15): eade3422. Published online 2023 Apr 12. doi: 10.1126/sciadv.ade3422
Correction in:
Sci Adv. 2023 Nov 10; 9(45): eadl3229.
PMCID:
PMC10096587
AbstractArticlePDF–3.9M
13.
A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins
Sriram Aiyer, G.V.T. Swapna, Li-Chung Ma, Gaohua Liu, Jingzhou Hao, Gordon Chalmers, Brian C. Jacobs, Gaetano T. Montelione, Monica J. Roth
Structure. Author manuscript; available in PMC 2021 Nov 5.
Published in final edited form as: Structure. 2021 Aug 5; 29(8): 886–898.e6. Published online 2021 Feb 15. doi: 10.1016/j.str.2021.01.010
PMCID:
PMC8349776
AbstractArticlePDF–3.0M
14.
BCL6 confers KRAS-mutant non–small-cell lung cancer resistance to BET inhibitors
Jiawei Guo, Yanan Liu, Jing Lv, Bin Zou, Zhi Chen, Kun Li, Juanjuan Feng, Zhenyu Cai, Lai Wei, Mingyao Liu, Xiufeng Pang
J Clin Invest. 2021 Jan 4; 131(1): e133090. Published online 2021 Jan 4. doi: 10.1172/JCI133090
PMCID:
PMC7773368
AbstractArticlePDF–10M
15.
Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system
Michael T. Werner, Hongxin Wang, Nicole Hamagami, Sarah C. Hsu, Jennifer A. Yano, Aaron J. Stonestrom, Vivek Behera, Yichen Zong, Joel P. Mackay, Gerd A. Blobel
J Biol Chem. 2020 Feb 14; 295(7): 1898–1914. Published online 2019 Dec 2. doi: 10.1074/jbc.RA119.010679
Correction in:
J Biol Chem. 2020 May 1; 295(18): 6251.
PMCID:
PMC7029111
AbstractArticlePDF–3.1M
16.
Bromodomain and Extraterminal (BET) Protein Inhibition Restores Redox Balance and Inhibits Myofibroblast Activation
Carmel J. W. Stock, Charalambos Michaeloudes, Patricia Leoni, Andrew L. Durham, Sharon Mumby, Athol U. Wells, Kian Fan Chung, Ian M. Adcock, Elisabetta A. Renzoni, Gisela E. Lindahl
Biomed Res Int. 2019; 2019: 1484736. Published online 2019 Apr 18. doi: 10.1155/2019/1484736
PMCID:
PMC6500679
AbstractArticlePDF–1.4M
17.
Metabolically-derived lysine acylations and neighboring modifications tune BET bromodomain binding to histone H4
Michael D. Olp, Nan Zhu, Brian C. Smith
Biochemistry. Author manuscript; available in PMC 2018 Oct 17.
Published in final edited form as: Biochemistry. 2017 Oct 17; 56(41): 5485–5495. Published online 2017 Oct 5. doi: 10.1021/acs.biochem.7b00595
PMCID:
PMC5970795
AbstractArticlePDF–1.0M
18.
BET Proteins Exhibit Transcriptional and Functional Opposition in the Epithelial-to-mesenchymal Transition
Guillaume P. Andrieu, Gerald V. Denis
Mol Cancer Res. Author manuscript; available in PMC 2019 Apr 1.
Published in final edited form as: Mol Cancer Res. 2018 Apr; 16(4): 580–586. Published online 2018 Feb 7. doi: 10.1158/1541-7786.MCR-17-0568
PMCID:
PMC5882530
AbstractArticlePDF–849K
19.
Bromo- and Extraterminal Domain Chromatin Regulators Serve as Cofactors for Murine Leukemia Virus Integration
Saumya Shree Gupta, Tobias Maetzig, Goedele N. Maertens, Azar Sharif, Michael Rothe, Magdalena Weidner-Glunde, Melanie Galla, Axel Schambach, Peter Cherepanov, Thomas F. Schulz
J Virol. 2013 Dec; 87(23): 12721–12736. doi: 10.1128/JVI.01942-13
Correction in:
J Virol. 2024 Apr; 98(4): e00135-24.
PMCID:
PMC3838128
AbstractArticlePDF–1.9M
20.
Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation
Matthew J. Cuneo, Brian G. O’Flynn, Yu-Hua Lo, Nafiseh Sabri, Tanja Mittag
Mol Cell. Author manuscript; available in PMC 2024 Mar 2.
Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 731–745.e4. Published online 2023 Jan 23. doi: 10.1016/j.molcel.2022.12.033
PMCID:
PMC9992347
AbstractArticlePDF–4.6M

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