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Select item 102604931.

RNF128 expression in lung adenocarcinoma is a favorable prognostic factor associated with decreased tumor‐associated macrophages

Syuusuke Fujimoto, Kadota Kyuichi, Yamada Kaede, Yoshida Chihiro, Ibuki Emi, Ishikawa Ryo, Haba Reiji, Yajima Toshiki, Hiroyasu Yokomise

Thorac Cancer. 2023 Jun; 14(17): 1581–1588. Published online 2023 Apr 26. doi: 10.1111/1759-7714.14901

PMCID:: PMC10260493

Abstract Article PDF–909K

Select item 98378302.

Ring finger protein 128 promotes, rather than inhibits, colorectal cancer progression by regulating the Hippo signaling pathway

Shili Ning, Yuzhuo Chen, Guangzhi Wang, Yongtai Liu, Yingchi Yang, Zhongtao Zhang

Front Oncol. 2022; 12: 1031160. Published online 2022 Dec 29. doi: 10.3389/fonc.2022.1031160

PMCID:: PMC9837830

Abstract Article PDF–26M

Select item 87481723.

RNF128 suppresses the malignancy of colorectal cancer cells via inhibition of Wnt/β-catenin signaling

Yue Zhu, Yujie Gan, Renrui Zou, Huanhuan Sha, Ya Lu, Yuan Zhang, Jifeng Feng

Am J Transl Res. 2021; 13(12): 13567–13578. Published online 2021 Dec 15.

PMCID:: PMC8748172

Abstract Article PDF–2.1M

Select item 62507204.

Grail attenuates influenza A virus infection and pathogenesis by inhibiting viral nucleoprotein

Hui-Tsu Lin, Cheng-Cheung Chen, Pei-Yao Liu, Hsueh-Ling Wu, Ti-Hui Wu, Chih-Heng Huang, Ying-Chuan Chen

Sci Rep. 2018; 8: 17242. Published online 2018 Nov 22. doi: 10.1038/s41598-018-35722-8

PMCID:: PMC6250720

Abstract Article PDF–3.3M

Select item 63999285.

Downregulation of RNF128 activates Wnt/β-catenin signaling to induce cellular EMT and stemness via CD44 and CTTN ubiquitination in melanoma

Chuan-Yuan Wei, Meng-Xuan Zhu, Yan-Wen Yang, Peng-Fei Zhang, Xuan Yang, Rui Peng, Chao Gao, Jia-Cheng Lu, Lu Wang, Xin-Yi Deng, Nan-Hang Lu, Fa-Zhi Qi, Jian-Ying Gu

J Hematol Oncol. 2019; 12: 21. Published online 2019 Mar 4. doi: 10.1186/s13045-019-0711-z

PMCID:: PMC6399928

Abstract Article PDF–12M

Select item 85936206.

UBCH5 Family Members Differentially Impact Stabilization of Mutant p53 via RNF128 Iso1 During Barrett’s Progression to Esophageal Adenocarcinoma

Paramita Ray, Derek J. Nancarrow, Daysha Ferrer-Torres, Zhuwen Wang, May San Martinho, Tonaye Hinton, Joshua H. Wu, Angeline Wu, Danielle Kim Turgeon, Max A. Hammer, Michael K. Dame, Theodore S. Lawrence, Patrick J. O’Brien, Jason R. Spence, David G. Beer, Dipankar Ray

Cell Mol Gastroenterol Hepatol. 2022; 13(1): 129–149. Published online 2021 Aug 17. doi: 10.1016/j.jcmgh.2021.08.003

PMCID:: PMC8593620

Abstract Article PDF–6.0M

Select item 79978937.

E3 ubiquitin ligase Grail promotes hepatic steatosis through Sirt1 inhibition

Pei-Yao Liu, Cheng-Cheung Chen, Chia-Ying Chin, Te-Jung Liu, Wen-Chiuan Tsai, Jian-Liang Chou, Chuan-Yu Huang, Yu-Guang Chen, Ying-Chuan Chen

Cell Death Dis. 2021 Apr; 12(4): 323. Published online 2021 Mar 26. doi: 10.1038/s41419-021-03608-9

PMCID:: PMC7997893

Abstract Article PDF–3.7M

Select item 74299818.

Isoforms of RNF128 Regulate the Stability of Mutant P53 in Barrett’s Esophageal Cells

Dipankar Ray, Paramita Ray, Daysha Ferrer-Torres, Zhuwen Wang, Derek Nancarrow, Hee-won Yoon, May San Martinho, Tonaye Hinton, Scott Owens, Dafydd Thomas, Hui Jiang, Theodore S. Lawrence, Jules Lin, Kiran Lagisetty, Andrew C. Chang, David G. Beer

Gastroenterology. Author manuscript; available in PMC 2021 Feb 1.

Published in final edited form as: Gastroenterology. 2020 Feb; 158(3): 583–597.e1. Published online 2019 Nov 9. doi: 10.1053/j.gastro.2019.10.040

PMCID:: PMC7429981

Abstract Article PDF–2.8M

Select item 43001109.

The Transmembrane E3 Ligase GRAIL Ubiquitinates and Degrades CD83 on CD4 T Cells

Leon L. Su, Hideyuki Iwai, Jack T. Lin, C. Garrison Fathman

J Immunol. Author manuscript; available in PMC 2015 Jan 20.

Published in final edited form as: J Immunol. 2009 Jul 1; 183(1): 438–444. doi: 10.4049/jimmunol.0900204

PMCID:: PMC4300110

Abstract Article PDF–1.7M

Select item 285337110.

Naive CD4 T Cell Proliferation Is Controlled by Mammalian Target of Rapamycin Regulation of GRAIL Expression

Jack T. Lin, Neil B. Lineberry, Michael G. Kattah, Leon L. Su, Paul J. Utz, C. Garrison Fathman, Linda Wu

J Immunol. Author manuscript; available in PMC 2010 Apr 12.

Published in final edited form as: J Immunol. 2009 May 15; 182(10): 5919–5928. doi: 10.4049/jimmunol.0803986

PMCID:: PMC2853371

Abstract Article PDF–839K

Select item 361924111.

Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesis

Y-C Chen, J Y-H Chan, Y-L Chiu, S-T Liu, G Lozano, S-L Wang, C-L Ho, S-M Huang

Cell Death Differ. 2013 May; 20(5): 732–743. Published online 2013 Feb 1. doi: 10.1038/cdd.2013.1

PMCID:: PMC3619241

Abstract Article PDF–4.0M

Select item 285337712.

Cutting Edge: The Transmembrane E3 Ligase GRAIL Ubiquitinates the Costimulatory Molecule CD40 Ligand during the Induction of T Cell Anergy

Neil B. Lineberry, Leon L. Su, Jack T. Lin, Greg P. Coffey, Christine M. Seroogy, C. Garrison Fathman

J Immunol. Author manuscript; available in PMC 2010 Apr 12.

Published in final edited form as: J Immunol. 2008 Aug 1; 181(3): 1622–1626. doi: 10.4049/jimmunol.181.3.1622

PMCID:: PMC2853377

Abstract Article PDF–566K

Select item 256891613.

The Single Subunit Transmembrane E3 Ligase Gene Related to Anergy in Lymphocytes (GRAIL) Captures and Then Ubiquitinates Transmembrane Proteins across the Cell Membrane

Neil Lineberry, Leon Su, Luis Soares, C. Garrison Fathman

J Biol Chem. 2008 Oct 17; 283(42): 28497–28505. doi: 10.1074/jbc.M805092200

PMCID:: PMC2568916

Abstract Article PDF–700K

Select item 1012727714.

Receptor Elimination by E3 Ubiquitin Ligase Recruitment (REULR): A Targeted Protein Degradation Toolbox

Dirk H. Siepe, Lora K. Picton, K. Christopher Garcia

ACS Synth Biol. 2023 Apr 21; 12(4): 1081–1093. Published online 2023 Apr 3. doi: 10.1021/acssynbio.2c00587

PMCID:: PMC10127277

Abstract Article PDF–5.0M

Select item 436728315.

CD81 Promotes Both the Degradation of Transferrin Receptor 2 (TfR2) and the Tfr2-mediated Maintenance of Hepcidin Expression

Juxing Chen, Caroline A. Enns

J Biol Chem. 2015 Mar 20; 290(12): 7841–7850. Published online 2015 Jan 29. doi: 10.1074/jbc.M114.632778

PMCID:: PMC4367283

Abstract Article PDF–1.5M

Select item 320319316.

The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors

Susanne Pfefferle, Julia Schöpf, Manfred Kögl, Caroline C. Friedel, Marcel A. Müller, Javier Carbajo-Lozoya, Thorsten Stellberger, Ekatarina von Dall’Armi, Petra Herzog, Stefan Kallies, Daniela Niemeyer, Vanessa Ditt, Thomas Kuri, Roland Züst, Ksenia Pumpor, Rolf Hilgenfeld, Frank Schwarz, Ralf Zimmer, Imke Steffen, Friedemann Weber, Volker Thiel, Georg Herrler, Heinz-Jürgen Thiel, Christel Schwegmann-Weßels, Stefan Pöhlmann, Jürgen Haas, Christian Drosten, Albrecht von Brunn

PLoS Pathog. 2011 Oct; 7(10): e1002331. Published online 2011 Oct 27. doi: 10.1371/journal.ppat.1002331

PMCID:: PMC3203193

Abstract Article PDF–1.7M

Select item 276528017.

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

Gabriel Markson, Christina Kiel, Russell Hyde, Stephanie Brown, Panagoula Charalabous, Anja Bremm, Jennifer Semple, Jonathan Woodsmith, Simon Duley, Kourosh Salehi-Ashtiani, Marc Vidal, David Komander, Luis Serrano, Paul Lehner, Christopher M. Sanderson

Genome Res. 2009 Oct; 19(10): 1905–1911. doi: 10.1101/gr.093963.109

PMCID:: PMC2765280

Abstract Article PDF–425K

Select item 733229318.

Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

Emma J Fenech, Federica Lari, Philip D Charles, Roman Fischer, Marie Laétitia-Thézénas, Katrin Bagola, Adrienne W Paton, James C Paton, Mads Gyrd-Hansen, Benedikt M Kessler, John C Christianson

eLife. 2020; 9: e57306. Published online 2020 Jul 2. doi: 10.7554/eLife.57306

PMCID:: PMC7332293

Abstract Article PDF–2.2M

Select item 823607819.

Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs

Katherine M. Almasy, Jonathan P. Davies, Lars Plate

Mol Cell Proteomics. 2021; 20: 100120. Published online 2021 Jun 27. doi: 10.1016/j.mcpro.2021.100120

PMCID:: PMC8236078

Abstract Article PDF–4.6M

Select item 266528620.

The DNA sequence of the human X chromosome

Mark T. Ross, Darren V. Grafham, Alison J. Coffey, Steven Scherer, Kirsten McLay, Donna Muzny, Matthias Platzer, Gareth R. Howell, Christine Burrows, Christine P. Bird, Adam Frankish, Frances L. Lovell, Kevin L. Howe, Jennifer L. Ashurst, Robert S. Fulton, Ralf Sudbrak, Gaiping Wen, Matthew C. Jones, Matthew E. Hurles, T. Daniel Andrews, Carol E. Scott, Stephen Searle, Juliane Ramser, Adam Whittaker, Rebecca Deadman, Nigel P. Carter, Sarah E. Hunt, Rui Chen, Andrew Cree, Preethi Gunaratne, Paul Havlak, Anne Hodgson, Michael L. Metzker, Stephen Richards, Graham Scott, David Steffen, Erica Sodergren, David A. Wheeler, Kim C. Worley, Rachael Ainscough, Kerrie D. Ambrose, M. Ali Ansari-Lari, Swaroop Aradhya, Robert I. S. Ashwell, Anne K. Babbage, Claire L. Bagguley, Andrea Ballabio, Ruby Banerjee, Gary E. Barker, Karen F. Barlow, Ian P. Barrett, Karen N. Bates, David M. Beare, Helen Beasley, Oliver Beasley, Alfred Beck, Graeme Bethel, Karin Blechschmidt, Nicola Brady, Sarah Bray-Allen, Anne M. Bridgeman, Andrew J. Brown, Mary J. Brown, David Bonnin, Elspeth A. Bruford, Christian Buhay, Paula Burch, Deborah Burford, Joanne Burgess, Wayne Burrill, John Burton, Jackie M. Bye, Carol Carder, Laura Carrel, Joseph Chako, Joanne C. Chapman, Dean Chavez, Ellson Chen, Guan Chen, Yuan Chen, Zhijian Chen, Craig Chinault, Alfredo Ciccodicola, Sue Y. Clark, Graham Clarke, Chris M. Clee, Sheila Clegg, Kerstin Clerc-Blankenburg, Karen Clifford, Vicky Cobley, Charlotte G. Cole, Jen S. Conquer, Nicole Corby, Richard E. Connor, Robert David, Joy Davies, Clay Davis, John Davis, Oliver Delgado, Denise DeShazo, Pawandeep Dhami, Yan Ding, Huyen Dinh, Steve Dodsworth, Heather Draper, Shannon Dugan-Rocha, Andrew Dunham, Matthew Dunn, K. James Durbin, Ireena Dutta, Tamsin Eades, Matthew Ellwood, Alexandra Emery-Cohen, Helen Errington, Kathryn L. Evans, Louisa Faulkner, Fiona Francis, John Frankland, Audrey E. Fraser, Petra Galgoczy, James Gilbert, Rachel Gill, Gernot Glöckner, Simon G. Gregory, Susan Gribble, Coline Griffiths, Russell Grocock, Yanghong Gu, Rhian Gwilliam, Cerissa Hamilton, Elizabeth A. Hart, Alicia Hawes, Paul D. Heath, Katja Heitmann, Steffen Hennig, Judith Hernandez, Bernd Hinzmann, Sarah Ho, Michael Hoffs, Phillip J. Howden, Elizabeth J. Huckle, Jennifer Hume, Paul J. Hunt, Adrienne R. Hunt, Judith Isherwood, Leni Jacob, David Johnson, Sally Jones, Pieter J. de Jong, Shirin S. Joseph, Stephen Keenan, Susan Kelly, Joanne K. Kershaw, Ziad Khan, Petra Kioschis, Sven Klages, Andrew J. Knights, Anna Kosiura, Christie Kovar-Smith, Gavin K. Laird, Cordelia Langford, Stephanie Lawlor, Margaret Leversha, Lora Lewis, Wen Liu, Christine Lloyd, David M. Lloyd, Hermela Loulseged, Jane E. Loveland, Jamieson D. Lovell, Ryan Lozado, Jing Lu, Rachael Lyne, Jie Ma, Manjula Maheshwari, Lucy H. Matthews, Jennifer McDowall, Stuart McLaren, Amanda McMurray, Patrick Meidl, Thomas Meitinger, Sarah Milne, George Miner, Shailesh L. Mistry, Margaret Morgan, Sidney Morris, Ines Müller, James C. Mullikin, Ngoc Nguyen, Gabriele Nordsiek, Gerald Nyakatura, Christopher N. O’Dell, Geoffery Okwuonu, Sophie Palmer, Richard Pandian, David Parker, Julia Parrish, Shiran Pasternak, Dina Patel, Alex V. Pearce, Danita M. Pearson, Sarah E. Pelan, Lesette Perez, Keith M. Porter, Yvonne Ramsey, Kathrin Reichwald, Susan Rhodes, Kerry A. Ridler, David Schlessinger, Mary G. Schueler, Harminder K. Sehra, Charles Shaw-Smith, Hua Shen, Elizabeth M. Sheridan, Ratna Shownkeen, Carl D. Skuce, Michelle L. Smith, Elizabeth C. Sotheran, Helen E. Steingruber, Charles A. Steward, Roy Storey, R. Mark Swann, David Swarbreck, Paul E. Tabor, Stefan Taudien, Tineace Taylor, Brian Teague, Karen Thomas, Andrea Thorpe, Kirsten Timms, Alan Tracey, Steve Trevanion, Anthony C. Tromans, Michele d’Urso, Daniel Verduzco, Donna Villasana, Lenee Waldron, Melanie Wall, Qiaoyan Wang, James Warren, Georgina L. Warry, Xuehong Wei, Anthony West, Siobhan L. Whitehead, Mathew N. Whiteley, Jane E. Wilkinson, David L. Willey, Gabrielle Williams, Leanne Williams, Angela Williamson, Helen Williamson, Laurens Wilming, Rebecca L. Woodmansey, Paul W. Wray, Jennifer Yen, Jingkun Zhang, Jianling Zhou, Huda Zoghbi, Sara Zorilla, David Buck, Richard Reinhardt, Annemarie Poustka, André Rosenthal, Hans Lehrach, Alfons Meindl, Patrick J. Minx, LaDeana W. Hillier, Huntington F. Willard, Richard K. Wilson, Robert H. Waterston, Catherine M. Rice, Mark Vaudin, Alan Coulson, David L. Nelson, George Weinstock, John E. Sulston, Richard Durbin, Tim Hubbard, Richard A. Gibbs, Stephan Beck, Jane Rogers, David R. Bentley

Nature. Author manuscript; available in PMC 2009 Apr 5.

Published in final edited form as: Nature. 2005 Mar 17; 434(7031): 325–337. doi: 10.1038/nature03440

PMCID:: PMC2665286

Abstract Article PDF–1.0M

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