PMC Links for Gene (Select 79109) - PMC

Xiao Zhu, Jinfang Zhang, Wenguo Fan, Yunguo Gong, Jianhua Yan, Zhidong Yuan, Lang Wu, Hongjing Cui, Haiqing Luo, Qingming Kong, Li Tang, Shuilong Leng, Yufeng Liao, Weiming Fu, Qin Xiao, Dongpei Li

PLoS One. 2014; 9(8): e105995. Published online 2014 Aug 25. doi: 10.1371/journal.pone.0105995

PMCID:: PMC4143368

Abstract Article PDF–1.2M

Select item 38929716.

Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells

Chenggang Li, Po-Shun Lee, Yang Sun, Xiaoxiao Gu, Erik Zhang, Yanan Guo, Chin-Lee Wu, Neil Auricchio, Carmen Priolo, Jing Li, Alfredo Csibi, Andrey Parkhitko, Tasha Morrison, Anna Planaguma, Shamsah Kazani, Elliot Israel, Kai-Feng Xu, Elizabeth Petri Henske, John Blenis, Bruce D. Levy, David Kwiatkowski, Jane J. Yu

J Exp Med. 2014 Jan 13; 211(1): 15–28. doi: 10.1084/jem.20131080

PMCID:: PMC3892971

Abstract Article PDF–3.4M

Select item 94404467.

Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt

Zanlin Yu, Junliang Chen, Enzo Takagi, Feng Wang, Bidisha Saha, Xi Liu, Lydia-Marie Joubert, Catherine E. Gleason, Mingliang Jin, Chengmin Li, Carlos Nowotny, David Agard, Yifan Cheng, David Pearce

J Biol Chem. 2022 Sep; 298(9): 102288. Published online 2022 Aug 1. doi: 10.1016/j.jbc.2022.102288

PMCID:: PMC9440446

Abstract Article PDF–2.8M

Select item 83799118.

RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity

Pau Castel, Srisathiyanarayanan Dharmaiah, Matthew J. Sale, Simon Messing, Gabrielle Rizzuto, Antonio Cuevas-Navarro, Alice Cheng, Michael J. Trnka, Anatoly Urisman, Dominic Esposito, Dhirendra K. Simanshu, Frank McCormick

Proc Natl Acad Sci U S A. 2021 Aug 17; 118(33): e2103261118. Published online 2021 Aug 11. doi: 10.1073/pnas.2103261118

PMCID:: PMC8379911

Abstract Article PDF–2.3M

Select item 62221049.

c-Jun N-terminal kinase (JNK)–mediated induction of mSin1 expression and mTORC2 activation in mesenchymal cells during fibrosis

Natalie M. Walker, Serina M. Mazzoni, Ragini Vittal, Diane C. Fingar, Vibha N. Lama

J Biol Chem. 2018 Nov 2; 293(44): 17229–17239. Published online 2018 Sep 14. doi: 10.1074/jbc.RA118.003926

PMCID:: PMC6222104

Abstract Article PDF–728K

Select item 537778710.

Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses

Barbara Kroczynska, Gavin T. Blyth, Robert L. Rafidi, Beata Majchrzak-Kita, Lucy Xu, Diana Saleiro, Ewa M. Kosciuczuk, Jacek Jemielity, Bing Su, Jessica K. Altman, Elizabeth A. Eklund, Eleanor N. Fish, Leonidas C. Platanias

J Biol Chem. 2017 Mar 17; 292(11): 4743–4752. Published online 2017 Feb 7. doi: 10.1074/jbc.M116.757666

PMCID:: PMC5377787

Abstract Article PDF–1.1M

Select item 392290511.

DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival

Ying Tu, Chao Ji, Bo Yang, Zhi Yang, Hua Gu, Chun-Cheng Lu, Rong Wang, Zhong-Lan Su, Bin Chen, Wei-Ling Sun, Ji-Ping Xia, Zhi-Gang Bi, Li He

Mol Cancer. 2013; 12: 172. Published online 2013 Dec 24. doi: 10.1186/1476-4598-12-172

PMCID:: PMC3922905

Abstract Article PDF–1.4M

Select item 332580412.

Structures of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1 and its human orthologue Sin1, an essential subunit of TOR complex 2

Dongqing Pan, Yoshiyuki Matsuura

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Apr 1; 68(Pt 4): 386–392. Published online 2012 Mar 27. doi: 10.1107/S1744309112007178

PMCID:: PMC3325804

Abstract Article PDF–1.3M

Select item 250392513.

A link between SIN1 (MAPKAP1) and poly(rC) binding protein 2 (PCBP2) in counteracting environmental stress

Debjani Ghosh, Gyan P. Srivastava, Dong Xu, Laura C. Schulz, R. Michael Roberts

Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33): 11673–11678. Published online 2008 Aug 7. doi: 10.1073/pnas.0803182105

PMCID:: PMC2503925

Abstract Article PDF–585K

Select item 116883614.

Mip1, an MEKK2-Interacting Protein, Controls MEKK2 Dimerization and Activation

Jinke Cheng, Dongyu Zhang, Kihwan Kim, Yingxin Zhao, Yingming Zhao, Bing Su

Mol Cell Biol. 2005 Jul; 25(14): 5955–5964. doi: 10.1128/MCB.25.14.5955-5964.2005

PMCID:: PMC1168836

Abstract Article PDF–408K

Select item 972105915.

Aurora kinase a promotes the progression of papillary thyroid carcinoma by activating the mTORC2-AKT signalling pathway

Zewei Zhao, Huijuan Wang, Ning Kang, Zhongyu Wang, Xiukun Hou, Linfei Hu, Shuo Qie, Jianping Guo, Songfeng Wei, Xianhui Ruan, Xiangqian Zheng

Cell Biosci. 2022; 12: 195. Published online 2022 Dec 5. doi: 10.1186/s13578-022-00934-z

PMCID:: PMC9721059

Abstract Article PDF–3.3M

Select item 463165416.

PtdIns(3,4,5)P₃-dependent Activation of the mTORC2 Kinase Complex

Pengda Liu, Wenjian Gan, Y. Rebecca Chin, Kohei Ogura, Jianping Guo, Jinfang Zhang, Bin Wang, John Blenis, Lewis C. Cantley, Alex Toker, Bing Su, Wenyi Wei

Cancer Discov. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Cancer Discov. 2015 Nov; 5(11): 1194–1209. Published online 2015 Aug 20. doi: 10.1158/2159-8290.CD-15-0460

PMCID:: PMC4631654

Abstract Article PDF–3.1M

Select item 692864117.

Functional Impacts of the BRCA1-mTORC2 Interaction in Breast Cancer

Kimiko L. Krieger, Wen-Feng Hu, Tyler Ripperger, Nicholas T. Woods

Int J Mol Sci. 2019 Dec; 20(23): 5876. Published online 2019 Nov 23. doi: 10.3390/ijms20235876

PMCID:: PMC6928641

Abstract Article PDF–2.8M

Select item 568013318.

Tumor suppressor Pdcd4attenuates Sin1 translation to inhibit invasion in colon carcinoma

Qing Wang, Jiang Zhu, Ya-Wen Wang, Yong Dai, Yanlei Wang, Chi Wang, Jinpeng Liu, Alyson Baker, Nancy H. Colburn, Hsin-Sheng Yang

Oncogene. Author manuscript; available in PMC 2018 Jan 10.

Published in final edited form as: Oncogene. 2017 Nov 9; 36(45): 6225–6234. Published online 2017 Jul 10. doi: 10.1038/onc.2017.228

PMCID:: PMC5680133

Abstract Article PDF–3.1M

Select item 382711719.

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signaling to suppress tumorigenesis

Pengda Liu, Wenjian Gan, Hiroyuki Inuzuka, Adam S Lazorchak, Daming Gao, Omotooke Arojo, Dou Liu, Lixin Wan, Bo Zhai, Yonghao Yu, Min Yuan, Byeong Mo Kim, Shavali Shaik, Suchithra Menon, Steven P. Gygi, Tae Ho Lee, John M Asara, Brendan D. Manning, John Blenis, Bing Su, Wenyi Wei

Nat Cell Biol. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: Nat Cell Biol. 2013 Nov; 15(11): 1340–1350. Published online 2013 Oct 27. doi: 10.1038/ncb2860

PMCID:: PMC3827117

Abstract Article PDF–1.6M

Select item 367508220.

Interaction between NBS1 and the mTOR/Rictor/SIN1 Complex through Specific Domains

Jian-Qiu Wang, Jian-Hong Chen, Yen-Chung Chen, Mei-Yu Chen, Chia-Ying Hsieh, Shu-Chun Teng, Kou-Juey Wu

PLoS One. 2013; 8(6): e65586. Published online 2013 Jun 6. doi: 10.1371/journal.pone.0065586

PMCID:: PMC3675082

Abstract Article PDF–2.2M

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