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Select item 96188851.

Sphingomyelin synthase 2 is a positive regulator of the CSF1R-STAT3 pathway in pancreatic cancer-associated macrophage

Shuhua He, Xiang Gu, Jintong Yang, Fei Xu, Jiachun Hu, Wei Wang, Yiheng Huang, Bin Lou, Tingbo Ding, Lu Zhou, Deyong Ye, Ker Yu, Jibin Dong

Front Pharmacol. 2022; 13: 902016. Published online 2022 Oct 17. doi: 10.3389/fphar.2022.902016

PMCID:: PMC9618885

Abstract Article PDF–5.1M

Select item 83879662.

Sphingomyelin synthase related protein is a mammalian phosphatidylethanolamine phospholipase C

Yeun-po Chiang, Zhiqiang Li, Yang Chen, Yu Cao, Xian-Cheng Jiang

Biochim Biophys Acta Mol Cell Biol Lipids. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Nov; 1866(11): 159017. Published online 2021 Jul 29. doi: 10.1016/j.bbalip.2021.159017

PMCID:: PMC8387966

Abstract Article PDF–1.2M

Select item 69152723.

Sphingomyelin Synthase 2 Inhibition Ameliorates Cerebral Ischemic Reperfusion Injury Through Reducing the Recruitment of Toll‐Like Receptor 4 to Lipid Rafts

Jing Xue, Yang Yu, Xiangjian Zhang, Cong Zhang, Yanan Zhao, Boyan Liu, Lan Zhang, Lina Wang, Rong Chen, Xuan Gao, Peng Jiao, Guohua Song, Xian‐Cheng Jiang, Shucun Qin

J Am Heart Assoc. 2019 Nov 19; 8(22): e012885. Published online 2019 Nov 13. doi: 10.1161/JAHA.119.012885

PMCID:: PMC6915272

Abstract Article PDF–4.4M

Select item 48069834.

Imaging Mass Spectrometry Reveals Acyl-Chain- and Region-Specific Sphingolipid Metabolism in the Kidneys of Sphingomyelin Synthase 2-Deficient Mice

Masayuki Sugimoto, Masato Wakabayashi, Yoichi Shimizu, Takeshi Yoshioka, Kenichi Higashino, Yoshito Numata, Tomohiko Okuda, Songji Zhao, Shota Sakai, Yasuyuki Igarashi, Yuji Kuge

PLoS One. 2016; 11(3): e0152191. Published online 2016 Mar 24. doi: 10.1371/journal.pone.0152191

PMCID:: PMC4806983

Abstract Article PDF–5.9M

Select item 32843175.

Sphingomyelin synthase 2 (SMS2) deficiency attenuates LPS-induced lung injury

Satish Gowda, Calvin Yeang, Sunil Wadgaonkar, Fatima Anjum, Natalia Grinkina, Michael Cutaia, Xian-Chen Jiang, Raj Wadgaonkar

Am J Physiol Lung Cell Mol Physiol. 2011 Mar; 300(3): L430–L440. Published online 2010 Dec 29. doi: 10.1152/ajplung.00208.2010

PMCID:: PMC3284317

Abstract Article

Select item 86488426.

Sphingomyelin synthases 1 and 2 exhibit phosphatidylcholine phospholipase C activity

Yeun-po Chiang, Zhiqiang Li, Yang Chen, Yu Cao, Xian-Cheng Jiang

J Biol Chem. 2021 Dec; 297(6): 101398. Published online 2021 Nov 10. doi: 10.1016/j.jbc.2021.101398

PMCID:: PMC8648842

Abstract Article PDF–1.8M

Select item 80223217.

Effect of liver total sphingomyelin synthase deficiency on plasma lipid metabolism

Zhiqiang Li, Yeun-Po Chiang, Mulin He, Ke Zhang, Jiao Zheng, Weihua Wu, Jiajia Cai, Yong Chen, Guangzhi Chen, Yunqin Chen, Jibin Dong, Tilla S. Worgall, Xian-Cheng Jiang

Biochim Biophys Acta Mol Cell Biol Lipids. Author manuscript; available in PMC 2021 May 1.

Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2021 May; 1866(5): 158898. Published online 2021 Feb 2. doi: 10.1016/j.bbalip.2021.158898

PMCID:: PMC8022321

Abstract Article PDF–1.8M

Select item 70556958.

Airway Resistance Caused by Sphingomyelin Synthase 2 Insufficiency in Response to Cigarette Smoke

Gayatri Gupta, Nathalie Baumlin, Justin Poon, Begum Ahmed, Yeun-Po Chiang, Christopher Railwah, Michael D. Kim, Melissa Rivas, Hannah Goldenberg, Ziyad Elgamal, Matthias Salathe, Apurav A. Panwala, Abdoulaye Dabo, Chongmin Huan, Robert Foronjy, Xian-Cheng Jiang, Raj Wadgaonkar, Patrick Geraghty

Am J Respir Cell Mol Biol. 2020 Mar; 62(3): 342–353. doi: 10.1165/rcmb.2019-0133OC

PMCID:: PMC7055695

Abstract Article PDF–1.5M

Select item 69186549.

Deficiency of sphingomyelin synthase 1 but not sphingomyelin synthase 2 reduces bone formation due to impaired osteoblast differentiation

Goichi Matsumoto, Chieko Hashizume, Ken Watanabe, Makoto Taniguchi, Toshiro Okazaki

Mol Med. 2019; 25: 56. Published online 2019 Dec 17. doi: 10.1186/s10020-019-0123-0

PMCID:: PMC6918654

Abstract Article PDF–2.2M

Select item 625433810.

2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity

Bin Lou, Qi Liu, Jiahui Hou, Inamul Kabir, Peipei Liu, Tingbo Ding, Jibin Dong, Mingguang Mo, Deyong Ye, Yang Chen, Hai H. Bui, Kenneth Roth, Yu Cao, Xian-Cheng Jiang

J Biol Chem. 2018 Nov 23; 293(47): 18328–18336. Published online 2018 Oct 10. doi: 10.1074/jbc.RA118.005904

Correction in:: J Biol Chem. 2019 May 31; 294(22): 8716.

PMCID:: PMC6254338

Abstract Article PDF–1.0M

Select item 512494611.

Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virus

Makoto Taniguchi, Takafumi Tasaki, Hideaki Ninomiya, Yoshibumi Ueda, Koh-ichi Kuremoto, Susumu Mitsutake, Yasuyuki Igarashi, Toshiro Okazaki, Tsutomu Takegami

Sci Rep. 2016; 6: 37829. Published online 2016 Nov 28. doi: 10.1038/srep37829

PMCID:: PMC5124946

Abstract Article PDF–1.6M

Select item 378434312.

Sphingomyelin synthase 2 activity and liver steatosis: an effect of ceramide-mediated PPARγ2 suppression

Yue Li, Jibin Dong, Tingbo Ding, Ming-Shang Kuo, Guoqing Cao, Xian-Cheng Jiang, Zhiqiang Li

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2014 Jul 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Jul; 33(7): 1513–1520. Published online 2013 May 2. doi: 10.1161/ATVBAHA.113.301498

PMCID:: PMC3784343

Abstract Article PDF–2.2M

Select item 347664613.

Deficiency of sphingomyelin synthase-1 but not sphingomyelin synthase-2 causes hearing impairments in mice

Mei-Hong Lu, Makoto Takemoto, Ken Watanabe, Huan Luo, Masataka Nishimura, Masato Yano, Hidekazu Tomimoto, Toshiro Okazaki, Yuichi Oike, Wen-Jie Song

J Physiol. 2012 Aug 15; 590(Pt 16): 4029–4044. Published online 2012 May 28. doi: 10.1113/jphysiol.2012.235846

PMCID:: PMC3476646

Abstract Article PDF–2.0M

Select item 342683314.

Selective reduction in the sphingomyelin content of atherogenic lipoproteins inhibits their retention in murine aortas and the subsequent development of atherosclerosis

Yifan Fan, Fujun Shi, Jing Liu, Jibin Dong, Hai H. Bui, David A. Peake, Ming-Shang Kuo, Guoqing Cao, Xian-Cheng Jiang

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2012 Aug 24.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2010 Nov; 30(11): 2114–2120. Published online 2010 Sep 2. doi: 10.1161/ATVBAHA.110.213363

PMCID:: PMC3426833

Abstract Article PDF–1.0M

Select item 327646615.

Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes

Liana C. Silva, Oshrit Ben David, Yael Pewzner-Jung, Elad L. Laviad, Johnny Stiban, Sibali Bandyopadhyay, Alfred H. Merrill, Jr., Manuel Prieto, Anthony H. Futerman

J Lipid Res. 2012 Mar; 53(3): 430–436. doi: 10.1194/jlr.M022715

PMCID:: PMC3276466

Abstract Article PDF–1.2M

Select item 318728616.

Reducing Plasma Membrane Sphingomyelin Increases Insulin Sensitivity

Zhiqiang Li, Hongqi Zhang, Jing Liu, Chien-Ping Liang, Yan Li, Yue Li, Gladys Teitelman, Thomas Beyer, Hai H. Bui, David A. Peake, Youyan Zhang, Phillip E. Sanders, Ming-Shang Kuo, Tae-Sik Park, Guoqing Cao, Xian-Cheng Jiang

Mol Cell Biol. 2011 Oct; 31(20): 4205–4218. doi: 10.1128/MCB.05893-11

PMCID:: PMC3187286

Abstract Article PDF–2.0M

Select item 315109617.

Dynamic Modification of Sphingomyelin in Lipid Microdomains Controls Development of Obesity, Fatty Liver, and Type 2 Diabetes

Susumu Mitsutake, Kota Zama, Hazuki Yokota, Tetsuya Yoshida, Miki Tanaka, Masaru Mitsui, Masahito Ikawa, Masaru Okabe, Yoshikazu Tanaka, Tadashi Yamashita, Hiroshi Takemoto, Toshiro Okazaki, Ken Watanabe, Yasuyuki Igarashi

J Biol Chem. 2011 Aug 12; 286(32): 28544–28555. Published online 2011 Jun 13. doi: 10.1074/jbc.M111.255646

PMCID:: PMC3151096

Abstract Article PDF–2.4M

Select item 276355318.

Sphingomyelin synthase 2 (SMS2) is one of the determinants for plasma and liver sphingomyelin levels in mice

Jing Liu, Hongqi Zhang, Zhiqiang Li, Tiruneh K. Hailemariam, Mahua Chakraborty, Daniel Qiu, Hai H. Bui, David A. Peake, Ming-Shang Kuo, Raj Wadgaonkar, Guoqing Cao, Xian-Cheng Jiang

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2010 Jun 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2009 Jun; 29(6): 850–856. Published online 2009 Mar 12. doi: 10.1161/ATVBAHA.109.185223

PMCID:: PMC2763553

Abstract Article PDF–698K

Select item 274693519.

Macrophage Sphingomyelin Synthase 2 (SMS2) Deficiency Decreases Atherosclerosis in Mice

Jing Liu, Chongmin Huan, Mahua Chakraborty, Hongqi Zhang, Da Lu, Ming-Shang Kuo, Guoqing Cao, Xian-Cheng Jiang

Circ Res. Author manuscript; available in PMC 2010 Jul 31.

Published in final edited form as: Circ Res. 2009 Jul 31; 105(3): 295–303. Published online 2009 Jul 9. doi: 10.1161/CIRCRESAHA.109.194613

PMCID:: PMC2746935

Abstract Article PDF–959K

Select item 344430220.

The Impact of Sphingomyelin Synthase 1 Deficiency on Sphingolipid Metabolism and Atherosclerosis in Mice

Zhiqiang Li, Yifan Fan, Jing Liu, Yan Li, Chongmin Quan, Hai H. Bui, Ming-Shang Kuo, Tae-Sik Park, Guoqing Cao, Xian-Cheng Jiang

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2013 Jul 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2012 Jul; 32(7): 1577–1584. Published online 2012 May 10. doi: 10.1161/ATVBAHA.112.251538