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Select item 11902971.

Disruption of Murine Mus81 Increases Genomic Instability and DNA Damage Sensitivity but Does Not Promote Tumorigenesis

Najoua Dendouga, Hui Gao, Dieder Moechars, Michel Janicot, Jorge Vialard, Clare H. McGowan

Mol Cell Biol. 2005 Sep; 25(17): 7569–7579. doi: 10.1128/MCB.25.17.7569-7579.2005

PMCID:: PMC1190297

Abstract Article PDF–798K

Select item 47357742.

Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S‐phase arrest and promoting apoptosis through CHK1 pathway

Fan Wu, Wei‐Jia Chen, Lun Yan, Guo‐Qian Tan, Wei‐Tao Li, Xuan‐Jin Zhu, Xiao‐Chuan Ge, Jian‐Wei Liu, Bai‐Lin Wang

Cancer Med. 2016 Feb; 5(2): 370–385. Published online 2015 Dec 29. doi: 10.1002/cam4.588

PMCID:: PMC4735774

Abstract Article PDF–1.2M

Select item 41507813.

Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair

Meghan Larin, David Gallo, Laura Tamblyn, Jay Yang, Hudson Liao, Nestor Sabat, Grant W. Brown, J. Peter McPherson

Nucleic Acids Res. 2014 Sep 2; 42(15): 9807–9820. Published online 2014 Jul 23. doi: 10.1093/nar/gku676

PMCID:: PMC4150781

Abstract Article PDF–12M

Select item 41429694.

Holliday Junction Resolvases

Haley D.M. Wyatt, Stephen C. West

Cold Spring Harb Perspect Biol. 2014 Sep; 6(9): a023192. doi: 10.1101/cshperspect.a023192

PMCID:: PMC4142969

Abstract Article PDF–1.6M

Select item 61987355.

Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation

Ingrid van der Pluijm, Joyce Burger, Paula M van Heijningen, Arne IJpma, Nicole van Vliet, Chiara Milanese, Kees Schoonderwoerd, Willem Sluiter, Lea-Jeanne Ringuette, Dirk H W Dekkers, Ivo Que, Erik L Kaijzel, Luuk te Riet, Elena G MacFarlane, Devashish Das, Reinier van der Linden, Marcel Vermeij, Jeroen A Demmers, Pier G Mastroberardino, Elaine C Davis, Hiromi Yanagisawa, Harry C Dietz, Roland Kanaar, Jeroen Essers

Cardiovasc Res. 2018 Nov 1; 114(13): 1776–1793. Published online 2018 Jun 21. doi: 10.1093/cvr/cvy150

PMCID:: PMC6198735

Abstract Article PDF–1.9M

Select item 51172286.

Function of Ltbp-4L and fibulin-4 in survival and elastogenesis in mice

Insa Bultmann-Mellin, Jeroen Essers, Paula M. van Heijingen, Harald von Melchner, Gerhard Sengle, Anja Sterner-Kock

Dis Model Mech. 2016 Nov 1; 9(11): 1367–1374. doi: 10.1242/dmm.026005

PMCID:: PMC5117228

Abstract Article

Select item 41778307.

Extracellular Matrix Defects in Aneurysmal Fibulin-4 Mice Predispose to Lung Emphysema

Natasja W. M. Ramnath, Koen M. van de Luijtgaarden, Ingrid van der Pluijm, Menno van Nimwegen, Paula M. van Heijningen, Sigrid M. A. Swagemakers, Bibi S. van Thiel, Ruziedi Y. Ridwan, Nicole van Vliet, Marcel Vermeij, Luuk J. A. C. Hawinkels, Anne de Munck, Oleh Dzyubachyk, Erik Meijering, Peter van der Spek, Robbert Rottier, Hiromi Yanagisawa, Rudi W. Hendriks, Roland Kanaar, Ellen V. Rouwet, Alex Kleinjan, Jeroen Essers

PLoS One. 2014; 9(9): e106054. Published online 2014 Sep 25. doi: 10.1371/journal.pone.0106054

PMCID:: PMC4177830

Abstract Article PDF–1.4M

Select item 31534868.

Impaired Vascular Contractility and Aortic Wall Degeneration in Fibulin-4 Deficient Mice: Effect of Angiotensin II Type 1 (AT₁) Receptor Blockade

Els Moltzer, Luuk te Riet, Sigrid M. A. Swagemakers, Paula M. van Heijningen, Marcel Vermeij, Richard van Veghel, Angelique M. Bouhuizen, Joep H. M. van Esch, Stephanie Lankhorst, Natasja W. M. Ramnath, Monique C. de Waard, Dirk J. Duncker, Peter J. van der Spek, Ellen V. Rouwet, A. H. Jan Danser, Jeroen Essers

PLoS One. 2011; 6(8): e23411. Published online 2011 Aug 9. doi: 10.1371/journal.pone.0023411

PMCID:: PMC3153486

Abstract Article PDF–1.5M

Select item 30981879.

Inactivation of Chk2 and Mus81 Leads to Impaired Lymphocytes Development, Reduced Genomic Instability, and Suppression of Cancer

Samah El Ghamrasni, Ashwin Pamidi, Marie Jo Halaby, Miyuki Bohgaki, Renato Cardoso, Li Li, Shriram Venkatesan, Swaminathan Sethu, Atsushi Hirao, Tak W. Mak, Manoor Prakash Hande, Anne Hakem, Razqallah Hakem

PLoS Genet. 2011 May; 7(5): e1001385. Published online 2011 May 19. doi: 10.1371/journal.pgen.1001385

PMCID:: PMC3098187

Abstract Article PDF–2.4M

Select item 252583810.

MUS81 Generates a Subset of MLH1-MLH3–Independent Crossovers in Mammalian Meiosis

J. Kim Holloway, James Booth, Winfried Edelmann, Clare H. McGowan, Paula E. Cohen

PLoS Genet. 2008 Sep; 4(9): e1000186. Published online 2008 Sep 12. doi: 10.1371/journal.pgen.1000186

PMCID:: PMC2525838

Abstract Article PDF–669K

Select item 161808811.

The structure-specific endonuclease Mus81–Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks

Katsuhiro Hanada, Magda Budzowska, Mauro Modesti, Alex Maas, Claire Wyman, Jeroen Essers, Roland Kanaar

EMBO J. 2006 Oct 18; 25(20): 4921–4932. Published online 2006 Oct 12. doi: 10.1038/sj.emboj.7601344

PMCID:: PMC1618088

Abstract Article PDF–626K

Select item 27543812.

Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells

Jacinth Abraham, Bénédicte Lemmers, M.Prakash Hande, Mary Ellen Moynahan, Charly Chahwan, Alberto Ciccia, Jeroen Essers, Katsuhiro Hanada, Richard Chahwan, Aik Kia Khaw, Peter McPherson, Amro Shehabeldin, Rob Laister, Cheryl Arrowsmith, Roland Kanaar, Stephen C. West, Maria Jasin, Razqallah Hakem

EMBO J. 2003 Nov 17; 22(22): 6137–6147. doi: 10.1093/emboj/cdg580

PMCID:: PMC275438

Abstract Article PDF–531K

Select item 380898713.

Cooperative Control of Holliday Junction Resolution and DNA Repair by the SLX1 and MUS81-EME1 Nucleases

Dennis Castor, Nidhi Nair, Anne-Cécile Déclais, Christophe Lachaud, Rachel Toth, Thomas J. Macartney, David M.J. Lilley, J.Simon C. Arthur, John Rouse

Mol Cell. 2013 Oct 24; 52(2): 221–233. doi: 10.1016/j.molcel.2013.08.036

PMCID:: PMC3808987

Abstract Article

Select item 362409014.

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi Anemia

Gerry P. Crossan, Louise van der Weyden, Ivan V. Rosado, Frederic Langevin, Pierre-Henri L. Gaillard, Rebecca E McIntyre, Sanger Mouse Genetics Project, Ferdia Gallagher, Mikko I Kettunen, David Y Lewis, Kevin Brindle, Mark J Arends, David J Adams, Ketan J Patel

Nat Genet. Author manuscript; available in PMC 2013 Apr 12.

Published in final edited form as: Nat Genet. 2011 Feb; 43(2): 147–152. Published online 2011 Jan 16. doi: 10.1038/ng.752

PMCID:: PMC3624090

Article PDF–3.3M

Select item 233532915.

Crystal structure of the Mus81–Eme1 complex

Jeong Ho Chang, Jeong Joo Kim, Jung Min Choi, Jung Hoon Lee, Yunje Cho

Genes Dev. 2008 Apr 15; 22(8): 1093–1106. doi: 10.1101/gad.1618708

PMCID:: PMC2335329

Abstract Article PDF–1.0M

Select item 958152916.

The structure-selective endonucleases GEN1 and MUS81 mediate complementary functions in safeguarding the genome of proliferating B lymphocytes

Keith Conrad Fernandez, Laura Feeney, Ryan M Smolkin, Wei-Feng Yen, Allysia J Matthews, William Alread, John HJ Petrini, Jayanta Chaudhuri

eLife. 2022; 11: e77073. Published online 2022 Oct 3. doi: 10.7554/eLife.77073

PMCID:: PMC9581529

Abstract Article PDF–9.1M

Select item 651100017.

Shugoshin protects centromere pairing and promotes segregation of nonexchange partner chromosomes in meiosis

Luciana Previato de Almeida, Jared M. Evatt, Hoa H. Chuong, Emily L. Kurdzo, Craig A. Eyster, Mara N. Gladstone, Laura Gómez-H, Elena Llano, Régis Meyer, Alberto M. Pendas, Roberto J. Pezza, Dean S. Dawson

Proc Natl Acad Sci U S A. 2019 May 7; 116(19): 9417–9422. Published online 2019 Apr 24. doi: 10.1073/pnas.1902526116

PMCID:: PMC6511000

Abstract Article PDF–1.2M

Select item 480305118.

Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction

Supawat Thongthip, Marina Bellani, Siobhan Q. Gregg, Sunandini Sridhar, Brooke A. Conti, Yanglu Chen, Michael M. Seidman, Agata Smogorzewska

Genes Dev. 2016 Mar 15; 30(6): 645–659. doi: 10.1101/gad.276261.115

PMCID:: PMC4803051

Abstract Article PDF–1.3M

Select item 464152819.

NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity

Ariana Jacome, Paula Gutierrez‐Martinez, Federica Schiavoni, Enrico Tenaglia, Paula Martinez, Sara Rodríguez‐Acebes, Emilio Lecona, Matilde Murga, Juan Méndez, Maria A Blasco, Oscar Fernandez‐Capetillo

EMBO J. 2015 Nov 3; 34(21): 2604–2619. Published online 2015 Oct 6. doi: 10.15252/embj.201591829

PMCID:: PMC4641528

Abstract Article PDF–3.5M

Select item 1683320.

Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray

Tetsuya S. Tanaka, Saied A. Jaradat, Meng K. Lim, George J. Kargul, Xiaohong Wang, Marija J. Grahovac, Serafino Pantano, Yuri Sano, Yulan Piao, Ramaiah Nagaraja, Hirofumi Doi, William H. Wood, III, Kevin G. Becker, Minoru S. H. Ko

Proc Natl Acad Sci U S A. 2000 Aug 1; 97(16): 9127–9132. doi: 10.1073/pnas.97.16.9127

PMCID:: PMC16833

Abstract Article PDF–847K

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