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Select item 109374211.

The IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner

Amanda J. Stock, Pierina Gonzalez Paredes, Luciana Previato de Almeida, Stanley D. Kosanke, Srinivaas Chetlur, Hannah Budde, Paul Wakenight, Theresa A. Zwingman, Aaron B.I. Rosen, Eric J. Allenspach, Kathleen J. Millen, Jane H. Buckner, David J. Rawlings, Jacquelyn A. Gorman

Front Immunol. 2024; 15: 1349601. Published online 2024 Feb 29. doi: 10.3389/fimmu.2024.1349601

PMCID:: PMC10937421

Abstract Article PDF–7.8M

Select item 106194992.

MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival

C. Korin Bullen, Alok K. Singh, Stefanie Krug, Shichun Lun, Preeti Thakur, Geetha Srikrishna, William R. Bishai

JCI Insight. 2023 Oct 23; 8(20): e166242. Published online 2023 Oct 23. doi: 10.1172/jci.insight.166242

PMCID:: PMC10619499

Abstract Article PDF–1.4M

Select item 99772973.

MDA5-dependent responses contribute to autoimmune diabetes progression and hindrance

Samuel I. Blum, Jared P. Taylor, Jessie M. Barra, Ashley R. Burg, Qiao Shang, Shihong Qiu, Oren Shechter, Aleah R. Hayes, Todd J. Green, Aron M. Geurts, Yi-Guang Chen, Hubert M. Tse

JCI Insight. 2023 Jan 24; 8(2): e157929. Published online 2023 Jan 24. doi: 10.1172/jci.insight.157929

PMCID:: PMC9977297

Abstract Article PDF–2.2M

Select item 96574344.

A Study on MDA5 Signaling in Splenic B Cells from an Imiquimod-Induced Lupus Mouse Model with Proteomics

Yu-Jih Su, Fu-An Li, Jim Jinn-Chyuan Sheu, Sung-Chou Li, Shao-Wen Weng, Feng-Chih Shen, Yen-Hsiang Chang, Huan-Yuan Chen, Chia-Wei Liou, Tsu-Kung Lin, Jiin-Haur Chuang, Pei-Wen Wang

Cells. 2022 Nov; 11(21): 3350. Published online 2022 Oct 24. doi: 10.3390/cells11213350

PMCID:: PMC9657434

Abstract Article PDF–2.4M

Select item 55997995.

The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreatic inflammation

Yu Dou, Howard CH Yim, Carl D Kirkwood, Bryan RG Williams, Anthony J Sadler

EMBO J. 2017 Sep 15; 36(18): 2742–2757. Published online 2017 Aug 29. doi: 10.15252/embj.201696273

PMCID:: PMC5599799

Abstract Article PDF–2.5M

Select item 46652476.

MDA5 Is Critical to Host Defense during Infection with Murine Coronavirus

Zachary B. Zalinger, Ruth Elliott, Kristine M. Rose, Susan R. Weiss

J Virol. 2015 Dec 15; 89(24): 12330–12340. Published online 2015 Sep 30. doi: 10.1128/JVI.01470-15

PMCID:: PMC4665247

Abstract Article PDF–1.9M

Select item 39777197.

Deficiency of Melanoma Differentiation–associated Protein 5 Results in Exacerbated Chronic Postviral Lung Inflammation

Won-keun Kim, Deepika Jain, Melissa D. Sánchez, Cynthia J. Koziol-White, Krystal Matthews, Moyar Q. Ge, Angela Haczku, Reynold A. Panettieri, Jr., Matthew B. Frieman, Carolina B. López

Am J Respir Crit Care Med. 2014 Feb 15; 189(4): 437–448. Published online 2014 Feb 15. doi: 10.1164/rccm.201307-1338OC

PMCID:: PMC3977719

Abstract Article PDF–2.2M

Select item 39105698.

Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality

Jian Wu, Linjie Tian, Xiao Yu, Sittiporn Pattaradilokrat, Jian Li, Mingjun Wang, Weishi Yu, Yanwei Qi, Amir E. Zeituni, Sethu C. Nair, Steve P. Crampton, Marlene S. Orandle, Silvia M. Bolland, Chen-Feng Qi, Carole A. Long, Timothy G. Myers, John E. Coligan, Rongfu Wang, Xin-zhuan Su

Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4): E511–E520. Published online 2014 Jan 13. doi: 10.1073/pnas.1316467111

PMCID:: PMC3910569

Abstract Article PDF–1.5M

Select item 32643889.

Melanoma Differentiation-Associated Gene 5 Is Critical for Protection against Theiler's Virus-Induced Demyelinating Disease

Young-Hee Jin, Seung Jae Kim, Eui Young So, Liping Meng, Marco Colonna, Byung S. Kim

J Virol. 2012 Feb; 86(3): 1531–1543. doi: 10.1128/JVI.06457-11

PMCID:: PMC3264388

Abstract Article PDF–4.9M

Select item 326296310.

Ifih1 gene dose effect reveals MDA5-mediated chronic type I IFN gene signature, viral resistance and accelerated autoimmunity

Steve P Crampton, Jonathan A Deane, Lionel Feigenbaum, Silvia Bolland

J Immunol. Author manuscript; available in PMC 2013 Feb 1.

Published in final edited form as: J Immunol. 2012 Feb 1; 188(3): 1451–1459. Published online 2011 Dec 28. doi: 10.4049/jimmunol.1102705

PMCID:: PMC3262963

Abstract Article PDF–2.5M

Select item 280977111.

Melanoma Differentiation-Associated Gene 5 (MDA5) Is Involved in the Innate Immune Response to Paramyxoviridae Infection In Vivo

Leonid Gitlin, Loralyn Benoit, Christina Song, Marina Cella, Susan Gilfillan, Michael J. Holtzman, Marco Colonna

PLoS Pathog. 2010 Jan; 6(1): e1000734. Published online 2010 Jan 22. doi: 10.1371/journal.ppat.1000734

PMCID:: PMC2809771

Abstract Article PDF–3.1M

Select item 266064612.

Astrocytes recognize intracellular polyinosinic-polycytidylic acid via MDA-5

Joari De Miranda, Kavitha Yaddanapudi, Mady Hornig, W. Ian Lipkin

FASEB J. 2009 Apr; 23(4): 1064–1071. doi: 10.1096/fj.08-121434

PMCID:: PMC2660646

Abstract Article

Select item 1059068913.

Long noncoding RNA 1392 regulates MDA5 by interaction with ELAVL1 to inhibit coxsackievirus B5 infection

Jing Li, Jinwei Li, Peiying Teng, Fan Yang, Jihong Zhang, Bo Sun, Wei Chen

Virol Sin. 2023 Oct; 38(5): 699–708. Published online 2023 Aug 3. doi: 10.1016/j.virs.2023.08.001

PMCID:: PMC10590689

Abstract Article PDF–1.8M

Select item 873952614.

ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathway

Xinfeng Guo, Silvia Liu, Rose Yan, Vy Nguyen, Mazen Zenati, Timothy R Billiar, Qingde Wang

Life Sci Alliance. 2022 Mar; 5(3): e202101191. Published online 2021 Dec 30. doi: 10.26508/lsa.202101191

PMCID:: PMC8739526

Abstract Article PDF–4.2M

Select item 678403815.

Expression and Functional Characterization of Retinoic Acid-Inducible Gene-I-Like Receptors of Mast Cells in Response to Viral Infection

Minoru Fukuda, Hiroko Ushio, Junko Kawasaki, Francois Niyonsaba, Mizuho Takeuchi, Tadashi Baba, Keiichi Hiramatsu, Ko Okumura, Hideoki Ogawa

J Innate Immun. 2013 Mar; 5(2): 163–173. Published online 2012 Nov 21. doi: 10.1159/000343895

PMCID:: PMC6784038

Abstract Article PDF–230K

Select item 650593816.

Distinct roles for MDA5 and TLR3 in the acute response to inhaled double-stranded RNA

Janelle M. Veazey, Timothy J. Chapman, Timothy R. Smyth, Sara E. Hillman, Sophia I. Eliseeva, Steve N. Georas

PLoS One. 2019; 14(5): e0216056. Published online 2019 May 8. doi: 10.1371/journal.pone.0216056

PMCID:: PMC6505938

Abstract Article PDF–748K

Select item 631068417.

Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis

Qin Yu, Kun Qu, Yorgo Modis

Mol Cell. 2018 Dec 20; 72(6): 999–1012.e6. doi: 10.1016/j.molcel.2018.10.012

PMCID:: PMC6310684

Abstract Article PDF–7.0M

Select item 628079118.

ADAR1‐mediated RNA editing is required for thymic self‐tolerance and inhibition of autoimmunity

Taisuke Nakahama, Yuki Kato, Jung In Kim, Tuangtong Vongpipatana, Yutaka Suzuki, Carl R Walkley, Yukio Kawahara

EMBO Rep. 2018 Dec; 19(12): e46303. Published online 2018 Oct 25. doi: 10.15252/embr.201846303

PMCID:: PMC6280791

Abstract Article PDF–3.2M

Select item 593371519.

A direct link between MITF, innate immunity, and hair graying

Melissa L. Harris, Temesgen D. Fufa, Joseph W. Palmer, Sandeep S. Joshi, Denise M. Larson, Arturo Incao, Derek E. Gildea, Niraj S. Trivedi, Autumne N. Lee, Chi-Ping Day, Helen T. Michael, Thomas J. Hornyak, Glenn Merlino, NISC Comparative Sequencing Program, William J. Pavan

PLoS Biol. 2018 May; 16(5): e2003648. Published online 2018 May 3. doi: 10.1371/journal.pbio.2003648