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Items: 1 to 20 of 45

1.
Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background
Mianmian Yin, Yang Jo Chung, R. Coleman Lindsley, Robert L. Walker, Yuelin J. Zhu, Benjamin L. Ebert, Paul S. Meltzer, Peter D. Aplan
Blood. 2019 Jun 13; 133(24): 2610–2614. Prepublished online 2019 Apr 16. doi: 10.1182/blood.2018864173
PMCID:
PMC6566592
AbstractArticle
2.
Activin Regulates Self-renewal and Differentiation of Trophoblast Stem Cells by Down-regulating the X Chromosome Gene Bcor
Gaoyang Zhu, Teng Fei, Zhongwei Li, Xiaohua Yan, Ye-Guang Chen
J Biol Chem. 2015 Sep 4; 290(36): 22019–22029. Published online 2015 Jul 28. doi: 10.1074/jbc.M115.674127
PMCID:
PMC4571955
AbstractArticlePDF–3.7M
3.
BCL6 interacting corepressor contributes to germinal center T follicular helper cell formation and B cell helper function
Jessica A. Yang, Noah J. Tubo, Micah D. Gearhart, Vivian J. Bardwell, Marc K. Jenkins
J Immunol. Author manuscript; available in PMC 2016 Jun 15.
Published in final edited form as: J Immunol. 2015 Jun 15; 194(12): 5604–5608. Published online 2015 May 11. doi: 10.4049/jimmunol.1500201
PMCID:
PMC4458443
AbstractArticlePDF–622K
4.
Role of the Transcriptional Corepressor Bcor in Embryonic Stem Cell Differentiation and Early Embryonic Development
Joseph Alan Wamstad, Connie Marie Corcoran, Anne Marjorie Keating, Vivian J. Bardwell
PLoS One. 2008; 3(7): e2814. Published online 2008 Jul 30. doi: 10.1371/journal.pone.0002814
PMCID:
PMC2535898
AbstractArticlePDF–573K
5.
Characterization of Bcor Expression in Mouse Development
Joseph A. Wamstad, Vivian J. Bardwell1
Gene Expr Patterns. Author manuscript; available in PMC 2007 Oct 9.
Published in final edited form as: Gene Expr Patterns. 2007 Apr; 7(5): 550–557. Published online 2007 Jan 31. doi: 10.1016/j.modgep.2007.01.006
PMCID:
PMC2002546
AbstractArticlePDF–1.7M
6.
Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice
Paolo Sportoletti, Daniele Sorcini, Anna G. Guzman, Jaime M. Reyes, Arianna Stella, Andrea Marra, Sara Sartori, Lorenzo Brunetti, Roberta Rossi, Beatrice Del Papa, Francesco Maria Adamo, Giulia Pianigiani, Camilla Betti, Annarita Scialdone, Valerio Guarente, Giulio Spinozzi, Valentina Tini, Maria Paola Martelli, Margaret A. Goodell, Brunangelo Falini
Leukemia. 2021; 35(7): 1949–1963. Published online 2020 Nov 6. doi: 10.1038/s41375-020-01075-3
PMCID:
PMC8257496
AbstractArticlePDF–2.4M
7.
BCOR Binding to MLL-AF9 Is Essential for Leukemia via Altered EYA1, SIX, and MYC Activity
Charles R. Schmidt, Nicholas J. Achille, Aravinda Kuntimaddi, Adam M. Boulton, Benjamin I. Leach, Shubin Zhang, Nancy J. Zeleznik-Le, John H. Bushweller
Blood Cancer Discov. 2020 Sep; 1(2): 162–177. Published online 2020 Jul 7. doi: 10.1158/2643-3230.BCD-20-0036
PMCID:
PMC7497807
AbstractArticlePDF–22M
8.
Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome
Shiro Tara, Yusuke Isshiki, Yaeko Nakajima-Takagi, Motohiko Oshima, Kazumasa Aoyama, Tomoyuki Tanaka, Daisuke Shinoda, Shuhei Koide, Atsunori Saraya, Satoru Miyagi, Ichiro Manabe, Hirotaka Matsui, Haruhiko Koseki, Vivian J. Bardwell, Atsushi Iwama
Blood. 2018 Dec 6; 132(23): 2470–2483. Prepublished online 2018 Sep 18. doi: 10.1182/blood-2018-01-827964
PMCID:
PMC6450057
AbstractArticle
9.
Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis
Madison J. Kelly, Joan So, Amy J. Rogers, Gareth Gregory, Jason Li, Magnus Zethoven, Micah D. Gearhart, Vivian J. Bardwell, Ricky W. Johnstone, Stephin J. Vervoort, Lev M. Kats
Nat Commun. 2019; 10: 1347. Published online 2019 Mar 22. doi: 10.1038/s41467-019-09250-6
PMCID:
PMC6430802
AbstractArticlePDF–3.2M
10.
Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene
Marcus Lefebure, Richard W. Tothill, Elizabeth Kruse, Edwin D. Hawkins, Jake Shortt, Geoffrey M. Matthews, Gareth P. Gregory, Benjamin P. Martin, Madison J. Kelly, Izabela Todorovski, Maria A. Doyle, Richard Lupat, Jason Li, Jan Schroeder, Meaghan Wall, Stuart Craig, Gretchen Poortinga, Don Cameron, Megan Bywater, Lev Kats, Micah D. Gearhart, Vivian J. Bardwell, Ross A. Dickins, Ross D. Hannan, Anthony T. Papenfuss, Ricky W. Johnstone
Nat Commun. 2017; 8: 14581. Published online 2017 Mar 6. doi: 10.1038/ncomms14581
PMCID:
PMC5343491
AbstractArticlePDF–1.1M
11.
Functional loss of a noncanonical BCOR–PRC1.1 complex accelerates SHH-driven medulloblastoma formation
Lena M. Kutscher, Konstantin Okonechnikov, Nadja V. Batora, Jessica Clark, Patricia B.G. Silva, Mikaella Vouri, Sjoerd van Rijn, Laura Sieber, Britta Statz, Micah D. Gearhart, Ryo Shiraishi, Norman Mack, Brent A. Orr, Andrey Korshunov, Brian L. Gudenas, Kyle S. Smith, Audrey L. Mercier, Olivier Ayrault, Mikio Hoshino, Marcel Kool, Katja von Hoff, Norbert Graf, Gudrun Fleischhack, Vivian J. Bardwell, Stefan M. Pfister, Paul A. Northcott, Daisuke Kawauchi
Genes Dev. 2020 Sep 1; 34(17-18): 1161–1176. doi: 10.1101/gad.337584.120
PMCID:
PMC7462063
AbstractArticlePDF–8.2M
12.
Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies
Tomoyuki Tanaka, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Shiro Tara, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Sha Si, Ichiro Manabe, Masashi Sanada, Manabu Nakayama, Masayoshi Masuko, Hirohito Sone, Haruhiko Koseki, Atsushi Iwama
J Exp Med. 2017 Oct 2; 214(10): 2901–2913. doi: 10.1084/jem.20170167
PMCID:
PMC5626398
AbstractArticlePDF–2.1M
13.
BCOR regulates myeloid cell proliferation and differentiation
Qi Cao, Micah D. Gearhart, Sigal Gery, Seyedmehdi Shojaee, Henry Yang, Haibo Sun, De-chen Lin, Jing-wen Bai, Monica Mead, Zhiqiang Zhao, Qi Chen, Wen-wen Chien, Serhan Alkan, Tamara Alpermann, Torsten Haferlach, Markus Müschen, Vivian J. Bardwell, H. Phillip Koeffler
Leukemia. Author manuscript; available in PMC 2016 Dec 1.
Published in final edited form as: Leukemia. 2016 May; 30(5): 1155–1165. Published online 2016 Feb 5. doi: 10.1038/leu.2016.2
PMCID:
PMC5131645
AbstractArticlePDF–2.9M
14.
PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment
Junichiro Takano, Shinsuke Ito, Yixing Dong, Jafar Sharif, Yaeko Nakajima-Takagi, Taichi Umeyama, Yong-Woon Han, Kyoichi Isono, Takashi Kondo, Yusuke Iizuka, Tomohiro Miyai, Yoko Koseki, Mika Ikegaya, Mizuki Sakihara, Manabu Nakayama, Osamu Ohara, Yoshinori Hasegawa, Kosuke Hashimoto, Erik Arner, Robert J. Klose, Atsushi Iwama, Haruhiko Koseki, Tomokatsu Ikawa
Nat Commun. 2022; 13: 7159. Published online 2022 Nov 28. doi: 10.1038/s41467-022-34856-8
PMCID:
PMC9705430
AbstractArticlePDF–4.0M
15.
KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis
Yusuke Isshiki, Yaeko Nakajima-Takagi, Motohiko Oshima, Kazumasa Aoyama, Mohamed Rizk, Shuhei Kurosawa, Atsunori Saraya, Takashi Kondo, Emiko Sakaida, Chiaki Nakaseko, Koutaro Yokote, Haruhiko Koseki, Atsushi Iwama
Blood Adv. 2019 Sep 10; 3(17): 2537–2549. Published online 2019 Aug 30. doi: 10.1182/bloodadvances.2018028522
PMCID:
PMC6737409
AbstractArticlePDF–1.7M
16.
BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors
Jessica A. Kotov, Dmitri I. Kotov, Jonathan L. Linehan, Vivian J. Bardwell, Micah D. Gearhart, Marc K. Jenkins
J Exp Med. 2019 Jun 3; 216(6): 1450–1464. Published online 2019 May 3. doi: 10.1084/jem.20182376
PMCID:
PMC6547868
AbstractArticlePDF–3.1M
17.
RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes
Nathan R Rose, Hamish W King, Neil P Blackledge, Nadezda A Fursova, Katherine JI Ember, Roman Fischer, Benedikt M Kessler, Robert J Klose
eLife. 2016; 5: e18591. Published online 2016 Oct 5. doi: 10.7554/eLife.18591
PMCID:
PMC5065315
AbstractArticlePDF–4.5M
18.
Mutations in BCOR, a co-repressor of CRX/OTX2, are associated with early-onset retinal degeneration
Maéva Langouët, Christine Jolicoeur, Awais Javed, Pierre Mattar, Micah D. Gearhart, Stephen P. Daiger, Mette Bertelsen, Lisbeth Tranebjærg, Nanna D. Rendtorff, Karen Grønskov, Catherine Jespersgaard, Rui Chen, Zixi Sun, Hui Li, Najmeh Alirezaie, Jacek Majewski, Vivian J. Bardwell, Ruifang Sui, Robert K. Koenekoop, Michel Cayouette
Sci Adv. 2022 Sep; 8(36): eabh2868. Published online 2022 Sep 7. doi: 10.1126/sciadv.abh2868
PMCID:
PMC9451151
AbstractArticlePDF–7.1M
19.
OFCD Syndrome and Extraembryonic Defects are Revealed by Conditional Mutation of the Polycomb-group Repressive Complex 1.1 (PRC1.1) Gene Bcor
Michelle Y. Hamline, Connie M. Corcoran, Joseph A. Wamstad, Isabelle Miletich, Jifan Feng, Jamie L. Lohr, Myriam Hemberger, Paul T. Sharpe, Micah D. Gearhart, Vivian J. Bardwell
Dev Biol. Author manuscript; available in PMC 2022 Oct 20.
Published in final edited form as: Dev Biol. 2020 Dec 1; 468(1-2): 110–132. Published online 2020 Jul 18. doi: 10.1016/j.ydbio.2020.06.013
PMCID:
PMC9583620
AbstractArticlePDF–4.9M
20.
Interferon Regulatory Factor 8 (IRF8) Interacts with the B Cell Lymphoma 6 (BCL6) Corepressor BCOR
Jeongheon Yoon, Xianxum Feng, Yong-Soo Kim, Dong-Mi Shin, Katerina Hatzi, Hongsheng Wang, Herbert C. Morse, III
J Biol Chem. 2014 Dec 5; 289(49): 34250–34257. Published online 2014 Oct 20. doi: 10.1074/jbc.M114.571182
PMCID:
PMC4256356
AbstractArticlePDF–1.2M

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