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Select item 107561371.

Type I Interferons induce endothelial destabilization in Systemic Lupus Erythematosus in a Tie2-dependent manner

Carlos Rafael-Vidal, Sara Martínez-Ramos, Beatriz Malvar-Fernández, Irene Altabás-González, Coral Mouriño, Douglas J. Veale, Achilleas Floudas, Ursula Fearon, José María Pego Reigosa, Samuel García

Front Immunol. 2023; 14: 1277267. Published online 2023 Dec 14. doi: 10.3389/fimmu.2023.1277267

PMCID:: PMC10756137

Abstract Article PDF–2.3M

Select item 104091442.

Tie2在口腔鳞状细胞癌中的表达及其对细胞增殖、迁移及上皮-间充质转化过程的影响

珉郑, 怡黄, 伟费, 阳沈, 雄聂, 明玉高

Sichuan Da Xue Xue Bao Yi Xue Ban. 2023 Mar 20; 54(2): 342–349. Chinese. doi: 10.12182/20230360106

PMCID:: PMC10409144

Abstract Article PDF–26M

Select item 91022553.

Increased frequency of proangiogenic tunica intima endothelial kinase 2 (Tie2) expressing monocytes in individuals with type 2 diabetes mellitus

M. Reijrink, J. van Ark, C. P. H. Lexis, L. M. Visser, M. E. Lodewijk, I. C. C. van der Horst, C. J. Zeebregts, H. van Goor, S. C. A. de Jager, G. Pasterkamp, B. H. R. Wolffenbuttel, J. L. Hillebrands

Cardiovasc Diabetol. 2022; 21: 72. Published online 2022 May 12. doi: 10.1186/s12933-022-01497-6

PMCID:: PMC9102255

Abstract Article PDF–3.0M

Select item 87514214.

Bockenheimer disease is associated with a TEK variant

Christopher L. Sudduth, Dennis J. Konczyk, Patrick J. Smits, Whitney Eng, Alyaa Al-Ibraheemi, Joseph Upton, Arin K. Greene

Cold Spring Harb Mol Case Stud. 2021 Dec; 7(6): a006119. doi: 10.1101/mcs.a006119

PMCID:: PMC8751421

Abstract Article PDF–5.7M

Select item 85648895.

Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19

Alec A. Schmaier, Gabriel M. Pajares Hurtado, Zachary J. Manickas-Hill, Kelsey D. Sack, Siyu M. Chen, Victoria Bhambhani, Juweria Quadir, Anjali K. Nath, Ai-ris Y. Collier, Debby Ngo, Dan H. Barouch, Nathan I. Shapiro, Robert E. Gerszten, Xu G. Yu, MGH COVID-19 Collection and Processing Team, Kevin G. Peters, Robert Flaumenhaft, Samir M. Parikh

JCI Insight. 2021 Oct 22; 6(20): e151527. Published online 2021 Oct 22. doi: 10.1172/jci.insight.151527

PMCID:: PMC8564889

Abstract Article PDF–4.0M

Select item 85608236.

Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody

Gyunghee Jo, Jeomil Bae, Ho Jeong Hong, Ah-reum Han, Do-Kyun Kim, Seon Pyo Hong, Jung A Kim, Sangkyu Lee, Gou Young Koh, Ho Min Kim

Nat Commun. 2021; 12: 6287. Published online 2021 Nov 1. doi: 10.1038/s41467-021-26620-1

PMCID:: PMC8560823

Abstract Article PDF–4.7M

Select item 81243677.

Effect of Whole Tissue Culture and Basic Fibroblast Growth Factor on Maintenance of Tie2 Molecule Expression in Human Nucleus Pulposus Cells

Kosuke Sako, Daisuke Sakai, Yoshihiko Nakamura, Jordy Schol, Erika Matsushita, Takayuki Warita, Natsumi Horikita, Masato Sato, Masahiko Watanabe

Int J Mol Sci. 2021 May; 22(9): 4723. Published online 2021 Apr 29. doi: 10.3390/ijms22094723

PMCID:: PMC8124367

Abstract Article PDF–2.4M

Select item 76440248.

High expression of Tie-2 predicts poor prognosis in primary high grade serous ovarian cancer

Minna Sopo, Hanna Sallinen, Kirsi Hämäläinen, Annukka Kivelä, Seppo Ylä-Herttuala, Veli-Matti Kosma, Leea Keski-Nisula, Maarit Anttila

PLoS One. 2020; 15(11): e0241484. Published online 2020 Nov 5. doi: 10.1371/journal.pone.0241484

PMCID:: PMC7644024

Abstract Article PDF–2.2M

Select item 74575049.

AKT/FOXO1 axis links cross-talking of endothelial cell and pericyte in TIE2-mutated venous malformations

Yameng Si, Jiadong Huang, Xiang Li, Yu Fu, Rongyao Xu, Yifei Du, Jie Cheng, Hongbing Jiang

Cell Commun Signal. 2020; 18: 139. Published online 2020 Aug 31. doi: 10.1186/s12964-020-00606-w

PMCID:: PMC7457504

Abstract Article PDF–12M

Select item 681782610.

Ionizing radiation induces endothelial transdifferentiation of glioblastoma stem-like cells through the Tie2 signaling pathway

Pauline Deshors, Christine Toulas, Florent Arnauduc, Laure Malric, Aurore Siegfried, Yvan Nicaise, Anthony Lemarié, Dorian Larrieu, Marie Tosolini, Elizabeth Cohen-Jonathan Moyal, Monique Courtade-Saidi, Solène M. Evrard

Cell Death Dis. 2019 Nov; 10(11): 816. Published online 2019 Oct 28. doi: 10.1038/s41419-019-2055-6

PMCID:: PMC6817826

Abstract Article PDF–2.5M

Select item 671025711.

Constitutive Active Mutant TIE2 Induces Enlarged Vascular Lumen Formation with Loss of Apico-basal Polarity and Pericyte Recruitment

Yuqi Cai, Sandra Schrenk, Jillian Goines, George E. Davis, Elisa Boscolo

Sci Rep. 2019; 9: 12352. Published online 2019 Aug 26. doi: 10.1038/s41598-019-48854-2

PMCID:: PMC6710257

Abstract Article PDF–3.3M

Select item 634803312.

A Tie2 kinase mutation causing venous malformations increases phosphorylation rates and enhances cooperativity

Madison A. Kennedy, Zeqing Xu, Yunjin Wu, Christal D. Sohl

Biochem Biophys Res Commun. Author manuscript; available in PMC 2020 Feb 19.

Published in final edited form as: Biochem Biophys Res Commun. 2019 Feb 19; 509(4): 898–902. Published online 2019 Jan 11. doi: 10.1016/j.bbrc.2019.01.020

PMCID:: PMC6348033

Abstract Article PDF–653K

Select item 622018513.

Plasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancer

Gordon C. Jayson, Cong Zhou, Alison Backen, Laura Horsley, Kalena Marti-Marti, Danielle Shaw, Nerissa Mescallado, Andrew Clamp, Mark P. Saunders, Juan W. Valle, Saifee Mullamitha, Mike Braun, Jurjees Hasan, Delyth McEntee, Kathryn Simpson, Ross A. Little, Yvonne Watson, Susan Cheung, Caleb Roberts, Linda Ashcroft, Prakash Manoharan, Stefan J. Scherer, Olivia del Puerto, Alan Jackson, James P. B. O’Connor, Geoff J. M. Parker, Caroline Dive

Nat Commun. 2018; 9: 4672. Published online 2018 Nov 7. doi: 10.1038/s41467-018-07174-1

PMCID:: PMC6220185

Abstract Article PDF–870K

Select item 566999814.

The selective Tie2 inhibitor rebastinib blocks recruitment and function of Tie2^Hi macrophages in breast cancer and pancreatic neuroendocrine tumors

Allison S. Harney, George S. Karagiannis, Jeanine Pignatelli, Bryan D. Smith, Ece Kadioglu, Scott C. Wise, Molly M. Hood, Michael D. Kaufman, Cynthia B. Leary, Wei-Ping Lu, Gada Al-Ani, Xiaoming Chen, David Entenberg, Maja H. Oktay, Yarong Wang, Lawrence Chun, Michele De Palma, Joan G. Jones, Daniel L. Flynn, John S. Condeelis

Mol Cancer Ther. Author manuscript; available in PMC 2018 Nov 1.

Published in final edited form as: Mol Cancer Ther. 2017 Nov; 16(11): 2486–2501. Published online 2017 Aug 24. doi: 10.1158/1535-7163.MCT-17-0241

PMCID:: PMC5669998

Abstract Article PDF–2.6M

Select item 494770515.

Systematic analysis of circulating soluble angiogenesis-associated proteins in ICON7 identifies Tie2 as a biomarker of vascular progression on bevacizumab

Cong Zhou, Andrew Clamp, Alison Backen, Carlo Berzuini, Andrew Renehan, Rosamonde E Banks, Richard Kaplan, Stefan J Scherer, Gunnar B Kristensen, Eric Pujade-Lauraine, Caroline Dive, Gordon C Jayson

Br J Cancer. 2016 Jul 12; 115(2): 228–235. Published online 2016 Jun 28. doi: 10.1038/bjc.2016.194

PMCID:: PMC4947705

Abstract Article PDF–348K

Select item 490062216.

Tie2 Expressing Monocytes in the Spleen of Patients with Primary Myelofibrosis

Rita Campanelli, Gabriela Fois, Paolo Catarsi, Valentina Poletto, Laura Villani, Benedetta Gaia Erba, Luigi Maddaluno, Basilio Jemos, Silvia Salmoiraghi, Paola Guglielmelli, Vittorio Abbonante, Christian Andrea Di Buduo, Alessandra Balduini, Alessandra Iurlo, Giovanni Barosi, Vittorio Rosti, Margherita Massa, AGIMM Investigators

PLoS One. 2016; 11(6): e0156990. Published online 2016 Jun 9. doi: 10.1371/journal.pone.0156990

PMCID:: PMC4900622

Abstract Article PDF–1.8M

Select item 482305617.

Tie-2 regulates the stemness and metastatic properties of prostate cancer cells

Kai-Dun Tang, Boris M. Holzapfel, Ji Liu, Terence Kin-Wah Lee, Stephanie Ma, Lidija Jovanovic, Jiyuan An, Pamela J. Russell, Judith A. Clements, Dietmar W. Hutmacher, Ming-Tat Ling

Oncotarget. 2016 Jan 19; 7(3): 2572–2584. Published online 2015 Apr 29. doi: 10.18632/oncotarget.3950

PMCID:: PMC4823056

Abstract Article PDF–2.0M

Select item 461470518.

Common and specific effects of TIE2 mutations causing venous malformations

Marjut Nätynki, Jaakko Kangas, Ilkka Miinalainen, Raija Sormunen, Riikka Pietilä, Julie Soblet, Laurence M. Boon, Miikka Vikkula, Nisha Limaye, Lauri Eklund

Hum Mol Genet. 2015 Nov 15; 24(22): 6374–6389. Published online 2015 Aug 28. doi: 10.1093/hmg/ddv349

PMCID:: PMC4614705

Abstract Article PDF–1.6M

Select item 405707419.

The renal angiopoietin/Tie2 system in lethal human sepsis

Adnan Aslan, Rianne M Jongman, Jill Moser, Coen A Stegeman, Harry van Goor, Arjan Diepstra, Marius C van den Heuvel, Peter Heeringa, Grietje Molema, Jan G Zijlstra, Matijs van Meurs

Crit Care. 2014; 18(2): 423. Published online 2014 Mar 31. doi: 10.1186/cc13806

PMCID:: PMC4057074

Article PDF–338K

Select item 310017720.

Tie2/TEK Modulates the Interaction of Glioma and Brain Tumor Stem Cells with Endothelial Cells and Promotes an Invasive Phenotype

Dan Liu, Vanesa Martin, Juan Fueyo, Ok-Hee Lee, Jing Xu, Nahir Cortes-Santiago, Marta M. Alonso, Kenneth Aldape, Howard Colman, Candelaria Gomez-Manzano

Oncotarget. 2010 Dec; 1(8): 700–709. Published online 2010 Dec 30. doi: 10.18632/oncotarget.204

PMCID:: PMC3100177

Abstract Article PDF–2.5M

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