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Select item 47551681.

Leukemia‐associated Rho guanine‐nucleotide exchange factor is not critical for RhoA regulation, yet is important for platelet activation and thrombosis in mice

C. M. Williams, M. T. Harper, R. Goggs, T. G. Walsh, S. Offermanns, A. W. Poole

J Thromb Haemost. 2015 Nov; 13(11): 2102–2107. Published online 2015 Oct 20. doi: 10.1111/jth.13129

PMCID:: PMC4755168

Abstract Article PDF–407K

Select item 40600002.

Jun kinase-induced overexpression of leukemia-associated Rho GEF (LARG) mediates sustained hypercontraction of longitudinal smooth muscle in inflammation

Othman Al-Shboul, Ancy D. Nalli, Divya P. Kumar, Ruizhe Zhou, Sunila Mahavadi, John F. Kuemmerle, John R. Grider, Karnam S. Murthy

Am J Physiol Cell Physiol. 2014 Jun 15; 306(12): C1129–C1141. Published online 2014 Apr 16. doi: 10.1152/ajpcell.00021.2014

PMCID:: PMC4060000

Abstract Article

Select item 36203513.

RhoGEF12 controls cardiac remodeling by integrating G protein– and integrin-dependent signaling cascades

Mikito Takefuji, Marcus Krüger, Kishor K. Sivaraj, Kozo Kaibuchi, Stefan Offermanns, Nina Wettschureck

J Exp Med. 2013 Apr 8; 210(4): 665–673. doi: 10.1084/jem.20122126

PMCID:: PMC3620351

Abstract Article PDF–2.2M

Select item 58457814.

Leukemia-associated Rho guanine nucleotide exchange factor (LARG) plays an agonist specific role in platelet function through RhoA activation

Siying Zou, Alexandra M. Teixeira, Mingzhu Yin, Yaozu Xiang, Juliana Xavier-Ferruccio, Ping-xia Zhang, John Hwa, Wang Min, Diane S. Krause

Thromb Haemost. Author manuscript; available in PMC 2018 Mar 12.

Published in final edited form as: Thromb Haemost. 2016 Aug 30; 116(3): 506–516. Published online 2016 Jun 23. doi: 10.1160/TH15-11-0848

PMCID:: PMC5845781

Abstract Article PDF–846K

Select item 55037095.

Potentiation of receptor responses induced by prolonged binding of Gα₁₃ and leukemia-associated RhoGEF

Eva-Lisa Bodmann, Anna-Lena Krett, Moritz Bünemann

FASEB J. 2017 Aug; 31(8): 3663–3676. Published online 2017 May 2. doi: 10.1096/fj.201700026R

PMCID:: PMC5503709

Abstract Article

Select item 31215076.

Identification of Critical Residues in Gα₁₃ for Stimulation of p115RhoGEF Activity and the Structure of the Gα₁₃-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain Complex

Nicole Hajicek, Mutsuko Kukimoto-Niino, Chiemi Mishima-Tsumagari, Christina R. Chow, Mikako Shirouzu, Takaho Terada, Maulik Patel, Shigeyuki Yokoyama, Tohru Kozasa

J Biol Chem. 2011 Jun 10; 286(23): 20625–20636. Published online 2011 Apr 20. doi: 10.1074/jbc.M110.201392

PMCID:: PMC3121507

Abstract Article PDF–2.7M

Select item 31073867.

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

Christophe Guilluy, Vinay Swaminathan, Rafael Garcia-Mata, E. Timothy O’Brien, Richard Superfine, Keith Burridge

Nat Cell Biol. Author manuscript; available in PMC 2011 Dec 1.

Published in final edited form as: Nat Cell Biol. 2011 Jun; 13(6): 722–727. Published online 2011 May 15. doi: 10.1038/ncb2254

PMCID:: PMC3107386

Abstract Article PDF–1.0M

Select item 1338448.

Leukemia-Associated Rho Guanine Nucleotide Exchange Factor Promotes Gαq-Coupled Activation of RhoA

Michelle A. Booden, David P. Siderovski, Channing J. Der

Mol Cell Biol. 2002 Jun; 22(12): 4053–4061. doi: 10.1128/MCB.22.12.4053-4061.2002

PMCID:: PMC133844

Abstract Article PDF–369K

Select item 92121709.

Identification of Arhgef12 and Prkci as genetic modifiers of retinal dysplasia in the Crb1^rd8 mouse model

Sonia M. Weatherly, Gayle B. Collin, Jeremy R. Charette, Lisa Stone, Nattaya Damkham, Lillian F. Hyde, James G. Peterson, Wanda Hicks, Gregory W. Carter, Jürgen K. Naggert, Mark P. Krebs, Patsy M. Nishina

PLoS Genet. 2022 Jun; 18(6): e1009798. Published online 2022 Jun 8. doi: 10.1371/journal.pgen.1009798

PMCID:: PMC9212170

Abstract Article PDF–6.4M

Select item 574361010.

LARG GEF and ARHGAP18 Orchestrate RhoA Activity to Control Mesenchymal Stem Cell Lineage

William R. Thompson, Sherwin S. Yen, Gunes Uzer, Zhihui Xie, Buer Sen, Maya Styner, Keith Burridge, Janet Rubin

Bone. Author manuscript; available in PMC 2019 Feb 1.

Published in final edited form as: Bone. 2018 Feb; 107: 172–180. Published online 2017 Dec 5. doi: 10.1016/j.bone.2017.12.001

PMCID:: PMC5743610

Abstract Article PDF–1.1M

Select item 293083211.

S1P Receptor 2 Signals Through the RGS-RhoGEF, LARG, To Promote Smooth Muscle Cell Differentiation

Matt D. Medlin, Dean P. Staus, Adi D. Dubash, Joan M. Taylor, Christopher P. Mack

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2011 Sep 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2010 Sep; 30(9): 1779–1786. Published online 2010 Aug 11. doi: 10.1161/ATVBAHA.110.209395

PMCID:: PMC2930832

Abstract Article PDF–948K

Select item 217418812.

LARG and mDia1 Link Gα_12/13 to Cell Polarity and Microtubule Dynamics

Polyxeni Goulimari, Helga Knieling, Ulrike Engel, Robert Grosse

Mol Biol Cell. 2008 Jan; 19(1): 30–40. doi: 10.1091/mbc.E06-11-1045

PMCID:: PMC2174188

Abstract Article PDF–2.9M

Select item 677797913.

Myogenic vasoconstriction requires G₁₂/G₁₃ and LARG to maintain local and systemic vascular resistance

Ramesh Chennupati, Angela Wirth, Julie Favre, Rui Li, Rémy Bonnavion, Young-June Jin, Astrid Wietelmann, Frank Schweda, Nina Wettschureck, Daniel Henrion, Stefan Offermanns

eLife. 2019; 8: e49374. Published online 2019 Sep 24. doi: 10.7554/eLife.49374

PMCID:: PMC6777979

Abstract Article PDF–4.6M

Select item 439424114.

RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock

Constantinos M. Mikelis, May Simaan, Koji Ando, Shigetomo Fukuhara, Atsuko Sakurai, Panomwat Amornphimoltham, Andrius Masedunskas, Roberto Weigert, Triantafyllos Chavakis, Ralf Adams, Stefan Offermanns, Naoki Mochizuki, Yi Zheng, J. Silvio Gutkind

Nat Commun. Author manuscript; available in PMC 2015 Oct 10.

Published in final edited form as: Nat Commun. 2015; 6: 6725. Published online 2015 Apr 10. doi: 10.1038/ncomms7725

PMCID:: PMC4394241

Abstract Article PDF–2.6M

Select item 350136015.

Procontractile G protein–mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling

Till F. Althoff, Julián Albarrán Juárez, Kerstin Troidl, Cong Tang, Shengpeng Wang, Angela Wirth, Mikito Takefuji, Nina Wettschureck, Stefan Offermanns

J Exp Med. 2012 Nov 19; 209(12): 2277–2290. doi: 10.1084/jem.20120350

PMCID:: PMC3501360

Abstract Article PDF–3.7M

Select item 363690716.

PDZ-RhoGEF and LARG Are Essential for Embryonic Development and Provide a Link between Thrombin and LPA Receptors and Rho Activation

Constantinos M. Mikelis, Todd R. Palmby, May Simaan, Wenling Li, Roman Szabo, Ruth Lyons, Daniel Martin, Hiroshi Yagi, Shigetomo Fukuhara, Hiroki Chikumi, Rebeca Galisteo, Yoh-suke Mukouyama, Thomas H. Bugge, J. Silvio Gutkind

J Biol Chem. 2013 Apr 26; 288(17): 12232–12243. Published online 2013 Mar 6. doi: 10.1074/jbc.M112.428599

PMCID:: PMC3636907

Abstract Article PDF–3.7M

Select item 383714217.

Agonist-induced Ca²⁺ Sensitization in Smooth Muscle: REDUNDANCY OF RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS (RhoGEFs) AND RESPONSE KINETICS, A CAGED COMPOUND STUDY

Mykhaylo V. Artamonov, Ko Momotani, Andra Stevenson, David R. Trentham, Urszula Derewenda, Zygmunt S. Derewenda, Paul W. Read, J. Silvio Gutkind, Avril V. Somlyo

J Biol Chem. 2013 Nov 22; 288(47): 34030–34040. Published online 2013 Oct 8. doi: 10.1074/jbc.M113.514596

PMCID:: PMC3837142

Abstract Article PDF–1.8M

Select item 392605318.

Genetic dissection of plexin signaling in vivo

Thomas Worzfeld, Jakub M. Swiercz, Aycan Sentürk, Berit Genz, Alexander Korostylev, Suhua Deng, Jingjing Xia, Mikio Hoshino, Jonathan A. Epstein, Andrew M. Chan, Brigitte Vollmar, Amparo Acker-Palmer, Rohini Kuner, Stefan Offermanns

Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6): 2194–2199. Published online 2014 Jan 27. doi: 10.1073/pnas.1308418111

PMCID:: PMC3926053

Abstract Article PDF–1.3M

Select item 710974519.

ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients

Yangyang Xie, Li Gao, Chunhui Xu, Liming Chu, Lei Gao, Ruichi Wu, Yu Liu, Ting Liu, Xiao-jian Sun, Ruibao Ren, Jingyan Tang, Yi Zheng, Yong Zhou, Shuhong Shen

Haematologica. 2020 Apr; 105(4): 925–936. Prepublished online 2019 Aug 29. doi: 10.3324/haematol.2018.210286

PMCID:: PMC7109745

Abstract Article PDF–2.7M

Select item 145888420.

Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis

Megan K. Mulligan, Igor Ponomarev, Robert J. Hitzemann, John K. Belknap, Boris Tabakoff, R. Adron Harris, John C. Crabbe, Yuri A. Blednov, Nicholas J. Grahame, Tamara J. Phillips, Deborah A. Finn, Paula L. Hoffman, Vishwanath R. Iyer, George F. Koob, Susan E. Bergeson

Proc Natl Acad Sci U S A. 2006 Apr 18; 103(16): 6368–6373. Published online 2006 Apr 17. doi: 10.1073/pnas.0510188103