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Select item 107177461.

Association of Ala589Ser polymorphism of WNK4 gene with essential hypertension in a high-risk Chinese population

Zhi-Jun Sun, Yan Li, Jing-Yu Lu, Qian Ding, Yu Liang, Jing-Pu Shi, Jesse Li-Ling, Yan-Yan Zhao

J Physiol Sci. 2009 Mar; 59(2): 81–86. Published online 2008 Dec 17. doi: 10.1007/s12576-008-0011-9

PMCID:: PMC10717746

Abstract Article PDF–231K

Select item 65655452.

A familial case of pseudohypoaldosteronism type II (PHA2) with a novel mutation (D564N) in the acidic motif in WNK4

Takashi Sakoh, Akinari Sekine, Takayasu Mori, Hiroki Mizuno, Masahiro Kawada, Rikako Hiramatsu, Eiko Hasegawa, Noriko Hayami, Masayuki Yamanouchi, Tatsuya Suwabe, Naoki Sawa, Yoshifumi Ubara, Takuya Fujimaru, Eisei Sohara, Uchida Shinichi, Junichi Hoshino, Kenmei Takaichi

Mol Genet Genomic Med. 2019 Jun; 7(6): e705. Published online 2019 May 1. doi: 10.1002/mgg3.705

PMCID:: PMC6565545

Abstract Article PDF–311K

Select item 49031253.

Novel Association of WNK4 Gene, Ala589Ser Polymorphism in Essential Hypertension, and Type 2 Diabetes Mellitus in Malaysia

Nooshin Ghodsian, Patimah Ismail, Salma Ahmadloo, Farzad Heidari, Polin Haghvirdizadeh, Sima Ataollahi Eshkoor, Ali Etemad

J Diabetes Res. 2016; 2016: 8219543. Published online 2016 May 29. doi: 10.1155/2016/8219543

PMCID:: PMC4903125

Abstract Article PDF–728K

Select item 41953964.

Comprehensive Assessment of the Association of WNK4 Polymorphisms with Hypertension: Evidence from a Meta-Analysis

Xiao-gang Guo, Jie Ding, Hui Xu, Tian-ming Xuan, Wei-quan Jin, Xiang Yin, Yun-peng Shang, Fu-rong Zhang, Jian-hua Zhu, Liang-rong Zheng

Sci Rep. 2014; 4: 6507. Published online 2014 Sep 30. doi: 10.1038/srep06507

PMCID:: PMC4195396

Abstract Article PDF–1.1M

Select item 37986775.

Regulation of large-conductance Ca²⁺-activated K⁺ channels by WNK4 kinase

Zhijian Wang, Arohan R. Subramanya, Lisa M. Satlin, Núria M. Pastor-Soler, Marcelo D. Carattino, Thomas R. Kleyman

Am J Physiol Cell Physiol. 2013 Oct 15; 305(8): C846–C853. Published online 2013 Jul 24. doi: 10.1152/ajpcell.00133.2013

PMCID:: PMC3798677

Abstract Article

Select item 35436156.

Disease-causing R1185C mutation of WNK4 disrupts a regulatory mechanism involving calmodulin binding and SGK1 phosphorylation sites

Tao Na, Guojin Wu, Wei Zhang, Wen-Ji Dong, Ji-Bin Peng

Am J Physiol Renal Physiol. 2013 Jan 1; 304(1): F8–F18. Published online 2012 Oct 10. doi: 10.1152/ajprenal.00284.2012

PMCID:: PMC3543615

Abstract Article

Select item 66886137.

Unveiling the distinct mechanisms by which disease-causing mutations in the Kelch domain of KLHL3 disrupt the interaction with the acidic motif of WNK4 through molecular dynamics simulation

Lingyun Wang, Chen Jiang, Ruiqi Cai, Xing-Zhen Chen, Ji-Bin Peng

Biochemistry. Author manuscript; available in PMC 2020 Apr 23.

Published in final edited form as: Biochemistry. 2019 Apr 23; 58(16): 2105–2115. Published online 2019 Apr 10. doi: 10.1021/acs.biochem.9b00066

PMCID:: PMC6688613

Abstract Article PDF–1.2M

Select item 52757308.

Phosphorylation of KLHL3 at serine 433 impairs its interaction with the acidic motif of WNK4: a molecular dynamics study

Lingyun Wang, Ji‐Bin Peng

Protein Sci. 2017 Feb; 26(2): 163–173. Published online 2016 Oct 26. doi: 10.1002/pro.3063

PMCID:: PMC5275730

Abstract Article PDF–1.6M

Select item 31545879.

WNK4 kinase inhibits Maxi K channel activity by a kinase-dependent mechanism

Jieqiu Zhuang, Xuemei Zhang, Dexuan Wang, Juan Li, Bo Zhou, Zhen Shi, Dingying Gu, Donald D. Denson, Douglas C. Eaton, Hui Cai

Am J Physiol Renal Physiol. 2011 Aug; 301(2): F410–F419. Published online 2011 May 25. doi: 10.1152/ajprenal.00518.2010

PMCID:: PMC3154587

Abstract Article

Select item 257025810.

WNK4 regulates the secretory pathway via which TRPV5 is targeted to the plasma membrane

Yi Jiang, Peilong Cong, Shawn R. Williams, Wei Zhang, Tao Na, He-Ping Ma, Ji-Bin Peng

Biochem Biophys Res Commun. Author manuscript; available in PMC 2009 Oct 17.

Published in final edited form as: Biochem Biophys Res Commun. 2008 Oct 17; 375(2): 225–229. Published online 2008 Aug 12. doi: 10.1016/j.bbrc.2008.08.010

PMCID:: PMC2570258

Abstract Article PDF–1.0M

Select item 638666111.

Calcineurin dephosphorylates Kelch-like 3, reversing phosphorylation by angiotensin II and regulating renal electrolyte handling

Kenichi Ishizawa, Qin Wang, Jinping Li, Osamu Yamazaki, Yoshifuru Tamura, Yoshihide Fujigaki, Shunya Uchida, Richard P. Lifton, Shigeru Shibata

Proc Natl Acad Sci U S A. 2019 Feb 19; 116(8): 3155–3160. Published online 2019 Feb 4. doi: 10.1073/pnas.1817281116

PMCID:: PMC6386661

Abstract Article PDF–1.1M

Select item 617258012.

Kidney-specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC

Eduardo R. Argaiz, Maria Chavez-Canales, Mauricio Ostrosky-Frid, Alejandro Rodríguez-Gama, Norma Vázquez, Xochiquetzal Gonzalez-Rodriguez, Jesus Garcia-Valdes, Juliette Hadchouel, David Ellison, Gerardo Gamba

Am J Physiol Renal Physiol. 2018 Sep 1; 315(3): F734–F745. Published online 2018 May 30. doi: 10.1152/ajprenal.00145.2018

PMCID:: PMC6172580

Abstract Article

Select item 529301413.

Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4

Maria Castañeda-Bueno, Juan Pablo Arroyo, Junhui Zhang, Jeremy Puthumana, Orlando Yarborough, III, Shigeru Shibata, Lorena Rojas-Vega, Gerardo Gamba, Jesse Rinehart, Richard P. Lifton

Proc Natl Acad Sci U S A. 2017 Jan 31; 114(5): E879–E886. Published online 2017 Jan 17. doi: 10.1073/pnas.1620315114

PMCID:: PMC5293014

Abstract Article PDF–1.4M

Select item 439429014.

Src-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK)

Dao-Hong Lin, Peng Yue, Orlando Yarborough, III, Ute I. Scholl, Gerhard Giebisch, Richard P. Lifton, Jesse Rinehart, Wen-Hui Wang

Proc Natl Acad Sci U S A. 2015 Apr 7; 112(14): 4495–4500. Published online 2015 Mar 24. doi: 10.1073/pnas.1503437112

PMCID:: PMC4394290

Abstract Article PDF–905K

Select item 318736915.

Antagonistic Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Cell Surface Expression by Protein Kinases WNK4 and Spleen Tyrosine Kinase

Ana Isabel Mendes, Paulo Matos, Sónia Moniz, Simão Luz, Margarida D. Amaral, Carlos M. Farinha, Peter Jordan

Mol Cell Biol. 2011 Oct; 31(19): 4076–4086. doi: 10.1128/MCB.05152-11

PMCID:: PMC3187369

Abstract Article PDF–1.5M

Select item 303166916.

Concerted actions of NHERF2 and WNK4 in regulating TRPV5

Haiyan Jing, Tao Na, Wei Zhang, Guojin Wu, Chuanyong Liu, Ji-Bin Peng

Biochem Biophys Res Commun. Author manuscript; available in PMC 2012 Jan 28.

Published in final edited form as: Biochem Biophys Res Commun. 2011 Jan 28; 404(4): 979–984. Published online 2010 Dec 25. doi: 10.1016/j.bbrc.2010.12.095