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Select item 109002721.

Expression of GPX4 by oncolytic vaccinia virus can significantly enhance CD8⁺T cell function and its impact against pancreatic ductal adenocarcinoma

Wei Wei, Linqing Tian, Xiaoyan Zheng, Lei Zhong, Yuan Chen, Hui Dong, Guibing Zhang, Shibing Wang, Xiangmin Tong

Oncoimmunology. 2024; 13(1): 2322173. Published online 2024 Feb 27. doi: 10.1080/2162402X.2024.2322173

PMCID:: PMC10900272

Abstract Article PDF–7.5M

Select item 108711522.

Modulation of sarcopenia phenotypes by glutathione peroxidase 4 overexpression in mice

Hongyang Xu, Agnieszka Czyżowska, Holly Van Remmen, Jacob L. Brown

J Physiol. Author manuscript; available in PMC 2024 Feb 16.

Published in final edited form as: J Physiol. 2023 Dec; 601(23): 5277–5293. Published online 2023 Oct 25. doi: 10.1113/JP285259

PMCID:: PMC10871152

Abstract Article PDF–1.7M

Select item 102761433.

Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness

Agnieszka Czyżowska, Jacob Brown, Hongyang Xu, Kavitha Sataranatarajan, Michael Kinter, Victoria J. Tyrell, Valerie B. O'Donnell, Holly Van Remmen

Redox Biol. 2023 Aug; 64: 102761. Published online 2023 Jun 1. doi: 10.1016/j.redox.2023.102761

PMCID:: PMC10276143

Abstract Article PDF–11M

Select item 98113304.

GPX4 deficiency-dependent phospholipid peroxidation drives motor deficits of ALS

Long-Fang Tu, Tian-Ze Zhang, Yang-Fan Zhou, Qing-Qing Zhou, Hai-Biao Gong, Lei Liang, Lin-Na Hai, Nan-Xin You, Yang Su, Yong-Jun Chen, Xu-Kai Mo, Chang-Zheng Shi, Liang-Ping Luo, Wan-Yang Sun, Wen-Jun Duan, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong He

J Adv Res. 2023 Jan; 43: 205–218. Published online 2022 Mar 4. doi: 10.1016/j.jare.2022.02.016

PMCID:: PMC9811330

Abstract Article PDF–4.2M

Select item 96374845.

Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx

Shaoyi Wang, Weiwei Li, Pengfei Zhang, Zihao Wang, Xiaoyuan Ma, Chuanju Liu, Krasimir Vasilev, Lei Zhang, Xiaocong Zhou, Liang Liu, John Hayball, Shuli Dong, Yuhua Li, Yuan Gao, Lei Cheng, Yunpeng Zhao

J Adv Res. 2022 Nov; 41: 63–75. Published online 2022 Jan 11. doi: 10.1016/j.jare.2022.01.004

PMCID:: PMC9637484

Abstract Article PDF–5.3M

Select item 94584716.

GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection

Eduardo P. Amaral, Taylor W. Foreman, Sivaranjani Namasivayam, Kerry L. Hilligan, Keith D. Kauffman, Caio Cesar Barbosa Bomfim, Diego L. Costa, Beatriz Barreto-Duarte, Clarissa Gurgel-Rocha, Monique Freire Santana, Marcelo Cordeiro-Santos, Elsa Du Bruyn, Catherine Riou, Kate Aberman, Robert John Wilkinson, Daniel L. Barber, Katrin D. Mayer-Barber, Bruno B. Andrade, Alan Sher

J Exp Med. 2022 Nov 7; 219(11): e20220504. Published online 2022 Sep 7. doi: 10.1084/jem.20220504

PMCID:: PMC9458471

Abstract Article PDF–7.5M

Select item 91794117.

Functional Deficits of 5×FAD Neural Stem Cells Are Ameliorated by Glutathione Peroxidase 4

Nawab John Dar, Ren Na, Qitao Ran

Cells. 2022 Jun; 11(11): 1770. Published online 2022 May 28. doi: 10.3390/cells11111770

PMCID:: PMC9179411

Abstract Article PDF–2.2M

Select item 89803378.

Mitochondrial glutathione peroxidase 4 is indispensable for photoreceptor development and survival in mice

Kunihiro Azuma, Tomoko Koumura, Ryo Iwamoto, Masaki Matsuoka, Ryo Terauchi, Shu Yasuda, Tomoyasu Shiraya, Sumiko Watanabe, Makoto Aihara, Hirotaka Imai, Takashi Ueta

J Biol Chem. 2022 Apr; 298(4): 101824. Published online 2022 Mar 11. doi: 10.1016/j.jbc.2022.101824

PMCID:: PMC8980337

Abstract Article PDF–4.8M

Select item 83459999.

Expression Silencing of Glutathione Peroxidase 4 in Mouse Erythroleukemia Cells Delays In Vitro Erythropoiesis

Marlena Rademacher, Hartmut Kuhn, Astrid Borchert

Int J Mol Sci. 2021 Aug; 22(15): 7795. Published online 2021 Jul 21. doi: 10.3390/ijms22157795

PMCID:: PMC8345999

Abstract Article PDF–2.0M

Select item 821380510.

Overexpression of ferroptosis defense enzyme Gpx4 retards motor neuron disease of SOD1G93A mice

Liuji Chen, Ren Na, Kirsten Danae McLane, Cody Sylvester Thompson, Ju Gao, Xinglong Wang, Qitao Ran

Sci Rep. 2021; 11: 12890. Published online 2021 Jun 18. doi: 10.1038/s41598-021-92369-8

PMCID:: PMC8213805

Abstract Article PDF–6.1M

Select item 779112311.

Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis

Faisal Thayyullathil, Anees Rahman Cheratta, Ameer Alakkal, Karthikeyan Subburayan, Siraj Pallichankandy, Yusuf A. Hannun, Sehamuddin Galadari

Cell Death Dis. 2021 Jan; 12(1): 26. Published online 2021 Jan 7. doi: 10.1038/s41419-020-03297-w

PMCID:: PMC7791123

Abstract Article PDF–3.0M

Select item 715651612.

Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease

Lisa Mayr, Felix Grabherr, Julian Schwärzler, Isabelle Reitmeier, Felix Sommer, Thomas Gehmacher, Lukas Niederreiter, Gui-Wei He, Barbara Ruder, Kai T. R. Kunz, Piotr Tymoszuk, Richard Hilbe, David Haschka, Clemens Feistritzer, Romana R. Gerner, Barbara Enrich, Nicole Przysiecki, Markus Seifert, Markus A. Keller, Georg Oberhuber, Susanne Sprung, Qitao Ran, Robert Koch, Maria Effenberger, Ivan Tancevski, Heinz Zoller, Alexander R. Moschen, Günter Weiss, Christoph Becker, Philip Rosenstiel, Arthur Kaser, Herbert Tilg, Timon E. Adolph

Nat Commun. 2020; 11: 1775. Published online 2020 Apr 14. doi: 10.1038/s41467-020-15646-6

PMCID:: PMC7156516

Abstract Article PDF–2.2M

Select item 663712213.

Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

Masahiro Yoshida, Shunsuke Minagawa, Jun Araya, Taro Sakamoto, Hiromichi Hara, Kazuya Tsubouchi, Yusuke Hosaka, Akihiro Ichikawa, Nayuta Saito, Tsukasa Kadota, Nahoko Sato, Yusuke Kurita, Kenji Kobayashi, Saburo Ito, Hirohumi Utsumi, Hiroshi Wakui, Takanori Numata, Yumi Kaneko, Shohei Mori, Hisatoshi Asano, Makoto Yamashita, Makoto Odaka, Toshiaki Morikawa, Katsutoshi Nakayama, Takeo Iwamoto, Hirotaka Imai, Kazuyoshi Kuwano

Nat Commun. 2019; 10: 3145. Published online 2019 Jul 17. doi: 10.1038/s41467-019-10991-7

PMCID:: PMC6637122

Abstract Article PDF–3.9M

Select item 626463614.

A carnosine analog mitigates metabolic disorders of obesity by reducing carbonyl stress

Ethan J. Anderson, Giulio Vistoli, Lalage A. Katunga, Katsuhiko Funai, Luca Regazzoni, T. Blake Monroe, Ettore Gilardoni, Luca Cannizzaro, Mara Colzani, Danilo De Maddis, Giuseppe Rossoni, Renato Canevotti, Stefania Gagliardi, Marina Carini, Giancarlo Aldini

J Clin Invest. 2018 Dec 3; 128(12): 5280–5293. Published online 2018 Oct 22. doi: 10.1172/JCI94307

PMCID:: PMC6264636

Abstract Article PDF–7.3M

Select item 531254915.

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

William Sealy Hambright, Rene Solano Fonseca, Liuji Chen, Ren Na, Qitao Ran

Redox Biol. 2017 Aug; 12: 8–17. Published online 2017 Feb 1. doi: 10.1016/j.redox.2017.01.021

PMCID:: PMC5312549

Abstract Article PDF–1.4M

Select item 507252316.

The Antioxidant Requirement for Plasma Membrane Repair in Skeletal Muscle

Mohamed Labazi, Anna K. McNeil, Timothy Kurtz, Taylor C. Lee, Ronald B. Pegg, Jose Friedmann, Marcus Conrad, Paul L. McNeil

Free Radic Biol Med. Author manuscript; available in PMC 2016 Oct 20.

Published in final edited form as: Free Radic Biol Med. 2015 Jul; 84: 246–253. Published online 2015 Apr 3. doi: 10.1016/j.freeradbiomed.2015.03.016

PMCID:: PMC5072523

Abstract Article PDF–1.0M

Select item 505315917.

Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4

Robert Janowski, Sandra Scanu, Dierk Niessing, Tobias Madl

Acta Crystallogr F Struct Biol Commun. 2016 Oct 1; 72(Pt 10): 743–749. Published online 2016 Sep 22. doi: 10.1107/S2053230X16013686

PMCID:: PMC5053159

Abstract Article PDF–920K

Select item 465366918.

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

Liuji Chen, William Sealy Hambright, Ren Na, Qitao Ran

J Biol Chem. 2015 Nov 20; 290(47): 28097–28106. Published online 2015 Sep 23. doi: 10.1074/jbc.M115.680090

PMCID:: PMC4653669

Abstract Article PDF–2.9M

Select item 447066419.

Role of Glutathione Peroxidase 4 in Glutamate-Induced Oxytosis in the Retina

Osamu Sakai, Takatoshi Uchida, Murilo F. Roggia, Hirotaka Imai, Takashi Ueta, Shiro Amano

PLoS One. 2015; 10(6): e0130467. Published online 2015 Jun 17. doi: 10.1371/journal.pone.0130467

PMCID:: PMC4470664

Abstract Article PDF–2.1M

Select item 444329420.

Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy

Lalage A. Katunga, Preeti Gudimella, Jimmy T. Efird, Scott Abernathy, Taylor A. Mattox, Cherese Beatty, Timothy M. Darden, Kathleen A. Thayne, Hazaim Alwair, Alan P. Kypson, Jitka A. Virag, Ethan J. Anderson

Mol Metab. 2015 Jun; 4(6): 493–506. Published online 2015 Apr 21. doi: 10.1016/j.molmet.2015.04.001

Correction in:: Mol Metab. 2015 Oct; 4(10): 753.

PMCID:: PMC4443294

Abstract Article PDF–2.7M

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