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Select item 97053141.

Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models

Stephane Illiano, Bruno Poirier, Claire Minoletti, Olivier Pasquier, Laurence Riva, Xavier Chenede, Isabelle Menguy, Michel Guillotel, Philippe Prigent, Stéphane Le Claire, Florence Gillot, Gilbert Thill, François Lo Presti, Alain Corbier, Jean-Christophe Le Bail, Patrick Grailhe, Edith Monteagudo, Raffaele Ingenito, Elisabetta Bianchi, Christophe Philippo, Olivier Duclos, Sergio Mallart, Ross Bathgate, Philip Janiak

Sci Rep. 2022; 12: 20435. Published online 2022 Nov 28. doi: 10.1038/s41598-022-24716-2

PMCID:: PMC9705314

Abstract Article PDF–3.4M

Select item 51481412.

Expression of RXFP1 Is Decreased in Idiopathic Pulmonary Fibrosis. Implications for Relaxin-based Therapies

Jiangning Tan, John R. Tedrow, Justin A. Dutta, Brenda Juan-Guardela, Mehdi Nouraie, Yanxia Chu, Humberto Trejo Bittar, Kritika Ramani, Partha S. Biswas, Kristen L. Veraldi, Naftali Kaminski, Yingze Zhang, Daniel J. Kass

Am J Respir Crit Care Med. 2016 Dec 1; 194(11): 1392–1402. Published online 2016 Dec 1. doi: 10.1164/rccm.201509-1865OC

PMCID:: PMC5148141

Abstract Article PDF–1.0M

Select item 48041963.

Identification of small molecule agonists of human relaxin family receptor 1 (RXFP1) by utilizing a homogenous cell-based cAMP assay

Catherine Z. Chen, Noel Southall, Jingbo Xiao, Juan J. Marugan, Marc Ferrer, Xin Hu, Raisa E. Jones, Shu Feng, Irina U. Agoulnik, Wei Zheng, Alexander I. Agoulnik

J Biomol Screen. Author manuscript; available in PMC 2016 Mar 23.

Published in final edited form as: J Biomol Screen. 2013 Jul; 18(6): 670–677. Published online 2012 Dec 4. doi: 10.1177/1087057112469406

PMCID:: PMC4804196

Abstract Article PDF–557K

Select item 37847254.

The Relaxin Receptor (RXFP1) Utilizes Hydrophobic Moieties on a Signaling Surface of Its N-terminal Low Density Lipoprotein Class A Module to Mediate Receptor Activation

Roy C. K. Kong, Emma J. Petrie, Biswaranjan Mohanty, Jason Ling, Jeremy C. Y. Lee, Paul R. Gooley, Ross A. D. Bathgate

J Biol Chem. 2013 Sep 27; 288(39): 28138–28151. Published online 2013 Aug 7. doi: 10.1074/jbc.M113.499640

PMCID:: PMC3784725

Abstract Article PDF–1.8M

Select item 29546015.

Relaxin Signaling in Uterine Fibroids

Zhen Li, Jennifer K. Burzawa, Anne Troung, Shu Feng, Irina U. Agoulnik, Xiaowen Tong, Matthew L. Anderson, Ertug Kovanci, Aleksandar Rajkovic, Alexander I. Agoulnik

Ann N Y Acad Sci. Author manuscript; available in PMC 2010 Oct 14.

Published in final edited form as: Ann N Y Acad Sci. 2009 Apr; 1160: 374–378. doi: 10.1111/j.1749-6632.2008.03803.x

PMCID:: PMC2954601

Abstract Article PDF–337K

Select item 29455006.

Relaxin/RXFP1 Signaling in Prostate Cancer Progression

Shu Feng, Irina U. Agoulnik, Zhen Li, Hee Dong Han, Gabriel Lopez-Berestein, Anil Sood, Michael M. Ittmann, Alexander I. Agoulnik

Ann N Y Acad Sci. Author manuscript; available in PMC 2010 Sep 25.

Published in final edited form as: Ann N Y Acad Sci. 2009 Apr; 1160: 379–380. doi: 10.1111/j.1749-6632.2008.03793.x

PMCID:: PMC2945500

Abstract Article PDF–268K

Select item 26718917.

Characterization of Relaxin Receptor (RXFP1) Desensitization and Internalization in Primary Human Decidual Cells and RXFP1-Transfected HEK293 Cells

András Kern, Gillian D. Bryant-Greenwood

Endocrinology. 2009 May; 150(5): 2419–2428. Published online 2008 Dec 30. doi: 10.1210/en.2008-1385

PMCID:: PMC2671891

Abstract Article

Select item 22753658.

Cloning, Expression, and Functional Characterization of Relaxin Receptor (Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 7) Splice Variants from Human Fetal Membranes

András Kern, Daniela Hubbard, Aaron Amano, Gillian D. Bryant-Greenwood

Endocrinology. 2008 Mar; 149(3): 1277–1294. Published online 2007 Dec 13. doi: 10.1210/en.2007-1348

PMCID:: PMC2275365

Abstract Article

Select item 2934259.

Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates

Richard Ivell, Marga Balvers, Yvonne Pohnke, Ralph Telgmann, Olaf Bartsch, Karin Milde-Langosch, Ana-maria Bamberger, Almuth Einspanier

Reprod Biol Endocrinol. 2003; 1: 114. Published online 2003 Nov 24. doi: 10.1186/1477-7827-1-114

PMCID:: PMC293425

Abstract Article PDF–881K

Select item 871973110.

Identification of a distal RXFP1 gene enhancer with differential activity in fibrotic lung fibroblasts involving AP-1

Ting-Yun Chen, Xiaoyun Li, Gillian C. Goobie, Ching-Hsia Hung, Tin-Kan Hung, Kyle Hamilton, Harinath Bahudhanapati, Jiangning Tan, Daniel J. Kass, Yingze Zhang

PLoS One. 2021; 16(12): e0254466. Published online 2021 Dec 31. doi: 10.1371/journal.pone.0254466

PMCID:: PMC8719731

Abstract Article PDF–3.0M

Select item 698885611.

Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis

Elena M. Kaftanovskaya, Hooi Hooi Ng, Mariluz Soula, Bryan Rivas, Courtney Myhr, Brian A. Ho, Briana A. Cervantes, Thomas D. Shupe, Mahesh Devarasetty, Xin Hu, Xin Xu, Samarjit Patnaik, Kenneth J. Wilson, Elena Barnaeva, Marc Ferrer, Noel T. Southall, Juan J. Marugan, Colin E. Bishop, Irina U. Agoulnik, Alexander I. Agoulnik

FASEB J. 2019 Nov; 33(11): 12435–12446. Published online 2019 Nov. doi: 10.1096/fj.201901046R

PMCID:: PMC6988856

Abstract Article

Select item 644204112.

MicroRNA-144-3p targets relaxin/insulin-like family peptide receptor 1 (RXFP1) expression in lung fibroblasts from patients with idiopathic pulmonary fibrosis

Harinath Bahudhanapati, Jiangning Tan, Justin A. Dutta, Stephen B. Strock, John Sembrat, Diana Àlvarez, Mauricio Rojas, Benedikt Jäger, Antje Prasse, Yingze Zhang, Daniel J. Kass

J Biol Chem. 2019 Mar 29; 294(13): 5008–5022. Published online 2019 Feb 1. doi: 10.1074/jbc.RA118.004910

PMCID:: PMC6442041

Abstract Article PDF–2.7M

Select item 513468013.

Hormone Receptor Expression in Human Fascial Tissue

C. Fede, G. Albertin, L. Petrelli, M.M. Sfriso, C. Biz, R. De Caro, C. Stecco

Eur J Histochem. 2016 Nov 2; 60(4): 2710. Published online 2016 Nov 2. doi: 10.4081/ejh.2016.2710

PMCID:: PMC5134680

Abstract Article PDF–463K

Select item 483748214.

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1

Ashish Sethi, Shoni Bruell, Nitin Patil, Mohammed Akhter Hossain, Daniel J. Scott, Emma J. Petrie, Ross A. D. Bathgate, Paul R. Gooley

Nat Commun. 2016; 7: 11344. Published online 2016 Apr 18. doi: 10.1038/ncomms11344

PMCID:: PMC4837482

Abstract Article PDF–889K

Select item 431757715.

Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability

Vinojini B. Nair, Ross A. D. Bathgate, Frances Separovic, Chrishan S. Samuel, Mohammed Akhter Hossain, John D. Wade

Biomed Res Int. 2015; 2015: 731852. Published online 2015 Jan 22. doi: 10.1155/2015/731852

PMCID:: PMC4317577

Abstract Article PDF–1.0M

Select item 385533016.

Expression of LGR7 in the Primate Corpus Luteum Implicates the Corpus Luteum as a Relaxin Target Organ

Priya B. Maseelall, Aimee Seungdamrong, Gerson Weiss, Andrea S. Wojtczuk, Robert Donnelly, Richard L. Stouffer, Laura T. Goldsmith.

Ann N Y Acad Sci. Author manuscript; available in PMC 2013 Dec 7.

Published in final edited form as: Ann N Y Acad Sci. 2009 Apr; 1160: 10.1111/j.1749-6632.2009.03946.x. doi: 10.1111/j.1749-6632.2009.03946.x

PMCID:: PMC3855330

Abstract Article PDF–355K

Select item 371364617.

Relaxin, Its Receptor (RXFP1), and Insulin-Like Peptide 4 Expression Through Gestation and in Placenta Accreta

William Goh, Sandra Y. Yamamoto, Karen S. Thompson, Gillian D. Bryant-Greenwood

Reprod Sci. 2013 Aug; 20(8): 968–980. doi: 10.1177/1933719112472735

PMCID:: PMC3713646

Abstract Article PDF–961K

Select item 348762218.

The Different Ligand-Binding Modes of Relaxin Family Peptide Receptors RXFP1 and RXFP2

Daniel J. Scott, K. Johan Rosengren, Ross A. D. Bathgate

Mol Endocrinol. 2012 Nov; 26(11): 1896–1906. Published online 2012 Sep 12. doi: 10.1210/me.2012-1188

PMCID:: PMC3487622

Abstract Article

Select item 298898519.

Endometrial expression of relaxin and relaxin receptor in endometriosis

Sara S. Morelli, Felice Petraglia, Gerson Weiss, Stefano Luisi, Pasquale Florio, Andrea Wojtczuk, Laura T. Goldsmith

Fertil Steril. Author manuscript; available in PMC 2011 Dec 1.

Published in final edited form as: Fertil Steril. 2010 Dec; 94(7): 2885–2887. Published online 2010 Jul 23. doi: 10.1016/j.fertnstert.2010.06.051

PMCID:: PMC2988985

Abstract Article PDF–295K

Select item 281492420.

RELAXIN ACTIVATES PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA

Sudhir Singh, Robert G Bennett

Mol Cell Endocrinol. Author manuscript; available in PMC 2011 Feb 5.

Published in final edited form as: Mol Cell Endocrinol. 2010 Feb 5; 315(1-2): 239. Published online 2009 Aug 25. doi: 10.1016/j.mce.2009.08.014

PMCID:: PMC2814924

Abstract Article PDF–794K

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