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Select item 101209111.

High expression of serine protease 2 (PRSS2) associated with invasion, metastasis, and proliferation in gastric cancer

Haifeng Qin, Shushu Zhang, Linling Shen, Chenjian Mao, Guangyu Gao, Hui Wang

Aging (Albany NY) 2023 Apr 15; 15(7): 2473–2484. Published online 2023 Mar 23. doi: 10.18632/aging.204604

PMCID:: PMC10120911

Abstract Article PDF–1.3M

Select item 27469142.

A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis

Heiko Witt, Miklós Sahin-Tóth, Olfert Landt, Jian-Min Chen, Thilo Kähne, Joost PH Drenth, Zoltán Kukor, Edit Szepessy, Walter Halangk, Stefan Dahm, Klaus Rohde, Hans-Ulrich Schulz, Cédric Le Maréchal, Nejat Akar, Rudolf W Ammann, Kaspar Truninger, Mario Bargetzi, Eesh Bhatia, Carlo Castellani, Giulia Martina Cavestro, Milos Cerny, Giovanni Destro-Bisol, Gabriella Spedini, Hans Eiberg, Jan BMJ Jansen, Monika Koudova, Eva Rausova, Milan Macek, Jr., Núria Malats, Francisco X Real, Hans-Jürgen Menzel, Pedro Moral, Roberta Galavotti, Pier Franco Pignatti, Olga Rickards, Julius Spicak, Narcis Octavian Zarnescu, Wolfgang Böck, Thomas M Gress, Helmut Friess, Johann Ockenga, Hartmut Schmidt, Roland Pfützer, Matthias Löhr, Peter Simon, Frank Ulrich Weiss, Markus M Lerch, Niels Teich, Volker Keim, Thomas Berg, Bertram Wiedenmann, Werner Luck, David Alexander Groneberg, Michael Becker, Thomas Keil, Andreas Kage, Jana Bernardova, Markus Braun, Claudia Güldner, Juliane Halangk, Jonas Rosendahl, Ulrike Witt, Matthias Treiber, Renate Nickel, Claude Férec

Nat Genet. Author manuscript; available in PMC 2009 Sep 19.

Published in final edited form as: Nat Genet. 2006 Jun; 38(6): 668–673. Published online 2006 May 14. doi: 10.1038/ng1797

PMCID:: PMC2746914

Abstract Article PDF–780K

Select item 27000363.

A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2)

Zsolt Rónai, Heiko Witt, Olga Rickards, Giovanni Destro-Bisol, Andrew R. M. Bradbury, Miklós Sahin-Tóth

Biochem J. Author manuscript; available in PMC 2009 Aug 15.

Published in final edited form as: Biochem J. 2009 Feb 15; 418(1): 155–161. doi: 10.1042/BJ20081848

PMCID:: PMC2700036

Abstract Article PDF–638K

Select item 23636334.

The levels of trypsinogen isoenzymes in ovarian tumour cyst fluids are associated with promatrix metalloproteinase-9 but not promatrix metalloproteinase-2 activation

A Paju, T Sorsa, T Tervahartiala, E Koivunen, C Haglund, A Leminen, T Wahlström, T Salo, U-H Stenman

Br J Cancer. 2001 May; 84(10): 1363–1371. doi: 10.1054/bjoc.2001.1806

PMCID:: PMC2363633

Summary PDF–367K

Select item 18857755.

Expression and Characterization of Trypsinogen Produced in the Human Male Genital Tract

Annukka Paju, Anders Bjartell, Wan-Ming Zhang, Stig Nordling, Anders Borgström, Jens Hansson, Ulf-Håkan Stenman

Am J Pathol. 2000 Dec; 157(6): 2011–2021. doi: 10.1016/S0002-9440(10)64840-7

PMCID:: PMC1885775

Abstract Article PDF–1023K

Select item 98922036.

Pancreatitis-associated PRSS1-PRSS2 haplotype alters T cell receptor beta (TRB) repertoire more strongly than PRSS1 expression.

Dongni Fu, Brandon M Blobner, Phil J. Greer, Robert Lafyatis, Melena D Bellin, David C. Whitcomb, Prospective Autos study, GREAT1 study, North American Pancreatitis Study Group

Gastroenterology. Author manuscript; available in PMC 2024 Feb 1.

Published in final edited form as: Gastroenterology. 2023 Feb; 164(2): 289–292.e4. Published online 2022 Oct 1. doi: 10.1053/j.gastro.2022.09.036

PMCID:: PMC9892203

Article PDF–481K

Select item 76971837.

Role of the Common PRSS1-PRSS2 Haplotype in Alcoholic and Non-Alcoholic Chronic Pancreatitis: Meta- and Re-Analyses

Anthony F. Herzig, Emmanuelle Génin, David N. Cooper, Emmanuelle Masson, Claude Férec, Jian-Min Chen

Genes (Basel) 2020 Nov; 11(11): 1349. Published online 2020 Nov 13. doi: 10.3390/genes11111349

PMCID:: PMC7697183

Abstract Article PDF–1.2M

Select item 27523328.

Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl

Niels Teich, Zsófia Nemoda, Henrik Köhler, Wolfram Heinritz, Joachim Mössner, Volker Keim, Miklós Sahin-Tóth

Hum Mutat. Author manuscript; available in PMC 2009 Sep 25.

Published in final edited form as: Hum Mutat. 2005 Apr; 25(4): 343–347. doi: 10.1002/humu.20148

PMCID:: PMC2752332

Abstract Article PDF–785K

Select item 23741059.

The energetic cost of induced fit catalysis: Crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity

Annette Pasternak, Andre White, Constance J. Jeffery, Nivia Medina, Marguerite Cahoon, Dagmar Ringe, Lizbeth Hedstrom

Protein Sci. 2001 Jul; 10(7): 1331–1342. doi: 10.1110/ps.44101

PMCID:: PMC2374105

Abstract Article PDF–260K

Select item 121694310.

Inhibition of human pancreatic proteinases by mucus proteinase inhibitor, eglin c and aprotinin.

D Belorgey, S Dirrig, M Amouric, C Figarella, J G Bieth

Biochem J. 1996 Jan 15; 313(Pt 2): 555–560. doi: 10.1042/bj3130555

PMCID:: PMC1216943

Summary PDF–392K

Select item 979469911.

PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression

Lufei Sui, Suming Wang, Debolina Ganguly, Tyler P. El Rayes, Cecilie Askeland, Astrid Børretzen, Danielle Sim, Ole Johan Halvorsen, Gøril Knutsvik, Jarle Arnes, Sura Aziz, Svein Haukaas, William D. Foulkes, Diane R. Bielenberg, Arturas Ziemys, Vivek Mittal, Rolf A. Brekken, Lars A. Akslen, Randolph S. Watnick

Nat Commun. 2022; 13: 7959. Published online 2022 Dec 27. doi: 10.1038/s41467-022-35649-9

PMCID:: PMC9794699

Abstract Article PDF–9.7M

Select item 379573412.

Autocrine Extra-Pancreatic Trypsin 3 Secretion Promotes Cell Proliferation and Survival in Esophageal Adenocarcinoma

Song Han, Constance W. Lee, Jose G. Trevino, Steven J. Hughes, George A. Sarosi, Jr

PLoS One. 2013; 8(10): e76667. Published online 2013 Oct 11. doi: 10.1371/journal.pone.0076667

PMCID:: PMC3795734

Abstract Article PDF–1.5M

Select item 371848913.

Trypsin-mediated enzymatic degradation of type II collagen in the human vitreous

Mariëlle van Deemter, Roel Kuijer, Hendri Harm Pas, Roelofje Jacoba van der Worp, Johanna Martina Maria Hooymans, Leonoor Inge Los

Mol Vis. 2013; 19: 1591–1599. Published online 2013 Jul 20.

PMCID:: PMC3718489

Abstract Article PDF–2.1M

Select item 794913014.

Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis

András Szabó, Vanda Toldi, Lívia Diána Gazda, Alexandra Demcsák, József Tőzsér, Miklós Sahin-Tóth

J Biol Chem. 2021 Jan-Jun; 296: 100343. Published online 2021 Jan 28. doi: 10.1016/j.jbc.2021.100343

PMCID:: PMC7949130

Abstract Article PDF–2.2M

Select item 5312615.

CD4-binding regions of human immunodeficiency virus envelope glycoprotein gp120 defined by proteolytic digestion.

S R Pollard, W Meier, P Chow, J J Rosa, D C Wiley

Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24): 11320–11324. doi: 10.1073/pnas.88.24.11320

PMCID:: PMC53126

Summary Page Browse PDF–1.3M

Select item 287688516.

Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage

Jue Chen, Lian Li, Lih-Shen Chin

Hum Mol Genet. 2010 Jun 15; 19(12): 2395–2408. Published online 2010 Mar 18. doi: 10.1093/hmg/ddq113

PMCID:: PMC2876885

Abstract Article PDF–718K

Select item 351034417.

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

David C. Whitcomb, Jessica LaRusch, Alyssa M. Krasinskas, Lambertus Klei, Jill P. Smith, Randall E. Brand, John P. Neoptolemos, Markus M. Lerch, Matt Tector, Bimaljit S. Sandhu, Nalini M. Guda, Lidiya Orlichenko, Alzheimer's Disease Genetics Consortium, Samer Alkaade, Stephen T. Amann, Michelle A. Anderson, John Baillie, Peter A. Banks, Darwin Conwell, Gregory A. Coté, Peter B. Cotton, James DiSario, Lindsay A. Farrer, Chris E. Forsmark, Marianne Johnstone, Timothy B. Gardner, Andres Gelrud, William Greenhalf, Jonathan L. Haines, Douglas J. Hartman, Robert A. Hawes, Christopher Lawrence, Michele Lewis, Julia Mayerle, Richard Mayeux, Nadine M. Melhem, Mary E. Money, Thiruvengadam Muniraj, Georgios I. Papachristou, Margaret A. Pericak-Vance, Joseph Romagnuolo, Gerard D. Schellenberg, Stuart Sherman, Peter Simon, Vijay K. Singh, Adam Slivka, Donna Stolz, Robert Sutton, Frank Ulrich Weiss, C. Mel Wilcox, Narcis Octavian Zarnescu, Stephen R. Wisniewski, Michael R. O'Connell, Michelle L. Kienholz, Kathryn Roeder, M. Michael Barmada, Dhiraj Yadav, Bernie Devlin, Marilyn S. Albert, Roger L. Albin, Liana G. Apostolova, Steven E. Arnold, Clinton T. Baldwin, Robert Barber, Lisa L. Barnes, Thomas G. Beach, Gary W. Beecham, Duane Beekly, David A. Bennett, Eileen H. Bigio, Thomas D. Bird, Deborah Blacker, Adam Boxer, James R. Burke, Joseph D. Buxbaum, Nigel J. Cairns, Laura B. Cantwell, Chuanhai Cao, Regina M. Carney, Steven L. Carroll, Helena C. Chui, David G. Clark, David H. Cribbs, Elizabeth A. Crocco, Carlos Cruchaga, Charles DeCarli, F. Yesim Demirci, Malcolm Dick, Dennis W. Dickson, Ranjan Duara, Nilufer Ertekin-Taner, Kelley M. Faber, Kenneth B. Fallon, Martin R. Farlow, Steven Ferris, Tatiana M. Foroud, Matthew P. Frosch, Douglas R. Galasko, Mary Ganguli, Marla Gearing, Daniel H. Geschwind, Bernardino Ghetti, John R. Gilbert, Sid Gilman, Jonathan D. Glass, Alison M. Goate, Neill R. Graff-Radford, Robert C. Green, John H. Growdon, Hakon Hakonarson, Kara L. Hamilton-Nelson, Ronald L. Hamilton, Lindy E. Harrell, Elizabeth Head, Lawrence S. Honig, Christine M. Hulette, Bradley T. Hyman, Gregory A. Jicha, Lee-Way Jin, Gyungah Jun, M. Ilyas Kamboh, Anna Karydas, Jeffrey A. Kaye, Ronald Kim, Edward H. Koo, Neil W. Kowall, Joel H. Kramer, Patricia Kramer, Walter A. Kukull, Frank M. LaFerla, James J. Lah, James B. Leverenz, Allan I. Levey, Ge Li, Chiao-Feng Lin, Andrew P. Lieberman, Oscar L. Lopez, Kathryn L. Lunetta, Constantine G. Lyketsos, Wendy J. Mack, Daniel C. Marson, Eden R. Martin, Frank Martiniuk, Deborah C. Mash, Eliezer Masliah, Ann C. McKee, Marsel Mesulam, Bruce L. Miller, Carol A. Miller, Joshua W. Miller, Thomas J. Montine, John C. Morris, Jill R. Murrell, Adam C. Naj, John M. Olichney, Joseph E. Parisi, Elaine Peskind, Ronald C. Petersen, Aimee Pierce, Wayne W. Poon, Huntington Potter, Joseph F. Quinn, Ashok Raj, Murray Raskind, Eric M. Reiman, Barry Reisberg, Christiane Reitz, John M. Ringman, Erik D. Roberson, Howard J. Rosen, Roger N. Rosenberg, Mary Sano, Andrew J. Saykin, Julie A. Schneider, Lon S. Schneider, William W. Seeley, Amanda G. Smith, Joshua A. Sonnen, Salvatore Spina, Robert A. Stern, Rudolph E. Tanzi, John Q. Trojanowski, Juan C. Troncoso, Debby W. Tsuang, Otto Valladares, Vivianna M. Van Deerlin, Linda J. Van Eldik, Badri N. Vardarajan, Harry V. Vinters, Jean Paul Vonsattel, Li-San Wang, Sandra Weintraub, Kathleen A. Welsh-Bohmer, Jennifer Williamson, Randall L. Woltjer, Clinton B. Wright, Steven G. Younkin, Chang-En Yu, Lei Yu

Nat Genet. Author manuscript; available in PMC 2013 Jun 1.

Published in final edited form as: Nat Genet. 2012 Dec; 44(12): 1349–1354. Published online 2012 Nov 11. doi: 10.1038/ng.2466

PMCID:: PMC3510344

Abstract Article PDF–565K

Select item 160368518.

Trypsin-2 Degrades Human Type II Collagen and Is Expressed and Activated in Mesenchymally Transformed Rheumatoid Arthritis Synovitis Tissue

Mathias Stenman, Mari Ainola, Leena Valmu, Anders Bjartell, Guofeng Ma, Ulf-Håkan Stenman, Timo Sorsa, Reijo Luukkainen, Yrjö T. Konttinen

Am J Pathol. 2005 Oct; 167(4): 1119–1124. doi: 10.1016/S0002-9440(10)61200-X

PMCID:: PMC1603685

Abstract Article PDF–728K

Select item 382780219.

Microsatellite Scan Identifies New Candidate Genes for Susceptibility to Alcoholic Chronic Pancreatitis in Japanese Patients

Kei Kitahara, Shigeyuki Kawa, Yoshihiko Katsuyama, Takeji Umemura, Yayoi Ozaki, Mari Takayama, Norikazu Arakura, Masao Ota

Dis Markers. 2008; 25(3): 175–180. Published online 2008 Dec 16. doi: 10.1155/2008/426764

PMCID:: PMC3827802

Summary PDF–204K

Select item 274257420.

Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk

Robert R. McWilliams, William R. Bamlet, Mariza de Andrade, David N. Rider, Fergus J. Couch, Julie M. Cunningham, Martha E. Matsumoto, Kari G. Rabé, Traci J. Hammer, Gloria M. Petersen

Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2010 Sep 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2009 Sep; 18(9): 2549–2552. Published online 2009 Aug 18. doi: 10.1158/1055-9965.EPI-09-0605

PMCID:: PMC2742574

Abstract Article PDF–292K

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