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Items: 1 to 20 of 77

1.
Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes
Katherine Fodder, Megha Murthy, Patrizia Rizzu, Christina E. Toomey, Rahat Hasan, Jack Humphrey, Towfique Raj, Katie Lunnon, Jonathan Mill, Peter Heutink, Tammaryn Lashley, Conceição Bettencourt
Acta Neuropathol. 2023; 146(1): 77–95. Published online 2023 May 7. doi: 10.1007/s00401-023-02583-z
PMCID:
PMC10261190
AbstractArticlePDF–5.5M
2.
OTUD4 enhances TGFβ signalling through regulation of the TGFβ receptor complex
Patrick William Jaynes, Prasanna Vasudevan Iyengar, Sarah Kit Leng Lui, Tuan Zea Tan, Natali Vasilevski, Sarah Christine Elizabeth Wright, Giuseppe Verdile, Anand D. Jeyasekharan, Pieter Johan Adam Eichhorn
Sci Rep. 2020; 10: 15725. Published online 2020 Sep 24. doi: 10.1038/s41598-020-72791-0
PMCID:
PMC7519109
AbstractArticlePDF–2.3M
3.
HIV-1 promotor insertion revealed by selective detection of chimeric provirus-host gene transcripts.
I Raineri, H P Senn
Nucleic Acids Res. 1992 Dec 11; 20(23): 6261–6266. doi: 10.1093/nar/20.23.6261
PMCID:
PMC334514
SummaryPage BrowsePDF–1.2M
4.
OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway
Mingxin Ci, Gaichao Zhao, Chongyang Li, Ruochen Liu, Xiaosong Hu, Jun Pan, Yang Shen, Guanghui Zhang, Yongsen Li, Li Zhang, Ping Liang, Hongjuan Cui
Cell Death Dis. 2024 Mar; 15(3): 179. Published online 2024 Mar 1. doi: 10.1038/s41419-024-06569-x
PMCID:
PMC10907623
AbstractArticlePDF–5.3M
5.
OTUD4 is a phospho-activated K63 deubiquitinase that regulates MyD88-dependent signaling
Yu Zhao, Miranda C. Mudge, Jennifer M. Soll, Rachel B. Rodrigues, Andrea K. Byrum, Elizabeth A. Schwarzkopf, Tara R. Bradstreet, Steven P. Gygi, Brian T. Edelson, Nima Mosammaparast
Mol Cell. Author manuscript; available in PMC 2019 Oct 29.
Published in final edited form as: Mol Cell. 2018 Feb 1; 69(3): 505–516.e5. doi: 10.1016/j.molcel.2018.01.009
PMCID:
PMC6819006
AbstractArticlePDF–3.6M
6.
Ataxia, Dementia, and Hypogonadotropism Caused by Disordered Ubiquitination
David H. Margolin, Maria Kousi, Yee-Ming Chan, Elaine T. Lim, Jeremy D. Schmahmann, Marios Hadjivassiliou, Janet E. Hall, Ibrahim Adam, Andrew Dwyer, Lacey Plummer, Stephanie V. Aldrin, Julia O’Rourke, Andrew Kirby, Kasper Lage, Aubrey Milunsky, Jeff M. Milunsky, Jennifer Chan, E. Tessa Hedley-Whyte, Mark J. Daly, Nicholas Katsanis, Stephanie B. Seminara
N Engl J Med. Author manuscript; available in PMC 2013 Nov 23.
Published in final edited form as: N Engl J Med. 2013 May 23; 368(21): 1992–2003. Published online 2013 May 8. doi: 10.1056/NEJMoa1215993
PMCID:
PMC3738065
AbstractArticlePDF–3.4M
7.
SPOP and OTUD7A Control EWS–FLI1 Protein Stability to Govern Ewing Sarcoma Growth
Siyuan Su, Jianfeng Chen, Yao Jiang, Ying Wang, Tamara Vital, Jiaming Zhang, Christian Laggner, Kong T. Nguyen, Zhichuan Zhu, Alex W. Prevatte, Natalie K. Barker, Laura E. Herring, Ian J. Davis, Pengda Liu
Adv Sci (Weinh) 2021 Jul; 8(14): 2004846. Published online 2021 Jun 1. doi: 10.1002/advs.202004846
PMCID:
PMC8292909
AbstractArticlePDF–4.0M
8.
Regulation of Virus-triggered Signaling by OTUB1- and OTUB2-mediated Deubiquitination of TRAF3 and TRAF6
Shu Li, Hao Zheng, Ai-Ping Mao, Bo Zhong, Ying Li, Yu Liu, Yan Gao, Yong Ran, Po Tien, Hong-Bing Shu
J Biol Chem. 2010 Feb 12; 285(7): 4291–4297. Published online 2009 Dec 7. doi: 10.1074/jbc.M109.074971
PMCID:
PMC2836033
AbstractArticlePDF–3.3M
9.
Evolutionary Loss of Activity in De-Ubiquitylating Enzymes of the OTU Family
Marcell Louis, Kay Hofmann, Meike Broemer
PLoS One. 2015; 10(11): e0143227. Published online 2015 Nov 20. doi: 10.1371/journal.pone.0143227
PMCID:
PMC4654579
AbstractArticlePDF–2.8M
10.
OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis
Muping Di, Jingjing Miao, Qiuzhong Pan, Zonglong Wu, Boyu Chen, Muru Wang, Jingjing Zhao, Huageng Huang, Jiewen Bai, Qijing Wang, Yan Tang, Yongqiang Li, Jia He, Tong Xiang, Desheng Weng, Lin Wang, Jianchuan Xia, Chong Zhao
J Exp Clin Cancer Res. 2022; 41: 328. Published online 2022 Nov 21. doi: 10.1186/s13046-022-02533-9
PMCID:
PMC9677691
AbstractArticlePDF–20M
11.
The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis
Tongde Du, Hongchang Li, Yongsheng Fan, Lin Yuan, Xiaodan Guo, Qiong Zhu, Yuying Yao, Xin Li, Chunlei Liu, Xinhe Yu, Zhaofei Liu, Chun-Ping Cui, Chuanchun Han, Lingqiang Zhang
Nat Commun. 2019; 10: 2914. Published online 2019 Jul 2. doi: 10.1038/s41467-019-10824-7
PMCID:
PMC6606649
AbstractArticlePDF–4.7M
12.
Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS
Tianzi Liuyu, Keying Yu, Liya Ye, Zhidong Zhang, Man Zhang, Yujie Ren, Zeng Cai, Qiyun Zhu, Dandan Lin, Bo Zhong
Cell Res. 2019 Jan; 29(1): 67–79. Published online 2018 Nov 8. doi: 10.1038/s41422-018-0107-6
PMCID:
PMC6318273
AbstractArticlePDF–2.9M
13.
USP37 is a SNAI1 deubiquitinase
Zhenna Xiao, Liang Chang, Jongchan Kim, Peijing Zhang, Qinglei Hang, Shannon Yap, Youming Guo, Zhicheng Zhou, Liyong Zeng, Xiaoyu Hu, Ashley Siverly, Yutong Sun, Li Ma
Am J Cancer Res. 2019; 9(12): 2749–2759. Published online 2019 Dec 1.
PMCID:
PMC6943346
AbstractArticlePDF–1.2M
14.
TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation
Hannah Greenfeld, Kaoru Takasaki, Michael J. Walsh, Ina Ersing, Katharina Bernhardt, Yijie Ma, Bishi Fu, Camille W. Ashbaugh, Jackson Cabo, Sarah B. Mollo, Hufeng Zhou, Shitao Li, Benjamin E. Gewurz
PLoS Pathog. 2015 May; 11(5): e1004890. Published online 2015 May 21. doi: 10.1371/journal.ppat.1004890
PMCID:
PMC4440769
AbstractArticlePDF–5.7M
15.
OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis
Tycho E.T. Mevissen, Manuela K. Hospenthal, Paul P. Geurink, Paul R. Elliott, Masato Akutsu, Nadia Arnaudo, Reggy Ekkebus, Yogesh Kulathu, Tobias Wauer, Farid El Oualid, Stefan M.V. Freund, Huib Ovaa, David Komander
Cell. 2013 Jul 3; 154(1): 169–184. doi: 10.1016/j.cell.2013.05.046
PMCID:
PMC3705208
AbstractArticle
16.
Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase
Yu Zhao, Mona C Majid, Jennifer M Soll, Joshua R Brickner, Sebastian Dango, Nima Mosammaparast
EMBO J. 2015 Jun 12; 34(12): 1687–1703. Published online 2015 May 5. doi: 10.15252/embj.201490497
PMCID:
PMC4475402
AbstractArticlePDF–2.2M
17.
EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis
Wendy Béguelin, Matt Teater, Micah D. Gearhart, María Teresa Calvo Fernández, Rebecca L. Goldstein, Mariano G. Cárdenas, Katerina Hatzi, Monica Rosen, Hao Shen, Connie M. Corcoran, Michelle Y. Hamline, Randy D. Gascoyne, Ross L. Levine, Omar Abdel-Wahab, Jonathan D. Licht, Rita Shaknovich, Olivier Elemento, Vivian J. Bardwell, Ari M. Melnick
Cancer Cell. Author manuscript; available in PMC 2017 Aug 8.
Published in final edited form as: Cancer Cell. 2016 Aug 8; 30(2): 197–213. doi: 10.1016/j.ccell.2016.07.006
PMCID:
PMC5000552
AbstractArticlePDF–4.1M
18.
The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53
Chen Hu, Mu Zhang, Niko Moses, Cong-li Hu, Lisa Polin, Wei Chen, Hyejeong Jang, Joshua Heyza, Agnes Malysa, Joseph A. Caruso, Shengyan Xiang, Steve Patrick, Paul Stemmer, Zhenkun Lou, Wenlong Bai, Chuangui Wang, Gerold Bepler, Xiaohong Mary Zhang
Cell Death Dis. 2020 May; 11(5): 328. Published online 2020 May 7. doi: 10.1038/s41419-020-2519-8
PMCID:
PMC7206099
AbstractArticlePDF–2.1M
19.
C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways
David R. Amici, Daniel J. Ansel, Kyle A. Metz, Roger S. Smith, Claire M. Phoumyvong, Sitaram Gayatri, Tomasz Chamera, Stacey L. Edwards, Brendan P. O’Hara, Shashank Srivastava, Sonia Brockway, Seesha R. Takagishi, Byoung-Kyu Cho, Young Ah Goo, Neil L. Kelleher, Issam Ben-Sahra, Daniel R. Foltz, Jian Li, Marc L. Mendillo
Proc Natl Acad Sci U S A. 2022 Jul 5; 119(27): e2111262119. Published online 2022 Jul 1. doi: 10.1073/pnas.2111262119
PMCID:
PMC9271168
AbstractArticlePDF–2.6M
20.
Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability
Dominika Kwasna, Syed Arif Abdul Rehman, Jayaprakash Natarajan, Stephen Matthews, Ross Madden, Virginia De Cesare, Simone Weidlich, Satpal Virdee, Ivan Ahel, Ian Gibbs-Seymour, Yogesh Kulathu
Mol Cell. 2018 Apr 5; 70(1): 150–164.e6. doi: 10.1016/j.molcel.2018.02.023
PMCID:
PMC5896202
AbstractArticle

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