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Select item 83466601.

Neutrophils require SKAP2 for reactive oxygen species production following C-type lectin and Candida stimulation

Giang T. Nguyen, Shuying Xu, Walter Adams, John M. Leong, Stephen C. Bunnell, Michael K. Mansour, David B. Sykes, Joan Mecsas

iScience. 2021 Aug 20; 24(8): 102871. Published online 2021 Jul 16. doi: 10.1016/j.isci.2021.102871

PMCID:: PMC8346660

Abstract Article PDF–5.9M

Select item 57884782.

SKAP2 regulates Arp2/3 complex for actin-mediated asymmetric cytokinesis by interacting with WAVE2 in mouse oocytes

Shu-Wen He, Bai-Hui Xu, Yu Liu, Ya-Long Wang, Ming-Huang Chen, Lin Xu, Bao-Qiong Liao, Rui Lui, Fei-Ping Li, Yan-Hong Lin, Xian-Pei Fu, Bin-Bin Fu, Zi-Wei Hong, Yu-Xin Liu, Zhong-Quan Qi, Hai-Long Wang

Cell Cycle. 2017; 16(23): 2272–2281. Published online 2017 Nov 9. doi: 10.1080/15384101.2017.1380126

PMCID:: PMC5788478

Abstract Article PDF–483K

Select item 26285933.

The Skap-hom Dimerization and PH Domains Comprise a 3′-Phosphoinositide-Gated Molecular Switch

Kenneth D. Swanson, Yong Tang, Derek F. Ceccarelli, Florence Poy, Jan P. Sliwa, Benjamin G. Neel, Michael J. Eck

Mol Cell. Author manuscript; available in PMC 2009 Nov 21.

Published in final edited form as: Mol Cell. 2008 Nov 21; 32(4): 564–575. doi: 10.1016/j.molcel.2008.09.022

PMCID:: PMC2628593

Abstract Article PDF–3.7M

Select item 12343254.

Regulation of In Vitro and In Vivo Immune Functions by the Cytosolic Adaptor Protein SKAP-HOM

M. Togni, K. D. Swanson, S. Reimann, S. Kliche, A. C. Pearce, L. Simeoni, D. Reinhold, J. Wienands, B. G. Neel, B. Schraven, A. Gerber

Mol Cell Biol. 2005 Sep; 25(18): 8052–8063. doi: 10.1128/MCB.25.18.8052-8063.2005

PMCID:: PMC1234325

Abstract Article PDF–386K

Select item 72505675.

SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst

Giang T Nguyen, Lamyaa Shaban, Matthias Mack, Kenneth D Swanson, Stephen C Bunnell, David B Sykes, Joan Mecsas

eLife. 2020; 9: e56656. Published online 2020 Apr 30. doi: 10.7554/eLife.56656

PMCID:: PMC7250567

Abstract Article PDF–3.9M

Select item 72418466.

Yersinia pseudotuberculosis YopH targets SKAP2-dependent and independent signaling pathways to block neutrophil antimicrobial mechanisms during infection

Lamyaa Shaban, Giang T. Nguyen, Benjamin D. Mecsas-Faxon, Kenneth D. Swanson, Shumin Tan, Joan Mecsas

PLoS Pathog. 2020 May; 16(5): e1008576. Published online 2020 May 11. doi: 10.1371/journal.ppat.1008576

PMCID:: PMC7241846

Abstract Article PDF–2.7M

Select item 53396707.

Skap2 is required for β₂ integrin–mediated neutrophil recruitment and functions

Mark Boras, Stephanie Volmering, Arne Bokemeyer, Jan Rossaint, Helena Block, Bernadette Bardel, Veerle Van Marck, Barbara Heitplatz, Stefanie Kliche, Annegret Reinhold, Clifford Lowell, Alexander Zarbock

J Exp Med. 2017 Mar 6; 214(3): 851–874. doi: 10.1084/jem.20160647

PMCID:: PMC5339670

Abstract Article PDF–3.4M

Select item 39226678.

SKAP2, a novel target of HSF4b, associates with NCK2/F-actin at membrane ruffles and regulates actin reorganization in lens cell

Li Zhou, Zhenguo Zhang, Yufang Zheng, Yufei Zhu, Zejun Wei, Heng Xu, Quan Tang, Xiangyin Kong, Landian Hu

J Cell Mol Med. 2011 Apr; 15(4): 783–795. Published online 2010 Mar 9. doi: 10.1111/j.1582-4934.2010.01048.x

PMCID:: PMC3922667

Abstract Article PDF–1.3M

Select item 37726319.

MULTI-STAGE T CELL-DENDRITIC CELL INTERACTIONS CONTROL OPTIMAL CD4 T CELL ACTIVATION THROUGH THE ADAP-SKAP55 SIGNALING MODULE

Jason S. Mitchell, Brandon J. Burbach, Rupa Srivastava, Brian T. Fife, Yoji Shimizu

J Immunol. Author manuscript; available in PMC 2014 Sep 1.

Published in final edited form as: J Immunol. 2013 Sep 1; 191(5): 2372–2383. Published online 2013 Aug 5. doi: 10.4049/jimmunol.1300107

PMCID:: PMC3772631

Abstract Article PDF–4.0M

Select item 376478110.

Regulation of the Src Kinase-associated Phosphoprotein 55 Homologue by the Protein Tyrosine Phosphatase PTP-PEST in the Control of Cell Motility

Emily Ayoub, Anita Hall, Adam M. Scott, Mélanie J. Chagnon, Géraldine Miquel, Maxime Hallé, Masaharu Noda, Andreas Bikfalvi, Michel L. Tremblay

J Biol Chem. 2013 Sep 6; 288(36): 25739–25748. Published online 2013 Jul 29. doi: 10.1074/jbc.M113.501007

PMCID:: PMC3764781

Abstract Article PDF–1.7M

Select item 356186111.

Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement

Francis J. Alenghat, Quentin J. Baca, Nooreen T. Rubin, Lily I. Pao, Takashi Matozaki, Clifford A. Lowell, David E. Golan, Benjamin G. Neel, Kenneth D. Swanson

J Cell Sci. 2012 Nov 15; 125(22): 5535–5545. doi: 10.1242/jcs.111260

PMCID:: PMC3561861

Abstract Article

Select item 284401912.

Role for ADAP in shear flow–induced platelet mechanotransduction

Ana Kasirer-Friede, Zaverio M. Ruggeri, Sanford J. Shattil

Blood. 2010 Mar 18; 115(11): 2274–2282. Prepublished online 2009 Dec 7. doi: 10.1182/blood-2009-08-238238

PMCID:: PMC2844019

Abstract Article

Select item 316241213.

Substrate Specificity of Lymphoid-specific Tyrosine Phosphatase (Lyp) and Identification of Src Kinase-associated Protein of 55 kDa Homolog (SKAP-HOM) as a Lyp Substrate

Xiao Yu, Ming Chen, Sheng Zhang, Zhi-Hong Yu, Jin-Peng Sun, Lina Wang, Sijiu Liu, Tsuyoshi Imasaki, Yuichiro Takagi, Zhong-Yin Zhang

J Biol Chem. 2011 Sep 2; 286(35): 30526–30534. Published online 2011 Jun 30. doi: 10.1074/jbc.M111.254722

PMCID:: PMC3162412

Abstract Article PDF–2.0M

Select item 159288414.

The ADAP/SKAP55 Signaling Module Regulates T-Cell Receptor-Mediated Integrin Activation through Plasma Membrane Targeting of Rap1

Stefanie Kliche, Dennis Breitling, Mauro Togni, Rico Pusch, Katja Heuer, Xiaoqian Wang, Christian Freund, Ana Kasirer-Friede, Gael Menasche, Gary A. Koretzky, Burkhart Schraven

Mol Cell Biol. 2006 Oct; 26(19): 7130–7144. doi: 10.1128/MCB.00331-06

PMCID:: PMC1592884

Abstract Article PDF–922K

Select item 190001815.

RIAM Links the ADAP/SKAP-55 Signaling Module to Rap1, Facilitating T-Cell-Receptor-Mediated Integrin Activation

Gaël Ménasché, Stefanie Kliche, Emily J. H. Chen, Theresia E. B. Stradal, Burkhart Schraven, Gary Koretzky

Mol Cell Biol. 2007 Jun; 27(11): 4070–4081. Published online 2007 Apr 2. doi: 10.1128/MCB.02011-06

PMCID:: PMC1900018

Abstract Article PDF–579K

Select item 219338516.

The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain

Henning Kirchgessner, Jes Dietrich, Jeanette Scherer, Pia Isomäki, Vladimir Korinek, Ivan Hilgert, Eddy Bruyns, Albrecht Leo, Andrew P. Cope, Burkhart Schraven

J Exp Med. 2001 Jun 4; 193(11): 1269–1284. doi: 10.1084/jem.193.11.1269

PMCID:: PMC2193385

Abstract Article PDF–890K

Select item 948197517.

Understanding the development of oral epithelial organs through single cell transcriptomic analysis

Qianlin Ye, Arshia Bhojwani, Jimmy K. Hu

Development. 2022 Aug 15; 149(16): dev200539. Published online 2022 Aug 17. doi: 10.1242/dev.200539

PMCID:: PMC9481975

Abstract Article

Select item 741599118.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 831323919.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 18788520.

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome

Jens Hansen, Thomas Floss, Petra Van Sloun, Ernst-Martin Füchtbauer, Franz Vauti, Hans-Hennig Arnold, Frank Schnütgen, Wolfgang Wurst, Harald von Melchner, Patricia Ruiz

Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17): 9918–9922. Published online 2003 Aug 6. doi: 10.1073/pnas.1633296100