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Select item 108261641.

Actin-binding protein profilin1 is an important determinant of cellular phosphoinositide control

Morgan M.C. Ricci, Andrew Orenberg, Lee Ohayon, David Gau, Rachel C. Wills, Yongho Bae, Tuhin Das, David Koes, Gerald R.V. Hammond, Partha Roy

J Biol Chem. 2024 Jan; 300(1): 105583. Published online 2023 Dec 21. doi: 10.1016/j.jbc.2023.105583

PMCID:: PMC10826164

Abstract Article PDF–3.6M

Select item 92493922.

Visualizing molecules of functional human profilin

Morgan L Pimm, Xinbei Liu, Farzana Tuli, Jennifer Heritz, Ashley Lojko, Jessica L Henty-Ridilla

eLife. 2022; 11: e76485. Published online 2022 Jun 6. doi: 10.7554/eLife.76485

PMCID:: PMC9249392

Abstract Article PDF–13M

Select item 82422473.

Upregulated Expression of Profilin1 on Dendritic Cells in Patients With Severe Aplastic Anemia

Hong Yu, Yang Zhao, Xiaofeng Pan, Chunyan Liu, Rong Fu

Front Immunol. 2021; 12: 631954. Published online 2021 Jun 16. doi: 10.3389/fimmu.2021.631954

PMCID:: PMC8242247

Abstract Article PDF–1.9M

Select item 82018304.

ALS-linked PFN1 variants exhibit loss and gain of functions in the context of formin-induced actin polymerization

Eric J. Schmidt, Salome Funes, Jeanne E. McKeon, Brittany R. Morgan, Sivakumar Boopathy, Lauren C. O’Connor, Osman Bilsel, Francesca Massi, Antoine Jégou, Daryl A. Bosco

Proc Natl Acad Sci U S A. 2021 Jun 8; 118(23): e2024605118. Published online 2021 May 31. doi: 10.1073/pnas.2024605118

PMCID:: PMC8201830

Abstract Article PDF–1.4M

Select item 78658105.

Profilin 1 and Mitochondria—Partners in the Pathogenesis of Coronary Artery Disease?

Elżbieta Paszek, Wojciech Zajdel, Tomasz Rajs, Krzysztof Żmudka, Jacek Legutko, Paweł Kleczyński

Int J Mol Sci. 2021 Feb; 22(3): 1100. Published online 2021 Jan 22. doi: 10.3390/ijms22031100

PMCID:: PMC7865810

Abstract Article PDF–761K

Select item 76679596.

Actin-binding protein profilin1 promotes aggressiveness of clear-cell renal cell carcinoma cells

Abigail Allen, David Gau, Paul Francoeur, Jordan Sturm, Yue Wang, Ryan Martin, Jodi Maranchie, Anette Duensing, Adam Kaczorowski, Stefan Duensing, Lily Wu, Michael T. Lotze, David Koes, Walter J. Storkus, Partha Roy

J Biol Chem. 2020 Nov 13; 295(46): 15636–15649. Published online 2020 Sep 3. doi: 10.1074/jbc.RA120.013963

PMCID:: PMC7667959

Abstract Article PDF–2.4M

Select item 69777847.

A Familial Phenotypic and Genetic Study of Mutations in PFN1 Associated with Amyotrophic Lateral Sclerosis

Jieshan Chi, Junling Chen, Yan Li, Zhiheng Huang, Lijuan Wang, Yuhu Zhang

Neurosci Bull. 2020 Feb; 36(2): 174–178. Published online 2019 Dec 4. doi: 10.1007/s12264-019-00448-8

PMCID:: PMC6977784

Article PDF–404K

Select item 68949848.

Profilin-mediated actin allocation regulates the growth of epithelial microvilli

James J. Faust, Bryan A. Millis, Matthew J. Tyska

Curr Biol. Author manuscript; available in PMC 2020 Oct 21.

Published in final edited form as: Curr Biol. 2019 Oct 21; 29(20): 3457–3465.e3. Published online 2019 Oct 10. doi: 10.1016/j.cub.2019.08.051

PMCID:: PMC6894984

Abstract Article PDF–1.8M

Select item 67071929.

Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis

Anthony Giampetruzzi, Eric W. Danielson, Valentina Gumina, Maryangel Jeon, Sivakumar Boopathy, Robert H. Brown, Antonia Ratti, John E. Landers, Claudia Fallini

Nat Commun. 2019; 10: 3827. Published online 2019 Aug 23. doi: 10.1038/s41467-019-11837-y

PMCID:: PMC6707192

Abstract Article PDF–8.0M

Select item 659172510.

A novel phosphorylation site mutation in profilin 1 revealed in a large screen of US, Nordic, and German amyotrophic lateral sclerosis/frontotemporal dementia cohorts

Caroline Ingre, John E. Landers, Naji Rizik, Alexander E. Volk, Chizuru Akimoto, Anna Birve, Annemarie Hübers, Pamela J. Keagle, Katarzyna Piotrowska, Rayomand Press, Peter Munch Andersen, Albert C. Ludolph, Jochen H. Weishaupt

Neurobiol Aging. Author manuscript; available in PMC 2019 Jun 25.

Published in final edited form as: Neurobiol Aging. 2013 Jun; 34(6): 1708.e1–1708.e6. Published online 2012 Nov 8. doi: 10.1016/j.neurobiolaging.2012.10.009

PMCID:: PMC6591725

Abstract Article PDF–250K

Select item 658399811.

In silico analysis of PFN1 related to amyotrophic lateral sclerosis

Gabriel Rodrigues Coutinho Pereira, Giovanni Henrique Almeida Silva Tellini, Joelma Freire De Mesquita

PLoS One. 2019; 14(6): e0215723. Published online 2019 Jun 19. doi: 10.1371/journal.pone.0215723

PMCID:: PMC6583998

Abstract Article PDF–3.4M

Select item 623049312.

Changes in Biophysical Characteristics of PFN1 Due to Mutation Causing Amyotrophic Lateral Sclerosis

Mina Nekouei, Parviz Ghezellou, Atousa Aliahmadi, Sareh Arjmand, Mahmoud Kiaei, Alireza Ghassempour

Metab Brain Dis. Author manuscript; available in PMC 2019 Dec 1.

Published in final edited form as: Metab Brain Dis. 2018 Dec; 33(6): 1975–1984. Published online 2018 Sep 10. doi: 10.1007/s11011-018-0305-4

PMCID:: PMC6230493

Abstract Article PDF–786K

Select item 611725513.

ALS-causing mutations in profilin-1 alter its conformational dynamics: A computational approach to explain propensity for aggregation

Mahmoud Kiaei, Meenakshisundaram Balasubramaniam, Vivek Govind Kumar, Robert J. Shmookler Reis, Mahmoud Moradi, Kottayil I. Varughese

Sci Rep. 2018; 8: 13102. Published online 2018 Aug 30. doi: 10.1038/s41598-018-31199-7

PMCID:: PMC6117255

Abstract Article PDF–1.8M

Select item 602896914.

Stability of an aggregation-prone partially folded state of human profilin-1 correlates with aggregation propensity

Edoardo Del Poggetto, Angelo Toto, Chiara Aloise, Francesco Di Piro, Ludovica Gori, Francesco Malatesta, Stefano Gianni, Fabrizio Chiti, Francesco Bemporad

J Biol Chem. 2018 Jun 29; 293(26): 10303–10313. Published online 2018 May 14. doi: 10.1074/jbc.RA118.002087

PMCID:: PMC6028969

Abstract Article PDF–1.6M

Select item 578841915.

A balanced level of profilin-1 promotes stemness and tumor-initiating potential of breast cancer cells

Chang Jiang, Zhijie Ding, Marion Joy, Souvik Chakraborty, Su Hyeong Kim, Ralph Bottcher, John Condeelis, Shivendra Singh, Partha Roy

Cell Cycle. 2017; 16(24): 2366–2373. Published online 2017 Jul 12. doi: 10.1080/15384101.2017.1346759

PMCID:: PMC5788419

Abstract Article PDF–785K

Select item 542214016.

A Loss of Profilin-1 in Late Stage Oral Squamous Cell Carcinoma

Guy R. Adami, Thomas N. O’Callaghan, Kolokythas Antonia, Robert. J. Cabay, Yalu Zhou, Joel L. Schwartz

J Oral Pathol Med. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: J Oral Pathol Med. 2017 Aug; 46(7): 489–495. Published online 2016 Dec 18. doi: 10.1111/jop.12523

PMCID:: PMC5422140

Abstract Article PDF–1.1M

Select item 534258717.

Silencing of Profilin-1 suppresses cell adhesion and tumor growth via predicted alterations in integrin and Ca²⁺ signaling in T24M-based bladder cancer models

Maria Frantzi, Zoi Klimou, Manousos Makridakis, Jerome Zoidakis, Agnieszka Latosinska, Daniel M. Borràs, Bart Janssen, Ioanna Giannopoulou, Vasiliki Lygirou, Andreas C. Lazaris, Nicholas P. Anagnou, Harald Mischak, Maria G. Roubelakis, Antonia Vlahou

Oncotarget. 2016 Oct 25; 7(43): 70750–70768. Published online 2016 Sep 23. doi: 10.18632/oncotarget.12218

PMCID:: PMC5342587

Abstract Article PDF–6.2M

Select item 531102218.

Profilin1 biology and its mutation, actin(g) in disease

Duah Alkam, Ezra Z. Feldman, Awantika Singh, Mahmoud Kiaei

Cell Mol Life Sci. 2017 Mar; 74(6): 967–981. Published online 2016 Sep 26. doi: 10.1007/s00018-016-2372-1

PMCID:: PMC5311022

Abstract Article PDF–1.3M

Select item 530294219.

Guttiferone K suppresses cell motility and metastasis of hepatocellular carcinoma by restoring aberrantly reduced profilin 1

Kaikai Shen, Zhichao Xi, Jianling Xie, Hua Wang, Chanlu Xie, C.Soon Lee, Paul Fahey, Qihan Dong, Hongxi Xu

Oncotarget. 2016 Aug 30; 7(35): 56650–56663. Published online 2016 Aug 1. doi: 10.18632/oncotarget.10992

PMCID:: PMC5302942

Abstract Article PDF–14M

Select item 506828520.

Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity

Chunxing Yang, Eric W. Danielson, Tao Qiao, Jake Metterville, Robert H. Brown, Jr., John E. Landers, Zuoshang Xu

Proc Natl Acad Sci U S A. 2016 Oct 11; 113(41): E6209–E6218. Published online 2016 Sep 28. doi: 10.1073/pnas.1605964113

PMCID:: PMC5068285

Abstract Article PDF–2.5M

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