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Select item 87602781.

Structure and function of a family of tick-derived complement inhibitors targeting properdin

Katharina Braunger, Jiyoon Ahn, Matthijs M. Jore, Steven Johnson, Terence T. L. Tang, Dennis V. Pedersen, Gregers R. Andersen, Susan M. Lea

Nat Commun. 2022; 13: 317. Published online 2022 Jan 14. doi: 10.1038/s41467-021-27920-2

PMCID:: PMC8760278

Abstract Article PDF–2.4M

Select item 79095142.

Properdin Is a Modulator of Tumour Immunity in a Syngeneic Mouse Melanoma Model

Izzat A. M. Al-Rayahi, Lee R. Machado, Cordula M. Stover

Medicina (Kaunas) 2021 Feb; 57(2): 85. Published online 2021 Jan 21. doi: 10.3390/medicina57020085

PMCID:: PMC7909514

Abstract Article PDF–816K

Select item 76833873.

The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa

Adriana Patricia Granados Martinez, Patrícia Antonia Estima Abreu, Silvio de Arruda Vasconcellos, Paulo Lee Ho, Viviana P. Ferreira, Gurpanna Saggu, Angela Silva Barbosa, Lourdes Isaac

Front Immunol. 2020; 11: 572562. Published online 2020 Nov 10. doi: 10.3389/fimmu.2020.572562

PMCID:: PMC7683387

Abstract Article PDF–822K

Select item 73874114.

Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation

Jin Y. Chen, Neeti S. Galwankar, Heather N. Emch, Smrithi S. Menon, Claudio Cortes, Joshua M. Thurman, Samuel A. Merrill, Robert A. Brodsky, Viviana P. Ferreira

Front Immunol. 2020; 11: 1460. Published online 2020 Jul 22. doi: 10.3389/fimmu.2020.01460

PMCID:: PMC7387411

Abstract Article PDF–2.3M

Select item 53911385.

Functional and structural insight into properdin control of complement alternative pathway amplification

Dennis V Pedersen, Lubka Roumenina, Rasmus K Jensen, Trine AF Gadeberg, Chiara Marinozzi, Capucine Picard, Tania Rybkine, Steffen Thiel, Uffe BS Sørensen, Cordula Stover, Veronique Fremeaux‐Bacchi, Gregers R Andersen

EMBO J. 2017 Apr 13; 36(8): 1084–1099. Published online 2017 Mar 6. doi: 10.15252/embj.201696173

PMCID:: PMC5391138

Abstract Article PDF–4.4M

Select item 52784936.

Properdin binding to complement activating surfaces depends on initial C3b deposition

Morten Harboe, Christina Johnson, Stig Nymo, Karin Ekholt, Camilla Schjalm, Julie K. Lindstad, Anne Pharo, Bernt Christian Hellerud, Kristina Nilsson Ekdahl, Tom Eirik Mollnes, Per H. Nilsson

Proc Natl Acad Sci U S A. 2017 Jan 24; 114(4): E534–E539. Published online 2017 Jan 9. doi: 10.1073/pnas.1612385114

PMCID:: PMC5278493

Abstract Article PDF–913K

Select item 37843237.

Identification of a novel mode of complement activation on stimulated platelets mediated by properdin and C3(H₂O)

Gurpanna Saggu, Claudio Cortes, Heather N. Emch, Galia Ramirez, Randall G. Worth, Viviana P. Ferreira

J Immunol. Author manuscript; available in PMC 2014 Jun 15.

Published in final edited form as: J Immunol. 2013 Jun 15; 190(12): 6457–6467. Published online 2013 May 15. doi: 10.4049/jimmunol.1300610

PMCID:: PMC3784323

Abstract Article PDF–2.6M

Select item 34243438.

The Role of Properdin in Zymosan- and Escherichia coli-Induced Complement Activation

Morten Harboe, Peter Garred, Julie K. Lindstad, Anne Pharo, Fredrik Müller, Gregory L. Stahl, John D. Lambris, Tom Eirik Mollnes

J Immunol. Author manuscript; available in PMC 2013 Sep 1.

Published in final edited form as: J Immunol. 2012 Sep 1; 189(5): 2606–2613. Published online 2012 Jul 30. doi: 10.4049/jimmunol.1200269

PMCID:: PMC3424343

Abstract Article PDF–1.1M

Select item 33082679.

Elevated Properdin and Enhanced Complement Activation in First-Degree Relatives of South Asian Subjects With Type 2 Diabetes

Riyaz Somani, Victoria R. Richardson, Kristina F. Standeven, Peter J. Grant, Angela M. Carter

Diabetes Care. 2012 Apr; 35(4): 894–899. Published online 2012 Mar 13. doi: 10.2337/dc11-1483

PMCID:: PMC3308267

Abstract Article PDF–580K

Select item 330648910.

A novel mutation W388X underlying properdin deficiency in a Finnish family

Merja Helminen, Sanna Seitsonen, Hanna Jarva, Seppo Meri, Irma E Järvelä

Scand J Immunol. Author manuscript; available in PMC 2013 Apr 1.

Published in final edited form as: Scand J Immunol. 2012 Apr; 75(4): 445–448. doi: 10.1111/j.1365-3083.2012.02674.x

PMCID:: PMC3306489

Abstract Article PDF–159K

Select item 294945011.

Native Polymeric Forms of Properdin Selectively Bind to Targets and Promote Activation of the Alternative Pathway of Complement

Viviana P. Ferreira, Claudio Cortes, Michael K. Pangburn

Immunobiology. Author manuscript; available in PMC 2011 Nov 1.

Published in final edited form as: Immunobiology. 2010 Nov; 215(11): 932–940. Published online 2010 Feb 12. doi: 10.1016/j.imbio.2010.02.002

PMCID:: PMC2949450

Abstract Article PDF–936K

Select item 293379012.

An evaluation of the role of properdin in alternative pathway activation on Neisseria meningitidis and Neisseria gonorrhoeae

Sarika Agarwal, Viviana P. Ferreira, Claudio Cortes, Michael K. Pangburn, Peter A. Rice, Sanjay Ram

J Immunol. Author manuscript; available in PMC 2011 Jul 1.

Published in final edited form as: J Immunol. 2010 Jul 1; 185(1): 507–516. Published online 2010 Jun 7. doi: 10.4049/jimmunol.0903598

PMCID:: PMC2933790

Abstract Article PDF–2.1M

Select item 244935813.

The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis

Claudia Kemper, Lynne M. Mitchell, Lijuan Zhang, Dennis E. Hourcade

Proc Natl Acad Sci U S A. 2008 Jul 1; 105(26): 9023–9028. Published online 2008 Jun 25. doi: 10.1073/pnas.0801015105

PMCID:: PMC2449358

Abstract Article PDF–1.0M

Select item 153669514.

Properdin deficiency in a family with fulminant meningococcal infections.

A G Sjöholm, J H Braconier, C Söderström

Clin Exp Immunol. 1982 Nov; 50(2): 291–297.

PMCID:: PMC1536695

Summary Page Browse PDF–761K

Select item 113315715.

Characterization of the human properdin gene.

K F Nolan, S Kaluz, J M Higgins, D Goundis, K B Reid

Biochem J. 1992 Oct 1; 287(Pt 1): 291–297. doi: 10.1042/bj2870291

PMCID:: PMC1133157

Summary Page Browse PDF–1.6M

Select item 751123316.

Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement

Jie Zhang, Lihong Song, Dennis V Pedersen, Anna Li, John D Lambris, Gregers Rom Andersen, Tom Eirik Mollnes, Ying Jie Ma, Peter Garred

eLife. 2020; 9: e60908. Published online 2020 Sep 10. doi: 10.7554/eLife.60908

PMCID:: PMC7511233

Abstract Article PDF–2.5M

Select item 674150017.

Myeloperoxidase Directs Properdin-Mediated Complement Activation

Joseph O'Flynn, Karen O. Dixon, Maria C. Faber Krol, Mohamed R. Daha, Cees van Kooten

J Innate Immun. 2014 Jun; 6(4): 417–425. Published online 2013 Dec 20. doi: 10.1159/000356980

PMCID:: PMC6741500

Abstract Article PDF–187K

Select item 536336218.

Properdin and factor H production by human dendritic cells modulates their T‐cell stimulatory capacity and is regulated by IFN‐γ

Karen O. Dixon, Joseph O'Flynn, Ngaisah Klar‐Mohamad, Mohamed R. Daha, Cees van Kooten

Eur J Immunol. 2017 Mar; 47(3): 470–480. Published online 2017 Mar 13. doi: 10.1002/eji.201646703

PMCID:: PMC5363362

Abstract Article PDF–1.7M

Select item 523412019.

Sven Micklisch, Yuchen Lin, Saskia Jacob, Marcus Karlstetter, Katharina Dannhausen, Prasad Dasari, Monika von der Heide, Hans-Martin Dahse, Lisa Schmölz, Felix Grassmann, Medhanie Alene, Sascha Fauser, Harald Neumann, Stefan Lorkowski, Diana Pauly, Bernhard H. Weber, Antonia M. Joussen, Thomas Langmann, Peter F. Zipfel, Christine Skerka

J Neuroinflammation. 2017; 14: 4. Published online 2017 Jan 5. doi: 10.1186/s12974-016-0776-3

PMCID:: PMC5234120

Abstract Article PDF–2.9M

Select item 488877420.

Properdin-mediated C5a production enhances stable binding of platelets to granulocytes in human whole blood

Adam Z. Blatt, Gurpanna Saggu, Koustubh V. Kulkarni, Claudio Cortes, Joshua M. Thurman, Daniel Ricklin, John D. Lambris, Jesus G. Valenzuela, Viviana P. Ferreira

J Immunol. Author manuscript; available in PMC 2017 Jun 1.

Published in final edited form as: J Immunol. 2016 Jun 1; 196(11): 4671–4680. Published online 2016 Apr 25. doi: 10.4049/jimmunol.1600040