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Select item 85866791.

PDK2 leads to cisplatin resistance through suppression of mitochondrial function in ovarian clear cell carcinoma

Sachiko Kitamura, Ken Yamaguchi, Ryusuke Murakami, Yoko Furutake, Koichiro Higasa, Kaoru Abiko, Junzo Hamanishi, Tsukasa Baba, Noriomi Matsumura, Masaki Mandai

Cancer Sci. 2021 Nov; 112(11): 4627–4640. Published online 2021 Sep 13. doi: 10.1111/cas.15125

PMCID:: PMC8586679

Abstract Article PDF–2.6M

Select item 21476632.

Structure of Pyruvate Dehydrogenase Kinase: NOVEL FOLDING PATTERN FOR A SERINE PROTEIN KINASE

C. Nicklaus Steussy, Kirill M. Popov, Melissa M. Bowker-Kinley, Robert B. Sloan, Jr., Robert A. Harris, Jean A. Hamilton

J Biol Chem. Author manuscript; available in PMC 2007 Dec 19.

Published in final edited form as: J Biol Chem. 2001 Oct 5; 276(40): 37443–37450. Published online 2001 Aug 1. doi: 10.1074/jbc.M104285200

PMCID:: PMC2147663

Abstract Article PDF–2.0M

Select item 16651093.

Effects of aerobic training on pyruvate dehydrogenase and pyruvate dehydrogenase kinase in human skeletal muscle

Paul J LeBlanc, Sandra J Peters, Rebecca J Tunstall, David Cameron-Smith, George J F Heigenhauser

J Physiol. 2004 Jun 1; 557(Pt 2): 559–570. Published online 2004 Mar 12. doi: 10.1113/jphysiol.2003.058263

PMCID:: PMC1665109

Abstract Article PDF–280K

Select item 11349424.

Role of protein–protein interactions in the regulation of pyruvate dehydrogenase kinase activity

Alina Tuganova, Kirill M. Popov

Biochem J. 2005 Apr 1; 387(Pt 1): 147–153. Prepublished online 2004 Oct 26. Published online 2005 Mar 22. doi: 10.1042/BJ20040805

PMCID:: PMC1134942

Abstract Article PDF–404K

Select item 59387015.

MiR-422a regulates cellular metabolism and malignancy by targeting pyruvate dehydrogenase kinase 2 in gastric cancer

Zhongyuan He, Zheng Li, Xuan Zhang, Kai Yin, Weizhi Wang, Zhipeng Xu, Bowen Li, Lei Zhang, Jianghao Xu, Guangli Sun, Lu Wang, Qing Li, Xiaoxu Huang, Lu Zhang, Diancai Zhang, Hao Xu, Zekuan Xu

Cell Death Dis. 2018 May; 9(5): 505. Published online 2018 May 2. doi: 10.1038/s41419-018-0564-3

PMCID:: PMC5938701

Abstract Article PDF–5.6M

Select item 45867426.

PDK2-mediated alternative splicing switches Bnip3 from cell death to cell survival

Hongying Gang, Rimpy Dhingra, Junjun Lin, Yan Hai, Yaron Aviv, Victoria Margulets, Mohammad Hamedani, Thatchawan Thanasupawat, Etienne Leygue, Thomas Klonisch, James R. Davie, Lorrie A. Kirshenbaum

J Cell Biol. 2015 Sep 28; 210(7): 1101–1115. doi: 10.1083/jcb.201504047

PMCID:: PMC4586742

Abstract Article PDF–19M

Select item 39243057.

Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket

Shih-Chia Tso, Xiangbing Qi, Wen-Jun Gui, Cheng-Yang Wu, Jacinta L. Chuang, Ingrid Wernstedt-Asterholm, Lorraine K. Morlock, Kyle R. Owens, Philipp E. Scherer, Noelle S. Williams, Uttam K. Tambar, R. Max Wynn, David T. Chuang

J Biol Chem. 2014 Feb 14; 289(7): 4432–4443. Published online 2013 Dec 19. doi: 10.1074/jbc.M113.533885

PMCID:: PMC3924305

Abstract Article PDF–2.8M

Select item 34717528.

Inactivation of Pyruvate Dehydrogenase Kinase 2 by Mitochondrial Reactive Oxygen Species

Thomas R. Hurd, Yvonne Collins, Irina Abakumova, Edward T. Chouchani, Bartlomiej Baranowski, Ian M. Fearnley, Tracy A. Prime, Michael P. Murphy, Andrew M. James

J Biol Chem. 2012 Oct 12; 287(42): 35153–35160. Published online 2012 Aug 21. doi: 10.1074/jbc.M112.400002

PMCID:: PMC3471752

Abstract Article PDF–1.1M

Select item 30237709.

Chronic CSE Treatment Induces the Growth of Normal Oral Keratinocytes via PDK2 Upregulation, Increased Glycolysis and HIF1α Stabilization

Wenyue Sun, Steven S. Chang, Yumei Fu, Yan Liu, Joseph A. Califano

PLoS One. 2011; 6(1): e16207. Published online 2011 Jan 19. doi: 10.1371/journal.pone.0016207

PMCID:: PMC3023770

Abstract Article PDF–526K

Select item 279721310.

Pivotal Role of the C-terminal DW-motif in Mediating Inhibition of Pyruvate Dehydrogenase Kinase 2 by Dichloroacetate

Jun Li, Masato Kato, David T. Chuang

J Biol Chem. 2009 Dec 4; 284(49): 34458–34467. Published online 2009 Oct 15. doi: 10.1074/jbc.M109.065557

PMCID:: PMC2797213

Abstract Article PDF–2.4M

Select item 272912611.

Mitochondrial mutations contribute to HIF1α accumulation via increased reactive oxygen species and upregulated PDK2 in head and neck squamous cell carcinoma

Wenyue Sun, Shaoyu Zhou, Steven S. Chang, Thomas McFate, Ajay Verma, Joseph A. Califano

Clin Cancer Res. Author manuscript; available in PMC 2010 Jan 15.

Published in final edited form as: Clin Cancer Res. 2009 Jan 15; 15(2): 476–484. doi: 10.1158/1078-0432.CCR-08-0930

PMCID:: PMC2729126

Abstract Article PDF–1.5M

Select item 122016012.

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.

T Kobayashi, P Cohen

Biochem J. 1999 Apr 15; 339(Pt 2): 319–328.

PMCID:: PMC1220160

Summary PDF–291K

Select item 122274313.

Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex.

Alina Tuganova, Igor Boulatnikov, Kirill M Popov

Biochem J. 2002 Aug 15; 366(Pt 1): 129–136. doi: 10.1042/BJ20020301

PMCID:: PMC1222743

Summary PDF–237K

Select item 122203314.

Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites.

E Kolobova, A Tuganova, I Boulatnikov, K M Popov

Biochem J. 2001 Aug 15; 358(Pt 1): 69–77. doi: 10.1042/0264-6021:3580069

PMCID:: PMC1222033

Summary PDF–195K

Select item 652630515.

SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism

Shuaiyi Chen, Xin Yang, Miao Yu, Zhe Wang, Boya Liu, Minghui Liu, Lu Liu, Mengmeng Ren, Hao Qi, Junhua Zou, Ivana Vucenik, Wei-Guo Zhu, Jianyuan Luo

Neoplasia. 2019 Jul; 21(7): 665–675. Published online 2019 May 17. doi: 10.1016/j.neo.2019.04.008

PMCID:: PMC6526305

Abstract Article PDF–2.3M

Select item 555729216.

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

Kyuho Han, Edwin E. Jeng, Gaelen T. Hess, David W. Morgens, Amy Li, Michael C. Bassik

Nat Biotechnol. Author manuscript; available in PMC 2017 Sep 20.

Published in final edited form as: Nat Biotechnol. 2017 May; 35(5): 463–474. Published online 2017 Mar 20. doi: 10.1038/nbt.3834

PMCID:: PMC5557292

Abstract Article PDF–3.4M

Select item 499245617.

Mitochondrial protein interaction mapping identifies new regulators of respiratory chain function

Brendan J. Floyd, Emily M. Wilkerson, Mike T. Veling, Catie E. Minogue, Chuanwu Xia, Emily T. Beebe, Russell L. Wrobel, Holly Cho, Laura S. Kremer, Charlotte L. Alston, Katarzyna A. Gromek, Brendan K. Dolan, Arne Ulbrich, Jonathan A. Stefely, Sarah L. Bohl, Kelly M. Werner, Adam Jochem, Michael S. Westphall, Jarred W. Rensvold, Robert W. Taylor, Holger Prokisch, Jung-Ja P. Kim, Joshua J. Coon, David J. Pagliarini

Mol Cell. Author manuscript; available in PMC 2017 Aug 18.

Published in final edited form as: Mol Cell. 2016 Aug 18; 63(4): 621–632. Published online 2016 Aug 4. doi: 10.1016/j.molcel.2016.06.033

PMCID:: PMC4992456

Abstract Article PDF–1.7M

Select item 294347618.

Genetic Variants in Nuclear-Encoded Mitochondrial Genes Influence AIDS Progression

Sher L. Hendrickson, James A. Lautenberger, Leslie Wei Chinn, Michael Malasky, Efe Sezgin, Lawrence A. Kingsley, James J. Goedert, Gregory D. Kirk, Edward D. Gomperts, Susan P. Buchbinder, Jennifer L. Troyer, Stephen J. O'Brien

PLoS One. 2010; 5(9): e12862. Published online 2010 Sep 21. doi: 10.1371/journal.pone.0012862

PMCID:: PMC2943476

Abstract Article PDF–461K

Select item 586483219.

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations

Xiaonan Liu, Kari Salokas, Fitsum Tamene, Yaming Jiu, Rigbe G. Weldatsadik, Tiina Öhman, Markku Varjosalo

Nat Commun. 2018; 9: 1188. Published online 2018 Mar 22. doi: 10.1038/s41467-018-03523-2

PMCID:: PMC5864832

Abstract Article PDF–4.5M

Select item 742732720.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

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