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Select item 14602341.

Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinase.

D S Olsen, B Jordan, D Chen, R C Wek, D R Cavener

Genetics. 1998 Jul; 149(3): 1495–1509. doi: 10.1093/genetics/149.3.1495

PMCID:: PMC1460234

Summary PDF–462K

Select item 101132842.

Prion disease modelled in Drosophila

Raymond Bujdoso, Andrew Smith, Oliver Fleck, John Spiropoulos, Olivier Andréoletti, Alana M. Thackray

Cell Tissue Res. 2023; 392(1): 47–62. Published online 2022 Jan 29. doi: 10.1007/s00441-022-03586-0

PMCID:: PMC10113284

Abstract Article PDF–2.2M

Select item 97487703.

Restricting a single amino acid cross-protects Drosophila melanogaster from nicotine poisoning through mTORC1 and GCN2 signalling

Tahlia L. Fulton, Christen K. Mirth, Matthew D. W. Piper

Open Biol. 2022 Dec; 12(12): 220319. Published online December 14, 2022. doi: 10.1098/rsob.220319

PMCID:: PMC9748770

Abstract Article PDF–954K

Select item 92613694.

The Role of GCN2 Kinase in Mediating the Effects of Amino Acids on Longevity and Feeding Behaviour in Drosophila

Anchal Srivastava, Jiongming Lu, Dennis Said Gadalla, Oliver Hendrich, Sebastian Grönke, Linda Partridge

Front Aging. 2022; 3: 944466. Published online 2022 Jun 21. doi: 10.3389/fragi.2022.944466

PMCID:: PMC9261369

Abstract Article PDF–4.3M

Select item 88889755.

Target of Rapamycin Drives Unequal Responses to Essential Amino Acid Depletion for Egg Laying in Drosophila Melanogaster

André N. Alves, Carla M. Sgrò, Matthew D. W. Piper, Christen K. Mirth

Front Cell Dev Biol. 2022; 10: 822685. Published online 2022 Feb 16. doi: 10.3389/fcell.2022.822685

PMCID:: PMC8888975

Abstract Article PDF–2.6M

Select item 102898126.

Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons

Théodore Grenier, Jessika Consuegra, Mariana G Ferrarini, Houssam Akherraz, Longwei Bai, Yves Dusabyinema, Isabelle Rahioui, Pedro Da Silva, Benjamin Gillet, Sandrine Hughes, Cathy I Ramos, Renata C Matos, François Leulier

eLife. 2023; 12: e76584. Published online 2023 Jun 9. doi: 10.7554/eLife.76584

PMCID:: PMC10289812

Abstract Article PDF–7.7M

Select item 35274467.

BUHO: A MATLAB Script for the Study of Stress Granules and Processing Bodies by High-Throughput Image Analysis

Marcelo Perez-Pepe, Victoria Slomiansky, Mariela Loschi, Luciana Luchelli, Maximiliano Neme, María Gabriela Thomas, Graciela Lidia Boccaccio

PLoS One. 2012; 7(12): e51495. Published online 2012 Dec 20. doi: 10.1371/journal.pone.0051495

PMCID:: PMC3527446

Abstract Article PDF–538K

Select item 3020138.

Association of GCN1–GCN20 regulatory complex with the N-terminus of eIF2α kinase GCN2 is required for GCN2 activation

Minerva Garcia-Barrio, Jinsheng Dong, Sandra Ufano, Alan G. Hinnebusch

EMBO J. 2000 Apr 17; 19(8): 1887–1899. doi: 10.1093/emboj/19.8.1887

PMCID:: PMC302013

Abstract Article PDF–835K

Select item 56145619.

PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila

Martin Borch Jensen, Yanyan Qi, Rebeccah Riley, Liya Rabkina, Heinrich Jasper

eLife. 2017; 6: e26952. Published online 2017 Sep 11. doi: 10.7554/eLife.26952

Correction in:: eLife. 2018; 7: e37316.

PMCID:: PMC5614561

Abstract Article PDF–2.1M

Select item 375277910.

Akt determines cell fate through the negative regulation of the PERK-eIF2α phosphorylation pathway

Zineb Mounir, Jothi Latha Krishnamoorthy, Shuo Wang, Barbara Papadopoulou, Shirley Campbell, William J. Muller, Maria Hatzoglou, Antonis E. Koromilas

Sci Signal. Author manuscript; available in PMC 2013 Aug 26.

Published in final edited form as: Sci Signal. 2011 Sep 27; 4(192): ra62. doi: 10.1126/scisignal.2001630

PMCID:: PMC3752779

Abstract Article PDF–3.6M

Select item 1091986511.

Maintenance of proteostasis by Drosophila Rer1 is essential for competitive cell survival and Myc-driven overgrowth

Pranab Kumar Paul, Shruti Umarvaish, Shivani Bajaj, Rishana Farin S., Hrudya Mohan, Wim Annaert, Varun Chaudhary

PLoS Genet. 2024 Feb; 20(2): e1011171. Published online 2024 Feb 26. doi: 10.1371/journal.pgen.1011171

PMCID:: PMC10919865

Abstract Article PDF–9.8M

Select item 538402112.

dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective

Ivana Celardo, Susann Lehmann, Ana C Costa, Samantha HY Loh, L Miguel Martins

Cell Death Differ. 2017 Apr; 24(4): 638–648. Published online 2017 Feb 17. doi: 10.1038/cdd.2016.158

Correction in:: Cell Death Differ. 2019 Sep; 26(9): 1861.

PMCID:: PMC5384021

Abstract Article PDF–1.8M

Select item 364414113.

Coordinate regulation of eIF2α phosphorylation by PPP1R15 and GCN2 is required during Drosophila development

Elke Malzer, Małgorzata Szajewska-Skuta, Lucy E. Dalton, Sally E. Thomas, Nan Hu, Helen Skaer, David A. Lomas, Damian C. Crowther, Stefan J. Marciniak

J Cell Sci. 2013 Mar 15; 126(6): 1406–1415. doi: 10.1242/jcs.117614

PMCID:: PMC3644141

Abstract Article

Select item 1040427714.

Loss of Paip1 causes translation reduction and induces apoptotic cell death through ISR activation and Xrp1

Maoguang Xue, Fei Cong, Wanling Zheng, Ruoqing Xu, Xiaoyu Liu, Hongcun Bao, Ying Ying Sung, Yongmei Xi, Feng He, Jun Ma, Xiaohang Yang, Wanzhong Ge

Cell Death Discov. 2023; 9: 288. Published online 2023 Aug 5. doi: 10.1038/s41420-023-01587-8

PMCID:: PMC10404277

Abstract Article PDF–7.9M

Select item 893839615.

A protein-trap allele reveals roles for Drosophila ATF4 in photoreceptor degeneration, oogenesis and wing development

Deepika Vasudevan, Hidetaka Katow, Huai-Wei Huang, Grace Tang, Hyung Don Ryoo

Dis Model Mech. 2022 Mar 1; 15(3): dmm049119. Published online 2022 Mar 16. doi: 10.1242/dmm.049119

PMCID:: PMC8938396

Abstract Article

Select item 894056116.

The Biology of Aging in Insects: From Drosophila to Other Insects and Back

Daniel E.L. Promislow, Thomas Flatt, Russell Bonduriansky

Annu Rev Entomol. Author manuscript; available in PMC 2023 Jan 7.

Published in final edited form as: Annu Rev Entomol. 2022 Jan 7; 67: 83–103. Published online 2021 Sep 30. doi: 10.1146/annurev-ento-061621-064341

PMCID:: PMC8940561

Abstract Article PDF–596K

Select item 522359817.

4E-BP is a target of the GCN2–ATF4 pathway during Drosophila development and aging

Min-Ji Kang, Deepika Vasudevan, Kwonyoon Kang, Kyunggon Kim, Jung-Eun Park, Nan Zhang, Xiaomei Zeng, Thomas A. Neubert, Michael T. Marr, II, Hyung Don Ryoo

J Cell Biol. 2017 Jan 2; 216(1): 115–129. doi: 10.1083/jcb.201511073