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Select item 69335101.

Microtubules Stabilization by Mutant Spastin Affects ER Morphology and Ca²⁺ Handling

Nicola Vajente, Rosa Norante, Nelly Redolfi, Andrea Daga, Paola Pizzo, Diana Pendin

Front Physiol. 2019; 10: 1544. Published online 2019 Dec 20. doi: 10.3389/fphys.2019.01544

PMCID:: PMC6933510

Abstract Article PDF–1.0M

Select item 67618292.

An allosteric network in spastin couples multiple activities required for microtubule severing

Colby R. Sandate, Agnieszka Szyk, Elena Zehr, Gabriel C. Lander, Antonina Roll-Mecak

Nat Struct Mol Biol. Author manuscript; available in PMC 2020 Jan 8.

Published in final edited form as: Nat Struct Mol Biol. 2019 Aug; 26(8): 671–678. Published online 2019 Jul 8. doi: 10.1038/s41594-019-0257-3

Correction in:: Nat Struct Mol Biol. 2020 Mar 19

PMCID:: PMC6761829

Abstract Article PDF–2.2M

Select item 64311583.

Spastin is a dual-function enzyme that severs microtubules and promotes their regrowth to increase the number and mass of microtubules

Yin-Wei Kuo, Olivier Trottier, Mohammed Mahamdeh, Jonathon Howard

Proc Natl Acad Sci U S A. 2019 Mar 19; 116(12): 5533–5541. Published online 2019 Mar 5. doi: 10.1073/pnas.1818824116

PMCID:: PMC6431158

Abstract Article PDF–1.8M

Select item 45448894.

Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders

Surya T. Madabattula, Joel C. Strautman, Andrew M. Bysice, Julia A. O’Sullivan, Alaura Androschuk, Cory Rosenfelt, Kacy Doucet, Guy Rouleau, Francois Bolduc

J Vis Exp. 2015; (100): 52741. Published online 2015 Jun 13. doi: 10.3791/52741

PMCID:: PMC4544889

Abstract Article PDF–316K

Select item 43952725.

Spastin Binds to Lipid Droplets and Affects Lipid Metabolism

Chrisovalantis Papadopoulos, Genny Orso, Giuseppe Mancuso, Marija Herholz, Sentiljana Gumeni, Nimesha Tadepalle, Christian Jüngst, Anne Tzschichholz, Astrid Schauss, Stefan Höning, Aleksandra Trifunovic, Andrea Daga, Elena I. Rugarli

PLoS Genet. 2015 Apr; 11(4): e1005149. Published online 2015 Apr 13. doi: 10.1371/journal.pgen.1005149

PMCID:: PMC4395272

Abstract Article PDF–4.5M

Select item 35135606.

Normal spastin gene dosage is specifically required for axon regeneration

Michelle C. Stone, Kavitha Rao, Kyle W. Gheres, Seahee Kim, Juan Tao, Caroline La Rochelle, Christin T. Folker, Nina T. Sherwood, Melissa M. Rolls

Cell Rep. Author manuscript; available in PMC 2012 Dec 4.

Published in final edited form as: Cell Rep. 2012 Nov 29; 2(5): 1340–1350. Published online 2012 Nov 1. doi: 10.1016/j.celrep.2012.09.032

PMCID:: PMC3513560

Abstract Article PDF–6.3M

Select item 26801117.

Mechanical control of global cell behaviour during dorsal closure in Drosophila

Nicole Gorfinkiel, Guy B. Blanchard, Richard J. Adams, Alfonso Martinez Arias

Development. 2009 Jun 1; 136(11): 1889–1898. Published online 2009 Apr 29. doi: 10.1242/dev.030866

PMCID:: PMC2680111

Abstract Article

Select item 12658578.

Genny Orso, Andrea Martinuzzi, Maria Giovanna Rossetto, Elena Sartori, Mel Feany, Andrea Daga

J Clin Invest. 2005 Nov 1; 115(11): 3026–3034. doi: 10.1172/JCI24694

PMCID:: PMC1265857

Abstract Article PDF–765K

Select item 96827309.

The enhanced association between mutant CHMP2B and spastin is a novel pathological link between frontotemporal dementia and hereditary spastic paraplegias

Yongping Chen, Gopinath Krishnan, Sepideh Parsi, Marine Pons, Veroniki Nikolaki, Lu Cao, Zuoshang Xu, Fen-Biao Gao

Acta Neuropathol Commun. 2022; 10: 169. Published online 2022 Nov 22. doi: 10.1186/s40478-022-01476-8

PMCID:: PMC9682730

Abstract Article PDF–2.0M

Select item 749982110.

Suppression of spastin Mutant Phenotypes by Pak3 Loss Implicates a Role for Reactive Glia in AD-HSP

Emily F. Ozdowski, Jill S. Wentzell, Stefanie M. Engert, Helena Abbott, Nina T. Sherwood

Front Neurosci. 2020; 14: 912. Published online 2020 Sep 4. doi: 10.3389/fnins.2020.00912

PMCID:: PMC7499821

Abstract Article PDF–3.2M

Select item 544915011.

Scaling of cytoskeletal organization with cell size in Drosophila

Alison K. Spencer, Andrew J. Schaumberg, Jennifer A. Zallen

Mol Biol Cell. 2017 Jun 1; 28(11): 1519–1529. doi: 10.1091/mbc.E16-10-0691

PMCID:: PMC5449150

Abstract Article PDF–3.8M

Select item 410732912.

Cold temperature improves mobility and survival in Drosophila models of autosomal-dominant hereditary spastic paraplegia (AD-HSP)

Sally L. Baxter, Denise E. Allard, Christopher Crowl, Nina Tang Sherwood

Dis Model Mech. 2014 Aug; 7(8): 1005–1012. Published online 2014 Jun 6. doi: 10.1242/dmm.013987

PMCID:: PMC4107329

Abstract Article

Select item 288279913.

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

Antonina Roll-Mecak, Ronald D. Vale

Nature. Author manuscript; available in PMC 2010 Jun 9.

Published in final edited form as: Nature. 2008 Jan 17; 451(7176): 363–367. doi: 10.1038/nature06482

PMCID:: PMC2882799

Abstract Article PDF–3.5M

Select item 287291814.

Clasp-mediated microtubule bundling regulates persistent motility and contact repulsion in Drosophila macrophages in vivo

Brian Stramer, Severina Moreira, Tom Millard, Iwan Evans, Chieh-Yin Huang, Ola Sabet, Martin Milner, Graham Dunn, Paul Martin, Will Wood

J Cell Biol. 2010 May 17; 189(4): 681–689. doi: 10.1083/jcb.200912134

PMCID:: PMC2872918

Abstract Article PDF–2.7M

Select item 286088915.

Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia

Fang Du, Emily F. Ozdowski, Ingrid K. Kotowski, Douglas A. Marchuk, Nina Tang Sherwood

Hum Mol Genet. 2010 May 15; 19(10): 1883–1896. Published online 2010 Feb 13. doi: 10.1093/hmg/ddq064

PMCID:: PMC2860889

Abstract Article PDF–548K

Select item 476419116.

Conserved pharmacological rescue of hereditary spastic paraplegia-related phenotypes across model organisms

Carl Julien, Alexandra Lissouba, Surya Madabattula, Yasmin Fardghassemi, Cory Rosenfelt, Alaura Androschuk, Joel Strautman, Clement Wong, Andrew Bysice, Julia O'sullivan, Guy A. Rouleau, Pierre Drapeau, J. Alex Parker, François V. Bolduc

Hum Mol Genet. 2016 Mar 15; 25(6): 1088–1099. Published online 2016 Jan 6. doi: 10.1093/hmg/ddv632