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Select item 108582291.

Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes

Mohamed H. Al-Sabri, Nourhane Ammar, Stanislava Korzh, Ahmed M. Alsehli, Kimia Hosseini, Robert Fredriksson, Jessica Mwinyi, Michael J. Williams, Hadi Boukhatmi, Helgi B. Schiöth

Sci Rep. 2024; 14: 3338. Published online 2024 Feb 9. doi: 10.1038/s41598-024-53446-w

PMCID:: PMC10858229

Abstract Article PDF–2.4M

Select item 87819692.

The Statin Target HMG-Coenzyme a Reductase (Hmgcr) Regulates Sleep Homeostasis in Drosophila

Ahmed M. Alsehli, Sifang Liao, Mohamed H. Al-Sabri, Lukas Vasionis, Archana Purohit, Neha Behare, Laura E. Clemensson, Michael J. Williams, Helgi B. Schiöth

Pharmaceuticals (Basel) 2022 Jan; 15(1): 79. Published online 2022 Jan 10. doi: 10.3390/ph15010079

PMCID:: PMC8781969

Abstract Article PDF–3.9M

Select item 32778373.

Suppressed Production of Methyl Farnesoid Hormones Yields Developmental Defects and Lethality in Drosophila Larvae

Davy Jones, Grace Jones, Peter Teal, Courey Hammac, Lexa Messmer, Kara Osborne, Yasser Hadj Belgacem, Jean-Rene Martin

Gen Comp Endocrinol. Author manuscript; available in PMC 2012 Feb 12.

Published in final edited form as: Gen Comp Endocrinol. 2010 Jan 15; 165(2): 244–254. Published online 2009 Jul 10. doi: 10.1016/j.ygcen.2009.07.006

PMCID:: PMC3277837

Abstract Article PDF–895K

Select item 3634834.

Developmental and metabolic regulation of the Drosophila melanogaster 3-hydroxy-3-methylglutaryl coenzyme A reductase.

F B Gertler, C Y Chiu, L Richter-Mann, D J Chin

Mol Cell Biol. 1988 Jul; 8(7): 2713–2721. doi: 10.1128/mcb.8.7.2713

PMCID:: PMC363483

Summary Page Browse PDF–1.8M

Select item 96885445.

Statins Induce Locomotion and Muscular Phenotypes in Drosophila melanogaster That Are Reminiscent of Human Myopathy: Evidence for the Role of the Chloride Channel Inhibition in the Muscular Phenotypes

Mohamed H. Al-Sabri, Neha Behare, Ahmed M. Alsehli, Samuel Berkins, Aadeya Arora, Eirini Antoniou, Eleni I. Moysiadou, Sowmya Anantha-Krishnan, Patricia D. Cosmen, Johanna Vikner, Thiago C. Moulin, Nourhene Ammar, Hadi Boukhatmi, Laura E. Clemensson, Mathias Rask-Andersen, Jessica Mwinyi, Michael J. Williams, Robert Fredriksson, Helgi B. Schiöth

Cells. 2022 Nov; 11(22): 3528. Published online 2022 Nov 8. doi: 10.3390/cells11223528

PMCID:: PMC9688544

Abstract Article PDF–7.8M

Select item 89465166.

The Statin Target Hmgcr Regulates Energy Metabolism and Food Intake through Central Mechanisms

Michael J. Williams, Ahmed M. Alsehli, Sarah N. Gartner, Laura E. Clemensson, Sifang Liao, Anders Eriksson, Kiriana Isgrove, Lina Thelander, Zaid Khan, Pavel M. Itskov, Thiago C. Moulin, Valerie Ambrosi, Mohamed H. Al-Sabri, Francisco Alejandro Lagunas-Rangel, Pawel K. Olszewski, Helgi B. Schiöth

Cells. 2022 Mar; 11(6): 970. Published online 2022 Mar 11. doi: 10.3390/cells11060970

PMCID:: PMC8946516

Abstract Article PDF–15M

Select item 18852587.

Live imaging of Drosophila gonad formation reveals roles for Six4 in regulating germline and somatic cell migration

Ivan BN Clark, Andrew P Jarman, David J Finnegan

BMC Dev Biol. 2007; 7: 52. Published online 2007 May 21. doi: 10.1186/1471-213X-7-52

PMCID:: PMC1885258

Abstract Article PDF–1.1M

Select item 65500218.

Functional analysis of Niemann-Pick disease type C family protein, NPC1a, in Drosophila melanogaster

Tzofia Bialistoky, Diane Manry, Peyton Smith, Christopher Ng, Yunah Kim, Sol Zamir, Victoria Moyal, Rachel Kalifa, Paul Schedl, Offer Gerlitz, Girish Deshpande

Development. 2019 May 15; 146(10): dev168427. Published online 2019 May 15. doi: 10.1242/dev.168427

PMCID:: PMC6550021

Abstract Article

Select item 57125259.

Cytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration

Xinping Chen, Hana Hall, Jeffrey P. Simpson, Walter D. Leon-Salas, Donald F. Ready, Vikki M. Weake

NPJ Aging Mech Dis. 2017; 3: 18. Published online 2017 Dec 4. doi: 10.1038/s41514-017-0019-6

PMCID:: PMC5712525

Abstract Article PDF–2.5M

Select item 177962310.

Hmgcr in the Corpus Allatum Controls Sexual Dimorphism of Locomotor Activity and Body Size via the Insulin Pathway in Drosophila

Yesser Hadj Belgacem, Jean-René Martin

PLoS One. 2007; 2(1): e187. Published online 2007 Jan 31. doi: 10.1371/journal.pone.0000187

PMCID:: PMC1779623

Abstract Article PDF–452K

Select item 13694011.

The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing

Jakob-Andreas Tschäpe, Christine Hammerschmied, Max Mühlig-Versen, Karin Athenstaedt, Günther Daum, Doris Kretzschmar

EMBO J. 2002 Dec 2; 21(23): 6367–6376. doi: 10.1093/emboj/cdf636

PMCID:: PMC136940

Abstract Article PDF–526K

Select item 260755612.

Gγ1, a Downstream Target for the hmgcr-Isoprenoid Biosynthetic Pathway, Is Required for Releasing the Hedgehog Ligand and Directing Germ Cell Migration

Girish Deshpande, Anuradha Godishala, Paul Schedl

PLoS Genet. 2009 Jan; 5(1): e1000333. Published online 2009 Jan 9. doi: 10.1371/journal.pgen.1000333

PMCID:: PMC2607556

Abstract Article PDF–1.1M

Select item 189461713.

toutvelu, a Regulator of Heparan Sulfate Proteoglycan Biosynthesis, Controls Guidance Cues for Germ-Cell Migration

Girish Deshpande, Nilay Sethi, Paul Schedl

Genetics. 2007 Jun; 176(2): 905–912. doi: 10.1534/genetics.107.071415

PMCID:: PMC1894617

Abstract Article PDF–2.1M

Select item 939637614.

Ginsenosides improve reproductive capability of aged female Drosophila through mechanism dependent on ecdysteroid receptor (ECR) and steroid signaling pathway

Baoyu Fu, Rui Ma, Fangbing Liu, Xuenan Chen, Xiaoyu Teng, Pengdi Yang, Jianzeng Liu, Daqing Zhao, Liwei Sun

Front Endocrinol (Lausanne) 2022; 13: 964069. Published online 2022 Aug 9. doi: 10.3389/fendo.2022.964069

PMCID:: PMC9396376

Abstract Article PDF–3.7M

Select item 436163715.

Methyl Farnesoate Plays a Dual Role in Regulating Drosophila Metamorphosis

Di Wen, Crisalejandra Rivera-Perez, Mohamed Abdou, Qiangqiang Jia, Qianyu He, Xi Liu, Ola Zyaan, Jingjing Xu, William G. Bendena, Stephen S. Tobe, Fernando G. Noriega, Subba R. Palli, Jian Wang, Sheng Li

PLoS Genet. 2015 Mar; 11(3): e1005038. Published online 2015 Mar 16. doi: 10.1371/journal.pgen.1005038